更新于：2024-11-18
Montmorillonite
蒙脱石
更新于：2024-11-18
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基本信息
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21
项与 蒙脱石 相关的临床试验A Comprehensive Analysis of the Comparative Efficacy of Multimodal Diarrhea Therapies
Prospective study of gold bifidum combined with montmorillonite powder in perioperative intestinal mucosal barrier protection in patients with colorectal cancer
The Safety, Tolerability, and Efficacy of Smectite in Children with Attention-Deficit/Hyperactivity Disorder: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial
100 项与 蒙脱石 相关的临床结果
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100 项与 蒙脱石 相关的转化医学
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100 项与 蒙脱石 相关的专利（医药）
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733
项与 蒙脱石 相关的文献（医药）2024-12-01SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Spectroscopic study on volasertib: Highly stable complexes with albumin and encapsulation into alginate/montmorillonite bionanocomposites
Article
作者: Darder, Margarita ; Albaladejo, José ; Herrera-Ochoa, Diego ; Fernández-Sainz, Jesús ; Pacheco-Liñán, Pedro J ; Garzón-Ruiz, Andrés ; Bravo, Iván
In the present work, we study different physicochemical properties related to LADME processes of volasertib, a Polo-like kinase 1 inhibitor in advanced clinical trials. Firstly, the protonation equilibria, the extent of ionization at the physiological pH and pKa values of this drug are studied combining spectroscopic techniques and computational calculations. Secondly, the binding process of volasertib to the human serum albumin (HSA) protein is analyzed by fluorescence spectroscopy. We report a high binding constant to HSA (Ka = 4.10 × 106 M-1) and their pharmacokinetic implications are discussed accordingly. The negative enthalpy and entropy (ΔH0 = -54.49 kJ/mol; ΔS0 = -58.90 J K-1 mol-1) determined for the binding process suggests the implication of hydrogen bonds and van der Waals interactions in the formation of the HSA-volasertib complex. Additionally, volasertib is encapsulated in an alginate/montmorillonite bionanocomposite as a proof of concept for an oral delivery nanocarrier. The physical properties of that nanocomposite as well as volasertib delivery kinetics are analyzed.
2024-12-01JOURNAL OF COLLOID AND INTERFACE SCIENCE
Montmorillonite restricts free fatty acid liberation and alters self-assembled structures formed during in vitro lipid digestion
Article
作者: Salim, Malinda ; Joyce, Paul ; Prestidge, Clive ; Boyd, Ben J ; Ariaee, Amin
The global rise in obesity necessitates innovative weight loss strategies. Naturally occurring smectite clays, such as montmorillonite (MMT), offer promise due to their unique properties that interfere with free fatty acid (FFA) liberation, reducing systemic uptake. However, the mechanisms of MMT-FFA interactions and their implications for weight management are undefined. This study investigates these interactions by adding MMT (10 % w/w) to in vitro lipolysis media containing medium chain triglycerides (MCTs), and monitoring FFA liberation using pH-stat titration. Nanoparticle tracking analysis (NTA) and synchrotron-based small-angle X-ray scattering (sSAXS) observed time-dependent structural changes, while electron microscopy examined clay morphology during digestion. A 35 % reduction in FFA liberation occurred after 25 min of digestion with MCT + MMT, with digestion kinetics following a biphasic model driven by calcium soap formation. NTA revealed a 17-fold decrease in vesicular structures with MCT + MMT, and sSAXS highlighted a rapid lamellar phase evolution linked to calcium soap formation. This acceleration is attributed to MMT's adsorption to unionized FFAs via hydrogen bonding, supported by TEM images showing a decrease in d-spacing, indicating FFA intercalation is not the main adsorption mechanism. These findings highlight MMT's potential as a novel intervention for reducing dietary lipid absorption in obesity and metabolic diseases.
2024-12-01ADVANCES IN COLLOID AND INTERFACE SCIENCE
Surface modification of bentonite and montmorillonite as novel nano-adsorbents for the removal of phenols, heavy metals and drug residues
Review
作者: Miller, Reinhard ; Arabmofrad, Sara ; Lazzara, Giuseppe ; Jafari, Seid Mahdi
Montmorillonite (Mt) is one of the eco-friendly and low-cost nano-adsorbents for water and wastewater treatment. Interactions of Mt. with various modifiers such as surfactants and polymers make it an ideal adsorbent with good selectivity for the removal of phenols, heavy metals and drug residues from water and wastewater. Surface modification can improve the adsorption potential of Mt. due to increasing the number of adsorption sites and functional groups to remove a wide variety of contaminants. This paper shows a general overview of the structure, adsorptive characteristics, and applications of Mt. and modified Mt. (m-Mt). Also, recent progress made in using of natural and modified bentonite and Mt. for removing phenols, heavy metals and pharmaceuticals from water and wastewater are explained. Furthermore, it discusses the strategies used to increase the adsorption capacity of Mt. by surface modification with cationic surfactants, acids, and polymers. This article delivers an exploration of the current uses of bentonite and Mt. for water and wastewater treatment and encouraging results obtained in this review could aid in the application Mt. and m-Mt for the recovery of high added value compounds and removal of contaminants from aquatic systems.
100 项与 蒙脱石 相关的药物交易
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 腹痛 | 中国 | 1998-01-01 | |
| 腹泻 | 法国 | 1975-01-01 |
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临床1期 | 35 | 鹽壓衊醖遞繭膚遞鏇壓(壓選構壓願鏇壓獵襯鏇) = 鹽願襯鹽蓋憲鹽鹽鏇憲 餘壓齋夢繭選鏇衊鬱顧 (鹹獵鹹鹹憲醖艱鑰鏇簾, 構選構範顧夢網鹹衊鬱 ~ 蓋範餘醖築夢選膚範壓) 更多 | - | 2019-03-11 |
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