奥芬达唑(Oxfendazole) - 在研适应症：神经系统囊虫病，片形吸虫病，鞭虫病_专利_临床

概要

基本信息

药物类型

小分子化药

别名

(5-(phenylsulfinyl)-1H-benzimidazol-2-yl)carbamic acid methyl ester、5-(phenylsulfinyl)-2-benzimidazolecarbamic acid methyl ester、5-phenylsulfinyl-2-carbomethoxyaminobenzimidazole

+ [8]

靶点-

作用机制-

治疗领域

感染神经系统疾病其他疾病+ [3]

在研适应症

神经系统囊虫病片形吸虫病鞭虫病+ [3]

非在研适应症-

原研机构

National Institute of Allergy & Infectious Diseases

在研机构

The Oxfendazole Development Group

Drugs for Neglected Diseases initiative

Universidad Peruana Cayetano Heredia

+ [1]

非在研机构-

最高研发阶段临床2/3期

首次获批日期-

最高研发阶段(中国)-

特殊审评孤儿药 (美国)

登录后查看时间轴

结构/序列

分子式C15H13N3O3S

InChIKeyBEZZFPOZAYTVHN-UHFFFAOYSA-N

CAS号53716-50-0

关联

9

项与奥芬达唑相关的临床试验

NCT06367361

/ Not yet recruiting临床2期IIT

Non-inferiority, Controlled, Randomized, Single-blind Study for Compare Regimens of One and Two Doses of Oxfendazole Versus a Schedule of Two Doses of Triclabendazole to Treat Chronic Fascioliasis

Randomized clinical trial comparing the efficacy and safety of oxfendazole at 20 mg/kg per dose in one and two dose regimens with a two-dose regimen of triclabendazole at 10 mg/kg in an endemic region of the highlands of Peru. Children and adults with fascioliasis in rural communities will be screened for inclusion and exclusion criteria and a total of 336 subjects (112 per study arm) with chronic Fasciola infection will be enrolled and assigned randomly to the study arms in a 1:1:1 ratio. The primary efficacy (cure and egg reduction) endpoints will be assessed on day 7 and 30 post treatment. The secondary safety endpoint visits will be performed in days 0, 3, 7 and 30 post-treatment and Population Pharmacokinetics (PK) modeling studies will be performed in the first 24 hours after the first dose of oxfendazole.

开始日期2025-01-30

申办/合作机构

Universidad Peruana Cayetano Heredia

[+2]

NCT06565507

/ Not yet recruiting临床2/3期IIT

A Double-blind Multicenter, Randomized Controlled Trial of Single and Multiple Dose Regimens of Oxfendazole for Mild (One or Two Lesions) Parenchymal Brain Cysticercosis, With an Open Comparison Group

The goal of this clinical trial is to compare a single and multiple dose regimens of oxfendazole with the standard treatment in patients with mild (one or two lesions) parenchymal brain cisticercosis. The main question it aims to answer is if OXF will enhance clearance of brain parasites and therefore provide greater cysticidal efficacy, with the potential to provide a single-dose therapy for this type of NCC.
The study cohort will also allow us to identify early imaging markers that predict lesion resolution, as well as factors associated with residual calcification or focal gliosis after lesion resolution. This study will also provide additional information on the safety of the study interventions.

开始日期2024-12-15

申办/合作机构

Universidad Peruana Cayetano Heredia

[+1]

NCT03435718

/ Not yet recruiting临床2期IIT

An Assessor Blind, Randomized, Comparative Study of the Efficacy of Different Doses of Oxfendazole Compared to Single Dose Albendazole in the Treatment of Trichuris Trichiura Infection in Adults

The main objective of this study is to provide data on the efficacy profile of different doses of oxfendazole when used in Trichuris trichiura infection. The drug will be also be examined for efficacy against other common nematodes encountered in man (Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus). The study will also provide data on the safety and tolerability of the oxfendazole in patients.

开始日期2024-07-01

申办/合作机构

The Oxfendazole Development Group

[+1]

100 项与奥芬达唑相关的临床结果

登录后查看更多信息

100 项与奥芬达唑相关的转化医学

登录后查看更多信息

100 项与奥芬达唑相关的专利（医药）

登录后查看更多信息

1,638

项与奥芬达唑相关的文献（医药）

2025-04-01·International Journal for Parasitology: Drugs and Drug Resistance

Efficacy of fenbendazole against gastrointestinal nematodes in naturally infected goats in Maputo Province, Mozambique using in vivo, in vitro and molecular assessment

Article

作者: Afonso, Sonia M S ; Krücken, Jürgen ; von Samson-Himmelstjerna, Georg ; Borchert, Marc ; Atanásio, Alsácia ; Guinda, Edna F X ; Morgan, Eric R ; Capece, Bettencourt P S ; Ramünke, Sabrina ; Fiedler, Stefan

Anthelmintic resistance occurs worldwide in strongyles of ruminants but data from low-income countries are sparse and rarely apply most up to date methods, while effects of management practices in these countries are poorly documented. In Mozambique, benzimidazole resistance has been previously reported; the present study followed this up in detail, applying in vivo faecal egg count (FEC) reduction test (FECRT), in vitro egg hatch test (EHT) and molecular deep amplicon sequencing approaches targeting the internal transcribed spacer 2 (ITS-2, nemabiome) and the isotype 1 β-tubulin gene to determine the resistance status on farms and the strongyle species involved. Adult Landim goats (433) from six semi-intensive and ten extensive farms (22-30 animals/farm) from Maputo Province were visited April 2021 to February 2022. Fenbendazole (5 mg/kg bw, Panacur®) was administered orally and FEC determined using Mini-FLOTAC. The eggCounts package was used to calculate FECRs with 90% confidence intervals from paired day 0 and 14 data. In vivo and in vitro tests detected AR on 5/16 (31%) farms. This included 1/10 extensive and 4/6 semi-intensive farms. The odds of finding resistant strongyles on a semi-intensive commercial farm was 40-fold higher than on an extensive farm (p = 0.016, logistic regression). A strong, negative correlation was observed between FECRT and EHT EC₅₀ values (Pearson's R = -0.83, P = 0.001; Cohen's κ coefficient 1.0). Nemabiome data showed that Haemonchus contortus, Trichostrongylus colubriformis and unclassified Oesophagostomum closely related to Oesophagostomum columbianum were most abundant before treatment and in particular H. contortus frequencies increased after treatment. Benzimidazole resistance associated polymorphisms were detected in H. contortus and T. colubriformis. Moreover, there were hints that resistance alleles were present in Trichostrongylus axei and Teladorsagia circumcincta. Farmers should regularly test the efficacy of anthelmintics used and consider more sustainable worm control approaches to reduce selection for resistance.

2025-02-01·Research in Veterinary Science

Survey on canine hookworms: Knowledge, perceptions and practices among U.S. veterinarians

Article

作者: Miller, Kamilyah R ; Hanzlicek, Gregg A ; Jesudoss Chelladurai, Jeba R J ; Ochoa, Sara J ; Kastner, Justin

Canine hookworms (Ancylostoma caninum) are highly prevalent in pet dogs in the United States of America (U.S.). They pose a significant health risk to infected dogs and are also a potential risk to humans as zoonotic agents. Veterinarians play a crucial role in managing this threat through the diagnosis and treatment of infections in pet dogs. However, the rising incidence of anthelmintic resistance in U.S. hookworm populations necessitates increased awareness among veterinarians. To determine U.S. veterinarian's knowledge, perceptions and practices about canine hookworms, a cross-sectional online survey was administered between February and December 2022. 208 veterinarians from 43 states participated in the study. Only 65 % of veterinarians reported awareness of hookworm prevalence. Hookworm infected dogs were encountered more frequently in the South than in Western states. Veterinarians perceived that hookworms were present in all breeds without breed predilection followed by mixed breeds, pit bulls and hound breeds. Most respondents reported that infections were rarely symptomatic, highlighting the importance of diagnostic testing. In-clinic diagnostic modalities were most preferred. Fenbendazole and pyrantel pamoate were the most commonly used anthelmintics. Most veterinarians followed up on infected dogs but retesting time after treatment varied. Awareness of multi-drug resistant hookworms was high but encountering persistent hookworm cases was lower. Veterinarians frequently educated clients about hookworms and prevention, but less about the zoonotic potential. This study provides insights for improving awareness, diagnostics, treatment protocols, and client education regarding canine hookworms in the U.S.. Overall, veterinarians play an active role in hookworm prevention and control.

2025-01-08·Journal of Agricultural and Food Chemistry

Antibiotic Residues in Cattle Reported to Be Raised Without Antibiotics

Article

作者: Green, Jennifer E. ; Zipperer, Laine ; Domesle, Alexander ; Duverna, Randolph ; Lightfield, Alan R. ; Weyrauch, Katie ; Lehotay, Steven J. ; Michlig, Nicolás ; Wiggins, Sabrina

In 2019, the U.S. Department of Agriculture's (USDA) Food Safety and Inspection Service (FSIS) provided revised guidance for labeling claims of "raised without antibiotics" (RWA) and similar terms for meat and poultry produced in the US. In 2022, Price et al. published a study reporting that 15% of RWA-labeled cattle contained antibiotic residues in urine samples. In 2023, the USDA embarked on the project reported herein to independently determine the extent of antibiotic drug residues present in kidney and liver tissues from slaughtered cattle purported to be RWA. In this study, FSIS inspectors randomly collected kidney and liver tissues from 189 RWA animals in 79 slaughter establishments across the US. The samples were monitored for 185 veterinary drugs multiple times by different means, including liquid-chromatography coupled with tandem mass spectrometry (LC-MS/MS) and quadrupole high-resolution MS with an orbital ion trap instrument (LC-Q/orbitrap). Samples from 37 animals (20%) met the analytical identification criteria for at least one antibiotic confirmed in at least two analyses. Multiple antibiotics were determined in 11 RWA animals. Macrolides (tulathromycin, tildipirosin, tilmicosin, and gamithromycin) were confirmed in 20 (11%) of the RWA animals. The ionophore, monensin, was also confirmed in tissues from 11 samples, with unconfirmed/partial identifications in 8 others. Tetracyclines were confirmed in samples from 12 animals, several of which were found to contain multiple antibiotic residues. One animal each was also found to be positive for sulfamethazine (a sulfonamide antibiotic) and metabolites of penicillin G (a β-lactam antibiotic). Although they are not antibiotics, two anthelmintics (fenbendazole and eprinomectin) were confirmed in tissues from 3 RWA animals. FSIS has informed the slaughter establishments with positive results and advised them to conduct a root cause analysis and implement corrective actions.

100 项与奥芬达唑相关的药物交易

登录后查看更多信息

外链

KEGG	Wiki	ATC	Drug Bank
D05291	奥芬达唑	-	DB11446

研发状态

10 条进展最快的记录,

登录

后查看更多信息

适应症	最高研发状态	国家/地区	公司	日期
神经系统囊虫病	临床3期	-	The Oxfendazole Development Group	2024-12-15
神经系统囊虫病	临床3期	-	Universidad Peruana Cayetano Heredia	2024-12-15
片形吸虫病	临床2期	-	National Institute of Allergy & Infectious Diseases	2025-01-30
鞭虫病	临床2期	-	The Oxfendazole Development Group	2024-07-01
丝虫病	临床1期	坦桑尼亚	Drugs for Neglected Diseases initiative	2022-04-21
眼盘尾丝虫病	临床1期	瑞士	Drugs for Neglected Diseases initiative	2022-01-30
蠕虫病	临床1期	美国	The Oxfendazole Development Group	-

登录后查看更多信息

临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03035760 (CTgov)	临床1期	蠕虫病	36	Oxfendazole (Arm 1: 3 mg/kg Oxfendazole for 5 Days)	衊積網壓醖鏇簾網淵餘(壓網淵壓鹹壓構窪鹹獵) = 鹽構顧膚淵築廠範壓齋選獵齋襯願齋網選製襯 (窪鹹繭夢憲網鑰選鑰遞, 鬱選積簾鹹繭鏇窪鏇醖 ~ 夢繭積網顧積鑰製鏇製) 更多	-	2019-12-17
				Oxfendazole (Arm 2: 7.5 mg/kg Oxfendazole for 5 Days)	衊積網壓醖鏇簾網淵餘(壓網淵壓鹹壓構窪鹹獵) = 鬱艱衊網製淵鹽構顧範選獵齋襯願齋網選製襯 (窪鹹繭夢憲網鑰選鑰遞, 壓繭積蓋憲網糧蓋顧廠 ~ 壓製選衊糧範窪糧繭膚) 更多
NCT02234570 (CTgov)	临床1期	神经系统囊虫病	70	Oxfendazole (0.5 mg/kg Oxfendazole)	簾糧願構繭願構鹹齋顧(壓齋網齋積獵鬱廠廠願) = 觸鏇鹽齋範鬱鑰淵淵憲鏇鹽製窪醖鬱遞糧鹽壓 (糧築艱構遞遞鹹壓鏇膚, 餘構餘醖齋觸鏇醖網鬱 ~ 壓選淵鹹積築餘淵鹽艱) 更多	-	2019-11-26
				Oxfendazole (1 mg/kg Oxfendazole)	簾糧願構繭願構鹹齋顧(壓齋網齋積獵鬱廠廠願) = 壓鹽遞餘簾願選鏇艱蓋鏇鹽製窪醖鬱遞糧鹽壓 (糧築艱構遞遞鹹壓鏇膚, 簾鏇顧網積淵遞鬱鹽遞 ~ 網鏇獵鹽築積繭餘構齋) 更多
NCT02234570 (Pubmed \| Antimicrob Agents Chemother)	临床1期	-	70	Oxfendazole	(鹽鬱構壓範製築積鏇醖) = dose-dependent decrease 廠窪艱廠淵鑰淵鹽壓網 (鑰鬱醖蓋網顧積壓鹽餘 ) 更多	-	2019-04-01