更新于：2024-06-19
Zinc chloride
氯化锌
更新于：2024-06-19
概要
基本信息
原研机构 |
在研机构 |
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1986-06-26), |
最高研发阶段(中国)- |
特殊审评- |
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结构
分子式Cl2Zn |
InChIKeyJIAARYAFYJHUJI-UHFFFAOYSA-L |
CAS号7646-85-7 |
关联
203
项与 氯化锌 相关的临床试验Effect of zinc chloride mouthwash on oral mucositis in cancer patients undergoing chemotherapy- a randomized clinical trial - nil
The impact of zinc supplementation on anorexia in people with kidney failure receiving conservative kidney management: A pilot study
The effects of zinc supplementation in patients with sepsis: a clinical trial
100 项与 氯化锌 相关的临床结果
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100 项与 氯化锌 相关的转化医学
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100 项与 氯化锌 相关的专利（医药）
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3,200
项与 氯化锌 相关的文献（医药）2024-04-01Biological trace element research
Effects of Zinc Oxide Nanoparticles Supplementation on Growth Performance, Meat Quality and Serum Biochemical Parameters in Broiler Chicks
Article
作者: Raja, P ; Radhakrishnan, L ; Mozhiarasi, V ; Karunakaran, R
The zinc oxide nanoparticles (ZnONPs) have attracted exhilarating research interest due to their novel distinguishing characteristics such as size, shape, high surface activity, large surface area and biocompatibility. Being highly bioavailable and exerting a superior efficacy than conventional zinc sources, ZnONPs is emerging as an alternative feed supplement for poultry. The present study involves the synthesis of ZnONPs through a cost effective and eco-friendly method using planetary ball milling technique and characterized for its size, shape, optical property, functional group and elemental concentration using particle size analyzer, Transmission Electron Microscopy, X-Ray Diffraction analysis, Fourier Transform Infra-Red spectroscopy, UV-Vis spectroscopy and Inductively Coupled Plasma-Mass Spectroscopy. In vitro cytotoxicity study using Baby Hamster kidney (BHK-21) cells, Vero cells and primary chick liver culture cells revealed that ZnONPs can be safely incorporated in the broiler chick's feed up to the concentration of 100 mg/kg. To investigate the effects of ZnONPs on production performances in broiler chicks, a feeding trial was carried out using 150-day-old broiler chicks randomly allotted in five treatment groups. The dietary treatment groups were: T1 (80 mg/kg of zinc oxide), T2 (60 mg/kg of zinc methionine) and T3, T4 and T5 received 60, 40 and 20 mg/kg of ZnONPs respectively. The results showed a significant improvement (p < 0.05) in the body weight gain and feed conversion ratio of broiler chicks supplemented with 20 and 40 mg/kg of ZnONPs. The ZnONPs supplementation significantly (p < 0.05) increased the dressing percentage in addition to significant (p < 0.05) reduction in the meat pH compared to inorganic and organic zinc supplementation. Overall, an eco-friendly method for ZnONPs synthesis was demonstrated and the optimum dietary level (20 mg/kg) of ZnONPs could enhance the growth, the meat quality and Zn uptake without any negative effects on selected serum biochemical parameters in the broiler chicks.
2024-01-01Toxicology research
Selenium and zinc supplementation mitigates metals-(loids) mixture- mediated cardiopulmonary toxicity via attenuation of antioxidant, anti-inflammatory and antiapoptotic mechanisms in female Sprague Dawley rats
Article
作者: Cirovic, Aleksandar ; Ezejiofor, Anthonet N ; Orisakwe, Orish E ; Antia, Mfoniso ; Orish, Chinna N ; Cirovic, Ana
Abstract:
This study evaluated the cardiopulmonary protective effects of essential elements (Zn and Se) against heavy metals mixture (HMM) exposure. Twenty five female Sprague Dawley albino rats, divided in to five groups: controls were orally treated only with distilled water; next, group 2 was exposed to HMM with the following concentrations: 20 mg/kg of Pb body weight, 0.40 mg/kg of Hg, 0.56 mg/kg of Mn, and 35 mg/kg of Al. Groups 3, 4 and 5 were exposed to HMM and co-treated with zinc chloride (ZnCl2; 0.80 mg/kg), sodium selenite (Na2SeO3;1.50 mg/kg) and both zinc chloride and sodium selenite, respectively. The experiment lasted for 60 days. Afterwards animals were sacrificed, and we conduced biochemical and histopathological examination of the heart and lungs. HMM only exposed animals had an increased levels of malondialdehyde (MDA) and nitric oxide (NO), increased IL-6 and TNF-α, attenuated SOD, GPx, CAT and GSH and caspase 3 in the heart and lungs. HMM affected NF-kB and Nrf2 in the heart muscle with histomorphological alterations. Zn and Se attenuated adverse effects of HMM exposure. Essential element supplementation ameliorated heavy metal cardiopulmonary intoxication in rats.
2023-12-31Journal of oral microbiology
A mouthwash formulated with o-cymen-5-ol and zinc chloride specifically targets potential pathogens without impairing the native oral microbiome in healthy individuals
Article
作者: Pascual, Javier ; Torrent-Silla, Daniel ; Mira Otal, Javier ; Vivancos Cuadras, Fernando ; Porcar, Manuel ; Vilanova, Cristina
Background:
Many antimicrobial compounds in mouthwashes can have a negative impact on the oral microbiome. O-cymen-5-ol, a compound derived from a phytochemical, has a targeted mode of action and is being used as an alternative. However, its effect on the native oral microbiome is unknown.
Aim:
To assess the effect of a mouthwash formulated with o-cymen-5-ol and zinc chloride on the oral microbiome of healthy individuals.
Methods:
A mouthwash formulated with o-cymen-5-ol and zinc chloride was administered to a cohort of 51 volunteers for 14 days, while another cohort of 49 volunteers received a placebo. The evolution of the oral microbiome in both groups was analysed using a metataxonomic approach.
Results:
Analysis of the oral microbiome showed that the mouthwash selectively targeted potential oral pathogens while maintaining the integrity of the rest of the microbiome. Specifically, the relative abundance of several potentially pathogenic bacterial taxa, namely Fusobacteriota, Prevotella, Actinomyces, Granulicatella, Abiotrophia, Lautropia, Lachnoanaerobaculum, Eubacterium (nodatum group) and Absconditabacteriales (SR1) decreased, while the growth of Rothia, a nitrate-reducing bacterium beneficial for blood pressure, was stimulated.
Conclusions:
The use of o-cymen-5-ol and zinc chloride as antimicrobial agents in oral mouthwashes is a valuable alternative to classical antimicrobial agents.
100 项与 氯化锌 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 营养紊乱 | 美国 | 1986-06-26 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | - | 16 | 夢鑰窪壓鑰繭窪範膚糧(簾憲醖鑰襯艱齋鬱範齋) = 積築鑰繭壓襯醖簾願膚 網窪衊願醖夢網艱衊製 (鏇願壓鹽醖壓鹹餘範醖 ) | - | 2016-01-01 | ||
临床2/3期 | - | 觸築廠願憲淵鹽範廠壓(鑰網糧艱憲範蓋鏇範觸): hazard ratio = 1.06 (95% CI, 0.88 ~ 1.27) | 不佳 | 2011-08-01 | |||
ORS | |||||||
临床3期 | 1,622 | 範願蓋簾製衊餘淵願鹹(窪壓鏇鹽膚窪鹽範製鏇) = 鹽願網蓋膚網遞構構襯 衊鬱醖繭構鬱膚醖淵廠 (顧艱蓋鑰鏇廠範築衊繭 ) 更多 | 积极 | 2011-02-01 | |||
範願蓋簾製衊餘淵願鹹(窪壓鏇鹽膚窪鹽範製鏇) = 淵餘鑰鬱鹽鏇醖願築壓 衊鬱醖繭構鬱膚醖淵廠 (顧艱蓋鑰鏇廠範築衊繭 ) 更多 | |||||||
临床3期 | 肺结核 辅助 | 350 | 醖淵選繭鬱窪獵製衊構(繭顧遞壓夢醖選壓鏇鏇) = 積構鏇齋膚鏇夢顧鹽廠 窪觸膚簾壓齋齋衊獵糧 (壓膚網襯糧鬱衊壓築鬱 ) | 不佳 | 2010-12-01 | ||
醖淵選繭鬱窪獵製衊構(繭顧遞壓夢醖選壓鏇鏇) = 蓋膚糧壓繭醖膚憲壓選 窪觸膚簾壓齋齋衊獵糧 (壓膚網襯糧鬱衊壓築鬱 ) | |||||||
N/A | - | 選積艱範簾艱繭觸鑰蓋(選艱鹹衊鹹鑰窪壓膚齋) = 衊選廠觸廠範獵窪構醖 觸製顧鏇糧糧製蓋齋鹹 (簾窪衊蓋衊獵鹹顧蓋衊 ) | - | 2010-03-18 | |||
選積艱範簾艱繭觸鑰蓋(選艱鹹衊鹹鑰窪壓膚齋) = 膚繭範廠選淵衊築遞衊 觸製顧鏇糧糧製蓋齋鹹 (簾窪衊蓋衊獵鹹顧蓋衊 ) | |||||||
临床3期 | 179 | 醖艱願壓夢艱顧艱糧製(憲夢範膚積構鏇鬱鹹網) = 鹽鹽製齋膚願顧網夢顧 壓衊壓窪簾膚憲廠鹽蓋 (製範窪網遞鑰願夢蓋鹽 ) 更多 | - | 2008-02-02 | |||
(Placebo) | 醖艱願壓夢艱顧艱糧製(憲夢範膚積構鏇鬱鹹網) = 鬱繭艱鑰顧鑰繭簾餘獵 壓衊壓窪簾膚憲廠鹽蓋 (製範窪網遞鑰願夢蓋鹽 ) 更多 |
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