氯乙烷(Ethyl chloride) - 在研适应症：疼痛_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Ethyl chloride (USP)、chloroethane、monochloroethane

靶点-

作用机制-

治疗领域

神经系统疾病

在研适应症

疼痛

非在研适应症-

原研机构

New York University School of Medicine

在研机构

New York University School of Medicine

非在研机构-

最高研发阶段临床1期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

登录后查看时间轴

结构

分子式C2H5Cl

InChIKeyHRYZWHHZPQKTII-UHFFFAOYSA-N

CAS号75-00-3

关联

18

项与氯乙烷相关的临床试验

NCT06596486 / Not yet recruitingN/AIIT

A Comparison of CoolStick and Ethyl Chloride Spray for the Assessment of Sensory Block to Light Touch and Cold Before Caesarean Section Under Spinal or Combined Spinal-epidural Anaesthesia

The main aim of this study is to compare CoolStick to ethyl chloride spray for the assessment of light touch following neuraxial anaesthesia for caesarean delivery.
Coolstick and ethyl chloride will also be compared for the assessment of cold sensation.
Participants will also be asked whether they experienced any intraoperative pain.

开始日期2024-11-01

申办/合作机构

Barts & The London NHS Trust

NCT06651788 / Not yet recruitingN/AIIT

Does "Freeze Spray" Work? Evaluating the Efficacy of Ethyl Chloride Usage Prior to Orthopaedic Injections

A procedure frequently performed by orthopaedic providers is the administration of corticosteroid injections for the management of various soft tissues and joint-related conditions, such as osteoarthritis, tendinitis, carpal tunnel syndrome, trigger finger, and de Quervain's tenosynovitis. While these injections have demonstrated effectiveness in alleviating symptoms, the discomfort associated with the procedure can be a source of anxiety and apprehension for patients. This discomfort arises from the sensation of the needle entering the affected area and the burning sensation induced by the corticosteroid solution.

开始日期2024-11-01

申办/合作机构

The University of Chicago

CTRI/2024/07/070481 / Not yet recruiting临床2/3期IIT

A Randomised Study to Compare the Effectiveness of One Spray versus Two Sprays of Ethyl Chloride of Reducing Venepuncture Induced Pain in Patients requiring IV Cannulation Before Surgery under Anaesthesia at SMS Medical College, Jaipur - Nil

开始日期2024-07-31

申办/合作机构-

100 项与氯乙烷相关的临床结果

登录后查看更多信息

100 项与氯乙烷相关的转化医学

登录后查看更多信息

100 项与氯乙烷相关的专利（医药）

登录后查看更多信息

585

项与氯乙烷相关的文献（医药）

2024-12-01·European Journal of Pharmaceutical Sciences

Evaluation of polymer combinations in vaginal mucoadhesive tablets for the extended release of acyclovir

Article

作者: Martín-Bartolomé, Laura ; Ruiz-Caro, Roberto ; Notario-Pérez, Fernando ; Veiga, María Dolores

Genital herpes, caused by herpes simplex virus type 2 (HSV-2), affects nearly 500 million people, mostly women. Since the main route of transmission is sexual contact, the development of an acyclovir extended-release vaginal microbicide would be a suitable tool for the prevention of virus transmission. In this work, we evaluated the potential of three polymers with different characteristics (chitosan, xanthan gum and ethyl cellulose) for obtaining acyclovir extended-release vaginal tablets. By combining the polymers, certain useful synergies were observed to modify their mucoadhesive capacity and control drug release. In the swelling studies, it observed that a polyelectrolyte complex with more moderate swelling and sustained gelation was formed between chitosan and xanthan gum exclusively in acidic medium (simulated vaginal fluid). This complex allowed prolonging the mucoadhesion of the tablets in ex vivo studies performed with vaginal mucosa, which would translate into better retention in the vagina after administration. In addition, the combination of chitosan and xanthan gum allowed obtaining a controlled release of acyclovir for 5 days, regardless of the pH of the medium, which would guarantee that drug release continues even in the presence of seminal fluid.

2024-11-01·Aquatic Toxicology

Ethyl butyrate inhibits caudal fin regeneration in adult zebrafish by disrupting extracellular matrix remodeling

Article

作者: Li, Yang ; Xiao, Shimei ; Zhong, Keyuan ; Lu, Huiqiang ; Zhang, Sijie ; Meng, Yunlong ; Wang, Hao ; Li, Mijia ; Duan, Shiyi ; Ye, Xinhao

Wound healing and tissue regeneration are influenced by a variety of factors. Adverse lifestyle habits, such as excessive alcohol consumption, delay wound healing and increase the risk of secondary infections. Ethyl butyrate is a common food additive widely used to enhance the aroma of alcoholic beverages. This additive is generally considered harmless to human health in both industrial and domestic settings. However, the ecotoxicity and its effects on wound healing have not been elucidated. In this study, we used zebrafish as the experimental animal, and the caudal fins were amputated to explore the effects of ethyl butyrate on wound healing and tissue regeneration. The effect of ethyl butyrate on blastema and bone regeneration and its impact on the transcriptional levels of regeneration-related genes and inflammation-related genes were evaluated. RNA-seq was conducted to determine the differentially expressed genes (DEGs) between the treatment and the control groups. KEGG and GO analysis was conducted to explore the functions of DEGs. Significantly enriched GO terms and KEGG pathways were identified to explore the molecular mechanism underlying the inhibition of zebrafish caudal fin regeneration by ethyl butyrate. The results demonstrated that ethyl butyrate significantly inhibited the regeneration of zebrafish caudal fins, including blastema and bone regeneration. Ethyl butyrate exposure significantly downregulated the expression of genes associated with bone and blastema regeneration and inflammation response. KEGG and GO functional analyses revealed that the DEGs were associated with significant enrichment of extracellular matrix-receptor interactions. Ethyl butyrate treatment downregulated the expression of most extracellular matrix-related genes. These findings indicate that ethyl butyrate potentially modulates pathways associated with the structure, adhesion, modification, and degradation of the extracellular matrix, thereby disrupting extracellular matrix remodeling, inhibiting wound inflammation, impairing blastema and bone regeneration and ultimately hindering caudal fin regeneration. In summary, the findings demonstrate that ethyl butyrate disrupts extracellular matrix remodeling and inhibits the regeneration of zebrafish caudal fins. These results provide valuable insights into the rational use of ethyl butyrate and further investigation of wound healing mechanisms.

2024-11-01·International Journal of Pharmaceutics

Fabrication of osmotic pump tablets utilizing semisolid extrusion three-dimensional printing technology

Article

作者: Wang, Xiangyu ; Pan, Hao ; Gong, Ye ; Ji, Yang ; Fang, Dongyang ; Chen, Hao

The utilization of three-dimensional (3D) printing technology is prevalent in the fabrication of oral sustained release preparations; however, there is a lack of research on 3D-printed osmotic pump tablets. A 3D-printed core-shell structure bezafibrate osmotic pump tablet was developed based on the characteristics of rapid absorption and short half-life of bezafibrate, utilizing semisolid extrusion (SSE) 3D printing technology. First, the properties of different shell materials were investigated to define the composition of the shell, and ultimately, the optimal formulation was found to be ethyl cellulose:cellulose acetate:polyethylene glycol = 2:1:2. The formulation of the tablet core was defined based on the printing performance and release behavior. The formulation consisted of bezafibrate, lactis anhydrous, sodium bicarbonate, sodium alginate, polyethylene oxide and sodium dodecyl sulfate at a ratio of 400:400:300:80:50:50. The tablet was capable of achieving zero-order release. The physicochemical properties were also characterized. The pharmacokinetic data analysis indicated that there were no statistically significant differences in the pharmacokinetic parameters between the 3D-printed tablets and the reference listed drugs. There was a strong correlation between the in vitro and in vivo results for the 3D-printed tablets. The results showed that SSE printing is a practical approach for manufacturing osmotic pump tablets.

100 项与氯乙烷相关的药物交易

登录后查看更多信息

外链

KEGG	Wiki	ATC	Drug Bank
D04088	-	-	DB13259

研发状态

10 条进展最快的记录,

登录

后查看更多信息

适应症	最高研发状态	国家/地区	公司	日期
疼痛	临床1期	-	New York University School of Medicine	-

登录后查看更多信息

临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT02587143 (CTgov)	N/A	疼痛 \| 麻醉	126	Alcohol (Control)	鹽遞網夢壓製鏇觸構範(願鹹簾窪繭鑰蓋觸淵製) = 衊選窪憲衊夢鑰糧繭構淵獵觸顧衊窪築鹽餘醖 (蓋襯範壓構艱鏇膚願鏇, 醖範觸齋網遞齋範鑰獵 ~ 鏇齋鬱襯簾窪鑰夢鑰襯) 更多	-	2020-01-22
				Ethyl chloride (Ethyl Chloride)	鹽遞網夢壓製鏇觸構範(願鹹簾窪繭鑰蓋觸淵製) = 築獵鹹鏇鑰醖願衊鹽襯淵獵觸顧衊窪築鹽餘醖 (蓋襯範壓構艱鏇膚願鏇, 範淵窪製廠觸構壓築壓 ~ 網構範築獵餘繭網選製) 更多
NCT03054740 (CTgov)	临床4期	疼痛	30	Gebauer Ethyl Chloride (Gebauer Ethyl Chloride)	繭顧範獵積鏇壓艱淵鬱(鑰鏇網鑰廠選衊淵鑰淵) = 壓遞糧夢鑰醖鹽襯衊觸選窪製積膚範鬱衊鹹壓 (壓憲繭構繭齋糧蓋鬱窪, 鹹遞鏇顧窪鹹壓選憲廠 ~ 醖窪製鹹鬱積鬱淵觸鹹) 更多	-	2018-10-03
				Nature's Tears (Nature's Tears)	繭顧範獵積鏇壓艱淵鬱(鑰鏇網鑰廠選衊淵鑰淵) = 願窪積衊窪糧鑰鑰糧築選窪製積膚範鬱衊鹹壓 (壓憲繭構繭齋糧蓋鬱窪, 膚積糧鹽遞網艱築繭網 ~ 襯觸遞選膚艱製淵壓鹽) 更多
NCT02592629 (CTgov)	临床4期	肩痛	19	lidocaine+Kenalog (no Topical or Subcutaneous Anesthetic)	衊鬱壓壓願糧蓋構網築(鬱餘鹽鏇糧簾艱遞膚蓋) = 壓廠夢齋襯繭範構網鹽選鏇齋窪夢鹹簾齋餘顧 (壓觸窪餘壓鑰鹽範鹹醖, 糧窪獵網廠憲製憲夢糧 ~ 鬱壓簾鏇糧鑰顧觸網蓋) 更多	-	2018-09-10
				lidocaine+Kenalog (Subcutaneous Lidocaine)	衊鬱壓壓願糧蓋構網築(鬱餘鹽鏇糧簾艱遞膚蓋) = 顧夢製糧襯齋襯憲窪窪選鏇齋窪夢鹹簾齋餘顧 (壓觸窪餘壓鑰鹽範鹹醖, 範選鬱壓顧淵餘醖願獵 ~ 憲齋獵襯網鏇艱齋糧窪) 更多