氯乙烷(Ethyl chloride) - 在研适应症：疼痛_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Ethyl chloride (USP)、chloroethane、monochloroethane

靶点-

作用机制-

治疗领域

神经系统疾病

在研适应症

疼痛

非在研适应症-

原研机构

New York University School of Medicine

在研机构

New York University School of Medicine

非在研机构-

最高研发阶段临床1期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C2H5Cl

InChIKeyHRYZWHHZPQKTII-UHFFFAOYSA-N

CAS号75-00-3

关联

21

项与氯乙烷相关的临床试验

NCT06651788

/ Not yet recruitingN/AIIT

Does "Freeze Spray" Work? Evaluating the Efficacy of Ethyl Chloride Usage Prior to Orthopaedic Injections

A procedure frequently performed by orthopaedic providers is the administration of corticosteroid injections for the management of various soft tissues and joint-related conditions, such as osteoarthritis, tendinitis, carpal tunnel syndrome, trigger finger, and de Quervain's tenosynovitis. While these injections have demonstrated effectiveness in alleviating symptoms, the discomfort associated with the procedure can be a source of anxiety and apprehension for patients. This discomfort arises from the sensation of the needle entering the affected area and the burning sensation induced by the corticosteroid solution.

开始日期2025-02-01

申办/合作机构

The University of Chicago

NCT06596486

/ Not yet recruitingN/AIIT

A Comparison of CoolStick and Ethyl Chloride Spray for the Assessment of Sensory Block to Light Touch and Cold Before Caesarean Section Under Spinal or Combined Spinal-epidural Anaesthesia

The main aim of this study is to compare CoolStick to ethyl chloride spray for the assessment of light touch following neuraxial anaesthesia for caesarean delivery.
Coolstick and ethyl chloride will also be compared for the assessment of cold sensation.
Participants will also be asked whether they experienced any intraoperative pain.

开始日期2024-11-01

申办/合作机构

Barts & The London NHS Trust

CTRI/2024/07/070481

/ Not yet recruiting临床2/3期IIT

A Randomised Study to Compare the Effectiveness of One Spray versus Two Sprays of Ethyl Chloride of Reducing Venepuncture Induced Pain in Patients requiring IV Cannulation Before Surgery under Anaesthesia at SMS Medical College, Jaipur - Nil

开始日期2024-07-31

申办/合作机构-

100 项与氯乙烷相关的临床结果

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100 项与氯乙烷相关的转化医学

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100 项与氯乙烷相关的专利（医药）

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605

项与氯乙烷相关的文献（医药）

2025-01-02·Clinical Toxicology

Ethyl chloride poisoning from inhalational misuse: clinical features and outcomes

Review

作者: Khoo, Shimona Q. X. ; Tan, You-Jiang ; Tan, Youhong

INTRODUCTIONEthyl chloride misuse remains a prevailing concern due to its accessibility, but detailed descriptions of the features of toxicity are limited to sporadic reports, resulting in knowledge gaps in their clinical features and diagnosis.OBJECTIVETo describe the clinical features, treatment, and outcomes of patients reported in the literature who developed toxicity from inhalational use of ethyl chloride.METHODSWe reviewed relevant literature over the past 50 years and analyzed the characteristics and outcomes of patients with toxicity from the inhalational use of ethyl chloride.RESULTSA total of 21 studies from 1979 to 2024 were identified, making available 22 patients for analysis. Their median age was 40 years (range 16-62 years), and there were more than four times as many males as females. Ethyl chloride-containing cleaning solvents (8/22, 36%) were most commonly used. Regular inhalation of ethyl chloride was documented in approximately two-thirds of the patients (14/22, 66%), with a median duration of five months of misuse (range 2-360 months). A large proportion of patients (15/22, 68%) inhaled ethyl chloride again within a week from the onset of toxicity. Although features of cerebellar dysfunction were very common at presentation (13/16, 81%), abnormalities on neuroimaging studies were rare. Death occurred in more than a quarter of cases (6/22, 27%), with patients either already deceased or dying shortly after. Half (3/6) of these deaths were directly attributable to the development of lethal cardiac dysrhythmias. Conversely, most survivors either improved or fully recovered within a few days to weeks (14/16, 88%), independent of their presenting symptoms, clinical signs, and the treatments they received.DISCUSSIONEthyl chloride users are likely young or middle-aged males, and clinical features of toxicity can range from transient neurological symptoms to cardiac dysrhythmias and death. The prominence of neurotoxicity may be attributed to the lipophilic nature of ethyl chloride and its tendency to accumulate in neural tissue, while cardiac dysrhythmias have been attributed to cardiac sensitization to catecholamines through ethyl chloride-induced inhibition of potassium, calcium, and sodium channels.CONCLUSIONSToxicity from the inhalational misuse of ethyl chloride should be considered in young or middle-aged males presenting with acute cerebellar dysfunction. We recommend that suspected cases undergo telemetric monitoring for 24 h, especially when tachycardia and/or palpitations are present, as deaths from lethal cardiac dysrhythmias are not uncommon.

2025-01-01·Otolaryngology–Head and Neck Surgery

Topical Anesthesia in Cutaneous Head and Neck Surgery: A Randomized Controlled Trial

Article

作者: McHugh, Nathaniel ; O'Neill, Rory ; Affendi, Adrinda ; Skinner, Liam

AbstractObjectiveCutaneous head and neck surgery can safely and effectively be performed using local anesthetic (LA). However, optimizing pain management during LA administration is paramount for patient comfort and procedural efficacy. The primary objective of this study was to investigate the comparative effectiveness of EMLA cream and ethyl chloride (EC) spray in mitigating pain associated with LA administration in cutaneous head and neck surgery.Study DesignRandomized controlled trial.SettingUniversity‐affiliated tertiary head and neck oncology center.MethodsSample size calculation was performed followed by computer randomization into the following groups: EMLA, EMLA placebo (aqueous cream), EC, and a control group (no topical agent). Demographics, pain, and procedural experience scores were recorded perioperatively. Statistical analysis was performed to analyse differences between groups utilizing the Mann‐Whitney U test, Kruskall‐Wallis test, Chi‐square test, and Spearman's Rho.Results121 cutaneous lesions with a median patient age of 76 were analyzed. There were no statistically significant differences in pain scores (median [IQR]) between patients receiving EMLA (4 [3.75]), EMLA placebo (4.8 [3.6]), EC (5.8 [2.8]), and no treatment (5 [4.1], P = .19). Procedural experience scores were clinically similar (P = .02). Risk factors associated with elevated nociceptive sensitivity were surgical site (scalp, P = .01), malignant lesions (P < .01) and lesion surface area (rs = 0.22, P = .01).ConclusionEMLA and EC did not mitigate LA‐associated pain in patients undergoing cutaneous head and neck surgery and as such practitioners should reconsider their use of these in this regard. Patients' operative experience remains excellent regardless of topical anesthetic use.Level of EvidenceIb.

2025-01-01·Ecotoxicology and Environmental Safety

Proteomic evaluation of pathways associated with phosphine-induced mitochondrial dysfunction and resistance mechanisms in Tribolium castaneum against phosphine fumigation: Whole and partial proteome identification

Article

作者: Kim, Donghyeon ; Lee, Sung-Eun

Phosphine (PH₃) fumigation is widely used to control insect pests in stored products globally. However, intensive PH₃ use has led to the emergence of significant resistance in target insects. To address this issue, this study investigated PH₃ resistance mechanisms by conducting both qualitative and quantitative proteomic analyses on the whole proteome of a PH₃-resistant Tribolium castaneum strain (AUS-07) using LC-MS/MS. Besides, proteins from both strains were separated in 1D-PAGE, and qualitatively analyzed using LC-MS/MS after in-gel digestion. Differentially expressed proteins (DEPs) with cut-off values (4-fold expression difference and p < 0.05) were selected, and 107 proteins were identified in the AUS-07 strain. Among them, several proteins involved in oxidative phosphorylation were notably upregulated in response to PH₃ exposure. Upregulation of Complex I and III in the electron transport chain of the AUS-07 strain may lead to the excessive generation of reactive oxygen species (ROS) in the form of superoxide, which can damage Fe-S cluster-containing proteins such as cytochrome P450s (CYP450s). Upregulation of detoxifying enzymes, such as CYP450s and glutathione S-transferases (GSTs), was observed, likely to repair superoxide-induced damage on CYP450s as well as quenching superoxide. Upregulation of aldose reductases involved in polyol pathways and downregulation of the trehalose transporter were observed, suggesting that PH₃-resistance may be linked to diapause-like physiological adaptations, including quiescence. Further studies are essential to quantify polyol levels in the AUS-07 strain and to conduct other molecular analyses to validate the roles of identified DEPs in PH₃ resistance. Altogether, our findings suggest a new control strategy to stored product insect pests by other type of fumigant such as ethyl formate with different molecular structure.

100 项与氯乙烷相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D04088	-	-	DB13259

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
疼痛	临床1期	-	New York University School of Medicine	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT02587143 (CTgov)	N/A	疼痛 \| 麻醉	126	Alcohol (Control)	顧襯窪廠壓廠築網餘艱(齋醖淵築齋簾艱網齋鹹) = 醖鏇壓選製齋觸築壓淵範願網鑰餘膚鏇積糧艱 (窪遞鑰網蓋糧艱衊鹹醖, 獵築觸淵願醖鹹蓋鏇觸 ~ 淵製獵鑰夢壓齋衊鹹衊) 更多	-	2020-01-22
				Ethyl chloride (Ethyl Chloride)	顧襯窪廠壓廠築網餘艱(齋醖淵築齋簾艱網齋鹹) = 獵醖鏇積製簾觸醖窪積範願網鑰餘膚鏇積糧艱 (窪遞鑰網蓋糧艱衊鹹醖, 築膚餘觸艱鹽艱糧壓簾 ~ 艱餘選鬱願築襯觸夢淵) 更多
NCT03054740 (CTgov)	临床4期	疼痛	30	Gebauer Ethyl Chloride (Gebauer Ethyl Chloride)	廠鏇鬱選獵顧簾壓築襯(網網壓願壓窪憲顧廠鹹) = 範窪鑰鑰襯廠糧憲淵壓選鬱夢築鏇製壓蓋築衊 (醖繭窪製製網壓製構糧, 壓鏇壓構廠夢餘醖醖築 ~ 醖壓襯積艱淵廠壓艱製) 更多	-	2018-10-03
				Nature's Tears (Nature's Tears)	廠鏇鬱選獵顧簾壓築襯(網網壓願壓窪憲顧廠鹹) = 窪憲網鏇壓廠範範廠衊選鬱夢築鏇製壓蓋築衊 (醖繭窪製製網壓製構糧, 鏇憲淵蓋蓋選願膚獵顧 ~ 齋築簾廠襯夢壓築窪鹹) 更多
NCT02592629 (CTgov)	临床4期	肩痛	19	lidocaine+Kenalog (no Topical or Subcutaneous Anesthetic)	範壓齋醖鬱遞構鬱餘廠(鹽簾鹹遞繭築憲鹽齋醖) = 襯顧積積鹹襯齋夢鬱襯襯顧鑰顧膚襯夢鑰膚齋 (築淵網製餘壓鏇蓋簾糧, 顧網製齋觸觸齋艱遞憲 ~ 衊鹹齋窪選鹽鹽網鹽遞) 更多	-	2018-09-10
				lidocaine+Kenalog (Subcutaneous Lidocaine)	範壓齋醖鬱遞構鬱餘廠(鹽簾鹹遞繭築憲鹽齋醖) = 餘獵鏇選製願襯憲窪壓襯顧鑰顧膚襯夢鑰膚齋 (築淵網製餘壓鏇蓋簾糧, 獵壓窪衊艱網壓鹽窪積 ~ 觸膚範鹽簾築醖廠觸範) 更多