evaluate clinically and biochemically the efficacy of topically applied selenium as complementary or alternative to triamcinolone acetonide 0.1% and tacrolimus 0.1% in patients with oral lichen planus.

开始日期2024-07-01

申办/合作机构

Al-Azhar University

NCT06413043 / Not yet recruitingN/AIIT

Study on Efficacy of Add on Selenium in Mild-to-moderate Graves Ophthalmopathy: A Randomized Control Trial

The Study on efficacy of add on selenium in mild-to-moderate Graves ophthalmopathy: A Randomized Control Trial.; The study aims to evaluate the response of adding selenium in patients with Graves ophthalmopathy, focusing on improving quality of life, CAS scoring, and thyroid status. The methodology involves a Randomized Control Trial with a sample size of 78 patients. Patients meeting specific criteria will receive either standard treatment with Anti Thyroid Drugs and Vitamin B complex or add on selenium with Vitamin B complex for 6 months. Outcome measures include CAS score reduction, thyroid function improvement, and quality of life enhancement. The study will last 18 months, with various investigations and ethical considerations outlined. The document emphasizes the importance of early diagnosis of Graves Ophthalmopathy to prevent vision loss and deformity, highlighting the significance of informed patients and healthcare professionals regarding TED symptoms and risk factors.

开始日期2024-05-06

申办/合作机构

All India Institute of Medical Sciences

IRCT20230701058631N1 / RecruitingN/A

Investigating the use of two zinc and selenium supplements on the prevalence of atrial fibrillation after open heart surgery in patients with coronary artery disease

开始日期2023-07-02

申办/合作机构

Isfahan University of Medical Sciences

100 项与二硫化硒相关的临床结果

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100 项与二硫化硒相关的转化医学

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100 项与二硫化硒相关的专利（医药）

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项与二硫化硒相关的文献（医药）

2023-11-01·Ecotoxicology (London, England)

Potential ecotoxicological effects of silver nanoparticles and silver sulphide on the endogeic earthworm Aporrectodea caliginosa (Savigny 1826)

Article

作者: Lowe, Christopher N ; Kister, Jeannette M ; Butt, Kevin R

Abstract:

Silver nanoparticles (AgNPs) are increasingly used in consumer products and subsequently arrive in wastewater systems, accumulating as silver sulphide (Ag2S) in the resulting biosolids, which are commonly spread onto agricultural fields as a fertiliser. Experiments were performed to investigate the effect of AgNPs, using the endogeic earthworm Aporrectodea caliginosa as a test organism. In an acute toxicity experiment, A. caliginosa were exposed to soil containing different concentrations of AgNPs (0, 1, 5, 10, 50, 100, 250, 500, 750, and 1000 mg kg−1 dry soil) and Ag2S (0, 10, 50, 100, 500, and 1000 mg kg−1 dry soil). Earthworm biomass and mortality were monitored. Earthworms exposed to 500, 750 and 1000 mg kg−1 fresh AgNPs had mortality rates of 20%, 60% and 70%, respectively. Changes in biomass were directly related to AgNP concentration. Exposure to Ag2S did not affect biomass or mortality. Further experiments used 0, 10, 50, 100 and 250 mg kg−1 AgNPs and 0, 50, 100, 500, and 1000 mg kg−1 Ag2S to evaluate sublethal effects on A. caliginosa. Avoidance behaviour in a linear gradient was evaluated after 14 days. Earthworms significantly preferred soil that was free of either AgNPs or Ag2S. The same concentrations were used to assess effects on cocoon production of A. caliginosa exposed to AgNPs and Ag2S. In the first 3 months of AgNP exposure, higher concentrations had a negative effect on cocoon production, but this effect diminished thereafter. Ag2S had no discernible effect on reproduction. Overall, introduction of AgNPs into the soil through the application of biosolids appears to be of low concern to the tested endogeic earthworm.

2023-10-22·Life (Basel, Switzerland)

Pityriasis Versicolor-A Narrative Review on the Diagnosis and Management.

Review

作者: Pogorzelska-Antkowiak, Anna ; Kubisiak-Rzepczyk, Honorata ; Łabędź, Nina ; Navarrete-Dechent, Cristian ; Bowszyc-Dmochowska, Monika ; Pietkiewicz, Paweł

This narrative review presents a comprehensive overview of the diagnosis and management of pityriasis versicolor (PV), a common superficial fungal infection caused by the yeast Malassezia. PV is characterised by scaly hypopigmented or hyperpigmented patches, primarily affecting the upper trunk, neck, and upper arms. Regarding commensal interactions, Malassezia utilises nutrient sources without affecting the human host. In cases of pathogenicity, Malassezia can directly harm the host via virulence factors or toxins, or indirectly by triggering damaging host responses. The diagnosis typically relies on recognising characteristic clinical features. Due to the wide variability in its clinical presentation, recognising the differential diagnosis is critical. In this paper, we discuss the clinical differentials, with their dermatoscopic presentation, but also describe a range of helpful diagnostic techniques (microscopy, conventional and ultraviolet-induced fluorescence dermatoscopy, and confocal microscopy). Topical therapies are the primary treatment for PV, encompassing non-specific antifungal agents like sulphur with salicylic acid, selenium sulphide 2.5%, and zinc pyrithione. Additionally, specific topical antifungal medications with either fungicidal or fungistatic properties may also be incorporated into the topical treatment regimen, such as imidazoles, allylamines, and ciclopirox olamine. Systemic therapies might occasionally be used. Patient education and the promotion of good personal hygiene are pivotal to reduce the risk of recurrence. In recurrent cases, particularly during warmer and more humid periods, prolonged prophylaxis with topical agents should be considered.

2023-10-01·Canadian journal of ophthalmology. Journal canadien d'ophtalmologie4区 · 医学

Evaluation of a novel treatment, selenium disulfide, in killing Demodex folliculorum in vitro

4区 · 医学

Article

作者: Heczko, Joshua ; Stein, Rebecca ; Perry, Henry D ; Pansick, Andrew ; Schell, Carson

OBJECTIVE:

To evaluate the effectiveness of varying concentrations of selenium sulfide, an active ingredient in antidandruff shampoo, in killing Demodex folliculorum.

METHODS:

Sixty-five eyelashes with live Demodex from 29 patients seen at the Nassau University Medical Center (17 patients) and Ophthalmic Consultants of Long Island (12 patients) were observed under light microscopy for 90 minutes in 0.1%, 0.5%, 1.0%, and 4% selenium sulfide with either carboxymethyl cellulose (CMC) solution or petroleum jelly ointment (Vaseline, Unilever, London) as excipients. Positive and negative controls also were evaluated as separate solutions of CMC, petroleum jelly, basic saline solution, 50% tea tree oil, and 100% tea tree oil. The number of Demodex deaths and time of death were recorded.

RESULTS:

Demodex deaths in the selenium sulfide reagents were observed in the 4% selenium sulfide solution with CMC (36.4% kill rate, 4 of 11 Demodex, average time of death 17.5 minutes, p = 0.038) and 4% selenium sulfide with petroleum jelly ointment (12.5% kill rate, 1 of 8 Demodex, time of death 75 minutes, p = 0.351). No Demodex deaths were witnessed in the other selenium sulfide treatment groups. All Demodex died in the 50% and 100% tea tree oil positive control group.

CONCLUSIONS:

Selenium sulfide has shown efficacy in killing Demodex at a 4% concentration with the CMC solution and mild activity with 4% petroleum jelly. More research on selenium sulfide solutions at higher concentrations is indicated.

项与二硫化硒相关的新闻（医药）

2024-05-23

·医药地理

2023年皮肤用药销售额再破高峰！

据估计，全球有超过13亿人患有皮肤病，其中我国皮肤病患者约有3.5亿人，约占全国人口的25%。有文献报道，新冠与甲流感染也会诱发皮肤病，发病率甚至高达20.5%，再加上快节奏时代来临，年轻人逐渐养成了熬夜、饮食不当等习惯，这使得我国皮肤病发病率逐年上升，皮肤病用药市场规模也在不断增容。皮肤用药总体市场情况从图1可以看出，我国皮肤用药市场规模呈逐年扩增趋势，2023年皮肤用药总销售额达到142.22亿元，同比2022年增长了14.61%。从图2可以发现，夏季仍然为皮肤用药的旺季，Q2-Q3的销售额居于前列，但是Q1的同比增长率出现高峰，说明2023年年初发生的甲流大规模感染给皮肤病患者带来了极大的影响。图1：2019-2023皮肤科用药市场销售额/年度同比增长率%数据来源：RPDB药品零售数据库-样本药店放大整体市场数据，中国医药工业信息中心图2：2023Q1-202Q43皮肤用药市场销售额/季度同比增长率%数据来源：RPDB药品零售数据库-样本药店放大整体市场数据，中国医药工业信息中心皮肤用药各品类市场占比在2023年皮肤用药领域中，外用抗感染制剂占比26.16%，排名第一，其热门品种包括莫匹罗星软膏、硝酸益康唑喷雾剂、盐酸特比萘芬喷雾剂等，全年销售额达到38.4亿元；其次是抗银屑病药，占比17.61%，排名第二；外用皮质激素制剂占比15.49%，排名第三。图3：2023年皮肤科用药市场各品类金额占比图数据来源：RPDB药品零售数据库-样本药店放大整体市场数据，中国医药工业信息中心表1：2023年皮肤用药市场各品类金额数据数据来源：RPDB药品零售数据库-样本药店放大整体市场数据，中国医药工业信息中心皮肤用药TOP 10药品从产品层面上看，司库奇尤和度普利尤这两款单抗注射液类药物的销售额占比较大，其余外用药中，复方酮康唑发用洗剂、莫匹罗星软膏和糠酸莫米松乳膏位列前三，具体金额如图表所示。图4：2023年皮肤科用药市场各产品金额占比图数据来源：RPDB药品零售数据库-样本药店放大整体市场数据，中国医药工业信息中心表2：2023年皮肤科用药市场各产品金额数据数据来源：RPDB药品零售数据库-样本药店放大整体市场数据，中国医药工业信息中心而排除单价影响，我们发现，最畅销的皮肤用药当属红霉素软膏，其2023全年销售量达到5342万支，市场占比8.17%，复方醋酸地塞米松乳膏和复方酮康唑发用洗剂紧随其后。图5：2023年皮肤科用药市场各产品包装数量占比图数据来源：RPDB药品零售数据库-样本药店放大整体市场数据，中国医药工业信息中心表3：2023年皮肤科用药市场各产品包装数量数据数据来源：RPDB药品零售数据库-样本药店放大整体市场数据，中国医药工业信息中心网上药店除此之外，淘宝/天猫和京东的店铺数据同样不可忽视，数据显示：2023年网上药店皮肤科用药销售总额达到47.74亿元，其中Q4时期需求量增多，达到全年最高峰值。图6：2023Q1-2023Q4皮肤科用药网上药店市场销售额/季度同比增长率%数据来源：RPDB药品零售数据库-网上药店整体市场数据，中国医药工业信息中心与线下药店不同的是，网上药店中最畅销的皮肤用药产品为米诺地尔酊，全年总销售额为11.3亿，占比23.71%。网上药店中销量前十的产品依次为米诺地尔酊、联苯苄唑溶液、盐酸阿莫罗芬搽剂、米诺地尔搽剂、二硫化硒洗剂、阿达帕林凝胶、酮康唑洗剂、复方酮康唑发用洗剂、盐酸特比萘芬喷雾剂、甲硝唑凝胶。图7：2023年皮肤科用药网上药店市场各产品金额占比图数据来源：RPDB药品零售数据库-网上药店整体市场数据，中国医药工业信息中心RPDB是国内样本覆盖药店数最多的药品零售信息平台，监测全国30个省级行政区300多个城市的样本药店数据，各销售规模的门店均有覆盖，月度更新零售终端的药品销售区域、品类、产品特性、价格、运营数据、营销手段和消费者特征等核心信息，以及京东、天猫等主要线上渠道的药品销售数据。想获知更具体的药品零售市场销售数据，欢迎您进一步了解中国医药工业信息中心RPDB中国药品零售数据服务。END如需获取更多数据洞察信息或公众号内容合作，请联系医药地理小助手微信号：pharmadl001

申请上市

2023-12-26

·今日头条

再取进展！饶毅团队公布新发现

本文为转化医学网原创，转载请注明出处作者：Jerry 导读：发现一种新的神经递质，特别是在中枢神经系统中发现一种神经递质，既重要又困难。 2023年12月21日，北京大学/首都医科大学饶毅团队在eLife 在线发表题为“Suggestion of creatine as a new neurotransmitter by approaches ranging from chemical analysis and biochemistry to electrophysiology”的研究论文，该研究证实肌酸是一种新的神经递质。在突触囊泡(SVs)中检测到肌酸(Cr)的水平低于谷氨酸和γ氨基丁酸，但高于乙酰胆碱和5-羟色胺。另外，2023年4月5日，饶毅团队在eLife 在线发表题为“Importance of glutamine in syNAptic vesicles revealed by functional studies of SLC6A17 and its mutations pathogenic for intellectual disability”的研究论文，该研究通过对SLC6A17转运蛋白的功能研究及其导致智力障碍突变揭示了突触囊泡中谷氨酰胺的重要性。 2023年3月2日，首都医科大学饶毅及刘琰共同在Neuron 在线发表题为“Molecular and cellular mechanisms of the first social relationship: A conserved role of 5-HT from mice to monkeys, upstream of oxytocin”的研究论文，该研究发现消除大脑中血清素合成所必需的Tph2基因减少了小鼠、大鼠和猴子的依恋行为。钙显像和c-fos免疫染色显示母体气味激活中缝核(RNs)的血清素能神经元和室旁核(PVN)的催产素能神经元。催产素(OXT)或其受体的遗传消除降低了母性依恋。OXT挽救了缺乏血清素的小鼠和猴子婴儿的母体依恋。从支配PVN的RN血清素能神经元中消除Tph2降低了母性依恋。抑制血清素能神经元后降低的母体依恋可通过催产素能神经元激活来挽救。总之，遗传学研究揭示了血清素在小鼠和大鼠与猴子之间的依恋中所起的作用，而电生理学、药理学、化学遗传学和光遗传学研究揭示了血清素下游的OXT。该研究认为血清素是哺乳动物社会行为中神经肽上游的主要调节因子。综上所述，该工作揭示了5-HT参与调控了哺乳动物一种重要的社会行为即幼崽对母亲的依恋行为。本研究从神经分子及环路机制出发，为理解母婴行为关系提供了新的方向。 https://elifesciences.org/articles/89317 研究背景 01 神经信号传导依赖于神经元与其靶细胞之间的化学传递。神经传递依赖于化学物质，如神经递质、神经调节剂和神经肽。在一种分子被确定为经典的神经递质之前，人们经历了数十年的研究，有时甚至是曲折的路径。19世纪人们获得了关于胆碱能信号传导的初步线索。胆碱和乙酰胆碱(ACh)是在20世纪之交发现其药理作用之前的几十年才被发现的。Henry Dale及其同事意识到ACh和副交感神经刺激的相似性，但直到1929年ACh在体内被检测到，1934年ACh被证明是外周神经系统(PNS)的一种神经递质。从发现肾上腺损伤或切除的影响，观察到肾上腺的活动，分离出一种无活性的衍生物，成功分离出肾上腺素，注意到肾上腺素和交感神经刺激之间的相似之处，到20世纪40年代中期乌尔夫·冯·欧拉证明去甲肾上腺素(NA)是交感神经的神经递质，经历了近100年的时间。在PNS中建立一种分子作为神经递质并不容易，而建立中枢神经系统(CNS)的神经递质则更加困难。从ACh被证实为PNS神经递质到其被确定为CNS神经递质，间隔了30年;从NA作为外周递质到中枢递质，间隔了20年。研究过程 02 在不同的时期，不同的研究者曾怀疑牛磺酸、脯氨酸、d -天冬氨酸、硫化氢、胍丁胺、多巴、雌二醇、β-丙氨酸和质子是神经递质，但它们并不符合所有标准。一些可疑分子可在刺激下被释放或被转运蛋白移除。通常，它们无法在SVs中重复发现。研究人员在SVs中发现了Cr，这大大提高了测试Cr候选性的优先性，进一步的研究发现了更多的证据表明Cr作为一种神经递质:(1)Cr储存在SVs中;(2)已经观察到刺激后Ca2+依赖性的Cr释放;(3) Slc6a8基因和AGAT基因缺失时，SVs中Cr的储存量和Cr的释放量均减少;(4) Cr抑制新皮层锥体神经元的活性;(5) Cr进入突触体需要SLC6A8;(6) SV对Cr的摄取依赖于ATP。在上述结果中，1、3、4和6是本文首次报道的结果。此外，研究人员已经证明，在SVs中检测到的Cr低于Glu和GABA，但高于ACh和5-HT，使Cr处于已知中枢递质的中间水平。Cr在SVs中的储存依赖于保留的H+梯度，Cr可以被转运到SVs中。之前有一个关于Ca2+依赖性释放[3H]Cr和内源性Cr响应电刺激的报告。研究人员现在提供的证据表明，Cr在细胞外K+刺激下(1-2分钟内)释放。此外，当Slc6a8或Agat基因被去除时，Cr释放减少。虽然与Glu和GABA相比，K+诱发的Cr释放的Ca2+依赖性成分较小，但它仍然存在，并被Slc6a8敲除至完全消除。电诱发的Cr释放表现出更多的Ca2+依赖性。综上所述，本数据和之前的报告支持Cr作为神经递质的作用。研究人员观察到的5-羟色胺或乙酰胆碱的极低外排率可能是由于切片中胆碱能或血清素能神经元的数量非常有限以及这些神经递质的酶降解速度非常快。 Cr从细胞外空间摄取到细胞中已经有两次报道，一次是通过脑切片显示钠依赖的[3H]Cr摄取，一次是通过突触体。新结果不仅复制了突触体的Cr摄取实验，而且显示了SLC6A8(一种在突触体中表达的膜转运蛋白)对Cr摄取到突触体的要求。Slc6A8将Cr转运到突触小体中，可能在突触间隙中清除Cr和将Cr再循环到神经元中的SVs中起作用。突触囊泡中Slc6a8和肌酸(Cr) 研究结论 03 综上所述，除了证实和扩展了之前的研究结果，研究人员获得了全新的研究结果，表明肌酸(Cr)可以作为一种神经递质。参考资料： https://elifesciences.org/articles/89317 注：本文旨在介绍医学研究进展，不能作为治疗方案参考。如需获得健康指导，请至正规医院就诊。热门·直播/活动 🕓 北京｜12月19日-20日 ▶第四届单细胞测序技术应用研讨会暨单细胞&空间组学研讨会（日程稍后公布）点击对应文字查看详情

2023-12-12

·PRNewswire

AMERICAN ACADEMY OF DERMATOLOGY: HOW TO TREAT DANDRUFF

Board-certified dermatologist's tips ROSEMONT, Ill., Dec. 12, 2023 /PRNewswire/ -- Dandruff, a common scalp condition, affects people of all ages, especially in the cold winter months. If you notice small pieces of dry skin flaking from your scalp or persistent itching, it may be time to seek treatment options. "It is a common misconception that dandruff is caused by poor hygiene," said Mona Sadeghpour, MD, FAAD, a board-certified dermatologist in Pittsburgh, Pa. and Lone Tree, Colo. "Causes range from oily skin to hair care habits, along with some medical conditions." Continue Reading "It is a common misconception that dandruff is caused by poor hygiene," said Mona Sadeghpour, MD, FAAD. Post this You can usually treat mild dandruff at home by regularly washing your hair. If this is not manageable or doesn't relieve your dandruff, Dr. Sadeghpour and the AAD recommend following these tips from board-certified dermatologists: Choose a dandruff shampoo. You can find shampoos specially formulated to treat dandruff over the counter at your local drugstore. If one shampoo doesn't work, try alternating between dandruff shampoos with different active ingredients. Look for a shampoo with one of the following ingredients: Zinc pyrithione; salicylic acid; sulfur; selenium sulfide; ketoconazole; or coal tar shampoo. Follow the instructions on the dandruff shampoo bottle. Dandruff shampoos need to be applied to and lathered on your scalp. You may also need to allow some dandruff shampoos to sit on your scalp for about 5-10 minutes before rinsing. These instructions will be different depending on the shampoo you choose and your hair texture. Shampoo according to your hair type. If you have fine or naturally straight hair, or an oily scalp, wash your hair often. For example, you may need to shampoo daily or every other day and use your dandruff shampoo twice a week. If you have coarse or naturally curly or coily hair, wash your hair when needed, and use your dandruff shampoo about once a week. Take care to only apply the dandruff shampoo to your scalp if you have curly or coily hair, as the ingredients that treat dandruff can dry your hair. There are some dandruff shampoos specifically for coarse hair that are more hydrating. You can also shampoo and condition your hair with your normal products after using your dandruff shampoo if it is needed for hair care. Protect your scalp from the sun. Some dandruff shampoos, such as those containing coal tar, can make your scalp more sensitive to the sun's harmful UV rays. A sunburn on your scalp can also increase flaking. To protect your scalp from the sun, seek shade, wear sun-protective clothing, like a wide-brimmed hat, and apply a broad-spectrum, water-resistant sunscreen with an SPF of 30 or higher to your scalp if you have thinning hair. Try powder or spray sunscreen for easier application to your scalp. "If these tips do not provide you relief from dandruff, it is best to make an appointment to see a board-certified dermatologist," Dr. Sadeghpour said. These tips are demonstrated in "How to treat dandruff" a video posted to the AAD website and YouTube channel. This video is part of the AAD's "Your Dermatologist Knows" series, which offers tips people can use to properly care for their skin, hair, and nails. To find a board-certified dermatologist in your area, visit aad.org/findaderm. More Information How to treat dandruff 10 reasons your scalp itches and how to get relief AAD B-Roll Library About the AAD Headquartered in Rosemont, Ill., the American Academy of Dermatology, founded in 1938, is the largest, most influential and most representative of all dermatologic associations. With a membership of more than 20,800 physicians worldwide, the AAD is committed to advancing the diagnosis and medical, surgical, and cosmetic treatment of the skin, hair, and nails; advocating high standards in clinical practice, education and research in dermatology; and supporting and enhancing patient care because skin, hair, and nail conditions can have a serious impact on your health and well-being. For more information, contact the AAD at (888) 462-DERM (3376) or aad.org. Follow @AADskin on Facebook, TikTok, Pinterest and YouTube and @AADskin1 on Instagram. SOURCE American Academy of Dermatology

100 项与二硫化硒相关的药物交易

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KEGG	Wiki	ATC	Drug Bank
D05815	-	D01AE13	DB00971

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ARVO2021	N/A	睑板腺功能障碍	-	Selenium Disulfide	構願觸鹹壓簾積繭製淵(觸願願廠鑰鏇遞鬱鹹餘) = 鑰築鹽鹹鹹顧選積醖壓網製壓網顧網鑰獵製鑰 (顧蓋範獵憲鏇廠糧範鬱 )	-	2021-06-01
				Selenium Disulfide	構願觸鹹壓簾積繭製淵(觸願願廠鑰鏇遞鬱鹹餘) = 網壓夢鑰鏇鹹糧憲遞願網製壓網顧網鑰獵製鑰 (顧蓋範獵憲鏇廠糧範鬱 )