更新于：2024-06-29
Betamethasone Sodium Phosphate
磷酸钠倍他米松
更新于：2024-06-29
概要
基本信息
原研机构 |
非在研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)- |
特殊审评- |
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结构
分子式C22H30FNa2O8P |
InChIKeyODEOTKLZVXBMJD-LWCNAHDDSA-N |
CAS号151-73-5 |
关联
16
项与 磷酸钠倍他米松 相关的临床试验Efficacy of Intramuscular Glucocorticoid Injection in Patients With Lumbar Radicular Pain
Preemptive Infiltration With Betamethasone and Ropivacaine for Postoperative Pain in Laminoplasty or Laminectomy (PRE-EASE)
Timing of Late Preterm Corticosteroid Administration and Neonatal Hypoglycemia
100 项与 磷酸钠倍他米松 相关的临床结果
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100 项与 磷酸钠倍他米松 相关的转化医学
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100 项与 磷酸钠倍他米松 相关的专利（医药）
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399
项与 磷酸钠倍他米松 相关的文献（医药）2024-06-01Parasitology international
Amphotericin B loaded nanoemulsion: Optimization, characterization and in-vitro activity against L. donovani promastigotes
Article
作者: Singh, Pankaj Kumar ; Mahajan, Srushti ; Maji, Indrani ; Singh, Kuljit ; Sriram, Anitha ; Dua, Kamal ; Kumari, Diksha ; Singh, Sachin Kumar ; Aalhate, Mayur ; Prajapat, Vikram Mohanlal ; Gupta, Ujala ; Kalia, Nitin Pal
The present work aimed to develop and evaluate AmB-loaded nano-emulsion (AmB-NE) which will augment the solubility of AmB and lead to enhanced anti-leishmanial activity. The composition of AmB-NE was optimized by systematic screening followed by DoE-extreme vertices mixture design. The optimized NE revealed mean droplet size and PDI of 44.19 ± 5.5 nm, 0.265 ± 0.0723, respectively. The NE could efficiently encapsulate AmB with drug content and efficiency 83.509 ± 0.369% and 81.659 ± 0.013%, respectively. The presence of cholesterol and stearyl amine retarded the release (P < 0.0001) of AmB significantly compared to AmB suspension. The AmB-NE and pure AmB suspension demonstrated the IC50 of 0.06309 μg/mL and 0.3309 μg/mL against L.donovani promastigotes after 48 h incubation. The formulation was robust at all exaggerated stability conditions such as freeze-thaw and centrifugation. These findings indicate that AmB-NE is an attractive approach to treat visceral leishmaniasis with improved activity.
2024-04-01Food science and technology international = Ciencia y tecnologia de los alimentos internacional
Ice cream with sucralose, stevioside, and erythritol as sugar substitutes: Sensory profile and customer preference
Article
作者: Wei, Yanling ; Long, Men ; Wu, Yejing ; Zhou, Di ; Cai, Huazhen ; Zhan, Ge ; Tao, Shoukui ; Wang, JingYi
Sugar-free food has been gaining popularity because of low-calorie content. But sugar replacement by high-intensity sweeteners can negatively affect sensory. In this study, the effect of the addition of sucralose (Suc), stevioside (Ste), and erythritol (Ery) as sugar substitutes on the sensory profile and overall acceptance of ice cream were evaluated by penalty analysis (PA) based on the check-all-that apply (CATA) method, with those of the partial least squares (PLS) regression. Twelve sweetening agents of ice cream samples were presented to 106 consumers who answered on an overall liking question using the 15-point hedonic scale and a CATA question with 32 attributes that described the sensory characteristics of ice cream. The results showed that mixed sweeteners (60%Suc+20%Ste+20%Ery or 60%Suc+10%Ste+30%Ery) can present an advantageous performance when used separately, and making ice cream similar to that of sucrose (Sac) added. Adding Suc, Ste, and Ery to ice cream hardly felt bitterness, astringency, and chemical-like sensations of the sweetening agent. The significant difference between different sweeteners is the intensity and speed of sweetness. Developing combination of high-potency sweeteners that can make sweetness appear quickly could open up new ways to design sugar-free ice cream.
2024-01-01Journal of ethnopharmacology
Ethnopharmacological analysis based on Thai traditional medicine theory and anti-inflammatory activity of Sa-Tri-Lhung-Klod remedy as a post-partum anti-inflammatory drug
Article
作者: Thisayakorn, Krittiya ; Davies, Neal M ; Khoenok, Wicheian ; Prommee, Nuntika ; Sriyam, Kanjana ; Itharat, Arunporn ; Pahusee, Darunee ; Inprasit, Janjira ; Ruangnoo, Srisopa ; Sukkasem, Kanmanee
ETHNOPHARMACOLOGICAL RELEVANCE:
Sa-Tri-Lhung-Klod (ST) remedy is a Thai traditional remedy used in obstetrics and gynecology to reduce inflammation and nourish the body post-partum. In Thai traditional medicine (TTM), there is a theory of formulating drugs based on the four elements and the tastes of herbs for use in treating diseases.
AIMS OF STUDY:
To determine relationships between taste theory and pharmacological properties for the anti-inflammatory effect of ST remedy and its chemical constituent components. To evaluate anti-inflammatory activity and also investigate the HPLC fingerprint of ST extracts.
MATERIALS AND METHODS:
ST remedy was extracted by maceration in 95% ethanol (STE) and decoction in distilled water (STW). ST extracts were evaluated for anti-inflammatory activity by nitric oxide inhibitory assay in RAW264.7 cells, carrageenan-induced rat paw edema, and prostaglandin E2 inhibitory assay in inflamed rat paw tissue. In addition, the chemical constituent fingerprints of ST extracts were examined using HPLC.
RESULTS:
STE contained seven main chemical compounds, and STW demonstrated only one identifiable chemical compound. The STE and STW displayed potent NO inhibitory activity with an IC50 value of 20.59 ± 0.03 and 52.93 ± 0.90 μg/mL, respectively. Moreover, the STE and STW (at doses of 100 - 400 mg/kg) promoted significant inhibition of inflammation in carrageenan-induced paw edema in rats (20.81 - 38.25%). Additionally, the STE (200 - 400 mg/kg) and STW (100 - 400 mg/kg) significantly reduced PGE2 levels in inflamed rat paw tissue.
CONCLUSION:
These findings suggest that the spicy, astringent, sweet, and fragrant taste of the ST remedy used to treat post-partum inflammation encompass constituents with potent anti-inflammatory activity. STE and STW possess anti-inflammatory properties and effectively inhibit the production of NO and PGE2. Results confirm the use of the ST remedy for treating inflammatory diseases in the post-partum period according to TTM knowledge.
100 项与 磷酸钠倍他米松 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 溃疡性结肠炎 | 日本 | 1992-03-13 | |
| 克罗恩病 | 日本 | 1992-03-13 | |
| 睑缘炎 | 日本 | 1985-11-20 | |
| 结膜炎 | 日本 | 1985-11-20 | |
| 角膜炎 | 日本 | 1985-11-20 | |
| 耳炎 | 日本 | 1985-11-20 | |
| 炎症 | 美国 | 1974-12-31 | |
| 胶原蛋白疾病 | 日本 | 1973-01-31 | |
| 内分泌系统疾病 | 日本 | 1973-01-31 | |
| 心脏衰竭 | 日本 | 1973-01-31 | |
| 肾病综合征 | 日本 | 1973-01-31 | |
| 类风湿关节炎 | 日本 | 1973-01-31 | |
| 眼部炎症 | 日本 | 1964-10-07 | |
| 外耳炎 | 日本 | 1964-10-07 | |
| 中耳炎 | 日本 | 1964-10-07 | |
| 过敏性鼻炎 | 日本 | 1964-10-07 |
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临床结果
临床结果
适应症
分期
评价
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临床2期 | 1 | (Bupivacaine Hydrochloride and Betamethasone Sodium Phosphate) | 壓鹽齋夢蓋繭夢衊遞築(蓋鑰淵願鹽膚憲鹹憲鹽) = 觸顧築蓋構醖構鹹鑰鬱 憲選蓋淵襯餘夢蓋鹹願 (遞憲艱鑰窪襯夢願獵鬱, 窪構顧壓願獵壓夢鹽繭 ~ 齋鬱齋築構構夢製築艱) 更多 | - | 2020-11-02 | ||
(Bupivacaine Hydrochloride) | 壓鹽齋夢蓋繭夢衊遞築(蓋鑰淵願鹽膚憲鹹憲鹽) = 積醖膚醖願餘襯憲憲壓 憲選蓋淵襯餘夢蓋鹹願 (遞憲艱鑰窪襯夢願獵鬱, 艱醖獵構淵憲餘膚齋窪 ~ 範範糧選鑰鑰鹽遞積獵) 更多 | ||||||
N/A | 糖尿病 blood glucose levels | 5 | 構積醖淵鬱蓋顧獵艱構(願蓋繭壓壓築醖鹹繭夢) = 構壓繭膚製糧遞鑰鹽顧 鏇鹽願膚遞膚鹹網繭壓 (淵網選獵壓窪製鑰廠夢 ) | 积极 | 2009-06-10 |
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