A Multi-Center, Randomized, Double-Masked Evaluation of the Efficacy of Cetirizine 0.1%/Fluticasone 0.005% Ophthalmic Solution Compared to Its Components and Vehicle in a Modified Conjunctival Allergen Challenge (CAC) Model During Pollen Season

The purpose of this study is to evaluate the efficacy of AC-150 compared to vehicle and its components in the prevention of the signs and symptoms of allergic conjunctivitis in Enviro-CAC™ Model.

开始日期2010-05-01

申办/合作机构

Nicox Ophthalmics, Inc.

100 项与 Cetirizine Hydrochloride/Fluticasone Propionate 相关的临床结果

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100 项与 Cetirizine Hydrochloride/Fluticasone Propionate 相关的转化医学

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1,159

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2025-05-01·Ceramics International

Effect of organometallic-derived TZP nanoparticles on the mechanical properties of ZTA ceramics

作者: Yang, Meijun ; Su, Yibing ; Li, Qizhong ; Guo, Xiaoping ; Zhang, Song ; Xu, Yijun ; Tu, Rong ; Goto, Takashi ; Han, Yuzhe

The incorporation of t-ZrO₂ into α-Al2O3 matrix is a widely established method for enhancing the mech. properties of ceramic materials, i.e., zicornia toughened alumina (ZTA).In this study, acetylacetonate zirconium and acetylacetonate yttrium were thoroughly mixed with α-Al2O3 powder and then calcined to achieve a uniform dispersion of organometallic-derived tetragonal zirconia polycrystal (TZP) particles in nano-size onto α-Al₂O₃, forming a composite powder.The TZP particle size increased from 8 to 39 nm with increasing calcination temperature from 600 to 1000°C.The TZP nanoparticles coated α-Al₂O₃ powder was sintered by spark plasma sintering (SPS) to obtain ZTA ceramics.TZP is embedded in the face-centered cubic skeleton formed by α-Al₂O₃ and restricts grain growth to each other.The highest hardness and toughness, i.e., 18.81 GPa and 10.31 MPa m^1/2, of the ZTA ceramics was achieved at 1400°C by using the composite powder calcined at 600°C.

2025-04-01·Ceramics International

High-performance triboelectric nanogenerator based on high-permittivity BaZr0.2Ti0.8O3 nanowires with enhanced surface potential

作者: Yuan, Xi ; Jia, Miao ; Liu, Yuan ; Gong, Hanyu ; Xu, Qianqian ; Xiang, Shan ; Zhang, Yan ; Zhou, Kechao ; Yan, Mingyang ; Li, Huimin ; Zhang, Dou

Triboelec. nanogenerators (TENGs) provide a feasible solution to energy problems.Although great progress has been made in the development of high-performance TENGs in recent years, they still exhibit insufficient performance as power systems with high power consumption.Here, we propose a surface potential regulation-based strategy to construct high-performance TENGs using optimized electroneg. poly (vinylidene fluoride-co-trifluoroethylene) (PVDF-TrFE) with a high β-phase (86.99%) and ultrahigh electropos. nylon 6 with high surface roughness and sp. surface area as friction materials.The introduction of barium zirconate titanate (BaZr_0.2Ti_0.8O₃) nanowires with high dielec. constant and high aspect ratio into PVDF-TrFE significantly promotes the formation of polar β-phase and increases the dielec. constant and surface potential of the neg. material.This effective strategy achieves a significant increase in the output voltage and current of TENG, which is resp. about 146% and 154% of the original.The TENG containing 4 wt% BZT nanowires can generate an open circuit voltage of 243.2 V, a short circuit current of 41.9μA, and an excellent power d. of 7.5 W/m², which exceeds the previously reported PVDF-based TENG.In addition, the high-performance TENG is able to charge a 22μF capacitor to 4.1 V within 2 min at a low frequency (2.5 Hz) and power a calculator, demonstrating its great potential in efficient energy supply.

2025-04-01·Journal of Luminescence

Deep-red emitting SrNaZrO3:Mn4+ phosphor for greenhouse cultivation LEDs application

作者: Ramirez-DelaCruz, A. ; Kroon, R. E. ; Ahemen, I. ; Erasmus, L. J. B. ; Nathan-Abutu, A. ; Reyes-Rojas, A.

A sequence of deep red-emitting phosphors, Sr_0.9Na_0.2Zr_1-xO₃:Mn⁴⁺, was synthesized using a modified sol-gel method.The Rietveld anal. indicates that the optical properties are influenced by the coordination environment of the host material.The Zr atom′s 4a site symmetry is occupied by Mn²⁺ and Mn⁴⁺ ions in an octahedral coordination, leading to a reduction in V°^°o.When excited at 325 nm, photoluminescence (PL) at room temperature (303.15 K) and higher temperatures exhibited strong blue emission at 423 nm and a zero-phonon deep-red emission band at 698 nm.These emissions stem from the ⁴T₁→⁶A₁ and ²E_g → ⁴A_2g transition in the 3d orbit of manganese ions.At higher concentrations, PL intensity was quenched due to energy transfer and exchange interactions between adjacent ions.Temperature-dependent PL measurements showed a quenching in emission intensity with increasing temperature, attributed to the dominance of nonradiative transitions.The Sr_0.9Na_0.2Zr_1-xO_3:0.01Mn⁴⁺ nanophosphors demonstrated high stability, retaining 50 % of their emission intensity at 422 K, with a thermal relative sensitivity of 2.49 %K^-1.The red phosphor achieved CIE color coordinates of (0.707, 0.293), comparable to com. NTSC-standard red-emitting phosphors, with 93 % color purity.These properties make it suitable for applications in thermal optical sensors and high-power LEDs.

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适应症	最高研发状态	国家/地区	公司	日期
变应性结膜炎	临床2期	美国	Nicox Ophthalmics, Inc.	2010-05-01

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01134328 (CTgov)	临床2期	变应性结膜炎	83	AC-150 Combo (AC-150 Combo)	醖願繭鑰廠窪襯選鏇壓(鏇憲簾獵選窪繭餘艱襯) = 糧齋繭壓鹹衊獵夢淵壓襯鹽顧鏇壓淵醖鹹製艱 (選醖範鏇襯壓艱醖餘淵, 鹽網網衊齋淵製選築鏇 ~ 蓋願築衊壓顧鑰糧獵築) 更多	-	2017-09-14
				AC-150A 0.1% (AC-150A 0.1%)	醖願繭鑰廠窪襯選鏇壓(鏇憲簾獵選窪繭餘艱襯) = 繭簾衊廠鹽餘淵構醖憲襯鹽顧鏇壓淵醖鹹製艱 (選醖範鏇襯壓艱醖餘淵, 糧構齋廠糧廠顧遞範艱 ~ 築鏇糧蓋觸廠膚築齋衊) 更多