Effects of C16:0 Versus C18:0 on HDL Metabolism and Other Cardiometabolic Risk Markers: A Dietary Intervention Study in Healthy Normal-weight and Overweight Subjects

The purpose of this study is to determine whether palmitic acid (C16:0) and stearic acid (C18:0) have different effects on HDL metabolism during the fasted state.

开始日期2016-04-14

申办/合作机构

Maastricht UMC+

[+1]

100 项与 Stearic acid 相关的临床结果

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100 项与 Stearic acid 相关的转化医学

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100 项与 Stearic acid 相关的专利（医药）

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1,775

项与 Stearic acid 相关的文献（医药）

2025-11-01·SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Combining Vis-NIR and NIR hyperspectral imaging techniques with a data fusion strategy for rapid and nondestructive determination of multiple nutritional qualities in flaxseed

Article

作者: Zhu, Dongyu ; Qi, Yanni ; Han, Junying ; Liu, Chengzhong ; Zhang, Jianping

Protein, oil content, stearic acid, linolenic acid, and linoleic acid are key indicators for evaluating the quality of flaxseed in order to optimize the detection method of nutritional quality of flaxseed and to improve the efficiency of the screening of high-quality flax germplasm resources. This study integrated visible near-infrared (Vis-NIR) and near-infrared (NIR) hyperspectral imaging to determine protein, oil, stearic acid, linolenic acid, and linoleic acid contents in diverse flaxseed varieties, along with conducting correlation analyses. After seven data preprocessing methods and three feature selection methods, quantitative prediction models were developed using partial least squares regression (PLSR), principal component regression (PCR), support vector regression (SVR), and multiple linear regression (MLR). Experimental results demonstrated that NIR and fused spectral data outperformed Vis-NIR data across all five quality indices. NIR spectroscopy showed optimal performance for predicting oil content (R_p² = 0.9671, RMSEP = 0.4364 %), linolenic acid (R_p² = 0.9517, RMSEP = 0.8795 %), and linoleic acid (R_p² = 0.9458, RMSEP = 0.3037 %). Fused spectral data achieved superior predictions for protein content (R_p² = 0.9712, RMSEP = 0.2360 %) and stearic acid (R_p² = 0.9195, RMSEP = 0.3454 %). And the spatial distribution of flaxseed's internal nutrient contents was also visualized by map. The results showed that the NIR and fusion spectral sets could be successfully used to evaluate multiple nutritional qualities of flaxseed, which provides a new option for nondestructive determination of the nutritional qualities of flaxseed in the future.

2025-07-03·JOURNAL OF DRUG TARGETING

Exploring the potential of ferulic acid-loaded nanostructured lipid carriers: angiotensin inhibition via docking, formulation and pharmacokinetic and pharmacodynamics studies

Article

作者: Meshram, Preeti Rajabhau ; Ranpise, Nisharani Sudhakar

Ferulic acid (FA) is a natural phenolic compound that has been documented for its antioxidant properties and potential in managing hypertension. However, its use is limited due to poor solubility and permeability (BCS Class IV classification). To overcome this, nanostructured lipid carriers (NLCs) of FA were developed using the emulsification probe sonication technique, with formulation optimized through Box-Behnken design. The optimized FA-NLCs (F12) demonstrated a particle size of 103.4 nm, zeta potential of -43.6 mV, polydispersity index of 0.531, and entrapment efficiency of 88.9%. Key Findings of the research manifested, that during in-vitro release studies, FA-NLCs showed sustained release action (40.34% over 24 h) compared to plain FA (103.13% in 4 h). Pharmacokinetics of FA-NLC suggested that increased C_max by 2.6-fold, AUC by 1.9-fold, and half-life significantly (p < .001), also Pharmacodynamics revealed that FA-NLCs reduced blood pressure more effectively (39.9 mmHg vs. 30.8 mmHg for plain FA; p < .001). Furthermore, FA-NLC was showing successful intestinal uptake through lymphatic absorption via clathrin-mediated endocytosis, bypassing first-pass metabolism, hence showed enhancement in bioavailability, Thus the study concluded that FA-NLCs significantly improve therapeutic efficacy and sustained blood pressure reduction compared to plain FA.

2025-07-01·FOOD CHEMISTRY

A novel synergistic inhibition mechanism of pancreatic lipase by 2-mercaptobenzothiazole and stearic acid migrants from dairy contact rubbers

Article

作者: Ma, Da ; McClements, David Julian ; Wang, Yujie ; Chen, Jing ; Cheng, Juan

This study explores the inhibitory effects of two migrants-2-mercaptobenzothiazole (MBT) and stearic acid-from dairy rubber contact materials on pancreatic lipase (PL). Enzyme assays showed significant, dose-dependent inhibition, with stearic acid being more potent. MBT and stearic acid exhibited reversible inhibition, with MBT acting competitively and stearic acid non-competitively. Fluorescence spectroscopy and circular dichroism indicated conformational changes in PL upon binding, while molecular docking confirmed specific interactions at the active site (MBT) and near it (stearic acid). Binding affinities for MBT-PL and stearic acid-PL complexes were - 24.90 and - 20.23 kJ/mol, respectively. High concentrations of both compounds exhibited synergistic inhibition, potentially affecting lipid digestion in dairy products. This study highlights the influence of rubber-derived migrants on PL activity and suggests limiting their use in food contact materials to safeguard dairy nutritional quality.

项与 Stearic acid 相关的新闻（医药）

2024-12-11

·Pharmaindustrial

Sustainable Solutions in Pharma Supply Chains: Reducing Carbon Footprint with Sustainable Excipients

2024-12-12 The pharmaceutical industry is under increasing pressure to adopt more sustainable practices, especially when it comes to reducing the carbon footprint of supply chains. One key area for improvement is the use of eco-friendly excipients—ingredients that play an essential role in drug formulations. Sudeep Pharma Limited is addressing this need through its range of sustainable lubricants, including RSPO-certified palm-based magnesium stearate and stearic acid, as well as rice bran-based magnesium stearate and stearic acid. These products not only offer superior performance but also contribute to more environmentally responsible pharmaceutical manufacturing. The Role of Excipients in Drug Formulations Excipients form the bulk of most drug formulations, enhancing stability, manufacturability, and patient compliance. While they are often overlooked in terms of sustainability, their environmental impact can be significant. By opting for sustainable excipients, the pharmaceutical industry can reduce its carbon footprint and contribute to a more eco-conscious supply chain. Sudeep Pharma’s Sustainable Lubricants: A Step Towards Green Pharma Lubricants, such as magnesium stearate and stearic acid, are crucial in pharmaceutical manufacturing as they prevent materials from sticking to machinery during tablet and capsule production. Sudeep Pharma offers two types of sustainable lubricants: RSPO-certified palm-based products and rice bran-based alternatives. These products are designed to reduce environmental impact while maintaining the high-quality standards required in pharmaceutical production. Environmental Benefits of Lubricants The use of sustainable lubricants has several environmental advantages: Aligning with the Future of Pharma As the pharmaceutical industry faces increasing regulatory and consumer pressure to adopt greener practices, sustainable excipients play a critical role in the transition to more responsible supply chains. By choosing sustainable lubricants, pharmaceutical companies can not only reduce their environmental impact but also meet the growing demand for eco-friendly products. Sudeep Pharma: Leading the Charge in Sustainable Pharma Solutions Sudeep Pharma’s commitment to sustainability is reflected in its diverse range of eco-friendly excipients. By offering both RSPO-certified palm-based and rice bran-based magnesium stearate and stearic acid, the company is setting new standards in pharmaceutical excipient production. These innovations enable pharmaceutical manufacturers to meet their sustainability goals without compromising on product quality or performance.