左旋薄荷醇(Levomenthol) - 药物靶点：TRPA1 x TRPM8 x κ opioid receptor_专利_临床

概要

基本信息

药物类型

小分子化药

别名

(-)-(1R,3R,4S)-menthol、(-)-Menthol、(1R,3R,4S)-(-)-menthol

+ [12]

靶点

TRPA1 x TRPM8 x κ opioid receptor

作用方式

抑制剂、激动剂、拮抗剂

作用机制

TRPA1抑制剂(瞬时受体电位离子通道亚基1抑制剂)、TRPM8激动剂(瞬时受体电位离子通道亚科M成员8激动剂)、κ opioid receptor拮抗剂(κ-阿片受体拮抗剂)

治疗领域

消化系统疾病

在研适应症-

非在研适应症

肠道疾病

原研机构

University Hospitals Cleveland Medical Center

在研机构

Fuji Pharma Co., Ltd.

非在研机构

Nihon Pharmaceutical Co., Ltd.

最高研发阶段批准上市

首次获批日期

日本 (1986-01-20)

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C10H20O

InChIKeyNOOLISFMXDJSKH-KXUCPTDWSA-N

CAS号2216-51-5

关联

25

项与左旋薄荷醇相关的临床试验

NCT05888597

/ Recruiting临床2期

Effect of L-menthol on Breathlessness and Exercise Capacity in Chronic Obstructive Pulmonary Disease: a Randomized

The purpose of this study is to assess the effect of L-menthol on breathlessness in patients with chronic obstructive pulmonary disease (COPD).

开始日期2023-05-24

申办/合作机构

Region Skåne Holding AB

[+1]

RBR-7tgfwmk

/ Not yet recruitingN/AIIT

Use of L-menthol solution as an esophageal antispasmodic in Upper Digestive Endoscopy: pilot project

开始日期2021-08-01

申办/合作机构-

JPRN-jRCTs031200400

/ Completed临床2期IIT

Effects of olfactory stimulation by L-menthol on dyspnea on exertion in chronic lung disease: A pilot study

开始日期2021-04-14

申办/合作机构-

100 项与左旋薄荷醇相关的临床结果

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100 项与左旋薄荷醇相关的转化医学

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100 项与左旋薄荷醇相关的专利（医药）

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12,413

项与左旋薄荷醇相关的文献（医药）

2025-04-01·Food Chemistry

Construction and controlled flavor release of high internal phase emulsion stabilized by pH-driven-assembled soy peptide nanoparticles

Article

作者: Li, Guanghui ; Liu, Xiaoting ; Zeng, Xiaofang ; Yu, Limei ; Fang, Yu ; Zhang, Yuanhong ; Zhang, Weijia

This study aimed to evaluate the potential of pH-driven assembled soy peptide nanoparticle (SPN) to prepare high internal phase emulsions (HIPEs) containing sweet orange essential oil (SOEO), and the effects of SPN concentration and oil phase fraction on the formation, stability and flavor release characteristics were investigated. Results showed that stable HIPEs with excellent self-supporting state were successfully fabricated at relative high SPN concentrations (0.5-3.0 wt%). And the increase in SPN concentration could cause smaller droplet size, better viscoelastic properties and stability. The flavor release of SOEO in SPN-stabilized HIPEs could be slowed down and modulated by regulating SPN concentration, and the retention of key flavor compound (d-limonene) in SOEO encapsulated in HIPEs could be reached to higher than 70 % after 120 days of storage. All these indicated the effective encapsulation and delivery of SOEO in SPN-stabilized HIPEs and their prospective application as fat substitutes in plant-based food systems.

2025-04-01·Food Chemistry

Odor-induced saltiness enhancement of volatile compounds screened from duck stewed with chili pepper

Article

作者: Zhang, Jianyou ; Qiu, Yue ; Ding, Yuting ; Zheng, Wenbo ; Cheng, Zhi ; He, Xinglan ; Lyu, Fei

Odor-induced saltiness enhancement (OISE) is thought to be a unique salt reduction technique which capitalizes on olfactory-gustatory interaction. Volatile compounds of stewed duck obtained from orthonasal (no-treatment) and retronasal (saliva-treatment) pathways and their capacity on OISE were analyzed by GC-O-MS and molecular simulation in order to ascertain the role of odors in duck stewed with chili pepper on saltiness enhancement. Totally 17 unique volatile compounds were identified in retronasal pathways. Eight salty-congruent volatile compounds were screened from the stewed duck, one of which being E-2-decenal, specific to retronasal volatile compounds following oral enzymatic digestion. These volatile compounds' OISE in NaCl solution was confirmed, and the retronasal pathway effect outweighed the orthonasal one. Molecular docking revealed that volatile compounds interacted with saltiness receptors through hydrogen bonding and hydrophobic force, which may be responsible for its enhanced saltiness. These findings suggest that olfactory pathways and specific odors might simultaneously mediate OISE.

2025-04-01·Journal of Molecular Liquids

Thermodynamic and spectroscopic study of solutions of therapeutic deep eutectic solvents (THEDES) in supercritical CO2

作者: Perez, Eduardo ; Diaz, Sara ; Olmos-Greco, Ramiro J. ; Gutierrez, Sebastian ; Cabanas, Albertina

The solubilities of the Deep Eutectic Solvents (DES) ibuprofen:thymol and ibuprofen:L-menthol in supercritical CO₂ were determined up to 250 bar at 40, 50 and 60 °C using a variable volume view cell.The solubility of DES at different compositions was compared to that of the individual components showing little deviation from the linear trend.The vapor-phase compositions for some conditions were also determined by ¹H NMR showing that the CO₂ preferentially extracts the most volatile component.A FTIR spectroscopic study of the DES at room pressure and the DES dissolved in CO₂ was also conducted.At room temperature, ibuprofen was present either forming a dimer or bonded to the terpene.When the DES was dissolved in CO₂, significant amounts of free ibuprofen were also found.A simple association model was proposed and some thermodn. magnitudes were determinedThe spectroscopic information is consistent with the thermodn. data.

100 项与左旋薄荷醇相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	左旋薄荷醇	-	DB00825

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
肠道疾病	药物发现	日本	Nihon Pharmaceutical Co., Ltd.	2014-10-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


UEGW2017	N/A	-	-	Menthol infusion	窪鏇積鑰鹹簾憲鹹廠選(願積鏇壓蓋憲蓋鑰壓積) = 淵鹽衊鹹觸獵觸範鏇積遞鹽糧觸製顧網襯餘積 (窪艱鹹製艱鏇簾觸鹹願, 116.2) 更多	-	2017-10-01
UEGW2017	N/A	-	-	L-Menthol (Baseline recording)	窪鏇積鑰鹹簾憲鹹廠選(願積鏇壓蓋憲蓋鑰壓積) = 餘壓積積廠衊壓襯範窪遞鹽糧觸製顧網襯餘積 (窪艱鹹製艱鏇簾觸鹹願, 126.2) 更多	-	2017-10-01
NCT01687101 (CTgov)	N/A	偏头痛 \| 头痛	32	STOPAIN topical gel	鹽蓋範範糧夢製膚糧鏇(餘築願積醖製築糧顧膚) = 願鏇遞淵憲糧壓觸構構艱蓋廠膚糧鹽顧製鑰壓 (簾衊膚齋糧鏇網觸觸廠, 網鑰蓋網選顧蓋範夢範 ~ 積網夢壓壓衊鏇膚鹹遞) 更多	-	2015-04-27