dFGF (MIT)(dFGF (MIT)) - 药物靶点：FGFRs_专利_临床

概要

基本信息

药物类型

合成多肽

别名-

靶点

FGFRs

作用机制

FGFRs刺激剂(成纤维细胞生长因子受体家族刺激剂)

治疗领域

神经系统疾病心血管疾病

在研适应症-

非在研适应症

脑卒中

原研机构

Massachusetts Institute of Technology

在研机构-

非在研机构

ViaCell, Inc.

Massachusetts Institute of Technology

最高研发阶段无进展药物发现

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 dFGF (MIT) 相关的临床结果

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100 项与 dFGF (MIT) 相关的转化医学

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100 项与 dFGF (MIT) 相关的专利（医药）

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2

项与 dFGF (MIT) 相关的文献（医药）

2005-01-01·Restorative neurology and neuroscience

Dimeric fibroblast growth factor-2 enhances functional recovery after focal cerebral ischemia.

Article

作者: Ren, JingMei ; Berry, David ; Finklestein, Seth P ; Sietsma, Dana K ; Sasisekharan, Ram ; Kwan, Chi-Pong

PURPOSE:

The purpose of this study was to examine the effects of dimerized basic fibroblast growth factor (dFGF), a novel engineered growth factor, in a model of functional recovery following focal cerebral infarction (stroke) in rats.

METHODS:

A focal stroke was made in mature male rats by occlusion of the middle cerebral artery (MCA). dFGF was administered by intracisternal injection at one and three days after stroke. Tests to evaluate sensorimotor recovery of the contralateral limbs were done during the next three weeks after stroke.

RESULTS:

dFGF significantly enhanced recovery of sensorimotor function in limb placing and body swing tests compared to vehicle treatment. There were no differences in body weight or infarct volume in dFGF- vs. vehicle-treated animals.

CONCLUSIONS:

dFGF represents a potential treatment to enhance functional recovery after stroke and offers several advantages over bFGF, including stability and independence from extracellular heparan sulfates.

1959-11-01·Arquivo de patologia

[Thyroid hormones and related compounds of the saliva (Contribution to the study of the metabolism of iodine)].

Article

作者: SOBRAL, J M ; CEIA, M ; CLODE, W

100 项与 dFGF (MIT) 相关的药物交易

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