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更新于：2025-02-15
Apocyanin
香草乙酮
更新于：2025-02-15
概要
基本信息
结构/序列
分子式C9H10O3 |
InChIKeyDFYRUELUNQRZTB-UHFFFAOYSA-N |
CAS号498-02-2 |
关联
8
项与 香草乙酮 相关的临床试验CTIS2023-508791-11-00
A placebo-controlled, double-blinded, randomized, dose-finding trial using a combination of apocynin and paeonol (APPA) for the treatment of knee osteoarthritis
EUCTR2020-000249-14-DK
A placebo-controlled, double-blinded, randomized, trial using a combination of apocynin and paeonol (APPA) for the treatment of knee osteoarthritis
IRCT20200418047122N1
Evaluation of the protective effect of a combination drug including Apocynin, Niacin, and Tannin on prevention of cardiovascular and respiratory morbidities and mortality in COVID-19 infection: A Clinical Trial
100 项与 香草乙酮 相关的临床结果
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100 项与 香草乙酮 相关的转化医学
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100 项与 香草乙酮 相关的专利（医药）
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6,918
项与 香草乙酮 相关的文献（医药）2025-06-01SEPARATION AND PURIFICATION TECHNOLOGY
Catalytic oxidative depolymerization of lignin to aromatic compounds using transition metal doped ionic Liquid-based polyoxometalate catalysts
作者: Shi, Junyou ; Zhao, Luyao ; Zhang, Yu ; Deng, Haoyu ; Xu, Wenbiao ; Li, Mingfei
Significant attention has been focused on the depolymerization of lignin into monophenolics, as lignin is the most abundant biomass feedstock, and its valorization is considered crucial for a complete biomass refinery.In this study, we investigate catalytic oxidative depolymerization using novel bimetallic transition metal (Ni and Co) doped ionic liquid-polyoxometalate (ILPOM) composites under aerobic conditions.We systematically evaluate various catalysts, including [MIMPS]H2PW12O40, Ni[MIMPS]PW12O40, Co[MIMPS]PW12O40, [MIMPS]H2PMo12O40, Ni[MIMPS]PMo12O40, and Co[MIMPS]PMo12O40, assessing their impact on monomer yield and selectivity.Notably, Co[MIMPS]PMo12O40 emerges as a superior catalyst, producing high yields of key aromatic monomers, primarily vanillin and Me vanillate, under optimized conditions.Addnl., the Co[MIMPS]PMo12O40 catalyst demonstrates effective cleavage of the C-O and/or Cα-Cβ bonds within a β-O-4 dimer model compound, indicating potential catalytic cracking capabilities.This investigation elucidates the intricate interplay among transition metals, ionic liquids (ILs), and lignin, providing a novel pathway for lignin transformation.
2025-04-01TISSUE & CELL
Assessing diapocynin's different effects on osteosarcoma and breast cancer cells: An in vitro study
Article
作者: Ximenes, Valdecir Farias ; Pessoa, Adriano de Souza ; Sanches, Mariana Liessa Rovis ; Santos, Fernanda Cesar Dos ; Mochetti, Matheus Menão ; Inacio, Kelly Karina ; Tokuhara, Cíntia Kazuko ; Oliveira, Rodrigo Cardoso de
Osteosarcoma is the most common primary bone cancer, accounting for approximately 5 % of new cancer cases globally. In contrast, breast cancer remains the most prevalent malignancy and a leading cause of cancer-related mortality among women. Given the limitations of current therapies, novel treatment strategies are urgently needed. This study evaluates the effects of diapocynin, a derivative of apocynin, on osteosarcoma (UMR-106) and breast cancer (MDA-MB-231) cell lines. Our results demonstrate a dose-dependent cytotoxicity of diapocynin in both cell types, with UMR-106 cells showing higher sensitivity than MDA-MB-231 cells. Notably, treatment with diapocynin induced significant morphological changes in both cell lines, and both IC25 and IC50 concentrations effectively inhibited cell migration, particularly in osteosarcoma cells. However, no significant changes were detected in matrix metalloproteinases -2 and -9 activity following treatment, suggesting that diapocynin may exert its effects through alternative pathways. These results highlight diapocynin as a promising candidate for cancer therapy, warranting further investigation into its mechanisms of action and potential clinical applications.
2025-03-01Acta Physiologica
Blocking the mineralocorticoid receptor prevents cardiac and mitochondrial dysfunction through the activation of NOX‐4 in female hormone deprivation rats
Article
作者: Varner, Kurt J. ; Guatimosim, Silvia ; Scalzo, Sergio ; Rodrigues, Nathália ; Ximenes, Carolina F. ; Eliezeck, Marcos ; Ribeiro, Eduardo Hertel ; Stefanon, Ivanita ; Rodrigues, Samya Mere L. ; Ronconi, Karoline ; Costa, Anna Karolina Nascimento ; Monteiro, André ; Ferreira, Katyana K. S. ; Fernandes, Aurélia Araújo ; Sanches, Bruno ; Vieira, Livia Barroca ; da Silva, Maria Luiza Yago ; Spalenza, Thiago
Abstract:
Aim:
Young women exhibit lower rates of cardiovascular disease (CVD) than age‐matched men, a protective effect often attributed to estrogen's influence on cardiac and mitochondrial function. The risk of CVD increases in post‐menopausal women, likely due to estrogen deficiency and aldosterone's negative effects, including those on mitochondria and other cellular targets. This study aimed to explore the link between estrogen deficiency and mitochondrial dysfunction in cardiac health. We hypothesized that in estrogen‐deprived conditions, aldosterone could stimulate NADPH oxidase, leading to mitochondrial dysfunction, and reduced cardiac contractility.
Methods:
Wistar rats were divided into four groups: Sham, Ovariectomy‐induced hormone deprivation (Ovx), Ovx with apocynin treatment, and Ovx with spironolactone treatment for 60 days.
Results:
Both apocynin and spironolactone countered the adverse effects of hormone deprivation by preserving myocardial contractility, improving cellular responses to calcium and isoproterenol, and normalizing the expression of key mitochondrial proteins. These compounds also attenuated the increase in reactive oxygen species (ROS) and maintained mitochondrial respiration rates.
Conclusion:
We concluded that estrogen deficiency contributes to cardiac oxidative stress via the NADPH oxidase and mitochondrial pathways. Apocynin and spironolactone offer significant protective effects, opening new avenues for treating cardiac issues related to estrogen deficiency.
100 项与 香草乙酮 相关的药物交易
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研发状态
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 动脉粥样硬化 | 临床1期 | - | - | - |
| 糖尿病性神经病变 | 临床1期 | - | - | - |
| 高血压 | 临床1期 | - | - | - |
| 炎症性肠病 | 临床1期 | - | - | - |
| 帕金森病 | 临床1期 | - | - | - |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | - | - | 鏇鑰窪淵糧夢願憲簾壓(衊膚鹹憲遞鹽構鬱獵餘) = 範襯選壓積淵構衊廠夢 遞醖顧糧蓋築築範獵簾 (糧鏇壓獵顧顧鹽簾觸艱 ) | 积极 | 2024-06-05 | ||
築製蓋衊夢衊製製餘膚(壓顧鬱醖夢齋鹽築夢憲) = 齋膚憲簾窪醖廠鏇淵淵 淵衊鏇醖餘餘憲廠餘廠 (窪夢鹽憲獵選觸鬱醖網 ) 更多 | |||||||
N/A | - | Apocynin and paeonol (APPA) | 顧壓醖鹹窪餘顧憲蓋願(糧鹹繭艱鹹繭構構簾觸) = 艱鏇夢鹹膚夢鏇簾鹹鏇 蓋艱鬱獵廠蓋艱獵糧顧 (窪製壓範窪淵糧襯鹽壓 ) | 积极 | 2020-06-03 | ||
N/A | - | - | AN-1 | 鏇積構餘網鬱築築繭鏇(獵鹽鏇齋衊範選簾鏇鹹) = 範蓋醖餘構艱鬱鬱醖繭 憲蓋醖顧繭廠鹹範範繭 (範觸鹹網構範襯蓋醖夢 ) 更多 | - | 2013-07-30 | |
鏇積構餘網鬱築築繭鏇(獵鹽鏇齋衊範選簾鏇鹹) = 憲鬱構遞鑰糧膚餘構淵 憲蓋醖顧繭廠鹹範範繭 (範觸鹹網構範襯蓋醖夢 ) 更多 | |||||||
N/A | 高血压 reactive oxygen species (ROS) | - | 齋鑰觸獵選糧夢獵窪壓(衊觸夢鹹膚齋淵獵鑰膚) = 築繭願窪簾餘鬱選夢淵 遞遞壓遞簾蓋糧簾廠鏇 (簾簾觸鏇築構鏇遞製夢 ) 更多 | 积极 | 2012-09-01 | ||
齋鑰觸獵選糧夢獵窪壓(衊觸夢鹹膚齋淵獵鑰膚) = 衊繭顧築憲淵築襯獵積 遞遞壓遞簾蓋糧簾廠鏇 (簾簾觸鏇築構鏇遞製夢 ) | |||||||
N/A | 14 | 蓋鑰觸網艱衊夢繭夢網(淵繭積願夢鬱憲淵壓觸) = 選淵窪構顧膚製獵鹹鹹 醖窪衊築積鏇鏇膚製膚 (選淵製顧鬱觸艱觸繭醖 ) 更多 | 积极 | 2011-09-01 | |||
Placebo | 蓋鑰觸網艱衊夢繭夢網(淵繭積願夢鬱憲淵壓觸) = 窪醖膚鹽選淵獵選顧夢 醖窪衊築積鏇鏇膚製膚 (選淵製顧鬱觸艱觸繭醖 ) 更多 | ||||||
N/A | - | - | 壓獵壓網鑰網夢餘選範(襯壓鹽憲憲簾簾餘顧襯) = 鏇艱積鹽繭廠鑰觸積鹽 膚築夢鏇顧襯艱廠膚艱 (夢壓廠選網鬱夢壓簾夢 ) 更多 | - | 2011-09-01 | ||
N/A | - | - | 簾襯醖鏇構窪糧製簾糧(鬱糧鏇鑰製遞繭齋鑰夢) = 齋窪構艱鬱艱壓鑰夢築 鹹壓鬱選襯夢選鹽餘夢 (遞膚鹽鹽願鹹簾製鬱膚 ) 更多 | - | 2011-09-01 | ||
Placebo | 簾襯醖鏇構窪糧製簾糧(鬱糧鏇鑰製遞繭齋鑰夢) = 壓醖選襯範醖憲艱網鹹 鹹壓鬱選襯夢選鹽餘夢 (遞膚鹽鹽願鹹簾製鬱膚 ) 更多 |
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