更新于：2024-09-21
Sulfadiazine
磺胺嘧啶
更新于：2024-09-21
概要
基本信息
药物类型 小分子化药 |
别名 2-sulfanilamidopyrimidine、2-sulfanilylaminopyrimidine、4-amino-N-2-pyrimidinylbenzenesulfonamide + [18] |
作用机制 bacterial DHPS抑制剂(细菌二氢叶酸合成酶抑制剂) |
治疗领域 |
在研适应症 |
非在研适应症- |
最高研发阶段批准上市 |
首次获批日期 美国 (1941-08-11), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C10H10N4O2S |
InChIKeySEEPANYCNGTZFQ-UHFFFAOYSA-N |
CAS号68-35-9 |
关联
23
项与 磺胺嘧啶 相关的临床试验Comparison of the healing effect of dressing 2nd and 3rd degree burns with silver sulfadiazine cream compared to povidone iodine in patients with 30% to 50% burns: a clinical trial
Clinical Efficacy Test of Polyester Dressing Containing Herbal Extracts and Silver Sulfadiazine Cream Comparing with Silver Sulfadiazine Cream in Burn Wound Healing
Cilinical Study the Effect of Zoush in Comperhansive Sulfadiazine 1 Ointment on Second-degree Burned Wound Healing
100 项与 磺胺嘧啶 相关的临床结果
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100 项与 磺胺嘧啶 相关的转化医学
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100 项与 磺胺嘧啶 相关的专利（医药）
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4,080
项与 磺胺嘧啶 相关的文献（医药）2025-01-01Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Article
作者: Ravikantha, M N ; Vibha, K ; Thipperudrappa, J ; Reddy, R Annoji ; Kumar, H M Suresh ; Prachalith, N C
In this study, the absorption and fluorescence characteristics of sulfa drugs, specifically Sulfadiazine (SDZ), Sulfamerazine (SMZ), and Sulfamethazine (STZ), were examined across a pH range of 1-14. The absorption and fluorescence spectra of these sulfa drugs showed significant changes depending on the pH value. Analysis of their pH-dependent absorption and fluorescence properties indicated that these sulfa drugs could used to design molecular logic gates. The absorption and fluorescence behaviors at various wavelength maxima were utilized to design IMPLICATION and Improved-INHIBIT (I-INHIBIT) molecular logic gates.
2024-12-01Journal of Environmental Sciences
La3+@BC500-S2O82− system for removal of sulfonamide antibiotics in water
Article
作者: Wang, Juan ; Shen, Zheng ; Zhang, Yalei ; Wang, Bing ; Qiao, Hengbo ; Bi, Dongsu
Sulfonamide antibiotics (SAs) widely used have potentially negative effects on human beings and ecosystems. Adsorption and advanced oxidation methods have been extensively applied in SAs wastewater treatment. In this study, compared with Al3+@BC500 and Fe3+@BC500, La3+@BC500 for activating persulfate (S2O82-) had the best effect removal performance of sulfadiazine (SDZ) and sulfamethoxazole (SMX). Morphology, acidity, oxygen-containing functional groups, and loading of La3+@BC500 were analyzed by techniques, including EA, BET, XRD, XPS, FT-IR. XRD results show that with the increase of La3+ loading, the surface characteristics of biochar gradually changed from CaCO3 to LaCO3OH. Through EPR technology, it is proved that LaCO3OH on the surface of La3+@BC500 can not only activate S2O82- to generate SO4-•, but also to produce •OH. In the optimization experiment, the optimal dosage of La3+ is between 0.05 and 0.2 (mol/L)/g. SDZ had a good removal effect at pH (5-9), but SMX had a good removal effect only at pH=3. Zeta potential also proves that the material is more stable under acidic conditions. The removal process of SDZ is more in accord with pseudo-first-order kinetics (R2=0.9869), while SMX is more in line with pseudo-second order kinetics (R2=0.9926).
2024-11-01JOURNAL OF HAZARDOUS MATERIALS
Biofilm enhanced the mitigations of antibiotics and resistome in sulfadiazine and trimethoprim co-contaminated soils
Article
作者: Harindintwali, Jean Damascene ; Wang, Yu ; Hashsham, Syed A ; Wang, Fang ; Mei, Zhi ; Liu, Yu ; Tiedje, James M ; Zhang, Tong ; Fu, Yuhao ; Virta, Marko ; Deng, Yu ; Hashsham, Syed A. ; Tiedje, James M. ; Dou, Qingyuan ; Jiang, Xin
Reducing antibiotic levels in soil ecosystems is vital to curb the dissemination of antimicrobial resistance genes (ARGs) and mitigate global health threats. However, gaps persist in understanding how antibiotic resistome can be suppressed during antibiotic degradation. Herein, we investigate the efficacy of a biochar biofilm incorporating antibiotics-degrading bacterial strain (Arthrobacter sp. D2) to mitigate antibiotic resistome in non-manured and manure-amended soils with sulfadiazine (SDZ) and trimethoprim (TMP) contamination. Results show that biofilm enhanced SDZ degradation by 83.0% within three days and increased TMP attenuation by 55.4% over 60 days in non-manured soils. In the non-manured black soil, the relative abundance of ARGs increased initially after biofilm inoculation. However, by day 30, it decreased by 20.5% compared to the controls. Moreover, after 7 days, biofilm reduced TMP by 38.5% in manured soils and decreased the total ARG abundance by 19.0%. Thus, while SDZ degradation did not increase sulfonamide resistance genes, TMP dissipation led to a proliferation of insertion sequences and related TMP resistance genes. This study underscores the importance of antibiotic degradation in reducing related ARGs while cautioning against the potential proliferation and various ARGs transfer by resistant microorganisms.
100 项与 磺胺嘧啶 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 细菌感染 | 美国 | 1941-08-11 |
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临床结果
临床结果
适应症
分期
评价
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N/A | - | 願範製壓獵淵簾壓網鹹(顧網糧鹹蓋鹹齋齋鬱願) = Our patient developed severe but reversible post-obstructive AKI secondary to high-dose sulfadiazine-induced nephrolithiasis 顧遞築獵選膚齋膚鹹齋 (鹽獵糧夢齋淵窪衊築鹽 ) 更多 | 不佳 | 2020-10-19 | |||
临床2/3期 | 34 | silver sulfadiazine cream+Epidermal growth factor (Epidermal Growth Factor With Silver Sulfadiazine Cream) | 鏇淵衊鹹願製繭鏇糧蓋(衊衊選鹹艱遞鹽夢糧觸) = 鑰鬱醖顧衊構願鏇醖齋 憲廠鏇餘憲衊鏇獵顧醖 (窪觸窪顧築簾觸積膚築, 餘選鹹廠糧鹽顧齋夢鹹 ~ 鬱遞鹹艱襯獵網築築製) 更多 | - | 2012-08-09 | ||
(Silver Zinc Sulfadiazine Cream) | 鏇淵衊鹹願製繭鏇糧蓋(衊衊選鹹艱遞鹽夢糧觸) = 鹽廠壓製蓋蓋顧憲鑰鏇 憲廠鏇餘憲衊鏇獵顧醖 (窪觸窪顧築簾觸積膚築, 鬱淵繭鑰夢鏇獵簾蓋襯 ~ 範範網製醖艱積範廠淵) 更多 |
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