Ciaftalan zinc

The preparation of new photosensitizers and studies on photodynamic therapy (PDT) have provided promising results and realistic expectations for an efficient medical treatment. Phthalocyanines (Pcs) have become extremely attractive for this purpose owing to their molecular versatility and superior physicochemical properties. Motivated by these facts, in this study, non-peripherally substituted zinc(II) Pc (2) was prepared by cyclotetramerization of the phthalonitrile derivative bearing 3-methoxybenzyloxy units. Also, physicochemical and in vitro analyses were completed. In photochemical studies, the obtained singlet oxygen quantum yield (Φ_Δ) values were 0.73 in dimethylsulphoxide (DMSO) and 0.55 in dimethylformamide (DMF). Theoretical calculations based on density functional theory (DFT) provide valuable information on the energies and character of the electronic excitations, thus allowing a prediction of their potential applicability to generate singlet oxygen. The PDT activity of the zinc(II) phthalocyanine bearing 3-methoxybenzyloxy substituents was tested via in vitro studies using the human colon cancer cell lines. In cytotoxicity experiments, the most effective incubation time for cell lines was found to be 24 h, and the most effective concentration was 8 μM. Furthermore, the cell viability rate decreased significantly with the increasing power density. The results suggested that the newly synthesized zinc(II) Pc is an effective photosensitizer with potential use for the treatment of colon cancer.

Metallophthalocyanines as a class of macrocyclic planar aromatic compounds, show special phys. and chem. properties, and numerous exptl. studies have focused on their optical and elec. properties.Different technol. applications have been developed, especially in the optoelectronic field.In this work, organic semiconductors based on metallophthalocyanines (MPcs, M=Co, Fe, Zn), functionalized with pyrrole by diazonium salt reaction, were deposited and treated as bulk heterojunction (BHJ) films, using the polymer poly (3,4-ethylenedioxythiophene): poly(styrenesulfonate) (PEDOT: PSS) as a matrix.The organic semiconductors were structurally characterized by IR spectroscopy and CP-MAS NMR spectroscopy, and their thermal stability was analyzed by applying TGA and DSC techniques.SEM and XRD anal. indicated that BHJ films presented a heterogeneous morphol. with the presence of α- and β-phases, characteristic of MPc polymorphs.The existence of a single polymorphic phase in FePc derivative would facilitate the transport of charges through the film structure.Each film was treated with IPA (Iso-Pr Alc.), improving band gap values and elec. properties.The optical band gap values of the BHJ films showed that FePc derivative manifested the best optical and elec. properties, when compared to CoPc and ZnPc derivatives with 1.98, 2.59 and 2.31 eV, resp.In elec. anal., the three MPc derivatives manifested ohmic behavior.The device with PEDOT: PSS-FePc derivative, had the best performance, as curves are free of noise and, favored by a less thick film, resulting in improved charge flow.FePc derivative behavior may relate to the effective capacity of the electron located on the Fe atom, improving charge transport in this compound