The purpose of the study is to (1) to determine the rate of PSA decline (the number declining). Tissue will be obtained for ancillary studies and (2) to determine the number of patients with a PSA decline to <1.0 ng/ml at 3 months in patients receiving Nexrutine® with standard radiation therapy. The Secondary Objective is to confirm the tolerability of this regimen. The Third Objective (Ancillary studies) is To evaluate the molecular response of Nexrutine®. Molecular response is defined as changes in the molecular pathways.

开始日期2011-07-01

申办/合作机构

University of Texas Health Science Center At San Antonio

100 项与黄柏皮提取物相关的临床结果

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100 项与黄柏皮提取物相关的转化医学

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100 项与黄柏皮提取物相关的专利（医药）

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项与黄柏皮提取物相关的文献（医药）

2024-06-01·Journal of Pharmaceutical and Biomedical Analysis

Metabolic profile of Phellodendron amurense Rupr. in vivo of rat and its metabolomic study on intervention in rheumatoid arthritis

Article

作者: Deng, Yawei ; Hao, Ying ; Feng, Yuan ; Li, Chunhua ; Liu, Shiqiao ; Liu, Mingsong ; Wang, Bingcheng ; Zhang, Qingqing ; Xin, Xiaodong

To analyze the metabolites (blood, urine and feces) in normal rats after intragastric administration of the decoction of Phellodendri Amurensis Cortex (PAC) and to map the metabolic profile of PAC in vivo of rat; meanwhile, to evaluate the anti-rheumatoid arthritis (RA) effect of PAC by blood metabolomics technique and to explore its mechanism. Performing on UPLC-Q-TOF-MS technology with a Waters ACQUITY UPLC BEH-C₁₈ column (100 mm × 2.1 mm, 1.7 μm), the mobile phase was acetonitrile-0.1% formic acid aqueous solution (gradient elution). Prior to and following the administration of the decoction of PAC, the samples of blood, urine, and fecal were collected from the rats, in the positive ion mode, pharmacogenic metabolites in each biological sample were identified according to the accurate mass, fragment ions, retention time, metabolic reaction type, comparison of reference substance and retrieval of Pub Med database; The adjuvant-type arthritis (AA) rat model was established, and blood metabonomics method was used to study the improvement effect of rheumatoid arthritis after drug intervention with PAC, and its mechanism was preliminarily explored through analysis of metabolic pathway. A total of 72 exogenous components were identified, including 17 prototype components and 55 metabolites; 14 biomarkers were screened by blood metabolomics techniques combined with multivariate statistical analysis, and PAC significantly improved symptoms of rheumatoid arthritis in rats, and the metabolic pathway analysis mainly involves 5 metabolic pathways. The components in the aqueous decoction of PAC mainly undergo phase I metabolic reactions in rats, such as oxidation, reduction, dehydrogenation, demethylation, and phase II metabolic reactions, such as acetylation, glucuronidation, methylation; PAC has anti-rheumatoid arthritis effects, and its mechanism of action may be related to biosynthesis of aminoacyl-tRNA, metabolism of phenylalanine, metabolism of tryptophan, degradation of valine, leucine and isoleucine and biosynthesis of pantothenic acid and coenzyme A, providing a scientific basis for the study of the pharmacodynamic substances and the action mechanism of PAC against RA.

2024-04-01·Molecular Carcinogenesis

Corrigendum to “Nexrutine inhibits azoxymethane‐induced colonic aberrant crypt formation in rat colon and induced apoptotic cell death in colon adenocarcinoma cells”

2024-02-01·Biochemical and Biophysical Research Communications

Berberine alleviates inflammation and suppresses PLA2-COX-2-PGE2-EP2 pathway through targeting gut microbiota in DSS-induced ulcerative colitis

Article

作者: Zhang, Qian ; Xie, Zhiyong ; Zhou, Benjie ; Liao, Ziqiong ; Xia, Fan ; Yu, Hansheng ; Li, Ruiming ; Ma, Chong ; Zhang, Shaobao

Berberine, isolated from Coptis chinensis and Phellodendron amurense, can attenuate colonic injury and modulate gut microbiota disorders in ulcerative colitis (UC). However, the mechanism and causal relationship between gut microbiota and the efficacy of Berberine on UC are still unclear, which were investigated by pseudo-germ-free (PGF) mice, 16S rRNA gene analysis and transcriptome analysis in this study. The results demonstrated that Berberine improved gut microbiota disorders, colon damage, tight-junction proteins, inflammatory and anti-inflammatory cytokines in DSS-induced colitis mice with intact gut microbiota but not in PGF mice. Besides, immune-related and inflammation-related pathways were closely related to the efficacy that Berberine alleviated colitis by regulating gut microbiota. Furthermore, Berberine reduced PGE2, PLA2, COX-2, Ptges, EP2 and p-Stat3 only in colitis mice with intact gut microbiota. In summary, our study confirms that Berberine inhibits PLA2-COX-2-PGE2-EP2 pathway in UC through gut microbiota, leading to the alleviation of inflammation in colon, which further elucidates the underlying mechanism and promotes the application of Berberine in UC.

项与黄柏皮提取物相关的新闻（医药）

2024-01-02

·PRNewswire

Hi-Tech Pharmaceuticals Launches SLIMAGLUTIDE® for Weight Management and Blood Sugar Metabolism Support

NORCROSS, Ga., Jan. 2, 2024 /PRNewswire/ -- Hi-Tech Pharmaceuticals, a leading manufacturer of cutting-edge dietary supplements and weight management supplements, is proud to announce the launch of its latest product, SLIMAGLUTIDE®. This groundbreaking supplement provides a natural and effective solution for blood sugar metabolism support and healthy weight management.* Slimaglutide® is a groundbreaking weight management supplement utilizing 10 Glucagon-like Peptide-1 (GLP-1) Receptor agonist and secretagogues to provide a natural and effective solution for blood sugar metabolism support, healthy weight management and at an affordable cost.* Hi-Tech's Research and Development Team spent over a year researching the active ingredients and compounds that make Slimaglutide®. This Novel and Revolutionary weight management aid will turn the Diet Industry on its head! Hi-Tech Pharmaceuticals is a leader in phellodendron and berberine research with its Nexrutine® series of berberine extracts, which have over two decades of studies and real world results in many of Hi-Tech's branded products. Slimaglutide® utilizes a 97% pure Nexrutine®XS extract naturally derived from phellodendron bark. Hi-Tech launch of Slimaglutide® benefits from Hi-Tech being the forefront of Berberine research with its Nexrutine product. The berberine utilized in Slimaglutide® utilized a Berberine Pharmacokinetic study that showed improved berberine bioavailability (AUC) by over 10 times on molar basis and with observed dose linearity. Our berberine increased retention time from about 30-45 minutes to over 10 hours! The uniqueness of Nexrutine XS® Berberine derives directly from one of berberine's main limits: bioavailability. The raw extract has extremely poor oral bioavailability and bioabsorption profile. Nexrutine XS® Berberine groundbreaking supplement harnesses the power of berberine to provide a natural and effective solution for blood sugar metabolism support and healthy weight management. Slimaglutide® effectively support metabolic health, favorably modulating insulin response; improving the blood sugar profile, leveling both blood glycemic and insulin; having a positive effect on body composition and inducing the redistribution of adipose tissue. Hi-Tech's utilizes our proprietary Cyclosome®, a special structure of sunflower lecithin and cyclodextrin that ensures your body can absorb the plant extracts as they pass through your body. For Slimaglutide® we also incorporate sodium caprate (C10, a medium-chain triglyceride) to promote optimal absorption and maintenance of gastrointestinal comfort during berberine supplementation. As a society, our expanding waistlines have only increased our pre-existing concerns regarding our blood sugar and cholesterol levels. Slimaglutide® provides an effective, natural means of supporting our efforts toward more balanced blood sugar and weight management. The second pathway Hi-Tech researchers found effective compounds are from glucose-dependent Insulinotropic polypeptide (GIP). Hi-Tech developed a proprietary extract called TwinCretin® from the Fagonia Cretia, which stimulated both GLP-1 and GIP secretion, increased cellular hormone content, and upregulated gene expression of proglucagon, GIP and prohormone convertase. The release of GLP-1 and related effects delay gastric emptying and bowel motility, and in addition, exerts pressure on the hypothalamus to alter satiety; thereby, reducing appetite and assisting in weight management. Slimaglutide® is the only omni-faceted nutraceutical on the market to attack both GLP-1 and GIP secretion and is extremely potent when it comes to weight management. "Hi-Tech is often first to market with cutting-edge products, and Slimaglutide® may be our crown jewel," said Jared Wheat, President and CEO of Hi-Tech. "With the launch of Slimaglutide®, consumers can experience the remarkable weight management benefits of GLP-1 receptor agonists and the power of a one-of-a kind- GIP nutraceutical." *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent disease. Media Contact: Brandon Schopp [email protected] 770-797-9959 SOURCE Hi-Tech Pharmaceuticals, Inc.

上市批准

2023-12-28

·PRNewswire

Hi-Tech Pharmaceuticals Introduces SLIMAGLUTIDE® - A Revolutionary Breakthrough in Weight Management and Glucagon-like Peptide-1 (GLP-1) Receptor Agonist

NORCROSS, Ga., Dec. 28, 2023 /PRNewswire/ -- Hi-Tech Pharmaceuticals, a leading manufacturer of cutting-edge dietary supplements and weight management supplements, is proud to announce the launch of its latest product, SLIMAGLUTIDE®. This groundbreaking supplement provides a natural and effective solution for blood sugar metabolism support and healthy weight management.* Slimaglutide® is a groundbreaking weight management supplement utilizing berberine along with 10 other Glucagon-like Peptide-1 (GLP-1) Receptor agonist and secretagogues to provide a natural and effective solution for blood sugar metabolism support, healthy weight management and at an affordable cost.* Hi-Tech's Research and Development Team spent over a year researching the active ingredients and compounds that make Slimaglutide®, a Novel and Revolutionary weight management aid that will help millions of people feel great! Hi-Tech Pharmaceuticals is a leader in phellodendron and berberine research with its Nexrutine® series of berberine extracts, which have over two decades of studies and real world results in many of Hi-Tech's branded products. Slimaglutide® utilizes a 97% pure Nexrutine®XS extract naturally derived from phellodendron bark. Slimaglutide® also uses a high grade extract called YGDPure® that has been shown to work via the GLP-1 pathway among other pathways, and in multiple clinical trials has been shown in a 45 day trial that those taking YGD had incredible results! This is just another of the amazing GLP-1 compounds found in Slimaglutide®. Consumer interest in berberine, an herbal compound extracted from various plants, has skyrocketed in popularity in the past few weeks due to increased chatter over social media platforms, such as TikTok. Hi-Tech's Nexrutine® is the most studied berberine extract used for a variety of health related issues. Berberine has been used for centuries in traditional herbalism and ayurvedic medicine; however, berberine is notoriously difficult for the body to absorb effectively and often does not yield the desired results. Hi-Tech utilizes a proprietary and clinically-studied form of berberine called Nexrutine® XS Cyclosome®, which applies cutting-edge, ultra-absorption liposome and cyclodextrin technologies to address these challenges. The second pathway Hi-Tech researchers found effective compounds are from glucose-dependent Insulinotropic polypeptide (GIP). Hi-Tech developed a proprietary extract called TwinCretin® from the Fagonia Cretia, which stimulated both GLP-1 and GIP secretion, increased cellular hormone content, and upregulated gene expression of proglucagon, GIP and prohormone convertase. The release of GLP-1 and related effects delay gastric emptying and bowel motility, and in addition, exerts pressure on the hypothalamus to alter satiety; thereby, reducing appetite and assisting in weight management. Slimaglutide® is the only omni-faceted nutraceutical on the market to attack both GLP-1 and GIP secretion and is extremely potent when it comes to weight management. "Hi-Tech is committed to delivering products found in Nature and Backed by Science®," said Jared Wheat, President and CEO of Hi-Tech. "With the launch of Slimaglutide®, consumers can experience the remarkable weight management benefits of GLP-1 receptor agonists and the power of a one-of-a kind- GIP nutraceutical." About Hi-Tech: Hi-Tech Pharmaceuticals is an enormously successful company that creates, manufactures and sells high-quality products. Hi-Tech has been able to increase its market share in the United States through the acquisition of sixteen acquisitions in recent years, which included the manufacturing bases of Synergy Nutritional Industries in 2005 and Nittany Pharmaceuticals in Pennsylvania in 2012. Hi Tech also acquired many large brands such as: APS Nutrition, ALR, FormuTech Nutrition, Sports One, Innovative Laboratories, LG Sciences, iForce Nutrition, Prime Nutrition, Top Secret Nutrition, EAS and BPI Sports. Hi-Tech's recent strategy has been, and according to its leaders will continue to be, growth through Merger and Acquisition activity. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent disease. Media Contact: Brandon Schopp, (770) 797-9959, 370516@email4pr.com SOURCE Hi-Tech Pharmaceuticals

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100 项与黄柏皮提取物相关的药物交易

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适应症	最高研发状态	国家/地区	公司	日期
前列腺癌	临床前	美国	University of Texas Health Science Center At San Antonio	2009-05-01

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01705652 (Nexrutine, CTgov)	临床2期	前列腺癌	21	Nexrutine (Nexrutine Surgery Group)	積夢鏇鏇鏇膚壓鹽選築(憲膚積窪衊鹹窪齋構鏇) = 醖顧鑰鏇鏇鑰鏇鹹繭廠膚遞顧獵製醖齋衊遞遞 (憲壓鏇顧製餘廠築選網, 築鏇窪構積遞憲鏇膚鏇 ~ 壓遞襯艱齋夢鹹築窪壓) 更多	-	2015-06-11
				Nexrutine (Nexrutine Radiation Group)	積夢鏇鏇鏇膚壓鹽選築(憲膚積窪衊鹹窪齋構鏇) = 鏇淵範遞選餘網範淵廠膚遞顧獵製醖齋衊遞遞 (憲壓鏇顧製餘廠築選網, 鹽蓋廠膚構艱衊顧鹽製 ~ 遞艱蓋積窪糧壓觸醖憲) 更多