AbstractBackground: Measles infection can be fatal in pediatric patients with chronic renal failure or in patients who have undergone renal transplantation, both of whom are in the immunosuppressed state. The efficacy of single, live measles vaccination in preventing infection was examined.Methods: Of 156 children with renal failure who underwent renal transplantation, the changes in antibody titer were investigated before and after renal transplantation in 125 children whose measles antibody titer could be examined, together with disease and vaccination histories. Live measles vaccine was administered to 42 children with negative antibody titer. The antibody seroconversion rate was then investigated in these children, along with rate of antibody maintenance and degree of antibody titer elevation.Results: Seroconversion rate was 97.6%. Antibody titers measured on HI and EIA were 72 ± 118 fold (HI) and 36.9 ± 31.3 (EIA), respectively. The geometric mean of the increase in antibody titer 6 months after vaccination was 15. No side‐effects of vaccination were observed in any of the children.Conclusions: Live measles vaccination of children with chronic renal failure is effective and safe, because the seroconversion rate, rate of antibody titer maintenance and degree of antibody titer elevation in children with chronic renal failure were all equivalent to those of healthy children.

1998-08-01·Pediatrics International

The effect of live measles vaccines on serum vitamin A levels in healthy children

Article

作者: S SongÜL YalÇIn ; Kadriye YurdakÖK ; Turgay CoŞKun ; İMran ÖZalp

AbstractObjective: Serum retinol levels have been shown to be depressed during measles infection. This study aims to demonstrate whether there is any decrease in serum vitamin A level following immunization with live viral vaccine and its relation with vaccine seroconversion in children with measles. Since many children receive measles vaccine alone or in combination with measles‐mumps‐rubella vaccine, we studied serum vitamin A levels and antibody levels in healthy, well‐nourished children before and after immunization with monovalent and combined live attenuated measles vaccine.Methods: The first group included 21 healthy children between the ages of9–11 months who received live measles (Schwarz) vaccine. There were also 21 healthy children (range14–20 months of age) who received measles‐mumps‐rubella Trimovax® (Pasteur Merieux) vaccine. All children were tested for serum vitamin A levels before vaccination, on days9–14 and30–42 following both vaccinations. Measles specific antibody levels were also measured on admission and30–42 days following vaccinations.Results: In both vaccination groups, mean serum vitamin A levels reduced significantly on days9–14, but increased slightly on days30–42 in the measles‐mumps‐rubella vaccinated group (P < 0.05). The baseline and follow‐up levels of mean serum vitamin A did not differ between seroconverted and nonseroconverted cases within the measles vaccinated group.Conclusion: Serum vitamin A levels are reduced following vaccination with monovalent and combined live attenuated measles vaccines.

1987-07-04·BMJ

Live measles vaccine: a 21 year follow up.

Article

作者: Miller, C

21 years after receiving Schwartz strain live measles vaccine 4500 trial participants showed a continuing high level of protection compared with those who were unvaccinated. Over the last seven years of the follow up no cases of measles were reported in vaccinated participants who had had close contact with the disease. Immunity induced by the vaccine seems to survive the challenge of close contact with measles in young children, even after 21 years.

100 项与麻疹减毒活疫苗 (长春祈健生物) 相关的药物交易

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