Ciaftalan zinc

The determination of the Stern-Volmer constant (KSV) for photosensitizers, a key parameter for characterizing energy transfer efficiency to oxygen, enables the understanding and optimization of photosensitizer functionality.In this study, a strategy was proposed for determining the KSV by replacing the anal. of the oxygen-dependent behavior of fluorescence intensity with a direct correlation between singlet oxygen quantum yield (ΦΔ) and mol. oxygen.Zinc phthalocyanine (ZnPc) was selected for this work due to its promising photosensitizing properties.Through theor. anal. using the rate equation model and exptl. absorption measurements, the KSV of ZnPc was found to be 2.4(2) μM^-1.To verify the accuracy of the KSV, an oxygen-varying correlated fluorescence methodol. was applied, reinforcing the reliability of the results.In addition, the determination of the KSV is achievable even in the absence of specific ΦΔ values and without the use of a standard reference

Angiogenesis provides essential nutrients and oxygen to tumors during tumorigenesis, facilitating invasion and metastasis. Consequently, inhibiting tumor angiogenesis is an established strategy in anti-cancer therapy. In this study, we engineered a dual-function nanosystem with both antiangiogenic and photodynamic properties. We transformed the hydrophobic photosensitizer zinc phthalocyanine (PS) into a hydrophilic form via protein renaturation, resulting in a novel photosensitizer: Monocyte-Activating Polypeptide-II (EMAP-II:PS@NPs). Characterization through dynamic light scattering (DLS) and UV-vis spectroscopy showed that these nanoparticles exhibited uniform size and stability, and enhanced solubility. We further demonstrated that EMAP-II:PS@NPs effectively target tumor vascular endothelia causing intracellular photodynamic cytotoxicity. Notably, EMAP-II:PS@NPs achieved effective ablation of solid tumors at significantly reduced dosages of drugs compared to conventional therapies, due to their potent apoptotic effects on light-exposed cells. This study highlights the potential of combining anti-angiogenic activity with phototherapy, paving the way for innovative cancer treatment strategies.