预约演示
更新于：2025-03-29
Eprosartan Mesylate
依普沙坦
更新于：2025-03-29
概要
基本信息
药物类型 小分子化药 |
别名 (E)-2-butyl-1-(p-carboxybenzyl)-α-2-thenylimidazole-5-acrylic acid、(E)-3-[2-n-butyl-1-{(4-carboxyphenyl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenoic acid、(E)-α{[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazole-5-yl]methylene}-2-thiopheneproprionic acid + [18] |
靶点 |
作用方式 拮抗剂 |
作用机制 AT1R拮抗剂(血管紧张素II-1型受体拮抗剂) |
治疗领域 |
非在研适应症- |
原研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (1997-12-22), |
最高研发阶段(中国)批准上市 |
特殊审评- |
登录后查看时间轴
结构/序列
分子式C24H28N2O7S2 |
InChIKeyDJSLTDBPKHORNY-XMMWENQYSA-N |
CAS号144143-96-4 |
关联
9
项与 依普沙坦 相关的临床试验NCT04606563
Host Response Mediators in Coronavirus (COVID-19) Infection - Is There a Protective Effect of Losartan and Other ARBs on Outcomes of Coronavirus Infection?
EUCTR2010-019155-22-DE
A Prospective, Randomized, Double-Blind, Parallel-Group Study to Compare the Effect of Eprosartan and Eprosartan Mesylate on Blood Pressure in Subjects with Essential Hypertension
NCT01631227
A Prospective, Randomized Double-blind Parallel Group Study to Compare the Effect of Eprosartan and Eprosartan Mesylate on Blood Pressure in Subjects With Mild to Moderate Essential Hypertension
100 项与 依普沙坦 相关的临床结果
登录后查看更多信息
100 项与 依普沙坦 相关的转化医学
登录后查看更多信息
100 项与 依普沙坦 相关的专利（医药）
登录后查看更多信息
847
项与 依普沙坦 相关的文献（医药）2025-02-12CURRENT PHARMACEUTICAL DESIGN
Eprosartan Reduces Inflammation and Oxidative Stress in Ethanol-induced Hepatotoxicity
Article
作者: Mansourian, Mahboubeh ; Jahantab, Mohammad Bagher ; Karimi, Farzaneh ; Larki, Rozina Abbasi ; Mirghaed, Ali Taheri ; Azizi, Mahdokht ; Behrouj, Hamid ; Mehrabi, Sadrollah ; Daryabor, Gholamreza ; Abdzadeh, Soroor ; Doustimotlagh, Amir Hossein
Introduction::
Eprosartan is an effective blood pressure medication that blocks the Angiotensin
Type 1 (AT1) receptor. The studies conducted on Eprosartan showed anti-oxidative stress effects and modulating
inflammatory mechanisms. The current research is designed to clarify and examine the possible advantageous
impacts of Eprosartan against chronic ethanol-induced hepatic damage.
Method::
Twenty-four male Sprague-Dawley rats were haphazardly separated into four groups. The control
group received normal saline 1 g/kg for 35 days (group 1). The EtOH group received 7 g/kg of 40% ethanol
orally for 35 days (group 2). The EtOH+ EP group was pretreated with 60 mg/kg of Eprosartan dissolved in
normal saline orally and, after 60 minutes, received 7 g/kg of 40% ethanol orally for 35 days (group 3). The
EP group received only Eprosartan 60 mg/kg dissolved in normal saline for 35 days (group 4). The levels of
biochemical parameters, oxidative stress markers, pro-inflammatory cytokines, and histopathological staining
were evaluated in serum and liver tissue. The interactive behavior of Eprosartan with Tumor Necrosis Factor-α
(TNF-α) protein was also explained by molecular docking.
Results::
Pre-treatment with Eprosartan (60 mg/kg) notably diminished the elevation in serum alanine aminotransferase
(ALT), aspartate aminotransferase (AST) and Gamma-Glutamyl Transferase (GGT) enzymes, total
triglyceride, cholesterol, total bilirubin, and inflammatory cytokines including TNF-α, Interleukin-1β (IL-1β)
and Interleukin-6 (IL-6) levels, which were induced by alcohol administration (P-value ≤ 0.05). In the Eprosartan
pre-treated group, malondialdehyde and protein carbonyl content of liver tissue were remarkably diminished,
as compared to the ethanol-induced rats. In addition, histopathological results approved the indicated
finding. Molecular docking research gives insights into potential interactions of Eprosartan with TNF-α protein.
Conclusion::
Our results revealed that the pre-treatment with Eprosartan (60 mg/kg) preserves against chronic
alcohol-induced hepatic damage.
2024-12-01SCIENCE OF THE TOTAL ENVIRONMENT
Chemical profiling of organic contaminants in rural surface waters combining target and non-target LC-HRMS/MS analysis
Article
作者: Martínez-Piernas, Ana B. ; Moreno-González, David ; García-Reyes, Juan F. ; Gilbert-López, Bienvenida ; Fernández-García, Alfonso ; Martínez-Piernas, Ana B ; García-Reyes, Juan F
The pollution of natural waters by contaminants of emerging concern (CECs) is one of the pressing problems due to their global distribution and potential negative effects on the environment and human health. In rural areas with lower population density and limited industrial development, less contamination is expected. However, the lack of wastewater treatment plants (WWTPs) or their poor removal efficiency can lead to significant input of pollutants. In this context, 11 streams of rural areas in the Guadalquivir River basin, southeast of Spain, were studied over two years to obtain an overview of the origin and distribution of contaminants. A target method using solid-phase extraction and liquid chromatography coupled to high resolution mass spectrometry (LC-HRMS) was developed for the analysis of 316 compounds in surface waters. A total of 78 target analytes were detected, comprising pesticides, pharmaceuticals, personal care products (PCPs), transformation products (TPs), and industrial chemicals. The flame retardant tributyl phosphate (16-3572 ng L-1) was detected in all samples, followed by caffeine (30-8090 ng L-1) and the analgesic tramadol (3-1493 ng L-1). The target approach was combined with a non-target analysis (NTA) strategy to obtain an overall perspective of the chemical profile of unexpected or unknown compounds in the samples. Up to 79 contaminants were tentatively identified, and 12 of them were finally confirmed with standards. Most of the contaminants determined by NTA were pharmaceuticals and their TPs. The results indicated that most of CECs have an urban origin despite traditional agriculture is the main economic activity in this region. Moreover, the absence of WWTPs in small towns is significant, as contamination levels at these sites were comparable to or higher than those in larger populations with sewage treatments.
2024-11-01SCIENCE OF THE TOTAL ENVIRONMENT
Seasonal hot spots of pollution and risks in Western Kenya: A spatial-temporal analysis of almost 800 organic micropollutants
Article
作者: Brack, Werner ; Kiprop, Ambrose ; Shahid, Naeem ; Tanui, Isaac Cheruiyot ; Kandie, Faith ; Piotrowska, Aleksandra ; Krauss, Martin ; Liess, Matthias
The release of chemicals into the environment presents a significant threat to aquatic ecosystems dependent on the proximity to emission sources and seasonal dynamics of emission and mobilization. While spatial-temporal information on water pollution in Europe is increasing, there are substantial knowledge gaps on seasonal pollution dynamics in tropical countries. Thus, we took Lake Victoria South Basin in western Kenya as a case study to identify spatial and seasonal hot spots of contamination, quantified toxic risks to different groups of organisms, and identified seasonal risk drivers. For this purpose, we analyzed grab water samples from five rivers with agricultural and wastewater treatment plants in their catchment in four different seasons. We used liquid chromatography coupled to high resolution mass spectrometry (LC-HRMS) with a target list of 785 organic micropollutants. A total of 307 compounds were detected with concentrations ranging from 0.3 ng/L to 6.6 μg/L. Using a Toxic Unit (TU) approach based on mixture toxicity to standard test organisms, crustaceans were identified as the most affected group followed by algae and fish. For crustaceans, chronic risk thresholds were exceeded in 96 % of all the samples, while 56 % of all samples are expected to be acutely toxic, with the highest risk in February during the dry season. High toxic unit values for algae and fish were recorded in July dry season and May wet season. Diazinon, imidacloprid, clothianidin and pirimiphos-methyl were the major drivers for crustacean toxicity while triclosan and different herbicide mixtures drive risks to algae in dry and wet seasons, respectively. A total of 18 chemicals were found to exceed acute and chronic environmental risk thresholds. With this study, strong spatial-temporal patterns of pollution, risks and risk drivers could be confirmed informing prioritization of monitoring and abatement to enhance water quality and reduce toxic risks.
100 项与 依普沙坦 相关的药物交易
登录后查看更多信息
研发状态
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 原发性高血压 | 澳大利亚 | 1998-06-15 | |
| 高血压 | 美国 | 1997-12-22 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 原发性高血压 N-terminal pro-brain natriuretic peptide (NT-proBNP) | 165 | 膚蓋膚鏇膚窪鹹鑰壓鑰(願膚夢餘窪襯糧鹽範顧) = 襯糧築鑰鏇衊廠範顧襯 憲選構選鹽糧蓋醖鑰簾 (製膚遞衊製遞艱築積膚 ) | - | 2018-08-27 | ||
临床3期 | 665 | Placebo Eprosartan mesylate+Eprosartan (Eprosartan) | 簾壓築願鹹鹹襯顧夢鹹(淵鬱觸窪膚築醖製糧繭) = 衊選鬱遞簾襯膚壓構獵 選網鏇獵膚選積醖鹽繭 (夢鏇鹽襯蓋構鬱鏇遞簾, 7.7) 更多 | - | 2014-05-26 | ||
Placebo Eprosartan+Eprosartan Mesylate (Eprosartan Mesylate) | 簾壓築願鹹鹹襯顧夢鹹(淵鬱觸窪膚築醖製糧繭) = 觸廠衊構選膚蓋淵觸夢 選網鏇獵膚選積醖鹽繭 (夢鏇鹽襯蓋構鬱鏇遞簾, 7.5) 更多 | ||||||
临床4期 | 1,405 | 蓋壓衊鏇鹽憲廠範範鹽(壓憲鬱鬱壓觸鑰觸衊憲) = 襯憲鑰遞艱構範鬱壓鏇 憲製醖醖鏇憲網夢壓網 (繭醖網鬱願繭獵餘鬱膚 ) | - | 2005-06-01 | |||
蓋壓衊鏇鹽憲廠範範鹽(壓憲鬱鬱壓觸鑰觸衊憲) = 襯築繭鹹繭窪範鬱顧鬱 憲製醖醖鏇憲網夢壓網 (繭醖網鬱願繭獵餘鬱膚 ) |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
来和芽仔聊天吧
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用