预约演示
更新于：2025-05-17
Apocyanin
香草乙酮
更新于：2025-05-17
概要
基本信息
结构/序列
分子式C9H10O3 |
InChIKeyDFYRUELUNQRZTB-UHFFFAOYSA-N |
CAS号498-02-2 |
关联
8
项与 香草乙酮 相关的临床试验CTIS2023-508791-11-00
A placebo-controlled, double-blinded, randomized, dose-finding trial using a combination of apocynin and paeonol (APPA) for the treatment of knee osteoarthritis
EUCTR2020-000249-14-DK
A placebo-controlled, double-blinded, randomized, trial using a combination of apocynin and paeonol (APPA) for the treatment of knee osteoarthritis
IRCT20200418047122N1
Evaluation of the protective effect of a combination drug including Apocynin, Niacin, and Tannin on prevention of cardiovascular and respiratory morbidities and mortality in COVID-19 infection: A Clinical Trial
100 项与 香草乙酮 相关的临床结果
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100 项与 香草乙酮 相关的转化医学
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100 项与 香草乙酮 相关的专利（医药）
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6,904
项与 香草乙酮 相关的文献（医药）2025-09-01SEPARATION AND PURIFICATION TECHNOLOGY
Ni-substituted POM@UIO-66 catalyst for high-efficiency catalytic conversion of larch lignin
作者: Zhang, Dan ; Shi, Junyou ; Liu, Yuting ; Xu, Wenbiao ; Deng, Haoyu ; Li, Xiangyu
Converting abundant lignin resources into high-value chems. has always been a pivotal approach in biomass refining.Among various methods, catalytic oxidative depolymerization stands out as one of the most promising approaches due to its mild reaction conditions and remarkable efficiency.In this study, we present a series of transition metal-substituted Ni/Co-PMo/PW@UIO-66 catalysts, among which NiPMo@UIO-66 demonstrated the superior catalytic performance after thorough characterization.Through more in-depth research, it was found that under the optimal reaction conditions of 160 °C, 1.0 MPa O2, and 3 h, the strong Bronsted acidity inherent in POM, combined with the excellent redox properties, the moderate Lewis acidity provided by Ni and Zr, and the improved substrate-catalyst interfacial contact offered by the UIO-66 carrier, synergistically yielded the formation of the high amount of primary products and outstanding selectivity (>90 %).Therefore, the optimal yields of vanillin and Me vanillate reached 11.26 wt%.In terms of stability, the POM undergoes partial decomposition after multiple uses, while the UIO-66 framework maintains remarkable stability.This study aims to provide insightful and inspiring contributions to the design of catalysts within the lignin catalytic oxidative valorization system.
2025-08-01JOURNAL OF MOLECULAR STRUCTURE
Synthesis, structural characterization, and potential antifungal activity of schiff base probes: A molecular docking study
作者: Gupta, Sofia ; Jyoti ; Kaur, Harshbir ; Dalal, Anurag ; Khurana, Sumesh ; Kaur, Amarjit ; Komal ; Singh, Gurjaspreet ; Malik, Sudha
This study focuses on the design, synthesis, and evaluation of nine newSchiff bases 3(a-i) derived from a condensation reaction between 4-amino-1,2,4-triazol-3-one and diverse aldehyde derivativesThese compounds were synthesized through an efficient and straightforward protocol, yielding high-purity products.Comprehensive characterization was performed using 1H and 13C NMR spectroscopy, elemental anal., and mass spectrometry to confirm the mol. structures.Addnl., single-crystal X-ray diffraction anal. elucidated the detailed structures of three representative compounds (3b, 3f, and 3g).The antifungal potential of the synthesized Schiff bases was investigated via mol. docking studies against the fungal protein target (PDB ID: 2RKT).The docking results revealed binding energies ranging from -5.87 kcal/mol to -8.37 kcal/mol, highlighting significant variations in ligand-protein affinity.Notably, compounds 3g and 3j demonstrated the highest potential antifungal activity, attributed to their unique structural features, such as the presence of a sulfur atom and cyclohexane moiety, resp.These findings suggest that the synthesized Schiff bases exhibit promising inhibitory potential and could serve as candidates for developing new antifungal therapies.
2025-08-01APPLIED CATALYSIS B-ENVIRONMENTAL
High-performance CuNi-alloy catalysts for efficient solvent-free hydrogenation furfural to furfuryl alcohol
作者: Liu, Huai ; Zhang, Rui ; Zhao, Shuailong ; Sun, Yong ; Zhang, Junhua ; Rao, Zilong ; Jia, Wenlong ; Peng, Lincai ; Zhang, Yu
Achieving high substrate concentration and low hydrogen pressure in alc. production has long posed a challenge in catalysis, especially solvent-free hydrogenation reactions.Herein, we report a NiCu-alloy catalyst with both high activity and excellent stability for the solvent-free hydrogenation of furfural (FF) to furfuryl alc. (FA) at 110°C and 3 bar H2.Cu1Ni1Ox/C gave a turnover frequency as high as 13458.8 h-1, significantly outperforming reported reaction systems (<6273 h-1).Upon scaling up the reaction system to 100 mL, the yield of FA remained above 99%.The study of adsorption sites unveiled the critical role of Ni0(111) in the homolytic cleavage of H2 and FF adsorption via the mode of η2(O)-aldehyde.The upward shift of the d-band center in the copper-doped catalyst improved the adsorption configuration of FF and reduced the reaction barrier more efficiently.Moreover, Cu1Ni1Ox/C catalyst can be employed for the solvent-free hydrogenation of aldehydes and ketones derivatives with versatile structures.Overall, this research enhances the comprehension of electronic interactions at the interface of CuNi-alloy catalysts and offers a promising approach for designing catalysts for solvent-free hydrogenation of aldehydes and ketones.
100 项与 香草乙酮 相关的药物交易
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研发状态
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 动脉粥样硬化 | 临床1期 | - | - | - |
| 糖尿病性神经病变 | 临床1期 | - | - | - |
| 高血压 | 临床1期 | - | - | - |
| 炎症性肠病 | 临床1期 | - | - | - |
| 帕金森病 | 临床1期 | - | - | - |
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临床结果
临床结果
适应症
分期
评价
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N/A | - | - | 積獵積構觸齋繭網餘醖(鬱襯網窪鑰艱繭鹹簾顧) = 鏇觸壓遞窪衊壓齋簾願 壓窪網膚積淵遞膚蓋衊 (製遞觸觸糧鏇選觸製鑰 ) | 积极 | 2024-06-05 | ||
醖淵廠積築艱鬱鹽築醖(製鹹蓋醖窪窪壓廠鏇觸) = 襯鑰壓淵餘餘鬱膚觸鹹 範壓壓鏇願鹹觸簾餘網 (齋膚襯襯積鑰艱廠顧構 ) 更多 | |||||||
N/A | - | Apocynin and paeonol (APPA) | 遞夢觸糧願艱獵鬱襯醖(廠餘選糧簾廠願願觸獵) = 築憲淵憲鹽繭淵淵築鹽 顧糧壓願製鬱齋鏇範繭 (獵範壓鬱積憲鹽積醖襯 ) | 积极 | 2020-06-03 | ||
N/A | - | - | AN-1 | 鏇襯壓遞構構壓範鹽顧(鑰餘網鬱選網觸網醖壓) = 廠觸遞憲網鬱製窪鏇糧 餘顧憲醖範憲鏇夢齋簾 (醖網廠壓構壓壓壓鑰觸 ) 更多 | - | 2013-07-30 | |
鏇襯壓遞構構壓範鹽顧(鑰餘網鬱選網觸網醖壓) = 夢膚網鹹簾獵憲遞餘襯 餘顧憲醖範憲鏇夢齋簾 (醖網廠壓構壓壓壓鑰觸 ) 更多 | |||||||
N/A | 高血压 reactive oxygen species (ROS) | - | 鬱夢鹽壓製構膚網壓簾(襯選觸衊齋廠齋鹹獵選) = 鏇蓋膚餘製齋廠簾網網 築鏇膚壓觸鑰鬱衊選獵 (願選淵築鹹築齋範鹹壓 ) 更多 | 积极 | 2012-09-01 | ||
鬱夢鹽壓製構膚網壓簾(襯選觸衊齋廠齋鹹獵選) = 醖襯糧餘鹽醖壓鹹願艱 築鏇膚壓觸鑰鬱衊選獵 (願選淵築鹹築齋範鹹壓 ) | |||||||
N/A | - | - | 鹽衊願願齋顧築觸膚艱(艱蓋製廠築艱窪簾糧鬱) = 襯廠夢淵膚鑰鹽範遞蓋 鏇願鑰艱齋鹹獵範簾遞 (鑰鹽鑰膚願鑰製簾範齋 ) 更多 | - | 2011-09-01 | ||
N/A | 14 | 選願蓋淵壓廠廠醖網獵(積廠壓艱夢鹹鹹簾鹽膚) = 網醖衊簾鹹遞壓鑰網衊 齋艱蓋鑰窪淵鹽鑰膚網 (壓築製築壓襯鹹壓構廠 ) 更多 | 积极 | 2011-09-01 | |||
Placebo | 選願蓋淵壓廠廠醖網獵(積廠壓艱夢鹹鹹簾鹽膚) = 鹹築鏇窪積簾艱壓範窪 齋艱蓋鑰窪淵鹽鑰膚網 (壓築製築壓襯鹹壓構廠 ) 更多 | ||||||
N/A | - | - | 積鏇鬱範獵範醖膚夢餘(選觸憲膚鑰顧窪膚壓糧) = 範鹹築壓壓廠艱壓觸齋 窪鑰鏇積淵積簾餘鏇鑰 (衊選窪鏇鑰範選鹹醖網 ) 更多 | - | 2011-09-01 | ||
Placebo | 積鏇鬱範獵範醖膚夢餘(選觸憲膚鑰顧窪膚壓糧) = 繭醖鹽鬱憲鬱繭製壓膚 窪鑰鏇積淵積簾餘鏇鑰 (衊選窪鏇鑰範選鹹醖網 ) 更多 |
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