Collagenase(Advance Biofactures Corp.)

Oral presentations include additional comparative data between EscharEx® and SANTYL®, and new analyses show strong correlation between wound bed preparation and wound healing Analyses validate the planned design and endpoints of the upcoming Phase III study YAVNE, Israel, April 25, 2024 (GLOBE NEWSWIRE) -- MediWound Ltd. (Nasdaq: MDWD), the global leader in next-generation enzymatic therapeutics for tissue repair, announced today that recent clinical data from EscharEx® Phase II studies will be presented throughout May 2024 at the largest, most prestigious annual meetings in the field of chronic wound care: the European Wound Management Association (EWMA), the Wound Healing Society (WHS), and the Symposium on Advanced Wound Care (SAWC). The oral presentations on EscharEx will include: Comparative data of EscharEx vs. SANTYL® that demonstrate EscharEx’s superiority over the current leading enzymatic debridement agentNew analyses from the ChronEx phase II study, showing high correlation between wound bed preparation and wound healing These data indicate that EscharEx could substantially improve wound care for patients with debilitating chronic wounds, providing significant benefits over the current standard of care. Additionally, the findings support the design and endpoints of the upcoming Phase III study, which is expected to begin in the second half of 2024. "We are delighted to present the results of additional analyses from EscharEx Phase II studies in chronic hard-to-heal wounds, including the positive comparative data with SANTYL®, the current dominant standard of care for enzymatic debridement," said Dr. Robert J. Snyder, Chief Medical Officer of MediWound. "With its robust efficacy, favorable safety profile, and multimodal mechanistic effects demonstrated in these Phase II studies, we believe that EscharEx can significantly advance wound care and has the potential to become a major player in the global wound care market." 2024 European Wound Management Association (EWMA), London, United KingdomTime:May 1, at 11:45amTitle:Comparison of bromelain-based enzymatic debridement to collagenase ointmentPresenter:Cyaandi R. Dove, DPM Time:May 3, at 8:30amTitle:VLU wound bed preparation is highly correlated with wound closurePresenter:Robert J. Snyder, DPM, MSc, MBA 2024 Wound Healing Society Conference (WHS), Orlando, FloridaTime:May 16, at 10:30amTitle:Comparison of bromelain-based enzymatic debridement to collagenase SANTYL® ointmentPresenter:Cyaandi R. Dove, DPM Time:May 16, at 10:30amTitle:VLU wound bed preparation is highly correlated with wound closure Presenter:Marissa Carter, MA, PhD 2024 Symposium on Advanced Wound Care (SAWC), Orlando, FloridaTime:May 17, at 7:30amLocation:SAWC Innovation TheaterTitle:EscharEx, an innovative multimodal enzymatic debridement agent for the treatment of chronic woundsPresenters:Vickie R. Driver, DPM, MS, FACFAS, John C. Lantis, MD, Cyaandi R. Dove, DPM, and Robert J. Snyder, DPM, will discuss the importance of wound bed preparation in wound healing, EscharEx’s mechanism of action, results from the ChronEx Phase II study including case studies showcasing the treatment experience, and the design of the upcoming Phase III study in venous leg ulcers (VLU) About EscharEx EscharEx® is a bioactive, multimodal debridement therapy for the treatment of chronic and other hard-to-heal wounds, currently in advanced stages of clinical development. It is a concentrate of proteolytic enzymes enriched with bromelain for topical, easy to use daily applications. In several Phase II trials, EscharEx was shown to be safe and well-tolerated. It demonstrated efficacy in debridement, the promotion of granulation tissue, and the reduction of bioburden and biofilm in various hard-to-heal wounds. EscharEx’s mechanism of action is mediated by a mixture of multiple proteolytic enzymes that remove non-viable tissue preparing the wound bed for healing. A Phase III study in patients with VLU, is planned to start in the second half of 2024. About MediWound MediWound Ltd. (Nasdaq: MDWD) is the global leader in next-generation enzymatic therapeutics focused on non-surgical tissue repair. MediWound specializes in the development, production and commercialization of solutions that seek to improve existing standards of care. The Company is committed to providing rapid and effective biologics that improve patient experiences and outcomes, while reducing costs and unnecessary surgeries. MediWound’s first drug, NexoBrid®, is an FDA and EMA-approved orphan biologic for eschar removal in deep partial-thickness and/or full-thickness thermal burns, which can significantly reduce surgical interventions. Utilizing the same core biotherapeutic enzymatic platform technology, MediWound has developed a strong R&D pipeline, including the company’s lead drug under development, EscharEx®. EscharEx is a Phase III-ready biologic for the debridement of chronic wounds, offering significant potential advantages over the dominant $360+ million product and an opportunity to expand the market. For more information visit www.mediwound.com and follow the Company on LinkedIn and X. About European Wound Management Association (EWMA) The EWMA is a European not-for-profit umbrella organization, linking national wound management organizations, individuals and groups with interest in wound care. EWMA was established in 1991 as a charity organization registered in the UK. Central to EWMA’s objectives is to support implementation of interdisciplinary and cost-effective wound care of high quality. EWMA works to reach its objectives by being an educational resource, organizing conferences, contributing to international projects related to wound management, actively supporting the implementation of existing knowledge within wound management and providing information on all aspects of wound management. EWMA was founded in 1991, and the association works to promote the advancement of education and research into native epidemiology, pathology, diagnosis, prevention and management of wounds of all etiologies. About Symposium on Advanced Wound Care (SAWC) The SAWC, the official bi-annual meeting site of the Wound Healing Society, is the world’s most comprehensive wound event of the year featuring scientific abstracts highlighting updates on the most critical topics in wound care. The SAWC Spring, now in its 37th year, serves as a forum to connect the entire wound care team, physicians (DO, DPM, MD), nurses, physical therapists, researchers, scientists, and dietitians, with the foremost experts in wound care to improve patient outcomes through education. About Wound Healing Society (WHS) Founded in 1989, the Wound Healing Society (WHS) is the premier scientific organization focused on wound healing. A nonprofit organization composed of clinical and basic scientists and wound care specialists, the mission of the WHS is to improve wound healing outcomes through science, professional education, and communication. The WHS provides a forum for interaction among scientists, clinicians, and other wound care practitioners, industrial representatives, and government agencies. The WHS is open to individuals who are interested in the field of wound healing and presently comprises more than 500 members in the United States and other countries. The Society’s journal, Wound Repair and Regeneration, is the leading journal in the discipline. The WHS also publishes a periodical called Advances in Wound Care, an authoritative desktop reference for all wound care professionals. Cautionary Note Regarding Forward-Looking Statements MediWound cautions you that all statements other than statements of historical fact included in this press release that address activities, events, or developments that we expect, believe, or anticipate will or may occur in the future are forward-looking statements. Although we believe that we have a reasonable basis for the forward-looking statements contained herein, they are based on current expectations about future events affecting us and are subject to risks, assumptions, uncertainties, and factors, all of which are difficult to predict and many of which are beyond our control. Actual results may differ materially from those expressed or implied by the forward-looking statements in this press release. These statements are often, but are not always, made through the use of words or phrases such as “anticipates,” “intends,” “estimates,” “plans,” “expects,” “continues,” “believe,” “guidance,” “outlook,” “target,” “future,” “potential,” “goals” and similar words or phrases, or future or conditional verbs such as “will,” “would,” “should,” “could,” “may,” or similar expressions.Specifically, this press release contains forward-looking statements concerning the anticipated progress, development, study design, expected data timing, objectives anticipated timelines, expectations and commercial potential of our products and product candidates, including EscharEx®. Among the factors that may cause results to be materially different from those stated herein are the inherent uncertainties associated with the uncertain, lengthy and expensive nature of the product development process; the timing and conduct of our studies of our products and product candidates, including the timing, progress and results of current and future clinical studies, and our research and development programs; the approval of regulatory submission by the FDA, the European Medicines Agency or by any other regulatory authority, our ability to obtain marketing approval of our products and product candidates in the U.S. or other markets; the clinical utility, potential advantages and timing or likelihood of regulatory filings and approvals of our products and products; our expectations regarding future growth, including our ability to develop new products; market acceptance of our products and product candidates; our ability to maintain adequate protection of our intellectual property; competition risks; the need for additional financing; the impact of government laws and regulations and the impact of the current global macroeconomic climate on our ability to source supplies for our operations or our ability or capacity to manufacture, sell and support the use of our products and product candidates in the future. These and other significant factors are discussed in greater detail in MediWound’s annual report on Form 20-F for the year ended December 31, 2023, filed with the Securities and Exchange Commission (“SEC”) on March 21, 2024 and Quarterly Reports on Form 6-K and other filings with the SEC from time-to-time. These forward-looking statements reflect MediWound’s current views as of the date hereof and MediWound undertakes, and specifically disclaims, any obligation to update any of these forward-looking statements to reflect a change in their respective views or events or circumstances that occur after the date of this release except as required by law.

$19 million revenue in 2023; $24 million projected revenue in 2024NexoBrid® commercially launched in U.S., Japan, IndiaPotential blockbuster EscharEx® to begin Phase III in the second half of 2024$42 million cash runway through profitability Conference call today, March 21 at 8:30am Eastern Time YAVNE, Israel, March 21, 2024 (GLOBE NEWSWIRE) -- MediWound Ltd. (Nasdaq: MDWD), the global leader in next-generation enzymatic therapeutics for tissue repair, today announced financial results for the fourth quarter and full year ended December 31, 2023, and provided a corporate update. “2023 was an exceptional year for NexoBrid driven by new market launches, expanded indications, substantial new governmental grants, and increased global demand. Additionally, this lifesaving treatment was successfully battle-tested in real-life burn mass casualty incidents (BMCI) during the war in Israel. Furthermore, the full capacity of our new manufacturing facility in 2025 will enable us to meet the soaring demand of NexoBrid,” said Ofer Gonen, CEO of MediWound. “Recent clinical data further validates our pipeline product, EscharEx, demonstrating that it significantly outperformed SANTYL® in a head-to-head comparative analysis. The product has attracted research collaborations with industry leaders 3M, Mölnlycke and MIMEDX and the Phase III study is set to begin in the second half of 2024. We strongly believe in the exciting future ahead for MediWound.” 2023 Highlights and Recent Developments: NexoBrid® Expanded commercial availability to U.S., Japan, and India, leading to $19 million revenue in 2023, and a surge of orders for 2024, with $24 million projected revenue.Construction of a new GMP-compliant state-of-the-art manufacturing facility is on track for mid-2024 completion. It is projected to achieve a 6-fold manufacturing capacity increase in 2025.Commercial Activities: Launched in the U.S. by Vericel Corp, with more than 50 burn centers submitting packages to Pharmacy and Therapeutics (P&T) committees and more than 25 already approved. Furthermore, the Centers for Medicare & Medicaid Services (CMS) awarded NexoBrid a permanent J code and granted it transitional pass-through payment status, enhancing its accessibility and reimbursement potential.Launched in Japan through Kaken Pharmaceuticals, and in India through Bharat Serums and Vaccines (BSV).Expanded European market presence by establishing a collaboration with PolyMedics Innovations (PMI) for the promotion of NexoBrid in Germany, Austria, Belgium, the Netherlands, and Luxembourg.Successfully fulfilled emergency demand in Israel to treat mass burn casualties resulting from the war, consuming all available non-U.S. inventory. Government Funding: Awarded $13.0 million R&D funding by U.S. Department of Defense (DoD) to develop and produce a new NexoBrid temperature stable formulation for use as a non-surgical solution for field-care burn treatment for the U.S. Army.Awarded $10.1 million in additional funding from the Biomedical Advanced Research and Development Authority (BARDA) for emergency preparedness product replenishment and R&D activities. Pediatric label expansion: Gained European Commission approval for the removal of eschar in deep partial- and full-thickness thermal burns for all ages.Supplemental BLA for pediatric indication accepted for review by the U.S. Food and Drug Administration (FDA). Decision expected in the second half of 2024. EscharEx® Aligned the Phase III study protocol with the European Medicine Agency (EMA) and the FDA, and expected to submit a final protocol in the first half of 2024. 216 patients will be treated globally across 40 sites with either EscharEx or a gel vehicle placebo, with an interim assessment to be performed once 67% of participants complete the study. Study initiation is expected in the second half of 2024.Established research collaborations with 3M, Mölnlycke and MIMEDX to support the EscharEx Phase III clinical study.Conducted head-to-head comparative analysis of EscharEx vs SANTYL®. Data from a Phase II randomized controlled study demonstrated significant superiority of EscharEx over SANTYL in multiple clinical outcome measures: incidence of complete debridement; median time to achieve complete debridement; incidence of achieving wound bed preparation (WBP); median time to achieve WBP; and time to wound closure. The data is scheduled for oral presentation in May 2024 at three leading annual congresses dedicated to advanced wound care: The Wound Healing Society (WHS), the Symposium on Advanced Wound Care (SAWC), and the European Wound Management Association (EWMA). MW005 Reported positive results of the Phase I/II study to evaluate the safety and efficacy of MW005 in the treatment of low-risk Basal Cell Carcinoma (BCC). The data showed MW005 to be safe and well-tolerated, with patients achieving complete clinical and histological clearance of their target lesions. Fourth Quarter 2023 Financial Highlights Revenue: Revenue for the fourth quarter 2023 was $5.3 million, compared to $11.6 million in the fourth quarter of 2022. The decrease is primarily attributed to the BLA approval milestone payment from Vericel.Gross Profit: Gross profit in the fourth quarter 2023 was $0.7 million, representing 13.5% of the total revenue in the fourth quarter of 2023, compared to $8.2 million, representing 70.2% of total revenue in the fourth quarter of 2022. The decrease is primarily attributed to the BLA approval milestone payment from Vericel in the fourth quarter of 2022.Expenditures: Research and development expenses in the fourth quarter 2023 were $1.8 million compared to $2.7 million in the fourth quarter of 2022. This change is primarily attributed to the completion of EscharEx phase II study in 2022.Selling, general, and administrative expenses in the fourth quarter 2023 were $2.8 million, compared to $3.0 million in the fourth quarter of 2022. Operating Results: Operating loss in the fourth quarter of 2023 was $3.9 million, compared to an operating profit of $2.1 million in the fourth quarter of 2022.Net Loss: Net loss in the fourth quarter of 2023 was $1.7 million or $0.19 per share, compared to the net loss of $7.5 million, or $1.18 per share in the fourth quarter of 2022. The decrease is primarily attributed to a favorable adjustment from the revaluation of warrants.Non-GAAP Adjusted EBITDA: Adjusted EBITDA in the fourth quarter of 2023 was a loss of $3.2 million, compared to a profit of $3.4 million in the fourth quarter of 2022. Full Year 2023 Financial Highlights Revenue: Revenue for the year ended December 31, 2023, was $18.7 million, compared to $26.5 million for the year ended December 31, 2022. The decrease is primarily attributed to the BLA approval milestone payment from Vericel.Gross Profit: Gross profit for the year ended December 31, 2023, was $3.6 million with a gross margin of 19.1%, compared to $13.2 million with a gross margin of 49.7% in the prior year period. The decrease is primarily attributed to the BLA approval milestone payment from Vericel.Expenditures: Research and development expenses for the year ended December 31, 2023, were $7.5 million compared to $10.2 million in the prior year.Selling, general, and administrative expenses for the year ended December 31, 2023, were $11.6 million, compared to $10.6 million in the prior year. Operating Results: Operating loss for the year ended December 31, 2023, was $15.3 million, compared to an $8.3 million loss in the year ended December 31, 2022.Net Loss: Net loss in the year ended December 31, 2023 was $6.7 million or $0.75 per share, compared to the net loss of $19.6 million, or $3.93 per share for the year ended December 31, 2022.Non-GAAP Adjusted EBITDA: Adjusted EBITDA for the year ended December 31, 2023 was a loss of $12.3 million, compared to a loss of $4.4 million for the year ended December 31, 2022. Balance Sheet Highlights As of December 31, 2023, the Company’s cash, restricted cash, and investments were $42.1 million, compared to $34.1 million reported on December 31, 2022. In the first quarter of 2023, the Company raised a gross amount of $27.5 million through a registered direct offering. The company used $17.1 million to fund its activities. The existing cash and restricted cash, and investments will provide sufficient funds through profitability. Conference Call MediWound management will host a conference call for investors on Thursday, March 21, 2024, beginning at 8:30 a.m., Eastern Time to discuss these results and answer questions. Shareholders and other interested parties may participate in the conference call by dialing 1-833-630-1956 (in the U.S.), 1-80-921-2373 (Israel), or 1-412-317-1837 (outside the U.S. & Israel). The call will be available via webcast by clicking HERE or on the Events & Presentations page of Company’s website. A replay of the call will be available on the Company’s website at www.mediwound.com. Non-IFRS Financial Measures To supplement consolidated financial statements prepared and presented in accordance with IFRS, the Company has provided a supplementary non-IFRS measure to consider in evaluating the Company’s performance. Management uses Adjusted EBITDA, which it defines as earnings before interest, taxes, depreciation and amortization, impairment, one-time expenses, restructuring and share-based compensation expenses. Although Adjusted EBITDA is not a measure of performance or liquidity calculated in accordance with IFRS, we believe the non-IFRS financial measures we present provide meaningful supplemental information regarding our operating results primarily because they exclude certain non-cash charges or items that we do not believe are reflective of our ongoing operating results when budgeting, planning and forecasting and determining compensation, and when assessing the performance of our business with our senior management. However, investors should not consider these measures in isolation or as substitutes for operating income, cash flows from operating activities or any other measure for determining the Company’s operating performance or liquidity that is calculated in accordance with IFRS. In addition, because Adjusted EBITDA is not calculated in accordance with IFRS, it may not necessarily be comparable to similarly titled measures employed by other companies. The non-IFRS measures included in this press release have been reconciled to the IFRS results in the tables below. About MediWound MediWound Ltd. (Nasdaq: MDWD) is the global leader in next-generation enzymatic therapeutics focused on non-surgical tissue repair. The Company specializes in the development, production and commercialization of solutions that seek to improve existing standards of care. MediWound is committed to providing rapid and effective biologics that improve patient experiences and outcomes, while reducing costs and unnecessary surgeries. MediWound’s first drug, NexoBrid®, is an FDA-approved orphan biologic for eschar removal in severe burns that can replace surgical interventions and minimize associated costs and complications. Utilizing the same core biotherapeutic enzymatic platform technology, MediWound has developed a strong R&D pipeline including the Company’s lead drug under development, EscharEx®. EscharEx is a Phase III-ready biologic for debridement of chronic wounds with significant potential advantages over the $360 million dominant product and an opportunity to expand the market. MediWound’s pipeline also includes MW005, a topical therapeutic for the treatment of basal cell carcinoma that has demonstrated positive results in a Phase I/II study. For more information visit www.mediwound.com and follow the Company on LinkedIn and X. Cautionary Note Regarding Forward-Looking Statements MediWound cautions you that all statements other than statements of historical fact included in this press release that address activities, events, or developments that we expect, believe, or anticipate will or may occur in the future are forward-looking statements. Although we believe that we have a reasonable basis for the forward-looking statements contained herein, they are based on current expectations about future events affecting us and are subject to risks, assumptions, uncertainties, and factors, all of which are difficult to predict and many of which are beyond our control. Actual results may differ materially from those expressed or implied by the forward-looking statements in this press release. These statements are often, but are not always, made through the use of words or phrases such as “anticipates,” “intends,” “estimates,” “plans,” “expects,” “continues,” “believe,” “guidance,” “outlook,” “target,” “future,” “potential,” “goals” and similar words or phrases, or future or conditional verbs such as “will,” “would,” “should,” “could,” “may,” or similar expressions.Specifically, this press release contains forward-looking statements concerning the anticipated progress, development, study design, expected data timing, objectives anticipated timelines, expectations and commercial potential of our products and product candidates, including EscharEx® and NexoBrid®. Among the factors that may cause results to be materially different from those stated herein are the inherent uncertainties associated with the uncertain, lengthy and expensive nature of the product development process; the timing and conduct of our studies of our products and product candidates, including the timing, progress and results of current and future clinical studies, and our research and development programs; the approval of regulatory submission by the FDA, the European Medicines Agency or by any other regulatory authority, our ability to obtain marketing approval of our products and product candidates in the U.S. or other markets; the clinical utility, potential advantages and timing or likelihood of regulatory filings and approvals of our products and products; our expectations regarding future growth, including our ability to develop new products; risks related to our contracts with BARDA; market acceptance of our products and product candidates; our ability to maintain adequate protection of our intellectual property; competition risks; the need for additional financing; the impact of government laws and regulations and the impact of the current global macroeconomic climate on our ability to source supplies for our operations or our ability or capacity to manufacture, sell and support the use of our products and product candidates in the future. These and other significant factors are discussed in greater detail in MediWound’s annual report on Form 20-F for the year ended December 31, 2023, filed with the Securities and Exchange Commission (“SEC”) on March 21, 2024 and Quarterly Reports on Form 6-K and other filings with the SEC from time-to-time. These forward-looking statements reflect MediWound’s current views as of the date hereof and MediWound undertakes, and specifically disclaims, any obligation to update any of these forward-looking statements to reflect a change in their respective views or events or circumstances that occur after the date of this release except as required by law. Contacts: Hani LuxenburgDaniel FerryChief Financial OfficerManaging Director, LifeSci AdvisorsMediWound Ltd.617-430-7576ir@mediwound.comdaniel@lifesciadvisors.com Media Contact: Ellie Hanson FINN Partners for MediWound ellie.hanson@finnpartners.com 929-588-2008 MediWound, Ltd. Audited Condensed Consolidated Statements of Financial PositionU.S. dollars in thousands Dec 31, 2023 2022CURRENT ASSTS: Cash and cash equivalents and short-term deposits41,708 33,895Trade and other receivable5,141 9,982Inventories2,846 1,963Total current assets49,695 45,840 Non-current assets Other receivables673 364Property, plant and equipment, net9,228 2,366Right of use assets, net6,698 1,215Intangible assets, net165 231Total non-current assets16,764 4,176 Total assets66,459 50,016 CURRENT LIABILITIES: Current maturities of long-term liabilities1,410 2,242Trade payables and accrued expenses5,528 5,656Other payables3,891 4,159Total current liabilities10,829 12,057Warrants, net7,296 15,606Liabilities in respect of IIA grants7,677 7,445Liability in respect of TEVA2,256 2,788Lease liabilities6,350 846Severance pay liability, net456 360Total non-current liabilities24,035 27,045 Shareholders' equity31,595 10,914Total liabilities & equity66,459 50,016 MediWound, Ltd. Audited Condensed Consolidated Statements of Profit or Loss and Other Comprehensive Income or LossU.S. dollars in thousands (except of share and per share data) Twelve months ended Three months ended Dec 31, Dec 31, 2023 2022 2023 2022Total Revenues18,686 26,496 5,338 11,618Cost of revenues15,108 13,331 4,619 3,460Gross profit 3,578 13,165 719 8,158 Research and development7,467 10,181 1,808 2,699Selling and Marketing4,844 3,725 1,209 692General and administrative6,768 6,920 1,583 2,269Other (Income) expenses(211) 684 13 375Operating loss (15,290) (8,345) (3,894) 2,123 Financial income (expenses), net8,759 (11,176) 2,271 (9,515)Taxes on income(185) (78) (120) (65)Net loss (6,716) (19,599) (1,743) (7,457)Foreign currency translation adjustments(13) 14 (11) (20)Total comprehensive loss(6,729) (19,585) (1,754) (7,477) Basic and diluted loss per share: Net loss per share(0.75) (3.93) (0.19) (1.18) Weighted average number of ordinary shares9,013,144 4,987,069 9,219,923 6,332,981 MediWound, Ltd. Audited Condensed Consolidated Statements of Cash FlowsU.S. dollars in thousands Twelve months ended Three months ended Dec 31, Dec 31, 2023 2022 2023 2022 Audited UnauditedCash Flows from Operating Activities: Net Loss(6,716) (19,599) (1,743) (7,457)Adjustments to reconcile net loss to net cash used in operating activities: Adjustments to profit and loss items: Depreciation and amortization1,303 1,272 346 284Share-based compensation1,940 1,946 298 642Revaluation of warrants accounted at fair value(8,310) 8,977 (1,603) 8,977Issuance expenses of warrants through profit and loss- 1,911 - 1,523Revaluation of liabilities in respect of IIA grants427 (132) (282) (944)Revaluation of liabilities in respect of TEVA468 533 111 129Financing income and exchange differences of lease liability257 (109) 463 37Increase in severance liability, net83 109 3 45Other income(211) - 13 -Financial income, net(2,231) (74) (836) (408)Un-realized foreign currency loss (gain)189 525 (347) 60 (6,085) 14,958 (1,834) 10,345Changes in asset and liability items: Decrease (increase) in trade receivables5,658 (7,582) (528) (5,137)Decrease (increase) in inventories(906) (721) 782 (113)Decrease (increase) in other receivables(894) 364 (696) 221Increase (decrease) in trade payables and accrued expenses(594) 414 1,093 784Increase (decrease) in other payables(928) 281 311 2,107 2,336 (7,244) 962 (2,138)Net cash used in operating activities(10,465) (11,885) (2,615) 750 MediWound, Ltd. Audited Condensed Consolidated Statements of Cash FlowsU.S. dollars in thousands Cash Flows from Investing Activities: Purchase of property and equipment(6,464) (555) (2,209) (174)Interest received1,947 74 722 71Proceeds from (Investment in) short term bank deposits, net(29,804) - 6,515 2,499Net cash used in investing activities(34,321) (481) 5,028 2,396 Cash Flows from Financing Activities: Repayment of lease liabilities(778) (701) (204) (170)Proceeds from issuance of shares and warrants, net24,909 38,390 - 16,475Repayments of IIA grants, net(380) (258) - -Repayment of liabilities in respect of TEVA(834) (1,667) - (417)Net cash provided by (used in) financing activities22,917 35,764 (204) 15,588 Exchange rate differences on cash and cash equivalent balances(160) (549) 378 (44)Increase (decrease) in cash and cash equivalents(22,029) 22,849 2,587 18,990Balance of cash and cash equivalents at the beginning of the period33,895 11,046 9,279 14,905Balance of cash and cash equivalents at the end of the period11,866 33,895 11,866 33,895 MediWound, Ltd. Adjusted EBITDAU.S. dollars in thousands Twelve months ended Three months endedDec 31, Dec 31, 2023 2022 2023 2022Net loss (6,716) (19,599) (1,743) (7,457)Adjustments: Financial income (expenses), net8,759 (11,176) 2,271 (9,515)Other (Income) expenses, net211 (684) (13) (375)Taxes on income(185) (78) (120) (65)Depreciation and amortization(1,303) (1,272) (346) (284)Share-based compensation expenses(1,940) (1,946) (298) (642)Total adjustments5,542 (15,156) 1,494 (10,881)Adjusted EBITDA (12,258) (4,443) (3,237) 3,424