A Multi-Center, Randomized, Double-Masked Evaluation of the Efficacy of Cetirizine 0.1%/Fluticasone 0.005% Ophthalmic Solution Compared to Its Components and Vehicle in a Modified Conjunctival Allergen Challenge (CAC) Model During Pollen Season

The purpose of this study is to evaluate the efficacy of AC-150 compared to vehicle and its components in the prevention of the signs and symptoms of allergic conjunctivitis in Enviro-CAC™ Model.

开始日期2010-05-01

申办/合作机构

Nicox Ophthalmics, Inc.

100 项与 Cetirizine Hydrochloride/Fluticasone Propionate 相关的临床结果

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100 项与 Cetirizine Hydrochloride/Fluticasone Propionate 相关的转化医学

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100 项与 Cetirizine Hydrochloride/Fluticasone Propionate 相关的专利（医药）

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1,174

项与 Cetirizine Hydrochloride/Fluticasone Propionate 相关的文献（医药）

2025-06-01·Carbon Letters

Polyacrylonitrile-derived carbon nanofibers/carbon foams containing closed microspheres

作者: Su, Bingyao ; Wang, Heng ; Cao, Yue ; Wang, Bin ; Xue, Gongfei ; Hou, Linwei

Abstract: Lightweight materials with favorable mech., electromagnetic interference (EMI) shielding and thermal insulation performance are highly desirable for applications in harsh environments.Polyacrylonitrile (PAN)-derived carbon nanofibers/carbon foams containing hollow closed microspheres have been developed, and their balanced multifunction is noteworthy.The addition of CNFs resulted in a gradual enhancement of the specific compressive strength of carbon foams, reaching a maximum value of 26.6 MPa·cm³·g^-1 with content of 3 weight% CNFs, improved by as much as 62%, compared to that of pristine carbon foam.Addnl., the fracture toughness exhibited the maximum fracture energy absorption of 118.6 MJm^-3 at 3 weight% CNFs.The appropriate amount of CNFs and hollow carbon microspheres resulted in effective toughening and strengthening of carbon foams.Incorporation of CNFs into carbon foams also resulted in an improvement in their electromagnetic shielding performance, with a maximum EMI-shielding effectiveness of 65.8 dB.Reflection loss was the main contributor to electromagnetic shielding efficiency.Furthermore, carbon foams presented remarkable high-temperature thermal insulation, with a min. thermal conductivity of merely 0.509 W·m^-1·K^-1 at 800 °C.They exhibited the ability to withstand the butane flame ablation at 1000 °C, which substantiated the potential of carbon foams for aerospace applications.

2025-05-05·ACS Materials Letters

Tumor-Activated Nanoassemblies with Positive Feedback Loop for Photoacoustic Imaging-Guided Precise Cancer Therapy

作者: Zheng, Jing ; Xing, Xiaotong ; Wang, Xuan ; Dong, Ming-Jie ; Dong, Haifeng ; Liu, Huiyu ; Zhou, Zijia

To realize highly selective/sensitive tumor microenvironment (TME) activated precise cancer therapy, a phosphomolybdate/metal-organic framework composite (PMo/MIL-101-Fe, P/M) has been designed for acidic/reductive TME activated photoacoustic imaging (PAI)-guided photothermal therapy (PTT) and TME regulatory enhanced chemodynamic therapy (CDT).The P/M composite incorporates Keggin-type phosphomolybdate into the porous MIL-101-Fe framework, enabling targeted degradation within the reductive TME and then releasing reduced PMo and Fe²⁺.The reduced PMo self-assembles into large clusters, leading to enhanced tumor retention, amplified PAI signals, and effective photothermal therapy (PTT).Concurrently, the liberated Fe²⁺ efficiently catalyzes H₂O₂ to generate hydroxyl radicals (•OH), contributing to CDT.Notably, the depletion of glutathione (GSH) by both MIL-101-Fe and PMo further augments the efficacy of CDT.As a result, this composite enables improved antitumor effects both in vitro and in vivo.This work provides a promising avenue to produce TME specifically activated precise nanotheranostic paradigms through rationally designed nanostructures.

2025-05-01·CERAMICS INTERNATIONAL

Effect of organometallic-derived TZP nanoparticles on the mechanical properties of ZTA ceramics

作者: Han, Yuzhe ; Guo, Xiaoping ; Su, Yibing ; Tu, Rong ; Goto, Takashi ; Zhang, Song ; Li, Qizhong ; Xu, Yijun ; Yang, Meijun

The incorporation of t-ZrO₂ into α-Al2O3 matrix is a widely established method for enhancing the mech. properties of ceramic materials, i.e., zicornia toughened alumina (ZTA).In this study, acetylacetonate zirconium and acetylacetonate yttrium were thoroughly mixed with α-Al2O3 powder and then calcined to achieve a uniform dispersion of organometallic-derived tetragonal zirconia polycrystal (TZP) particles in nano-size onto α-Al₂O₃, forming a composite powder.The TZP particle size increased from 8 to 39 nm with increasing calcination temperature from 600 to 1000°C.The TZP nanoparticles coated α-Al₂O₃ powder was sintered by spark plasma sintering (SPS) to obtain ZTA ceramics.TZP is embedded in the face-centered cubic skeleton formed by α-Al₂O₃ and restricts grain growth to each other.The highest hardness and toughness, i.e., 18.81 GPa and 10.31 MPa m^1/2, of the ZTA ceramics was achieved at 1400°C by using the composite powder calcined at 600°C.

100 项与 Cetirizine Hydrochloride/Fluticasone Propionate 相关的药物交易

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适应症	最高研发状态	国家/地区	公司	日期
变应性结膜炎	临床2期	美国	Nicox Ophthalmics, Inc.	2010-05-01

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01134328 (CTgov)	临床2期	变应性结膜炎	83	AC-150 Combo (AC-150 Combo)	齋繭夢夢積憲網夢齋齋(壓鏇鏇遞願鏇壓觸衊蓋) = 廠網淵廠壓鹹襯鑰憲衊鬱壓鹽憲壓憲夢蓋壓選 (醖選膚壓淵鏇築築遞餘, 0.974) 更多	-	2017-09-14
				AC-150A 0.1% (AC-150A 0.1%)	齋繭夢夢積憲網夢齋齋(壓鏇鏇遞願鏇壓觸衊蓋) = 獵淵構衊蓋積壓艱簾壓鬱壓鹽憲壓憲夢蓋壓選 (醖選膚壓淵鏇築築遞餘, 0.752) 更多