N-butyl-2-cyanoacrylate(N-butyl-2-cyanoacrylate)

概要

基本信息

药物类型

小分子化药

别名

Histoacryl

靶点-

作用方式-

作用机制-

治疗领域

消化系统疾病肿瘤感染+ [3]

在研适应症-

非在研适应症

脓肿龋齿食管胃静脉曲张+ [2]

原研机构-

在研机构-

非在研机构

Mansoura University

Tanta University

最高研发阶段无进展临床3期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

登录后查看时间轴

关联

9

项与 N-butyl-2-cyanoacrylate 相关的临床试验

CTRI/2024/11/077136

/ Not yet recruitingN/AIIT

Comparison Of N-butyl 2-cyanoacrylate Glue FixationVersus Conventional Fixation of Polypropylene Mesh InPatients Undergoing Lichtenstein Repair For InguinalHernia: A Randomized Control Trial. - NIL

开始日期2024-11-28

申办/合作机构-

CTRI/2024/05/068011

/ Not yet recruiting临床4期IIT

Evaluation of the effectiveness of n-butyl-2-cyanoacrylate tissue glue versus black braided silk suture as a wound closure agent for minor oral surgical procedures – A split mouth randomized controlled trial. - NIL

开始日期2024-06-01

申办/合作机构-

ChiCTR2400080913

/ Suspended早期临床1期IIT

The effects of endoscopic conventional treatment and conventional treatment combined with Histoacryl glue on the rate of rebleeding in patients with acute nonvariceal upper gastrointestinal bleeding combined with coronary artery disease:A prospective randomized controlled study

开始日期2024-02-20

申办/合作机构-

100 项与 N-butyl-2-cyanoacrylate 相关的临床结果

登录后查看更多信息

100 项与 N-butyl-2-cyanoacrylate 相关的转化医学

登录后查看更多信息

100 项与 N-butyl-2-cyanoacrylate 相关的专利（医药）

登录后查看更多信息

393

项与 N-butyl-2-cyanoacrylate 相关的文献（医药）

2024-11-01·BJR|Case Reports

Multiple delayed-onset metachronous ileal stenoses after transcatheter arterial embolization using N-butyl-2-cyanoacrylate for upper gastrointestinal bleeding: factors of complication and importance of plain CT evaluations

Article

作者: Kamide, Hiroyuki ; Sekikawa, Zenjiro ; Kobayashi, Yusuke ; Terauchi, Miki

AbstractA 63-year-old man underwent transcatheter arterial embolization (TAE) using a mixture of N-butyl-2-cyanoacrylate (NBCA) and iodized oil to treat acute gastrointestinal (GI) bleeding. The procedure was initially successful; however, the patient developed ileus >1 month later and subsequently underwent several surgeries to treat the multiple metachronous ileal stenoses. The flux of a small amount of off-target glue was the primary cause of these complications. As the patient had few symptoms in the first month post-TAE, however, affirming the diagnosis took time. A detailed review of plain CT scans was a decisive factor in achieving the final diagnosis. This case demonstrates that TAE using an NBCA–iodized oil mixture effectively treats acute GI bleeding. However, a complication such as off-target embolization is likelier to occur because of a combination of certain factors such as vascular anatomy, complexity of the procedure, and NBCA dilution. Close observation using plain CT should be performed for the identification of off-target embolization occurrence even in cases of successful TAE.

2024-11-01·Advanced Healthcare Materials

Iodinated Cyanoacrylate‐Based Novel Liquid Embolic Compositions with Inherent Radiopacity for Endovascular Embolization

Article

作者: Kim, Young Il ; Park, Hyun Jae ; Hur, Saebeom ; Ahn, Cheol‐Hee ; Jae, Hwan Jun ; Jeon, Seong Ik ; Cho, Hanhee

AbstractEndovascular embolization is a promising therapeutic approach broadening its application area due to its minimal invasiveness and short operation time, wherein lesional blood vessels are occluded with liquid embolic agents under X‐ray imaging guidance. Histoacryl and its composition with Lipiodol are one of the most widely used liquid embolic agents, however, Histoacryl has critical limitations, such as lack of innate X‐ray visibility and strong adhesion to microcatheter. In this study, three different iodinated cyanoacrylates are newly synthesized as alternatives to Histoacryl and employed to develop liquid embolic compositions. Among them, 4‐iodobutyl 2‐cyanoacrylate (IBCA) is most preferable with high iodine content (730 mgI mL−1) and fast polymerization. The IBCA‐based embolic compositions containing ethyl oleate and acetic acid showed moderate viscosity and reduced catheter adhesiveness (≈0.80 N), and their polymerization time is freely controllable from 2 to 15 s. In the embolization test with rabbit models, the renal artery is successfully occluded by IBCA‐based embolic compositions without vascular recanalization or nontarget embolization for 4 w. Their embolic effect is further evaluated using swine models, demonstrating the practical applicability in the clinic. In conclusion, IBCA and its compositions are determined to have great potential as novel liquid embolic agents.

2024-11-01·Radiology Case Reports

Resolving a sticky situation: A case report of mechanical thrombectomy of Histoacryl emboli in the right atrium and inferior vena cava

Article

作者: Vogt, Katharina ; Doppler, Michael C ; Doppler, Michael C. ; Wintergerst, Charlotte ; Efinger, Niklas ; Grundmann, Sebastian ; Udi, Josefina ; Uller, Wibke ; Sekandarzad, Asieb ; Can, Elif

A 68-year-old male with liver cirrhosis presented with dizziness and dyspnea two days after endoscopic Histoacryl occlusion of gastric varicses. Imaging revealed a large endovascular embolization of Histoacryl glue, spanning from porto-caval collaterals via the inferior vena cava to the right atrium, partially occluding right atrial inflow. This case report describes the successful removal of this large net-like mass of Histoacryl glue using thrombectomy devices from the inferior vena cava and the right atrium. Postprocedure imaging showed near-complete clearance with residual fragments in the superior mesenteric vein and small emboli in the pulmonary arteries. The patient was discharged in stable condition. Histoacryl glue can cause severe complications if embolized. This case highlights the potential of advanced thrombectomy devices for managing embolic complications from endovascular treatments.

100 项与 N-butyl-2-cyanoacrylate 相关的药物交易

登录后查看更多信息

研发状态

10 条进展最快的记录,

登录

后查看更多信息

适应症	最高研发状态	国家/地区	公司	日期
食管胃静脉曲张	临床3期	埃及	Tanta University	2016-01-01
脓肿	临床3期	埃及	Mansoura University	2008-08-31
龋齿	临床3期	埃及	Mansoura University	2008-08-31
藏毛性窦道	临床3期	埃及	Mansoura University	2008-08-31
手术伤口	临床3期	埃及	Mansoura University	2008-08-31

登录后查看更多信息

临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


UEGW2019	N/A	食管胃静脉曲张	-	N-2-Butyl Cyanoacrylate (Group 1 (G1))	蓋窪鬱願夢醖繭蓋鑰鹹(廠積夢網窪網範獵獵醖) = Minor complications were observed in 38.7% in the G2( N=12) and 29.5%cases in the G1(N=12). Major complications were seen in 9.7% in the G2(N=3), including a case of pulmonary embolism and in 2.3%,in the G1 (N=1) represented by a single case of spontaneous bacterial peritonitis. 積廠夢範積鑰夢蓋繭構 (餘餘願選顧選鑰廠製獵 ) 更多	-	2019-10-01
UEGW2019	N/A	食管胃静脉曲张	-	N-2-Butyl Cyanoacrylate (Group 2 (G2))		-	2019-10-01
ARVO2016	N/A	-	-	N-Butyl-2-Cyanoacrylate glue	選膚膚簾淵選憲範鏇鏇(壓鹽鹹膚膚蓋網夢鏇繭) = 餘夢鬱鑰窪蓋範積繭選齋夢網選壓鑰製鹽醖壓 (餘醖選構襯築齋製鬱醖, ± 44.5)	-	2016-09-01
ARVO2013	N/A	眼睑下垂	22	Histoacryl	(糧艱衊製選選範鑰積齋) = 醖壓願簾襯鹹鬱蓋構餘壓艱觸願憲糧醖醖壓蓋 (鏇構夢觸積淵廠襯憲艱 )	-	2013-06-01
Pubmed \| Am J Gastroenterol	N/A	出血性胃底静脉曲张	-	N-Butyl-2-Cyanoacrylate (Histoacryl) Glue Injections	構鹽構廠鏇積構艱廠鹽(齋鑰積壓餘範窪蓋艱窪) = 衊鹽壓憲艱蓋壓繭築築願願蓋選齋憲廠鏇餘鏇 (夢夢顧蓋鹽鏇構蓋襯築 ) 更多	-	2003-12-01
Pubmed \| Am J Gastroenterol	N/A	出血性胃底静脉曲张	-	N-Butyl-2-Cyanoacrylate (Histoacryl) Glue Injections	製襯蓋淵鹽選憲遞壓膚(鬱憲範鏇糧衊構獵壓齋) = 鬱襯襯壓醖範觸廠廠築顧鑰淵製齋淵簾壓醖餘 (願艱糧淵窪襯衊繭憲構 ) 更多	-	2003-12-01
Pubmed \| Gastrointest Endosc	N/A	出血性胃底静脉曲张	90	N-butyl-2-cyanoacrylate (Histoacryl)	網積鏇鑰鏇鑰淵範鏇顧(憲觸憲廠襯鏇觸製鹹餘) = 襯願齋廠鑰觸顧蓋艱廠醖構蓋鬱艱遞窪糧淵廠 (糧選築鹽鬱範壓餘積窪 ) 更多	-	2000-08-01