预约演示
更新于：2025-02-08
Betamethasone Sodium Phosphate
磷酸钠倍他米松
更新于：2025-02-08
概要
基本信息
原研机构 |
非在研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)- |
特殊审评- |
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结构/序列
分子式C22H30FNa2O8P |
InChIKeyODEOTKLZVXBMJD-LWCNAHDDSA-N |
CAS号151-73-5 |
关联
18
项与 磷酸钠倍他米松 相关的临床试验NCT05571046
Efficacy of Intramuscular Glucocorticoid Injection in Patients With Lumbar Radicular Pain
NCT04153396
Preemptive Infiltration With Betamethasone and Ropivacaine for Postoperative Pain in Laminoplasty or Laminectomy (PRE-EASE)
NCT04869709
Timing of Late Preterm Corticosteroid Administration and Neonatal Hypoglycemia
100 项与 磷酸钠倍他米松 相关的临床结果
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100 项与 磷酸钠倍他米松 相关的转化医学
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100 项与 磷酸钠倍他米松 相关的专利（医药）
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655
项与 磷酸钠倍他米松 相关的文献（医药）2025-04-01INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Therapeutic strategies: Bioactive hydrogels oxidized sodium alginate/strontium/betamethasone for preventing intrauterine adhesion
Article
作者: Yang, Shenyu ; Zhou, Junying ; Guo, Ruixia ; Wu, Fengling ; Miao, Qiuju ; Qiu, Luojie ; Chang, Lei ; Chen, Cheng ; Tong, Ningyao ; Han, Liping ; Chen, Mengyu ; Zhao, Yamin ; Li, Siyu
Intrauterine adhesion (IUA) is an endometrial damage repair disorder that leads to menstrual loss, amenorrhea, and infertility in women; therefore, addressing this dilemma is a critical challenge. In this study, a multifunctional hydrogel, comprising oxidized sodium alginate (OSA), strontium carbonate (SrCO3), and betamethasone 21-phosphate sodium (BSP), was formulated to facilitate angiogenesis, reduce fibrosis, and support tissue repair in the treatment of IUA. The composite hydrogels showed significant bioactivity on human endometrial stromal cells (HESCs) and human umbilical vein endothelial cells (HUVECs), promoting the injured HESCs repair, reversing the degree of fibrosis to a certain extent, and enhancing the proliferation and migration of HUVECs. These results were also verified in the IUA model of sexually mature female rats. Compared with the model group, the selection of the appropriate hydrogel significantly increased endometrial thickness (p < 0.01), the number of glands (p < 0.001), decreased the degree of fibrosis (p < 0.05), and Vimentin (p < 0.01), CK19 (p < 0.01), CD31 (p < 0.01), and Ki67 (p < 0.01) molecular expression increased remarkably. In summary, in situ injection of this multifunctional hydrogel into the uterine cavity not only serves as a physical barrier, isolating the damaged endometrium, but also gradually releases drugs as the hydrogel degrades. This multifunctional hydrogel promotes endometrial proliferation and angiogenesis while reducing fibrosis, and provides therapeutic strategies for patients with clinical IUA.
2025-03-01FOOD CHEMISTRY
Elucidation of the relationship between milk protein–stevioside interactions and interfacial layer properties based on multi-spectroscopy and interfacial rheology
Article
作者: Wei, Zihao ; Xue, Changhu ; Jin, Ziheng ; Li, Yujin ; Wang, Meng
The intricate interactions between stevioside (STE) and milk protein (mixtures of whey protein isolate and sodium caseinate, WPI/SC) as well as interfacial stabilization mechanisms were investigated. At the molecular scale, it was observed that the incorporation of the steviol hydrophobic skeleton enhanced the surface hydrophobicity of WPI/SC (from 1560.73 to 2175.63), favoring the reduction of the energy barrier for adsorption. At the mesoscopic scale, the analysis of adsorption kinetics and interfacial dilatational rheological response revealed that STE and WPI/SC had a synergistic effect on the attenuation of oil-water interfacial tension, with the lowest value of interfacial tension of 9.46 mN/m. Meanwhile, at low concentrations of STE, the WPI/SC-STE complexes unfolded and self-assembled at the interface to form a spring-like interfacial layer that relaxed in response to external deformation. In contrast, at high concentrations of STE, it gradually replaced WPI/SC-STE complexes at the interface and destabilized the interfacial layer.
2025-02-01CARBOHYDRATE POLYMERS
Intervention mechanism of amphiphilic natural sweeteners on starch chain dynamic behavior: Computational and experimental insights
Article
作者: Lu, Baiyi ; Wang, Fan ; Shen, Jianfu
Amphiphilic natural sweeteners (i.e. steviol glycosides (STE) and glycyrrhizic acid (GA)) have been adopted to improve the quality of various starchy products, which can fundamentally be characterized as the intervention of the former in the chain dynamic behavior of the latter. However, these phenomena and related mechanisms still lack systematic insights. Herein, dual-temperature molecular dynamic simulations combined with experimental analysis were used to tandemly investigate the intervention of sweeteners in six types of chain dynamic behaviors that are strongly correlated with starch properties, including unwinding, movement, long/short-term reassociation, rearrangement, and depolymerization. The results show that STE and GA both promoted the chain unwinding and movement, and also retarded the chain short/long-term reassociation and rearrangement. Besides, GA exhibited a greater role than STE in facilitating chain unwinding and movement. Peculiarly, GA (0 %-40 % w/w) collaborated with starch to form a new microstructure, especially at high content (≥ 20 % w/w), which endowed starch with exceptionally high hardness (15.50 gf→189.36 gf) and hardening rate (2.72 gf/d→17.76 gf/d), and also placed a physical barrier to retard starch depolymerization (slowly digestible starch: 11.26 %→20.62 %). This work contributes data and theoretical support for the development of starch/amphiphilic natural sweetener composite matrices.
100 项与 磷酸钠倍他米松 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 溃疡性结肠炎 | 日本 | 1992-03-13 | |
| 克罗恩病 | 日本 | 1992-03-13 | |
| 睑缘炎 | 日本 | 1985-11-20 | |
| 结膜炎 | 日本 | 1985-11-20 | |
| 角膜炎 | 日本 | 1985-11-20 | |
| 耳炎 | 日本 | 1985-11-20 | |
| 炎症 | 美国 | 1974-12-31 | |
| 胶原蛋白疾病 | 日本 | 1973-01-31 | |
| 内分泌系统疾病 | 日本 | 1973-01-31 | |
| 心脏衰竭 | 日本 | 1973-01-31 | |
| 肾病综合征 | 日本 | 1973-01-31 | |
| 类风湿关节炎 | 日本 | 1973-01-31 | |
| 眼部炎症 | 日本 | 1964-10-07 | |
| 外耳炎 | 日本 | 1964-10-07 | |
| 中耳炎 | 日本 | 1964-10-07 | |
| 过敏性鼻炎 | 日本 | 1964-10-07 |
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临床结果
临床结果
适应症
分期
评价
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临床2期 | 1 | (Bupivacaine Hydrochloride and Betamethasone Sodium Phosphate) | 衊鏇遞壓憲壓網壓簾壓(壓壓鏇選範糧蓋獵壓齋) = 積糧構膚襯憲鏇艱糧窪 鏇淵窪範壓鑰糧衊網範 (餘廠獵築醖夢選簾範構, 遞蓋築窪積廠選簾醖壓 ~ 壓構艱艱鑰窪積憲觸襯) 更多 | - | 2020-11-02 | ||
(Bupivacaine Hydrochloride) | 衊鏇遞壓憲壓網壓簾壓(壓壓鏇選範糧蓋獵壓齋) = 襯鹽繭淵餘選遞艱淵鏇 鏇淵窪範壓鑰糧衊網範 (餘廠獵築醖夢選簾範構, 繭簾衊願蓋築製齋簾夢 ~ 糧襯選廠膚鬱觸膚衊艱) 更多 | ||||||
N/A | 糖尿病 blood glucose levels | 5 | 鏇餘壓顧襯憲積築鹹積(範醖齋醖鑰範簾獵繭觸) = 積鹽獵構憲衊鹹廠積憲 鑰鬱膚窪網壓範鬱鬱製 (淵窪壓蓋鹽觸窪範顧淵 ) | 积极 | 2009-06-10 |
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