A Phase I Trial of a Vaccine Combining Tyrosinase/GP100/Mart-1 Peptides Emulsified With Montanide ISA 51 With ProGP for Patients With Resected Stages III and IV Melanoma

RATIONALE: Vaccines made from melanoma cells may make the body build an immune response to kill tumor cells. Vaccine therapy plus filgrastim combined with a specific protein may be a more effective treatment for melanoma.
PURPOSE: This phase I trial is studying the side effects and best dose of vaccine therapy in treating patients with stage III or stage IV melanoma that has been completely removed during surgery.

开始日期2000-06-01

申办/合作机构

University of Southern California

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100 项与 Progenipoietin 相关的临床结果

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100 项与 Progenipoietin 相关的转化医学

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100 项与 Progenipoietin 相关的专利（医药）

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项与 Progenipoietin 相关的文献（医药）

2024-12-01·TISSUE & CELL

Alleviative effects of green-fabricated zinc oxide nanoparticles on acrylamide-induced oxidative and inflammatory reactions in the rat stomach via modulating gastric neuroactive substances and the MiR-27a-5p/ROS/NF-κB axis

Article

作者: Albaqami, Amirah ; Mohamed, Amany Abdel-Rahman ; Alosaimi, Manal ; Dahran, Naief ; Alosaimi, Manal E ; Mawkili, Wedad ; Samak, Mai A ; El-Shetry, Eman S. ; Alotaibi, Badriyah S. ; Alsharif, Ghadi ; Abd-Elhakim, Yasmina M. ; Khamis, Tarek ; El-Shetry, Eman S ; Metwally, Mohamed M M ; Samak, Mai A. ; Alosaimi, Manal E. ; Metwally, Mohamed M.M. ; Alotaibi, Badriyah S ; ElAshmouny, Naira ; Abd-Elhakim, Yasmina M

Little is known about the effects of acrylamide (AMD) on the stomach. So, this study evaluated the effect of oral AMD exposure (20 mg/kg b.wt) on oxidative status, apoptotic, and inflammatory reactions in rat's stomach for 60 days. To explore novel targets of AMD toxicity, a more detailed molecular and immune-expression study was performed. Besides, the possible protective effect of green synthesized zinc oxide nanoparticles (G-ZNP) (10 mg/kg b.wt) was explored. The results revealed that AMD significantly provoked oxidative and lipid peroxidative damage of the stomach in terms of increased ROS and MDA but reduced SOD, CAT, GSH, and GSH/GSSG. Additionally, the stomachs of AMD-exposed rats showed a significant increment of PGE2 but reduced NO. Histopathologically, AMD induced a significant increase in PAS stain and the immunoexpression of iNOS and NF-κB in the glandular stomach. A significant upregulation of CART, VACHT, EGFR, caspase-3, NOS-1, and miR-27a-5p was evident in the stomach of the AMD group. Yet, G-ZNP oral dosing significantly rescued the AMD-induced oxidative damage, apoptotic reaction, inflammatory effect, and altered miR-27a-5p and gene expressions in the stomach. Conclusively, these findings demonstrated the efficacy of G-ZNP in protecting against the harmful impacts of acrylamide on stomach tissues.

2023-04-20·Molecules (Basel, Switzerland)

Preparation and Anti-Lung Cancer Activity Analysis of Guaiacyl-Type Dehydrogenation Polymer.

Article

作者: Yue, Yuanyuan ; Zhou, Junyi ; Xie, Yimin ; Wei, Xin

In this paper, guaiacyl dehydrogenated lignin polymer (G-DHP) was synthesized using coniferin as a substrate in the presence of β-glucosidase and laccase. Carbon-13 nuclear magnetic resonance (¹³C-NMR) determination revealed that the structure of G-DHP was relatively similar to that of ginkgo milled wood lignin (MWL), with both containing β-O-4, β-5, β-1, β-β, and 5-5 substructures. G-DHP fractions with different molecular weights were obtained by classification with different polar solvents. The bioactivity assay indicated that the ether-soluble fraction (DC₂) showed the strongest inhibition of A549 lung cancer cells, with an IC₅₀ of 181.46 ± 28.01 μg/mL. The DC₂ fraction was further purified using medium-pressure liquid chromatography. Anti-cancer analysis revealed that the D₄ and D₅ compounds from DC₂ had better anti-tumor activity, with IC₅₀ values of 61.54 ± 17.10 μg/mL and 28.61 ± 8.52 μg/mL, respectively. Heating electrospray ionization tandem mass spectrometry (HESI-MS) results showed that both the D₄ and D₅ were β-5-linked dimers of coniferyl aldehyde, and the ¹³C-NMR and ¹H-NMR analyses confirmed the structure of the D₅. Together, these results indicate that the presence of an aldehyde group on the side chain of the phenylpropane unit of G-DHP enhances its anticancer activity.

2023-01-23·Inorganic chemistry

Composite with a Glassy Nonporous Coordination Polymer Enhances Gas Adsorption Selectivity

Article

作者: Uemura, Yohei ; Kato, Masaru ; Noro, Shin-ichiro ; Zheng, Xin ; Nakamura, Takayoshi ; Yagi, Ichizo ; Matsumura, Daiju ; Takahashi, Kiyonori

A glass-crystal composite (g-NCP/PCP), comprising a glassy nonporous coordination polymer (g-NCP) and a crystalline porous coordination polymer (PCP)/metal-organic framework, was synthesized by using a melt-quenched method. Compared to that of the PCP itself, g-NCP/PCP has an enhanced gas adsorption selectivity. The results should stimulate further studies of the chemistry of g-NCP/PCP glass-crystal composites.

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