预约演示
更新于：2025-05-15
Betamethasone Sodium Phosphate
磷酸钠倍他米松
更新于：2025-05-15
概要
基本信息
原研机构 |
非在研机构 |
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)- |
特殊审评- |
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结构/序列
分子式C22H30FNa2O8P |
InChIKeyODEOTKLZVXBMJD-LWCNAHDDSA-N |
CAS号151-73-5 |
关联
20
项与 磷酸钠倍他米松 相关的临床试验ISRCTN38950110
Comparison of the analgesic non-inferiority of ultrasound-guided injections of ACS (Orthokine) into the cervical fascial planes versus application along the cervical facet joints in patients with neck pain: A randomized, open-label, controlled clinical trial. (Protocol).
NCT05571046
Efficacy of Intramuscular Glucocorticoid Injection in Patients With Lumbar Radicular Pain
NCT04153396
Preemptive Infiltration With Betamethasone and Ropivacaine for Postoperative Pain in Laminoplasty or Laminectomy (PRE-EASE)
100 项与 磷酸钠倍他米松 相关的临床结果
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100 项与 磷酸钠倍他米松 相关的转化医学
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100 项与 磷酸钠倍他米松 相关的专利（医药）
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1,222
项与 磷酸钠倍他米松 相关的文献（医药）2025-06-01BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
Associations of Antenatal Corticosteroids With Neurodevelopment in Children Aged 27–30 Months: A Population‐Based Cohort Study
Article
作者: Burgner, David ; Krispin, Eyal ; Reynolds, Rebecca M. ; Fraser, Abigail ; Wood, Rachael ; Allegaert, Karel ; Decrue, Fabienne ; Mol, Ben W. ; Shi, Ting ; Schuit, Ewoud ; Stock, Sarah J. ; Norman, Jane ; McGoldrick, Emma ; Vogel, Joshua P. ; Lahti‐Pulkkinen, Marius ; Duhig, Kate ; Miller, Jessica E. ; Jacobsson, Bo ; Gissler, Mika ; Frier, Emily M. ; Sheikh, Aziz ; Murray, Sarah R. ; Roberts, Devender ; Florian, Lani ; Zoega, Helga ; Gyamfi‐Bannerman, Cynthia ; Been, Jasper V. ; Pedersen, Lars Henning ; Einarsdóttir, Kristjana ; Lin, Chun
ABSTRACT:
Objective:
To examine the associations of antenatal corticosteroid (ACS) exposure with neurodevelopment in early childhood, and how these vary with gestational age at birth.
Design:
Population‐based cohort study.
Setting:
Scotland, UK.
Population:
285 637 singleton children born at 28–41 weeks' gestation, between 1st January 2011 and 31st December 2017, who underwent health reviews at 27–30 months of age.
Methods:
Logistic and linear regression analyses, stratified by gestation at birth (28–33, 34–36, 37–38 and 39–41 weeks' gestation), were used to evaluate the associations between ACS exposure and neurodevelopmental outcomes, and adjusted for maternal age, body mass index, diabetes, antenatal smoking, parity, neighbourhood deprivation, birth year, child sex and age at review.
Main Outcome Measures:
Practitioner‐identified concerns about any neurodevelopmental domain, and the average of five domain scores on neurodevelopmental milestones from the parent‐rated Ages and Stages Questionnaire (ASQ‐3).
Results:
After adjustment for covariates, ACS exposure was associated with reduced neurodevelopmental concerns in children born at 28–33 weeks' gestation (OR = 0.79, 95% CI = 0.62–0.999) and with increased neurodevelopmental concerns in children born at 34–36 weeks' gestation (OR = 1.11, 95% CI = 1.01–1.21). No independent associations emerged in children born at later gestations. ACS exposure was not associated with ASQ‐3 scores in any gestational age group.
Conclusions:
In early childhood, ACS exposure was associated with statistically significantly reduced neurodevelopmental concerns in children born at 28–33 weeks' gestation, and with statistically significantly increased neurodevelopment concerns in children born at 34–36 weeks' gestation. However, the effect sizes of these associations were small. No independent associations were found between ACS exposure and neurodevelopment in term‐born children.
2025-05-07ACS Applied Materials & Interfaces
Green and Efficient Preparation of Chitosan-Based Sponge with In Situ Synthesized ZnO for Deep Trauma Bleeding and Wound Healing
Article
作者: Ji, Peihong ; Ding, Rongjian ; Mao, Hongli ; Xia, Hao ; Gu, Zhongwei ; Cao, Shujun
Deep trauma often leads to acute bleeding and infections, which are major causes of death. It is worth exploring the preparation of hemostatic materials and improving their hemostatic and antibacterial properties applied to deep trauma by green and efficient methods. In this study, porous chitosan/zinc oxide/alkylated chitosan (CS/ZnO/ACS) sponges were prepared by a freezing phase separation method. ACS induced the formation of stable foam, increasing the pore formation during the freezing phase separation process. The porous structure enabled the sponge to rapidly absorb blood and expand to close the wound. The in situ synthesis of ZnO within the sponge enhances its antibacterial properties. In the antibacterial test against S. aureus and E. coli, the CS/ZnO/ACS sponges can effectively inhibit bacterial growth. Besides, compared with CS sponges, the introduction of ACS increases the adhesion of the CS/ZnO/ACS sponges to blood cells and promotes coagulation. In addition, the CS/ZnO/ACS sponges were prepared by physical phase separation, which endows it with increased solubility under acidic conditions and can be quickly removed after hemostasis. Therefore, the CS/ZnO/ACS expandable sponges offer promising clinical applications for the treatment of deep trauma.
2025-05-01TOXICOLOGY LETTERS
Toxic effects of sterigmatocystin on porcine oocyte maturation and subsequent embryo development
Article
作者: Cha, Dabin ; Choi, Seunghyun ; Lee, Sanghoon ; Lee, Yumin ; Cho, Jongki
Sterigmatocystin (STE), a precursor of aflatoxin B1, is one of the mycotoxins that easily contaminates feed. Although previous studies have suggested the toxic effects of aflatoxin B1 on oocyte maturation, little attention has been given to the effects of STE. Therefore, we investigated the effects of STE on porcine oocyte maturation. In this study, porcine oocytes were subjected to in vitro maturation supplemented with various concentrations of STE (0, 5, 10, and 25 μM). The results showed that the cumulus cell expansion indexes of all STE-treated groups were significantly decreased compared to the control group, with 10 μM significantly decreasing the transcript expression of cumulus expansion-related genes. Regarding nuclear maturation, metaphase II rates in all STE-treated groups were significantly lower than in the control group, with 10 μM significantly decreasing the transcript expression of oocyte competence-, mitogen-activated protein kinase-, and maturation-promoting factor-related genes. While cleavage rates showed no significant differences, the blastocyst formation rates significantly declined in groups treated with more than 10 μM of STE. Based on these findings, the 10 μM STE group was selected for subsequent experiments. STE supplementation significantly increased reactive oxygen species levels and decreased glutathione levels in oocytes compared to the control group. Furthermore, STE significantly decreased mitochondrial quantity and membrane potential, while increasing the percentage of γ-H2AX-positive oocytes. The number of LC3-positive dots and Annexin-V-positive oocytes was also significantly higher in the STE-treated group than in the control group. In conclusion, STE impairs porcine oocyte maturation and subsequent embryo development by inducing oxidative stress, mitochondrial dysfunction, DNA damage, excessive autophagy, and early apoptosis.
100 项与 磷酸钠倍他米松 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 溃疡性结肠炎 | 日本 | 1992-03-13 | |
| 克罗恩病 | 日本 | 1992-03-13 | |
| 睑缘炎 | 日本 | 1985-11-20 | |
| 结膜炎 | 日本 | 1985-11-20 | |
| 角膜炎 | 日本 | 1985-11-20 | |
| 耳炎 | 日本 | 1985-11-20 | |
| 炎症 | 美国 | 1974-12-31 | |
| 胶原蛋白疾病 | 日本 | 1973-01-31 | |
| 内分泌系统疾病 | 日本 | 1973-01-31 | |
| 心脏衰竭 | 日本 | 1973-01-31 | |
| 肾病综合征 | 日本 | 1973-01-31 | |
| 类风湿关节炎 | 日本 | 1973-01-31 | |
| 眼部炎症 | 日本 | 1964-10-07 | |
| 外耳炎 | 日本 | 1964-10-07 | |
| 中耳炎 | 日本 | 1964-10-07 | |
| 过敏性鼻炎 | 日本 | 1964-10-07 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床2期 | 1 | (Bupivacaine Hydrochloride and Betamethasone Sodium Phosphate) | 壓築鑰蓋鹹遞獵衊襯顧(壓鬱鹹憲製鏇鏇衊蓋積) = 選醖壓壓鹽夢網憲鏇壓 膚廠鹹餘艱積餘簾繭築 (窪範繭廠蓋廠鹹餘窪餘, 鹽鏇艱獵製積築願襯醖 ~ 襯憲築衊憲簾襯構獵廠) 更多 | - | 2020-11-02 | ||
(Bupivacaine Hydrochloride) | 壓築鑰蓋鹹遞獵衊襯顧(壓鬱鹹憲製鏇鏇衊蓋積) = 鏇襯簾壓築蓋壓繭壓廠 膚廠鹹餘艱積餘簾繭築 (窪範繭廠蓋廠鹹餘窪餘, 構醖齋鬱餘鏇範淵積製 ~ 鹹夢觸鬱遞蓋艱願積顧) 更多 | ||||||
N/A | 糖尿病 blood glucose levels | 5 | 獵膚淵蓋構淵衊衊糧築(夢餘鏇鬱齋壓醖窪膚衊) = 襯醖壓廠鏇淵鹽餘鏇構 遞觸簾鹽膚繭繭鬱廠網 (膚夢獵襯憲鑰願積選鑰 ) | 积极 | 2009-06-10 |
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