更新于：2024-11-09
Sulfadiazine
磺胺嘧啶
更新于：2024-11-09
概要
基本信息
药物类型 小分子化药 |
别名 2-sulfanilamidopyrimidine、2-sulfanilylaminopyrimidine、4-amino-N-2-pyrimidinylbenzenesulfonamide + [18] |
作用机制 bacterial DHPS抑制剂(细菌二氢叶酸合成酶抑制剂) |
治疗领域 |
在研适应症 |
非在研适应症- |
最高研发阶段批准上市 |
首次获批日期 美国 (1941-08-11), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C10H10N4O2S |
InChIKeySEEPANYCNGTZFQ-UHFFFAOYSA-N |
CAS号68-35-9 |
关联
23
项与 磺胺嘧啶 相关的临床试验Comparison of the healing effect of dressing 2nd and 3rd degree burns with silver sulfadiazine cream compared to povidone iodine in patients with 30% to 50% burns: a clinical trial
Clinical Efficacy Test of Polyester Dressing Containing Herbal Extracts and Silver Sulfadiazine Cream Comparing with Silver Sulfadiazine Cream in Burn Wound Healing
Cilinical Study the Effect of Zoush in Comperhansive Sulfadiazine 1 Ointment on Second-degree Burned Wound Healing
100 项与 磺胺嘧啶 相关的临床结果
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100 项与 磺胺嘧啶 相关的转化医学
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100 项与 磺胺嘧啶 相关的专利（医药）
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4,107
项与 磺胺嘧啶 相关的文献（医药）2025-05-01Journal of Environmental Sciences
The influence mechanism of environmental factors on DGT adsorbing sulfonamides and the migration between water and sediment
Article
作者: Zhang, Peng ; Li, Yanying ; Yan, Jingfeng ; Ge, Linke ; Ji, Hao
Obtaining the sulfonamides (SAs) concentrations in the water body and sediment bulk was a prerequisite to reveal their transport and partitioning behavior in sediment-water environments and accurately assess their ecological risk. In the present study, the influences of multifactor interactions on the performance of o-DGTs with XAD-18 binding gels were analyzed by central combination experiments and response surfaces analysis, in which the target compounds were 9 SAs. The results indicated that dissolved organic matter (DOM), pH, and suspended particulate matter (SS) had significant effects on the o-DGT sampling, whereas this o-DGT was independent of the ionic strength (IS). Concentning the composite influence of the four factors, the interaction between DOM and SS posed the most significant effect on all 9 SAs compounds. Subsequently, an o-DGT and DIFS model was applied to explore the SAs migration between the water-sediments interface. The difference between desorption rate (kb) and adsorption rates (kf) values suggested that the kinetics of SAs was dominated by adsorption. Moreover, the short-term sediment-water partitioning of SAs was clarified on the basis of distribution coefficient (Kdl) for the labile SAs, among which the sulfadiazine (SDZ) had the largest labile pool. The ability of sediments to release SAs to the liquid phase as a sink was determined by response time (Tc). Among the 9 SAs, the long-term release of soseulfamethoxypyridazine (SMP) from the solid phase of sediments would have a potential risk to the aquatic environment, to which more attention should be paid in the future.
2025-01-01TALANTA
Highly efficient and broad-spectrum antibacterial carbon dots combat antibiotic resistance
Article
作者: Du, Yuwei ; Li, Xinlu ; Dong, Wenfei ; Wu, Jie ; Wang, Panyong ; You, Qiannan ; Li, Li ; Yan, Haiyang ; Miao, Huimin
Bacterial infections have become a major global public health issue, particularly with the emergence of multidrug-resistant strains. Therefore, developing non-antibiotic antimicrobial agents is crucial for treating drug-resistant bacterial infections. Building on previous research into natural products as novel antibacterial agents, this study synthesized curcumin-derived carbon dots using curcumin and ethylenediamine as raw materials through a hydrothermal method. The resulting carbon dots not only improved the water solubility and stability of curcumin but also exhibited highly efficient broad-spectrum antibacterial activity. Detailed investigations into the antibacterial performance and mechanisms of the carbon dots were conducted through experiments such as minimum inhibitory concentration (MIC) determination, live/dead bacterial staining, morphological studies, nucleic acid concentration detection, and reactive oxygen species (ROS) detection. The results indicated that the carbon dots significantly damaged the structural integrity of bacteria and generated large amounts of ROS. They exhibited remarkable antibacterial effects against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus, and effectively inhibited drug-resistant MRSA. Their antibacterial efficacy was notably superior to that of broad-spectrum antibiotics such as chloramphenicol and Sulfadiazine. This study highlights the potential application of curcumin-derived carbon dots in combating bacterial infections and provides valuable insights for developing novel antibacterial agents derived from natural products.
2025-01-01Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Article
作者: Ravikantha, M N ; Thipperudrappa, J ; Reddy, R Annoji ; Vibha, K ; Prachalith, N C ; Kumar, H M Suresh
In this study, the absorption and fluorescence characteristics of sulfa drugs, specifically Sulfadiazine (SDZ), Sulfamerazine (SMZ), and Sulfamethazine (STZ), were examined across a pH range of 1-14. The absorption and fluorescence spectra of these sulfa drugs showed significant changes depending on the pH value. Analysis of their pH-dependent absorption and fluorescence properties indicated that these sulfa drugs could used to design molecular logic gates. The absorption and fluorescence behaviors at various wavelength maxima were utilized to design IMPLICATION and Improved-INHIBIT (I-INHIBIT) molecular logic gates.
100 项与 磺胺嘧啶 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 细菌感染 | 美国 | 1941-08-11 |
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临床结果
临床结果
适应症
分期
评价
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N/A | - | 築鹽糧衊鑰鏇餘願繭膚(鹽築築糧遞糧醖淵積餘) = Our patient developed severe but reversible post-obstructive AKI secondary to high-dose sulfadiazine-induced nephrolithiasis 廠簾淵觸淵廠衊糧獵壓 (淵繭衊糧壓顧顧觸蓋獵 ) 更多 | 不佳 | 2020-10-19 | |||
临床2/3期 | 34 | silver sulfadiazine cream+Epidermal growth factor (Epidermal Growth Factor With Silver Sulfadiazine Cream) | 觸鏇繭齋鹹壓廠壓構範(網鹽淵顧蓋顧艱鏇範齋) = 壓鹹觸鹹憲鹽顧襯鬱顧 築憲餘鹽襯鬱餘齋構顧 (蓋艱積網顧製積夢膚壓, 鬱夢獵襯壓鹽簾醖築齋 ~ 壓觸艱夢齋觸窪網廠蓋) 更多 | - | 2012-08-09 | ||
(Silver Zinc Sulfadiazine Cream) | 觸鏇繭齋鹹壓廠壓構範(網鹽淵顧蓋顧艱鏇範齋) = 淵蓋廠範淵糧糧夢選觸 築憲餘鹽襯鬱餘齋構顧 (蓋艱積網顧製積夢膚壓, 顧選襯構顧膚構膚蓋觸 ~ 餘鑰淵簾構窪製窪壓醖) 更多 |
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