This study is designed to assess the systemic exposure and pharmacokinetics of sunscreen active ingredients (avobenzone, oxybenzone, ecamsule, octocrylene homosalate, octisalate and octinoxate) when sunscreen product is applied under maximal use conditions.
Part 1 is an open-label, randomized, 4-arm study in 24 healthy adult subjects with the primary objective to explore whether the active components (avobenzone, oxybenzone, ecamsule and octocrylene) of 4 sunscreen products (1 sunscreen product in each arm) are absorbed into the systemic circulation when a sunscreen product is applied under maximal use conditions.
One sunscreen product with the highest avobenzone exposure will be selected for the second part of the study. If there is no quantifiable exposure of avobenzone for any of the sunscreen products, the formulation with the highest oxybenzone exposure will be selected for Part 2. In addition, 3 new sunscreen products are included in Part 2.
Part 2 is an open label, 4-arm study in 48 healthy adult subjects with the primary objective to assess the pharmacokinetics of the active components in the selected product from Part 1 and 3 additional products with a combination of active ingredients (avobenzone, oxybenzone, octocrylene, ecamsule homosalate, octisalate and octinoxate as applicable/contained in the different products).

开始日期2018-07-18

申办/合作机构

US Food & Drug Administration

[+1]

NCT02668536 / Completed临床1期IIT

Assessing the Safety and Efficacy of Multifunctional Skin-adhesive Nanoparticles for UV Protection in Humans

The initial focus of the study will be on safety, sun protection factor (SPF) characterization, and substantivity (duration of protection) studies. The primary outcome of the study will be to measure the sun protection factor (SPF) of a bioadhesive nanoparticles (BNP) formulation in 20-25 healthy volunteers with fair skin.

开始日期2017-07-17

申办/合作机构

Yale University

NCT01695356 / Completed临床4期IIT

A Double Blind Randomized Study Comparing the Ultraviolet (UV) Photoprotection With UV Plus Visible Light Photoprotection in the Treatment of Melasma.

Melasma is an acquired discoloration of the skin characterized by brown colour changes commonly on the face. The duration of this double-blind clinical trial will be 12 weeks. The control group will receive treatment with topical Hydroquinone (4%) and a Broad spectrum UV sunscreen. The experimental group, 4% topical hydroquinone and a Broad spectrum UV-visible light sunscreen. Visible light has melanotic properties and avoiding it can be part of the treatment for melasma patients. The estimated number of subjects to be recruited and randomized for the study is at least 25 per group. The purpose of this study is determine if there is a difference in the improvement between these two sunscreens types. Melasma Area and Severity Index (MASI) score will be assessed at the beginning of the study and at weeks 4, 8, and 12. Photographs, colorimetry and histological assessment will be also evaluated. Occurrence of adverse effects will also be recorded.

开始日期2012-09-01

申办/合作机构

Universidad Autónoma De San Luis Potosí

100 项与羟苯甲酮相关的临床结果

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100 项与羟苯甲酮相关的转化医学

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100 项与羟苯甲酮相关的专利（医药）

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1,469

项与羟苯甲酮相关的文献（医药）

2024-03-18·Journal of toxicology and environmental health. Part A

Evaluation of the anti-androgenic and cytotoxic effects of benzophenone-3 in male Sprague-Dawley rats

Article

作者: Kwack, Seung Jun ; Park, Chan Ju ; Sung, Chi Rim ; Kim, Byeong Jun ; Lee, Yu Jin ; Park, Yeo Rim ; Oh, In Ah

Benzophenone-3 (BP-3, 2-hydroxy-4-methoxybenzophenone, oxybenzone) is one of the most widely used types of benzophenone organic sunscreen. However, this compound is a potentially harmful toxicant. The aim of this study was 2-fold to: (1) utilize a Hershberger bioassay in vivo in castrated male Sprague-Dawley rats to investigate the anti-androgenic activities of BP-3, and (2) use in vitro a methyl tetrazolium assay to compare the toxicity between Leydig cells (TM3 cells) and mouse fibroblast (NIH-3T3) cell lines. In the Hershberger assay, rats were divided into 6 groups (each of n = 7): a vehicle control, negative control, positive control, PB-3 low (40 mg/kg), BP-3 intermediate (200 mg/kg), and BP-3 high (1000 mg/kg)-dose. The weight of the ventral prostate was significantly decreased at BP-3 doses of 200 or 1,000 mg/kg/day. In addition, the levator anibulbocavernosus muscle weights were also significantly reduced at BP-3 doses of 40, 200, or 1,000 mg/kg/day. In the MTT assay, the viability of NIH-3T3 mouse fibroblast cells was within the normal range. However, the TM3 mouse testis Leydig cell viability was significantly lowered in a concentration-dependent manner. Therefore, data indicate that BP-3 might exert in vivo anti-androgenic and in vitro cytotoxic effects in cells associated with the male reproductive system compared to normal non-reproductive cells.Abbreviation: BP-3: benzophenone-3; CG: Cowper's gland; DMEM: Dulbecco's modified Eagle's medium; DMSO: dimethyl sulfoxide; GP: glans penis; LABC: levator anibulbocavernosus muscle; MTT: methyl tetrazolium; NC: negative control; PC: positive control; SV: seminal vesicle; TP: testosterone propionate; VC: vehicle control; VP: ventral prostate.

2024-03-01·Environmental research

Adsorption behavior and interaction mechanism of microplastics with typical hydrophilic pharmaceuticals and personal care products

Article

作者: Liu, Lu ; Gong, Yichao ; Liu, Pengyan ; Sun, Qizhi

Microplastics (MPs) and pharmaceuticals and personal care products (PPCPs) are two types of emerging contaminants widely present in the global aquatic ecosystem. The ecological risks associated with the coexistence of these two contaminants have garnered increasing attention from researchers. In this study, we selected 15 typical hydrophilic PPCPs, including Sulfacetamide (SA), Thiamphenicol, Florfenicol, Chloramphenicol (CHL), Ampicillin, Cephalexin, Ofloxacin, Fluorouracil, Phenytoin, Theophylline, Cimetidine, Methylparaben, Diethyltoluamide, Benzophenone-2 (BP-2), and Benzophenone-4, as adsorbates. We evaluated the adsorption potential of five traditional plastics (TPs), namely Polyamide 6 (PA6), Polystyrene (PS), Polyethylene terephthalate (PET), Polyvinyl chloride (PVC), and Polyurethane (TPU), as well as three biodegradable plastics (BDPs), including Polylactic acid (PLA), Polybutylene succinate (PBS), and Poly (ε-caprolactone) (PCL), for these adsorbates. Out of the 120 combinations of MPs and PPCPs tested, only 24 exhibited significant adsorption behavior. Notably, the adsorption performance of the three BDPs was stronger than that of the three typical TPs (PS, PET, and PVC). Based on their adsorption potential, PA6, BDPs, phenytoin, and BP-2 were identified as potential sources of high ecological risk. To further explore the adsorption mechanism, we investigated the adsorption behaviors of SA, BP-2, and CHL on PA6. The conclusions were as follows: SA, BP-2, and CHL all reached adsorption equilibrium within 24 h, with the partition coefficient (K_d) following this order: BP-2 (8.051) ≫ SA (0.052) > CHL (0.018). The primary forces of adsorption were electrostatic interactions, intermolecular hydrogen bonding, and hydrophobic interaction, respectively. Additionally, weak electrostatic effects were observed in the adsorption of CHL and BP-2. The effects of pH, ionic strength, and fulvic acid on adsorption capacity varied. These results highlight a complex adsorption mechanism between MPs and hydrophilic contaminants in the aquatic environment. This study provides a basis for further evaluating the ecological risks of MPs and PPCPs combined pollution.

2024-03-01·Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]

Synergism between molecules derived from Garcinia brasiliensis and antimicrobial drugs on field isolates of Mycoplasma hyopneumoniae

Article

作者: Silva-Júnior, Abelardo ; Dos Santos, Marcelo Henrique ; Moreira, Maria Aparecida Scatamburlo ; Rodrigues, Fábio Assad Feres ; Gonzaga, Natália Fialho ; Lopes, Bruna Araújo Euzébio Alves Jacob ; Caldeira, Jessica Lobo Albuquerque ; de Barros, Mariana ; de Souza, Luiz Fernando Lino ; Toledo, Leonardo Teófilo

Mycoplasma hyopneumoniae (M. hyopneumoniae) is one of the smallest free-living bacteria found in nature; it has an extremely small genome and lacks a cell wall. It is the main etiological agent of porcine enzootic pneumonia (EP), a chronic respiratory disease with worldwide distribution that causes significant losses in swine production. Due to the great economic impact caused by EP, new strategies for treating and controlling this agent are researched. The objective of this study was to verify the anti-M. hyopneumoniae activity of compounds derived from Garcinia brasiliensis and the synergism with the main antimicrobials used in the treatment of EP; this is the first study assessing the synergism between bioactive molecules and antimicrobial compounds in vitro against isolates of M. hyopneumoniae. The minimum inhibitory concentrations (MICs) of the antimicrobials tiamulin, valnemulin, and enrofloxacin, as well as the bioactive compounds guttiferone-A (Gut-A), 7-epiculsone (7-Epic), copper 7-epiculsone (7-Epic-Cu), and benzophenone, were determined. Subsequently, the interactions of antibiotics with the compounds were evaluated using the checkerboard method. Three field M. hyopneumoniae isolates were used, and the J strain was used as a control. The MIC values of the antimicrobials compared to the field isolates were equal to and lower than those of the reference strain J. Among the compounds used, 7-Epic-Cu showed the lowest MIC value. Synergistic association was observed for Gut-A with tiamulin and valnemulin, whereas 7-Epic and 7-Epic-Cu showed synergistic action with enrofloxacin. No synergistic effect was observed for benzophenone. Despite being an initial study, the results suggest that these combinations hold promise for the treatment of infections caused by M. hyopneumoniae.

项与羟苯甲酮相关的新闻（医药）

2023-11-07

·PRNewswire

ELEMENT EIGHT Closes $6M in SAFE Funding, launches a $6.25M Series A Round, Appoints Jake Galtere and Kristi McCluer as CMO and VP Global Sales and Education to Fuel Continued Expansion

NEW YORK, Nov. 7, 2023 /PRNewswire/ -- ELEMENT EIGHT, a premium brand bringing the cutting-edge advances of biomedicine to skincare through its proprietary OATH™: Oxygen Amplified Therapy, today announced that it has closed $6M in funding in a SAFE round. The brand reported $2.5M of investment from its existing investors, and was able to attract an additional $3.5M from new investors. Continue Reading "With forty five percent of the round coming from surgeons, dermatologists, and PhD scientists, we have a strong validation of the scientific acumen of the brand. We were very pleased to also have participation from private family offices with experience in beauty investing, who accounted for thirty four percent of the round," said Company Chairman Bradley Patt. "Finally, realizing fourteen percent participation from management, employees and members of the company's board of directors shows excitement about the Company's progress from the people inside." Including the successful SAFE Round that just closed, the Company has raised a total of $7.9M to date. Immediately upon closing this SAFE funding, the Company has announced it will proceed on to a new $6.25M Series A Round to continue to accelerate the growth of potent skincare products. ELEMENT EIGHT is redefining the anti-aging skincare market by bringing cutting-edge advances from the world of biotechnology to skincare. With its proprietary OATH™: Oxygen Amplified Therapy technology, which mimics the function of hemoglobin to deliver 20x more oxygen directly to skin cells up to 700 microns deep, ELEMENT EIGHT addresses skin's biological performance and counteracts the key signs of aging. This technology was developed by a team of world-renowned spine surgeons, biomaterial engineers, dermatologists and clinical researchers over the course of a decade, and has attracted investors and consumers on the forefront of the high-performance skincare industry to the brand. Founder and Board Member Gerard Camme said "ELEMENT EIGHT has a unique point of difference thanks to the innovative technology of OATH™, and fits into the fastest growing segment of the global skincare market. As we look ahead, we're excited to continue to innovate on the groundbreaking advances of our multi-expert team to bring new products to market and make ELEMENT EIGHT accessible on a wider scale." In addition to this newest round of funding, ELEMENT EIGHT announced the appointment of Jake Galtere as Chief Marketing Officer and Kristi McCluer as Vice President of Global Sales and Education to drive the brand's global strategy and oversee continued expansion. With over a decade of experience developing digital marketing strategies across the luxury market, Jake Galtere joins ELEMENT EIGHT after most recently serving as Vice President of Marketing for Ralph Lauren and Azzaro Fragrances. He has held posts at leading brands including Lancôme, YSL Beaute and Mugler, working to accelerate growth, driving innovation, awareness and consumer engagement. "Joining Element Eight was an easy decision. The brand has an extremely distinct DNA, from its origin in spine surgery to the multi-expert team who continue to innovate for the consumer," said Jake. " Importantly, the products really do work. I'm extremely excited to help bring this brand to market." Appointed as Vice President of Global Sales and Education, Kristi McCluer joins the ELEMENT EIGHT team with over 15 years of experience in luxury sales. Coming from the L'Oréal Luxury Division, Kristi was responsible for omni-channel retailer business development and strategy. Most recently, she earned an Executive Certificate in Digital Marketing Analytics from MIT. "I am thrilled to join ELEMENT EIGHT to advance the skincare industry. Our technology is unique and is proven through robust scientific research and clinical studies," said Kristi. "I see a remarkable opportunity to empower customers and redefine the way we experience healthy skin." "Jake and Kristi bring a wealth of expertise in the luxury beauty industry, having played central roles at leading luxury brands. They bring with them extensive experience and a deep understanding of the beauty industry that will be pivotal to the development of our global strategy and expansion of the ELEMENT EIGHT brand," said Gerard Camme. "I am incredibly pleased to appoint Jake and Kristi and look forward to supporting their vision for the brand in this next phase of our growth." As the Company rolls out its Series A offering it is pleased to announce it has joined Ohana & Co.'s incubation platform: "We have been following Element Eight since its inception and have been impressed with the traction gained and what CEO Gerard Camme has achieved in just one year since the launch," said Ohana & Co. Managing Partner, Karine Ohana. The Company is also excited to announce that Martin Brok, accomplished global executive with over 35 years of experience in senior roles, including as Global CEO of Sephora, Nike, Starbucks, and The Coca-Cola Co, will join the company's Business Advisory Board and will participate in the Series A financing. "I see dozens of ideas in this space," said Mr. Brok, "Element Eight stood out to me as a very different premium offering that is entering the most dynamic segment of the skincare market: heavy science and luxury leaning with a distinct voice that separates itself from the clutter and fills a white space. I am excited to be a part of this team." About ELEMENT EIGHT Founded in 2022, ELEMENT EIGHT is bringing the latest advances in oxygen-infusing medicine to skincare. Developed by a world-renowned team of spine surgeons, biomaterial engineers, dermatologists, clinical researchers and systems group engineers. Collectively they hold 16 MD-PHDs, 120 medical patents and over 100,000 uses of technologies they have developed. The team spent over a decade developing the brand's proprietary OATH™: Oxygen Amplified Therapy technology mimics the function of hemoglobin to deliver 20x more oxygen directly to skin cells up to 700 microns deep, counteracting the key signs of aging, all of which are caused by oxygen depletion in the skin. True to the brand's ethos of clean science, all ELEMENT EIGHT products are formulated without parabens, GMO's PEG's, sulfates, phthalates, formaldehyde or formaldehyde releasers, oxybenzone and octinoxate, hydroquinone, triclosan, coal tar, methylisothiazolinone and methylchloroisothiazolinone, and insoluble plastic microbeads. ELEMENT EIGHT is 100% vegan, gluten-free, cruelty-free and fragrance-free. ELEMENT EIGHT's packaging was developed with environmental impact at top of mind and is recyclable and FSC certified. For more information, visit the brand at . Media Contact: Paige Davis, [email protected], +1 502 472 8611 SOURCE ELEMENT EIGHT

高管变更

2023-05-09

·drugs

Summer's Near: What's the Best Sunscreen for You?

WEDNESDAY, May 10, 2023 -- It’s easy to keep your skin safer in the summer sun if you have the right sunscreen. UCLA Health offers some tips for picking the best type and SPF level. Getting sunburned just five times in a lifetime doubles the risk of getting melanoma, the most serious skin cancer, so making sure you’re protected is worth the effort, the experts at UCLA Health said in a news release. Types of sunscreens can be divided into two categories: mineral and chemical. Each type has its pros and cons. Mineral sunscreen sits on the skin’s surface. It physically blocks ultraviolet (UV) light before those rays can penetrate the skin. While offering instant protection, it can be harder to rub in, needs to be applied more frequently and tends to leave a white film on the skin. Yet, it’s also gentler than chemical sunblock, making it a good choice for sensitive skin, according to UCLA Health. Mineral sunscreen contains titanium dioxide and zinc oxide, both recognized as safe and effective by the U.S. Food and Drug Administration. Chemical sunscreens allow UV light to penetrate skin, after which the chemicals convert the UV light into heat. This is released from the skin. The downsides are that chemical sunscreens need to be applied at least 20 minutes before sun exposure and there are concerns about the ingredients in chemical sunscreens, especially oxybenzone, according to UCLA Health. Some of the ingredients in these sunscreens may cause environmental issues, including damage to coral reefs. They may also pose health risks such as hormone disruption and allergic skin reactions. Yet, they’re also easy to rub in and leave less residue. The FDA is waiting for more safety data before labeling them as safe and effective. Experts say the health risks of sun exposure far outweigh the potential risk of absorbing sunscreen chemicals. When choosing the SPF, or sun protection factor, know that the higher the number, the longer the protection should last. With SPF 30, for example, it should take you 30 times longer to burn than if you weren’t wearing sunscreen. But there’s more to it than that. All sunscreens protect against UVB rays, the main cause of sunburn and skin cancers. Broad-spectrum SPF also protects against UVA rays. Sunscreen that is SPF 30 lets 3% of rays through. A higher protection number, SPF 50, allows 2% of rays through. It's important to reapply, especially if you’re sweating and swimming. The Skin Cancer Foundation recommends using water-resistant, broad-spectrum sunscreen with SPF 30 or higher. You should reapply every two hours or immediately after swimming or sweating. SPF protection above 50 is only slightly better than SPF 30, so reaching for a higher number doesn’t matter as much. What’s important about the application method is this: what you are more likely to use and reapply. If that’s lotion, the Skin Cancer Foundation recommends applying at least 1 ounce, which is also 2 tablespoons or the amount that fills a shot glass. For spray, keep applying until your skin glistens. The bottle may say “no rub,” but smoothing it into your skin will ensure even coverage. Avoid using aerosol sprays on or near your face because they can contain ingredients that, when inhaled deeply, may cause irritation and possibly damage your lungs. It may be better to avoid spray for young children, but you can also spray it onto hands and rub it onto your face or your child. Stick sunscreen is great for small areas, such as the face and ears. Make four passes with the sunscreen over each area you’re protecting, UCLA Health advises. Rub the sunscreen in afterward, for even coverage. Even with this protection, opt to seek shade and wear protective clothing whenever possible. Sources UCLA Health, news release Posted May 2023

2022-12-02

·Science Daily

Microplastics could make other pollutants more harmful

Microplastics -- small plastic pieces less than five millimeters in length -- are becoming a ubiquitous ecological contaminant. Studies suggest that on their own, these tiny bits are potentially harmful, and it's unclear what effect they could have on pollutants that latch onto them. Now, researchers show that, when attached to microplastics, UV filters used in products such as sunscreens can make chromium metal more toxic. Microplastics -- small plastic pieces less than five millimeters in length -- are becoming a ubiquitous ecological contaminant. Studies suggest that on their own, these tiny bits are potentially harmful, and it's unclear what effect they could have on pollutants that latch onto them. Now, researchers reporting in ACS' Environmental Science & Technology Letters show that, when attached to microplastics, UV filters used in products such as sunscreens can make chromium metal more toxic. Because microplastics can accumulate other environmental contaminants on their surfaces, such as heavy metals or organic molecules, they could pose even more of a problem for wildlife, plants or humans than originally thought. Previous research has shown that heavy metals can easily attach to microplastics, and that this combination could potentially harm aquatic life. But beyond just sticking to other contaminants, microplastics and the cocktail of substances on them could interact with each other, altering their chemical properties. For example, certain metals, such as chromium (Cr), might take on different oxidation states while on the surfaces of microplastics. And although Cr(III) is relatively safe, Cr(VI) is toxic. So, Kelvin Sze-Yin Leung and colleagues wanted to investigate, for the first time, how the oxidation state of Cr could change when bound to microplastics, and how this could be affected by a common organic contaminant: UV filter molecules. The researchers created mixtures of Cr and polystyrene microplastic particles both with and without benzophenone-type UV filters. The team found that microplastics could aggregate even more Cr in the presence of a UV filter. In addition, the oxidation state of Cr was higher in the mixtures containing the filters. Finally, the team tested whether this increased oxidation state translated to environmental toxicity for a population of microalgae. The microalgae's growth was inhibited when exposed to the mixture containing the filter molecule, suggesting that Cr was now in its more toxic form. According to the researchers, this means that microplastics can aid in transforming pollutants into a more harmful form -- a previously unproven interaction. The authors acknowledge funding from the Hong Kong Research Grants Council and the Hong Kong Baptist University Seed Fund.

100 项与羟苯甲酮相关的药物交易

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03582215 (CTgov)	临床1期	-	72	Part 1: Cream (Part 1: Cream)	構膚觸簾壓觸鬱築衊齋(齋鑰鏇衊夢網艱窪艱齋) = 夢壓糧夢蓋願觸糧夢衊鬱簾顧網範鬱鑰鬱餘鑰 (醖膚餘觸廠鑰簾鏇壓夢, 鏇膚鬱鹹蓋鹽淵構鹽衊 ~ 襯鬱廠觸繭觸夢觸蓋齋) 更多	-	2020-04-21
				Octocrylene+Avobenzone+Oxybenzone (Part 1: Lotion)	構膚觸簾壓觸鬱築衊齋(齋鑰鏇衊夢網艱窪艱齋) = 鏇襯鑰膚遞鏇憲糧憲艱鬱簾顧網範鬱鑰鬱餘鑰 (醖膚餘觸廠鑰簾鏇壓夢, 襯網範構糧淵顧壓簾衊 ~ 夢範網網範壓壓顧廠範) 更多