[11C]CPPC([11C]CPPC) - 药物靶点：CSF-1R_在研适应症：肌萎缩侧索硬化，新冠肺炎后遗症_专利_临床

概要

基本信息

药物类型

化学药、诊断用放射药物

别名-

靶点

CSF-1R

作用机制

CSF-1R调节剂(集落刺激因子1受体调节剂)、PET imaging(正电子发射断层成像术增强剂)

治疗领域

神经系统疾病内分泌与代谢疾病其他疾病+ [2]

在研适应症

肌萎缩侧索硬化新冠肺炎后遗症

非在研适应症-

原研机构

The Johns Hopkins University

在研机构

Defense Language Institute Foreign Language Center

The Johns Hopkins University

非在研机构-

最高研发阶段临床1/2期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

3

项与 [11C]CPPC 相关的临床试验

NCT05602142 / Not yet recruiting临床1/2期IIT

A Phase 1/2 Study of [11C]CPPC as a Clinical PET Radioligand Biomarker of Microglial Activation in ALS

1. Establish the safety and tolerability of the 5-cyano-N-(4-(4-[11C]Methylpiperazin-1-yl)-2-(Piperidin-1-yl)Phenyl)Furan-2-carboxamide ([11C]CPPC) PET radioligand in ALS patients and controls
2. Examine whether [11C]CPPC PET uptake is elevated in brains of ALS patients and whether there is a correlation with clinical phenotype.
3. Correlate [11C]CPPC PET imaging with other ALS outcome measures and biofluid biomarkers
4. Examine longitudinal changes in [11C]CPPC PET imaging during disease course.

开始日期2025-01-01

申办/合作机构

The Johns Hopkins University

[+1]

NCT06223971 / Recruiting早期临床1期IIT

A Phase l Study to Assess the Safety and Tolerability of PET Imaging With [11 C]CPPC [5-cyano-N-( 4-( 4-[l l CJ me1hylpiperazin-l-yl)-2-(Piperidin-l-yl)Phenyl)Furan-2-carboxamide] Radioligand and Magnetic Resonance (MR) Imaging in Patients With Long COVID.

The goal of this study is to evaluate the safety of using the [5-cyano-N-(4-(4-[11C]Methylpiperazin-1-yl)-2-(Piperidin-1-yl)Phenyl)Furan-2-carboxamide] ([11C]CPPC) radiotracer in positron emission tomography (PET) imaging of people with history of COVID-19 infection, with and without symptoms. The investigators are also interested to see whether use of this radiotracer reveals imaging differences between patients with history of COVID-19 infection and still exhibiting symptoms or healthy patients with history of COVID-19 infection but exhibiting no current symptoms.

开始日期2024-08-06

申办/合作机构

The Johns Hopkins University

[+1]

NCT04749433 / Terminated临床1期IIT

A Phase 1 Study to Assess the Safety and Tolerability of PET Imaging With [11C]CPPC [5-cyano-N-(4-(4-[11C]Methylpiperazin-1-yl)-2-(Piperidin-1-yl)Phenyl)Furan-2-carboxamide] Radioligand in Patients With Amyotrophic Lateral Sclerosis

The goal of this study is to evaluate the safety of using the [5-cyano-N-(4-(4-[11C]Methylpiperazin-1-yl)-2-(Piperidin-1-yl)Phenyl)Furan-2-carboxamide] ([11C]CPPC) radiotracer in positron emission tomography (PET) imaging of people with amyotrophic lateral sclerosis (ALS). The investigators are also interested to see whether use of this radiotracer reveals imaging differences between patients with ALS and healthy patients.

开始日期2021-09-01

申办/合作机构

The Johns Hopkins University

[+1]

100 项与 [11C]CPPC 相关的临床结果

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100 项与 [11C]CPPC 相关的转化医学

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100 项与 [11C]CPPC 相关的专利（医药）

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1

项与 [11C]CPPC 相关的文献（医药）

American Journal of Nuclear Medicine and Molecular Imaging

Automated radiosynthesis of [11C]CPPC for in-human PET imaging applications

Article

作者: Guo, Yan ; Muzik, Otto ; Woodcock, Eric A ; Roy, Pritam ; Jiang, Huailei

The macrophage colony-stimulating factor 1 receptor (CSF1R) is almost exclusively expressed in microglia, representing a biomarker target for imaging of microglia availability. [¹¹C]CPPC has specific binding affinity to CSF1R and suitable kinetic properties for in vivo PET imaging of microglia. However, previous studies reported a low radiochemical yield, motivating additional research to optimize [¹¹C]CPPC radiochemistry. In this work, we report an automated radiosynthesis of [¹¹C]CPPC on a Synthra MeIPlus module with improved radiochemical yield. The final [¹¹C]CPPC product was obtained with excellent chemical/radiochemical purities and molecular activity, facilitating high-quality in-human PET imaging applications.

100 项与 [11C]CPPC 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
肌萎缩侧索硬化	临床2期	-	The Johns Hopkins University	2025-01-01
肌萎缩侧索硬化	临床2期	-	Defense Language Institute Foreign Language Center	2025-01-01
新冠肺炎后遗症	临床1期	美国	The Johns Hopkins University	2024-08-06

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临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


SNMMI2024	N/A	-	-	[11C]CPPC	齋齋衊憲蓋淵獵鬱觸壓(選願觸襯衊遞壓窪糧壓) = 繭鑰網膚遞鹽壓觸壓壓鑰製願衊願獵鏇繭餘鹽 (艱蓋願餘餘襯夢醖鑰鑰, 14) 更多	-	2024-06-09