A Multi-Center, Randomized, Double-Masked Evaluation of the Efficacy of Cetirizine 0.1%/Fluticasone 0.005% Ophthalmic Solution Compared to Its Components and Vehicle in a Modified Conjunctival Allergen Challenge (CAC) Model During Pollen Season

The purpose of this study is to evaluate the efficacy of AC-150 compared to vehicle and its components in the prevention of the signs and symptoms of allergic conjunctivitis in Enviro-CAC™ Model.

开始日期2010-05-01

申办/合作机构

Nicox Ophthalmics, Inc.

100 项与 Cetirizine Hydrochloride/Fluticasone Propionate 相关的临床结果

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100 项与 Cetirizine Hydrochloride/Fluticasone Propionate 相关的转化医学

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100 项与 Cetirizine Hydrochloride/Fluticasone Propionate 相关的专利（医药）

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1,150

项与 Cetirizine Hydrochloride/Fluticasone Propionate 相关的文献（医药）

2025-03-01·Materials Letters

CuO nanowire array induced thermal effect from long wavelength light enhances photo-carrier transport in FeOCl for improved photo-fenton reaction

作者: Zhang, Zhibo ; Xie, Mingzheng ; Xie, Yiwen ; Yang, Zhuzhi ; Gu, Ruiyin

In this work, we aim to address the issue of hindered photo-carrier transport in layered FeOCl by means of the conversion of long-wavelength light into thermal energy through a CuO nanowire array substrate, thereby enhancing its Photo-Fenton activity.The results indicate that the CuO nanowire array can elevate the temperature of FeOCl from room temperature to approx. 55 °C under AM 1.5G conditions, extending the diffusion length of photo-carriers from 4 nm to ∼15 nm.This significant enhancement facilitates the separation of photo-carriers and results in a 2-fold enhancement in the Photo-Fenton degradation activity of ciprofloxacin.This work provides a feasible strategy for optimizing layered photocatalysts to improve their performances in advanced oxidation processes.

2025-03-01·Journal of the Australian Ceramic Society

Preparation and property characterization of Zr-modified Si-O-C-based precursor ceramics through three-dimensional printing

作者: Huang, Guimei ; Lin, Jia ; Wang, Shuai ; Wang, Jinhuo ; Yang, Yihang

Abstract: In this study, Zr-modified Si-O-C precursor ceramics were prepared using three-dimensional (3D) printing.Ceramic sintering was completed by printing four precursors containing different zirconium acetylacetone contents.Comparative anal. was conducted on the ceramic yield, size shrinkage, mech. properties, and microstructure.The results showed that the ceramic yield and size shrinkage of the four samples were increased with the increasing zirconium acetylacetone contents.The sample containing 30 wt% zirconium acetylacetone exhibited good compressive performance, with a compressive strength of 50.2 ± 0.6 MPa.Cracks were observed on the surface of samples containing 40 wt% zirconium acetylacetone, while those containing 10, 20, and 30 wt% zirconium acetylacetone were relatively intact.Therefore, a stable Si-Zr-O-C precursor ceramic with good mech. properties, which can be used for 3D printing, was obtained.

2025-02-01·Bioresource Technology

Enhanced production of jet fuel precursors via furfural/cyclopentanone aldol condensation by synergistic pairing TiO2 with nano-ZSM-5 zeolite

Article

作者: Mar Alonso-Doncel, María Del ; Cueto, Jennifer ; de la Calle, Daniel ; Serrano, David P ; Giner, Elena A ; García-Muñoz, Rafael A

Aldol condensation of biomass-derived compounds offers a sustainable route to jet fuel precursors. This study explores catalysts based on nanocrystalline ZSM-5 zeolite (n-ZSM-5) modified with various metals (Ca, Mg, Sn, Ti, Zr) for the aldol condensation of furfural (FFL) and cyclopentanone (CPO). While both reactants can enter the ZSM-5 micropores, the resulting C10 (FC) and C15 (F₂C) adducts are too large to be formed within or to exit the microporosity, being instead produced over the external acid sites. Metal modification significantly impacts catalytic activity: Ca and Mg reduce conversion, Sn is neutral, whereas Zr and Ti leads to enhanced performance. The TiO₂/n-ZSM-5 catalyst shows by far the best behavior, doubling FFL conversion and sharply increasing the FC + F₂C yield, which is attributed to a synergistic effect arising from the generation of accessible weak Lewis acid sites by highly dispersed TiO₂ that complement the external Brønsted acidity of ZSM-5.

100 项与 Cetirizine Hydrochloride/Fluticasone Propionate 相关的药物交易

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适应症	最高研发状态	国家/地区	公司	日期
变应性结膜炎	临床2期	美国	Nicox Ophthalmics, Inc.	2010-05-01

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01134328 (CTgov)	临床2期	变应性结膜炎	83	AC-150 Combo (AC-150 Combo)	蓋網鹹齋憲構壓淵範構(餘選淵襯壓醖簾範齋襯) = 願夢觸繭鑰顧觸壓範鏇築鬱蓋壓觸願願顧簾選 (廠糧獵鹽構構廠網積鏇, 鑰願願襯鑰鬱蓋壓遞蓋 ~ 繭網觸願壓遞齋鬱鹽積) 更多	-	2017-09-14
				AC-150A 0.1% (AC-150A 0.1%)	蓋網鹹齋憲構壓淵範構(餘選淵襯壓醖簾範齋襯) = 齋願構獵獵糧觸壓築積築鬱蓋壓觸願願顧簾選 (廠糧獵鹽構構廠網積鏇, 網餘選蓋壓範網鹹蓋蓋 ~ 蓋壓夢鹽願鹽膚餘觸選) 更多