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更新于：2025-04-17
Tiapride Hydrochloride
盐酸硫必利
更新于：2025-04-17
概要
基本信息
药物类型 小分子化药 |
别名 Thiapride、Tiapride、Tiapride hydrochloride (JP17) + [10] |
作用方式 拮抗剂 |
作用机制 D2 receptor拮抗剂(多巴胺D2受体拮抗剂) |
非在研适应症 |
原研机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C15H25ClN2O4S |
InChIKeyOTFDPNXIVHBTKW-UHFFFAOYSA-N |
CAS号51012-33-0 |
关联
8
项与 盐酸硫必利 相关的临床试验ChiCTR2500097539
Comparative Effectiveness of Zonisamide Monotherapy, Tiapride Monotherapy, and Combination Therapy in Pediatric Tic Disorders: A Real-World Prospective Cohort Study
CTR20240869
盐酸硫必利片人体生物等效性试验
CTR20242255
盐酸硫必利片人体生物等效性试验
100 项与 盐酸硫必利 相关的临床结果
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100 项与 盐酸硫必利 相关的转化医学
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100 项与 盐酸硫必利 相关的专利（医药）
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818
项与 盐酸硫必利 相关的文献（医药）2025-06-01JOURNAL OF CHROMATOGRAPHY A
Analytical methodology for challenging persistent, mobile, and toxic substances in vegetal matrices after irrigation with contaminated water
Article
作者: Pitarch, Elena ; Gregorio-Lozano, Sergi ; Bolos-Sánchez, Victoria ; Bijlsma, Lubertus ; Pitarch-Motellón, Jorge
Reusing wastewater for irrigation is proposed as a strategy to address water scarcity. However, the long-term environmental consequences of this practice are still unknown, especially when reclaimed water contains contaminants of emerging concern, such as persistent, mobile, and toxic (PMT) compounds, due to the inefficiency of wastewater treatment plants in removing certain pollutants. As a result, irrigation with contaminated water could lead to their uptake by crops and enter the food chain. While data on the presence of PMTs in environmental samples is starting to emerge, the analysis of certain compounds in vegetable matrices remains unexplored. In this study, an analytical methodology was developed and validated for the determination of 8 PMTs (i.e., benzophenone-3, clarithromycin, imazalil, metformin, sulpiride, terbutryn, tiapride, and tramadol) in escarole, tomatoes, and tomato leaves. The proposed analytical methodology used a QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) extraction method prior to mixed-mode liquid chromatography tandem mass spectrometry analysis. Method validation, performed according to SANTE guidelines, presented satisfactory results at studied concentrations (1, 10 and 100 ng·g-1 for each compound/matrix combination, except for metformin in escarole (50 and 500 ng·g-1). Recoveries ranged from 70 to 120 %, with a precision of ≤ 20 % for most compounds. Benzophenone-3 and tiapride, for which no isotopically labelled internal standard was available, could be adjusted by applying a correction factor. The limit of quantification was 1 ng·g-1 for all compounds in the three matrices, except for benzophenone-3 and metformin in both escarole and tomato leaves. The applicability of the method was tested by analysing samples from an experimental greenhouse plot where crops were irrigated with water spiked with the selected PMTs.
2025-04-01Journal of Environmental Chemical Engineering
Ozone injection system based on NETmix technology for quaternary treatment of urban wastewater
作者: Rodil, Rosario ; Marrocos, Paulo H. ; Mendez, Sandra ; Pituco, Mateus Mestriner ; Vilar, Vitor J. P. ; Montes, Rosa ; Moreira, Francisca C.
An innovative high-intensity static mixer technol., known as NETmix, was applied as an ozone (O3) gas injection system to promote the quaternary treatment of urban wastewater (UWW), focusing on the elimination of contaminants of emerging concern (CECs).The NETmix network with an exclusive geometry boosts mass transfer rates and rapidly develops an O3-rich stream to react with CECs.The mixer operated in continuous mode promotes a rapid gas (O3)-liquid (water) dissolutionThe ozonation process' performance was evaluated for the abatement of 19 CECs spiked (10μg dm-3 each) in demineralized water and two tertiary-treated UWW matrixes, coming from (i) a secondary settler tank after a conventional activated sludge and (ii) the outlet of a membrane biol. reactor (MBR).In addition, the ozonation system was tested for removing a broad range of CECs at natural trace levels from the UWW matrix coming from the MBR.In the realistic wastewater contamination scenario, a maximum transferred O3 dose of 1.28 gO3 g-1DOC and 0.76 gO3 g-1DOC resulted in removal values ≥80% for 12 out of the 19 spiked CECs from the secondary settler tank, and 9 out of the 19 spiked CECs from the post-MBR treatment, resp., at a very short hydraulic residence time (55 s).Moreover, removals ≥80% were attained for 22 out of 25 CECs detected in the effluent from the MBR, applying a specific O3 dose of 0.6 gO3g-1DOC.The enhanced ozone-water mass transfer provided by the NETmix technol. enabled high removal efficiencies for CECs.
2025-02-01Journal of Traditional Chinese Medicine
Effects of acupuncture combined with bone-setting therapy to treat tourette syndrome: a three-arm randomized controlled trial.
Article
作者: Lingqing, Jin ; Jianchang, Luo ; Boxu, Lang ; Jiawang, Lang
OBJECTIVE:
To explore the efficacy and safety of acupuncture combined with atlantoaxial joint bone-setting therapy for the treatment of Tourette syndrome.
METHODS:
We randomly divided 600 patients at a ratio of 1∶1∶1 into three groups: group A (acupuncture combined with atlantoaxial joint bone setting therapy group), group B (acupuncture group), and group C (tiapride group). After two months of treatment, the Yale global tic severity scale (YGTSS) score reduction, improvement in social function impairment, clinical efficacy, and long-term efficacy in the three groups were compared.
RESULTS:
After treatment, in the analysis of YGTSS score reduction, social function impairment improvement, the clinical control rate, and long-term efficacy, the results were all Group A > Group B > Group C, with a statistically significant difference (P < 0.05). However, the total clinical efficacy of treatment in group A (94.9%) was not significantly different from that in group B (91.8%). Adverse reactions did not occur in groups A and B, and several adverse reactions occurred in 29% (n = 58) of the group C patients.
CONCLUSION:
Compared with traditional drug therapy, acupuncture combined with atlantoaxial joint bone setting therapy has better clinical and long-term efficacy. This treatment strategy can improve the social function of children and prevent adverse reactions to drugs.
100 项与 盐酸硫必利 相关的药物交易
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研发状态
批准上市
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 脑梗塞 | 日本 | 1987-03-31 | |
| 精神运动障碍 | 日本 | 1987-03-31 | |
| 运动失调 | 中国 | 1985-01-01 | |
| 帕金森病 | 中国 | 1985-01-01 |
未上市
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| Tourette 综合征 | 临床3期 | - | 2008-01-01 |
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