Letter
作者: Wu, Yingli ; Wu, Yunzhao ; Xiao, Xinhua ; Lei, Hu ; Cao, Yang ; Xu, Hanzhang ; Yao, Zhujun ; Shan, Huizhuang ; Zhu, Qi ; Liu, Meng
In this letter the author discusses about YL064 activates proteasomal-dependent degradation of c-Myc and synergistically enhances the anti-tumor activity of ABT-199 in diffuse large B cell lymphoma.YL064 induces ubiquitin-proteasome-dependent degradation of c-Myc in DLBCL cells.YL064 is a promising compound for the treatment of DLBCL through directly targeting c-Myc for degradationMoreover, we demonstrated the combination of a c-Myc degrader and a BCL-2 inhibitor exerts synergistic effectiveness against DLBCL.Further elucidating the interaction relationship between YL064 and c-Myc may pave the way for the development of novel c-Myc-specific degraders for the treatment of DLBCL.