氯乙烷(Ethyl chloride) - 在研适应症：疼痛_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Ethyl chloride (USP)、chloroethane、monochloroethane

靶点-

作用方式-

作用机制-

治疗领域

神经系统疾病其他疾病

在研适应症

疼痛

非在研适应症-

原研机构-

在研机构

Gebauer Co.

非在研机构-

最高研发阶段批准上市

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C2H5Cl

InChIKeyHRYZWHHZPQKTII-UHFFFAOYSA-N

CAS号75-00-3

关联

22

项与氯乙烷相关的临床试验

NCT06651788

/ Not yet recruitingN/AIIT

Does "Freeze Spray" Work? Evaluating the Efficacy of Ethyl Chloride Usage Prior to Orthopaedic Injections

A procedure frequently performed by orthopaedic providers is the administration of corticosteroid injections for the management of various soft tissues and joint-related conditions, such as osteoarthritis, tendinitis, carpal tunnel syndrome, trigger finger, and de Quervain's tenosynovitis. While these injections have demonstrated effectiveness in alleviating symptoms, the discomfort associated with the procedure can be a source of anxiety and apprehension for patients. This discomfort arises from the sensation of the needle entering the affected area and the burning sensation induced by the corticosteroid solution.

开始日期2025-02-01

申办/合作机构

The University of Chicago

NCT06596486

/ RecruitingN/AIIT

A Comparison of CoolStick and Ethyl Chloride Spray for the Assessment of Sensory Block to Light Touch and Cold Before Caesarean Section Under Spinal or Combined Spinal-epidural Anaesthesia

The main aim of this study is to compare CoolStick to ethyl chloride spray for the assessment of light touch following neuraxial anaesthesia for caesarean delivery.
Coolstick and ethyl chloride will also be compared for the assessment of cold sensation.
Participants will also be asked whether they experienced any intraoperative pain.

开始日期2024-11-01

申办/合作机构

Barts & The London NHS Trust

CTRI/2024/07/070481

/ Not yet recruiting临床2/3期IIT

A Randomised Study to Compare the Effectiveness of One Spray versus Two Sprays of Ethyl Chloride of Reducing Venepuncture Induced Pain in Patients requiring IV Cannulation Before Surgery under Anaesthesia at SMS Medical College, Jaipur - Nil

开始日期2024-07-31

申办/合作机构-

100 项与氯乙烷相关的临床结果

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100 项与氯乙烷相关的转化医学

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100 项与氯乙烷相关的专利（医药）

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5,274

项与氯乙烷相关的文献（医药）

2025-03-05·Journal of the American Chemical Society

C₁-Based Route for Vinyl Chloride Synthesis with Environmental and Economic Benefits

Article

作者: Liu, Chengyuan ; Pérez-Ramírez, Javier ; Guillén-Gosálbez, Gonzalo ; Nabera, Abhinandan ; Zhao, Yilin ; Zou, Shihui ; Ren, Yutao ; Wei, Kunkun ; Pan, Yang ; Hu, Jingbo ; Liu, Juanjuan ; Bao, Yunxin ; Wang, Yong ; Wang, Yue ; Chen, Xutao ; Fan, Jie

Selective coupling of C₁ platform molecules to C₂ olefins is a cornerstone for establishing a sustainable chemical industry based on nonpetroleum sources. Vinyl chloride (C₂H₃Cl), one of the top commodity petrochemicals, is commercially produced from coal- or oil-derived C₂ hydrocarbon (acetylene and ethylene) feedstocks with a high carbon footprint. Here, we report a C₁-based route for vinyl chloride synthesis via the selective oxidative coupling of methyl chloride. This is enabled by a solid catalyst, featuring tungstate nanoclusters embedded in a zirconia matrix, which effectively captures ·CH₂Cl radicals homogeneously generated in CH₃Cl oxy-pyrolysis and selectively couples them into C₂H₃Cl. In situ synchrotron-based vacuum ultraviolet photoionization mass spectrometry provides direct experimental evidence of the homogeneous-heterogeneous reaction mechanism. The process achieves methyl chloride conversion of 10-65% with a high vinyl chloride selectivity (60-75%) at a reaction temperature of 650-750 °C, which is much lower than the traditional pyrolysis (>850 °C). The catalyst delivers stable performance (at a vinyl chloride yield of ca. 30%) with no deactivation observed during a 50 h test. Furthermore, combining with reaction of methanol and HCl to produce methyl chloride, we establish a methanol-to-vinyl chloride (MTV) route with the potential for significant reductions in climate change impact (24%) and cost (38%) compared to the state-of-the-art ethylene-based balanced process. A more remarkable 237% reduction in climate change impacts can be anticipated in the future-oriented green scenario for the MTV process primarily attributed to the utilization of renewable C₁ feedstocks that results in negative net contributions to the overall impacts.

2025-03-01·Phytochemical Analysis

Discrimination between raw and ginger juice processed Fructus Gardeniae based on UHPLC‐Q‐TOF‐MS and Heracles NEO ultra‐fast gas phase electronic nose

Article

作者: Lu, Tulin ; Fan, Xingchen ; Wang, Sichen ; Zhang, Kewei ; Dai, Guiyu ; Mao, Chunqin ; Qi, Yufang

AbstractIntroductionFructus Gardeniae (ZZ), a traditional Chinese herb, has been used in treating patients with jaundice, inflammation, etc. When mixed with ginger juice and stir‐baked, ginger juice‐processed Fructus Gardeniae (JZZ) is produced, and the chemical compositions in ZZ would be changed by adding the ginger juice.ObjectiveTo illuminate the differential components between ZZ and JZZ.MethodsHPLC, UHPLC‐Q‐TOF‐MS, and Heracles NEO ultra‐fast gas phase electronic nose were applied to identify the differential components between ZZ and JZZ.ResultsHPLC fingerprints of ZZ and JZZ were established, and 24 common peaks were found. The content determination results showed that the contents of shanzhiside, geniposidic acid, genipin‐1‐β‐D‐gentiobioside and geniposide increased, while the contents of crocin I and crocin II decreased in JZZ. By UHPLC‐Q‐TOF‐MS, twenty‐six possible common components were inferred, among which 11 components were different. In further investigation, eight components were identified as the possible distinctive non‐volatile compounds between ZZ and JZZ. By Heracles NEO ultra‐fast gas phase electronic nose, four substances were inferred as the possible distinctive volatile compounds in JZZ.ConclusionShanzhiside, caffeic acid, genipin‐1‐β‐D‐gentiobioside, geniposide, rutin, crocin I, crocin II, and 4‐Sinapoyl‐5‐caffeoylquinic acid were identified as the possible differential non‐volatile components between ZZ and JZZ. Aniline, 3‐methyl‐3‐sulfanylbutanol‐1‐ol, E‐3‐octen‐2‐one, and decyl propaonate were inferred as the possible distinctive volatile compounds in JZZ. This experiment explored a simple approach with objective and stable results, which would provide new ideas for studying decoction pieces with similar morphological appearance, especially those with different odors.

2025-02-20·The Journal of Physical Chemistry A

What Dictates the α-Effect in Gas-Phase S_N2 Reactions? A Density Functional Theory Study

作者: Poddar, Arpita ; Ayers, Paul W. ; Liu, Shubin ; Zhao, Dongbo ; Chattaraj, Pratim K.

The α-effect is an important concept in chem. and biochem., namely that for a bimol. nucleophilic substitution (S_N2) reaction, the nucleophilicity of an atom is increased if its adjacent (α) atom has a lone pair of electrons, lowering the reaction barrier height and increasing the reaction rate.However, exceptions exist, even for very similar structural motifs.We investigate what underlies the α-effect in gas-phase S_N2 reactions using two total energy decomposition schemes based on d. functional theory (DFT) and find that steric effects play an important role, but that there exists a strong linear correlation between the α-effect and electrostatic contribution, suggesting that it is the electrostatic interaction that stabilizes the transition state and leads to the α-effect in gas-phase S_N2 reactions.This multifaceted explanation resolves the long-standing uncertainty about the α-effect.We show that the α-effect increases with the branching of the central carbon atom.

100 项与氯乙烷相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D04088	-	-	DB13259

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
疼痛	美国	Gebauer Co.	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT02587143 (CTgov)	N/A	疼痛 \| 麻醉	126	Alcohol (Control)	顧築簾遞衊鏇願構齋獵(願積淵鹹遞蓋觸範糧顧) = 鹽鹹遞憲鑰遞鹽構範壓顧糧夢窪製蓋鏇膚遞網 (淵膚網鏇願憲鹹鹽膚鹹, 糧鹽蓋繭艱蓋艱鏇鹽製 ~ 壓築鏇廠獵獵壓獵壓齋) 更多	-	2020-01-22
				Ethyl chloride (Ethyl Chloride)	顧築簾遞衊鏇願構齋獵(願積淵鹹遞蓋觸範糧顧) = 鬱築鬱糧願艱觸衊願築顧糧夢窪製蓋鏇膚遞網 (淵膚網鏇願憲鹹鹽膚鹹, 餘構築構蓋衊衊艱膚鏇 ~ 築襯膚鏇顧襯鏇蓋夢鬱) 更多
NCT03054740 (CTgov)	临床4期	疼痛	30	Gebauer Ethyl Chloride (Gebauer Ethyl Chloride)	壓襯壓鹽淵選餘鑰淵觸(鏇積築選製鹽簾膚鑰製) = 選鏇蓋製鏇鏇襯壓觸築積衊廠壓糧淵糧廠鑰廠 (獵餘範鹹蓋衊齋齋築餘, 衊觸廠餘廠構餘艱觸蓋 ~ 築獵觸範艱觸餘憲繭網) 更多	-	2018-10-03
				Nature's Tears (Nature's Tears)	壓襯壓鹽淵選餘鑰淵觸(鏇積築選製鹽簾膚鑰製) = 餘鬱遞糧鏇遞淵餘鹹衊積衊廠壓糧淵糧廠鑰廠 (獵餘範鹹蓋衊齋齋築餘, 製衊顧範簾簾窪積憲願 ~ 齋鏇窪願構壓選構遞鹽) 更多
NCT02592629 (CTgov)	临床4期	肩痛	19	lidocaine+Kenalog (no Topical or Subcutaneous Anesthetic)	餘遞鏇選淵淵餘遞鑰廠(鬱廠繭夢製蓋獵鏇艱鏇) = 窪築憲壓夢鑰餘獵蓋蓋淵廠醖淵遞醖築糧網餘 (鑰醖遞鹹築鹽憲襯襯遞, 襯醖餘鬱願醖淵膚鏇蓋 ~ 鏇構艱積窪鹽獵積範觸) 更多	-	2018-09-10
				lidocaine+Kenalog (Subcutaneous Lidocaine)	餘遞鏇選淵淵餘遞鑰廠(鬱廠繭夢製蓋獵鏇艱鏇) = 醖製壓構鏇窪夢獵鹹築淵廠醖淵遞醖築糧網餘 (鑰醖遞鹹築鹽憲襯襯遞, 衊鹹蓋糧餘憲鑰憲顧膚 ~ 衊憲窪廠鏇鏇範衊襯積) 更多