This study is designed to assess the systemic exposure and pharmacokinetics of sunscreen active ingredients (avobenzone, oxybenzone, ecamsule, octocrylene homosalate, octisalate and octinoxate) when sunscreen product is applied under maximal use conditions.
Part 1 is an open-label, randomized, 4-arm study in 24 healthy adult subjects with the primary objective to explore whether the active components (avobenzone, oxybenzone, ecamsule and octocrylene) of 4 sunscreen products (1 sunscreen product in each arm) are absorbed into the systemic circulation when a sunscreen product is applied under maximal use conditions.
One sunscreen product with the highest avobenzone exposure will be selected for the second part of the study. If there is no quantifiable exposure of avobenzone for any of the sunscreen products, the formulation with the highest oxybenzone exposure will be selected for Part 2. In addition, 3 new sunscreen products are included in Part 2.
Part 2 is an open label, 4-arm study in 48 healthy adult subjects with the primary objective to assess the pharmacokinetics of the active components in the selected product from Part 1 and 3 additional products with a combination of active ingredients (avobenzone, oxybenzone, octocrylene, ecamsule homosalate, octisalate and octinoxate as applicable/contained in the different products).

开始日期2018-07-18

申办/合作机构

US Food & Drug Administration

[+1]

NCT02668536 / Completed临床1期IIT

Assessing the Safety and Efficacy of Multifunctional Skin-adhesive Nanoparticles for UV Protection in Humans

The initial focus of the study will be on safety, sun protection factor (SPF) characterization, and substantivity (duration of protection) studies. The primary outcome of the study will be to measure the sun protection factor (SPF) of a bioadhesive nanoparticles (BNP) formulation in 20-25 healthy volunteers with fair skin.

开始日期2017-07-17

申办/合作机构

Yale University

NCT00530387 / CompletedN/A

A Prospective, Open, Multi-Centre Photopatch Test Study of Patients Suspected of Photoallergy to Organic Sunscreens and Topical Nonsteroidal Anti-inflammatory Drugs Used Within Europe.

It is known that people can develop an allergic skin reaction to a substance which is placed on the skin and then subjected to sunlight. This process is called Photocontact allergic dermatitis. It is known that people can develop Photocontact allergic dermatitis to sunscreen chemicals (filters) and also cream forms of pain-killing drugs called nonsteroidal anti-inflammatory drugs (NSAIDs).
The purpose of this study is to determine the frequency of Photocontact allergic dermatitis to 19 sunscreen filters and 5 topical NSAIDs in 1,000 European patients who present to a dermatologist with a sun-exposed site dermatitis.
Each participant will have the 24 test agents plus one control of petrolatum applied to the skin of the back for 24 or 48 hours. After removal of the substances, the area of skin will be exposed to a precise amount of ultraviolet-A light. The area is then assessed 24, 48 and 72 hours later to see if a photocontact allergic reaction has occured. This method is known as photopatch testing.
The study will run for one year, during which time it is planned to recruit 1,000 patients.

开始日期2008-07-01

申办/合作机构

NHS Tayside

100 项与羟苯甲酮相关的临床结果

登录后查看更多信息

100 项与羟苯甲酮相关的转化医学

登录后查看更多信息

100 项与羟苯甲酮相关的专利（医药）

登录后查看更多信息

1,565

项与羟苯甲酮相关的文献（医药）

2025-02-01·Journal of Environmental Sciences

Exposure of individuals aged 18–44 years to personal care products in Beijing, China: Exposure profiles, possible influencing factors, and risk assessment

Article

作者: Sun, Qi ; Han, Linxue ; Lin, Xiao ; Zhang, Xu ; Wang, Xiaochen ; Zhu, Ying ; Hu, Xiaojian

Personal care products (PCPs) are a class of emerging pollutants that have attracted public concern owing to their harmful effects on humans and the environment. Biomonitoring data is valuable for insight the levels of PCPs in the human body and can be crucial for identifying potential health hazards. To gain a better understanding of timely exposure profiles and health risk of reproductive-age population to PCPs, we determined six parabens, six benzophenone-type ultraviolet filters, and three disinfectants in 256 urine samples collected from young adults aged 18-44 years in Beijing, China. The urinary levels of benzophenone-3 (BP-3) and 4-hydroxybenzophenone (4-OHBP) were significantly higher in summer compared to winter, suggesting these compounds have different seasonal usage patterns. Moreover, the total concentration of 15 PCPs in female was 430 ng/mL, approximately two times higher than that in male. P‑chloro-m-xylenol (PCMX), as a new type of antibacterial agent, has the greatest level among all target analytes, indicating the increasingly use of this antibacterial alternative recently. Five potential influencing factors that lead to the elevated exposure level of PCPs were identified. Over 19% of the target population had a high hazard index value (greater than 1) which was attributed to exposure to propyl paraben (PrP), benzophenone-1 (BP-1), BP-3 and PCMX, indicating that PCPs may pose a relatively high exposure risk at environmental levels that should be a cause for concern.

2025-01-01·JOURNAL OF HAZARDOUS MATERIALS

Impacts of UV-filter pollution and low pH: Sperm and adult biomarkers in the mussel Mytilus galloprovincialis in a multi-stressor context.

Article

作者: Meucci, Valentina ; Freitas, Rosa ; Soares, Amadeu M V M ; Moreira, Anthony ; Cuccaro, Alessia ; De Marchi, Lucia ; Soares, Amadeu M.V.M. ; Pretti, Carlo

In an era of unprecedented environmental changes, understanding the combined effects of multiple stressors on species' performance is urgent. The increasing UV-filter incorporation in daily-life products raises concerns about their potential impact on marine-coastal environments upon release. As stressors rarely act alone, global change-induced factors, such as ocean acidification (OA), can amplify ecological hazards promoted by contaminants in coastal realms. This study investigated the combined impacts of UV-filters 4-methylbenzylidene camphor (4-MBC) and benzophenone-3 (BP-3), at ecologically relevant concentrations (1 and 10 µg/L), under two target pH levels (8.2 and 7.7, reflecting a ∆pH of 0 and -0.3 relative to the average pH at the sampling site), on the biological performance and male reproductive health of the mussel Mytilus galloprovincialis. Using sperm and adult assays alongside a multi-biomarker approach, the study revealed that pH was the primary driver of the decline in mussel physiological and biochemical performances, further intensifying UV-filters' impacts. While sperm cells showed adaptive responses to low pH conditions alone, characterized by reduced lipid peroxidation (LPO) levels and superoxide anion overproduction, adult mussels experienced more pronounced effects, particularly under simultaneous exposure to low pH and UV-filters. Specifically, the adults exhibited distinct bioconcentration patterns under low pH, enhanced cellular metabolic activity and energy-demand compensatory processes, activation of biotransformation pathways, and regulation of antioxidant defenses. Given the ecological and socio-economic importance of M. galloprovincialis and its demonstrated vulnerability to these stressors, these findings highlight the need for further studies on potential transgenerational impacts and evolutionary implications for mussel populations.

2025-01-01·ENVIRONMENTAL POLLUTION

Contaminants of emerging concern in an endangered population of common eiders (Somateria mollissima) in the Baltic Sea

Article

作者: Zhang, Junjie ; Frøyland, Sunniva H ; Asimakopoulos, Alexandros G ; Jaspers, Veerle L B ; Arzel, Céline ; Öst, Markus ; Prian, Wasique Z ; Wilson, Nora M ; Jolkkonen, Juho ; Eeva, Tapio ; Hansen, Martin ; Koivisto, Sanna ; Sonne, Christian ; Ask, Amalie V ; Vakili, Farshad S

Contaminants of emerging concern (CECs) are ubiquitous in aquatic environments and pose a range of biological effects including endocrine disruption. Yet, knowledge of their occurrence in wildlife including seabirds remains scarce. We investigated the occurrence of selected bisphenols, benzophenones, phthalate metabolites, benzotriazoles, benzothiazoles, parabens, triclosan, and triclocarban in plasma of 18 breeding female common eiders (Somateria mollissima) from an endangered population in the Baltic Sea as most of these CECs have never before been examined in eiders. We sampled blood at the start (T1) and end (T2) of incubation to investigate concentration changes during incubation. As early- and late-breeding eiders tend to differ in how they finance reproduction (local vs stored nutrient reserves), we compared early and late breeders to assess whether CEC concentrations differed by breeding phenology. Of the 58 targeted CECs, 21 were detected in at least one female, with bisphenol A (BPA) and benzophenone-3 (BzP-3) occurring most frequently (T1: 78% and 61%; T2: 61% and 67%, respectively), while mono(2-ethyl-1-hexyl) phthalate (mEHP), BPA, and monoethyl phthalate (mEP) were detected in the highest concentrations (median concentrations 27.1, 12.7, and 11.2 ng/g wet weight, respectively, at T1). No CEC concentrations differed between early and late incubation. Late breeders had significantly higher concentrations of BzP-3, monomethyl phthalate (mMP), and mEP during early incubation (4.55 vs 1.24 ng/g ww, 7.05 vs 3.52, and 11.2 vs < limit of detection (LOD), respectively) and significantly higher concentrations of mMP and mEP during late incubation (6.16 vs

项与羟苯甲酮相关的新闻（医药）

2023-11-07

·PRNewswire

ELEMENT EIGHT Closes $6M in SAFE Funding, launches a $6.25M Series A Round, Appoints Jake Galtere and Kristi McCluer as CMO and VP Global Sales and Education to Fuel Continued Expansion

NEW YORK, Nov. 7, 2023 /PRNewswire/ -- ELEMENT EIGHT, a premium brand bringing the cutting-edge advances of biomedicine to skincare through its proprietary OATH™: Oxygen Amplified Therapy, today announced that it has closed $6M in funding in a SAFE round. The brand reported $2.5M of investment from its existing investors, and was able to attract an additional $3.5M from new investors. Continue Reading "With forty five percent of the round coming from surgeons, dermatologists, and PhD scientists, we have a strong validation of the scientific acumen of the brand. We were very pleased to also have participation from private family offices with experience in beauty investing, who accounted for thirty four percent of the round," said Company Chairman Bradley Patt. "Finally, realizing fourteen percent participation from management, employees and members of the company's board of directors shows excitement about the Company's progress from the people inside." Including the successful SAFE Round that just closed, the Company has raised a total of $7.9M to date. Immediately upon closing this SAFE funding, the Company has announced it will proceed on to a new $6.25M Series A Round to continue to accelerate the growth of potent skincare products. ELEMENT EIGHT is redefining the anti-aging skincare market by bringing cutting-edge advances from the world of biotechnology to skincare. With its proprietary OATH™: Oxygen Amplified Therapy technology, which mimics the function of hemoglobin to deliver 20x more oxygen directly to skin cells up to 700 microns deep, ELEMENT EIGHT addresses skin's biological performance and counteracts the key signs of aging. This technology was developed by a team of world-renowned spine surgeons, biomaterial engineers, dermatologists and clinical researchers over the course of a decade, and has attracted investors and consumers on the forefront of the high-performance skincare industry to the brand. Founder and Board Member Gerard Camme said "ELEMENT EIGHT has a unique point of difference thanks to the innovative technology of OATH™, and fits into the fastest growing segment of the global skincare market. As we look ahead, we're excited to continue to innovate on the groundbreaking advances of our multi-expert team to bring new products to market and make ELEMENT EIGHT accessible on a wider scale." In addition to this newest round of funding, ELEMENT EIGHT announced the appointment of Jake Galtere as Chief Marketing Officer and Kristi McCluer as Vice President of Global Sales and Education to drive the brand's global strategy and oversee continued expansion. With over a decade of experience developing digital marketing strategies across the luxury market, Jake Galtere joins ELEMENT EIGHT after most recently serving as Vice President of Marketing for Ralph Lauren and Azzaro Fragrances. He has held posts at leading brands including Lancôme, YSL Beaute and Mugler, working to accelerate growth, driving innovation, awareness and consumer engagement. "Joining Element Eight was an easy decision. The brand has an extremely distinct DNA, from its origin in spine surgery to the multi-expert team who continue to innovate for the consumer," said Jake. " Importantly, the products really do work. I'm extremely excited to help bring this brand to market." Appointed as Vice President of Global Sales and Education, Kristi McCluer joins the ELEMENT EIGHT team with over 15 years of experience in luxury sales. Coming from the L'Oréal Luxury Division, Kristi was responsible for omni-channel retailer business development and strategy. Most recently, she earned an Executive Certificate in Digital Marketing Analytics from MIT. "I am thrilled to join ELEMENT EIGHT to advance the skincare industry. Our technology is unique and is proven through robust scientific research and clinical studies," said Kristi. "I see a remarkable opportunity to empower customers and redefine the way we experience healthy skin." "Jake and Kristi bring a wealth of expertise in the luxury beauty industry, having played central roles at leading luxury brands. They bring with them extensive experience and a deep understanding of the beauty industry that will be pivotal to the development of our global strategy and expansion of the ELEMENT EIGHT brand," said Gerard Camme. "I am incredibly pleased to appoint Jake and Kristi and look forward to supporting their vision for the brand in this next phase of our growth." As the Company rolls out its Series A offering it is pleased to announce it has joined Ohana & Co.'s incubation platform: "We have been following Element Eight since its inception and have been impressed with the traction gained and what CEO Gerard Camme has achieved in just one year since the launch," said Ohana & Co. Managing Partner, Karine Ohana. The Company is also excited to announce that Martin Brok, accomplished global executive with over 35 years of experience in senior roles, including as Global CEO of Sephora, Nike, Starbucks, and The Coca-Cola Co, will join the company's Business Advisory Board and will participate in the Series A financing. "I see dozens of ideas in this space," said Mr. Brok, "Element Eight stood out to me as a very different premium offering that is entering the most dynamic segment of the skincare market: heavy science and luxury leaning with a distinct voice that separates itself from the clutter and fills a white space. I am excited to be a part of this team." About ELEMENT EIGHT Founded in 2022, ELEMENT EIGHT is bringing the latest advances in oxygen-infusing medicine to skincare. Developed by a world-renowned team of spine surgeons, biomaterial engineers, dermatologists, clinical researchers and systems group engineers. Collectively they hold 16 MD-PHDs, 120 medical patents and over 100,000 uses of technologies they have developed. The team spent over a decade developing the brand's proprietary OATH™: Oxygen Amplified Therapy technology mimics the function of hemoglobin to deliver 20x more oxygen directly to skin cells up to 700 microns deep, counteracting the key signs of aging, all of which are caused by oxygen depletion in the skin. True to the brand's ethos of clean science, all ELEMENT EIGHT products are formulated without parabens, GMO's PEG's, sulfates, phthalates, formaldehyde or formaldehyde releasers, oxybenzone and octinoxate, hydroquinone, triclosan, coal tar, methylisothiazolinone and methylchloroisothiazolinone, and insoluble plastic microbeads. ELEMENT EIGHT is 100% vegan, gluten-free, cruelty-free and fragrance-free. ELEMENT EIGHT's packaging was developed with environmental impact at top of mind and is recyclable and FSC certified. For more information, visit the brand at . Media Contact: Paige Davis, [email protected], +1 502 472 8611 SOURCE ELEMENT EIGHT

高管变更

2023-05-09

·drugs

Summer's Near: What's the Best Sunscreen for You?

WEDNESDAY, May 10, 2023 -- It’s easy to keep your skin safer in the summer sun if you have the right sunscreen. UCLA Health offers some tips for picking the best type and SPF level. Getting sunburned just five times in a lifetime doubles the risk of getting melanoma, the most serious skin cancer, so making sure you’re protected is worth the effort, the experts at UCLA Health said in a news release. Types of sunscreens can be divided into two categories: mineral and chemical. Each type has its pros and cons. Mineral sunscreen sits on the skin’s surface. It physically blocks ultraviolet (UV) light before those rays can penetrate the skin. While offering instant protection, it can be harder to rub in, needs to be applied more frequently and tends to leave a white film on the skin. Yet, it’s also gentler than chemical sunblock, making it a good choice for sensitive skin, according to UCLA Health. Mineral sunscreen contains titanium dioxide and zinc oxide, both recognized as safe and effective by the U.S. Food and Drug Administration. Chemical sunscreens allow UV light to penetrate skin, after which the chemicals convert the UV light into heat. This is released from the skin. The downsides are that chemical sunscreens need to be applied at least 20 minutes before sun exposure and there are concerns about the ingredients in chemical sunscreens, especially oxybenzone, according to UCLA Health. Some of the ingredients in these sunscreens may cause environmental issues, including damage to coral reefs. They may also pose health risks such as hormone disruption and allergic skin reactions. Yet, they’re also easy to rub in and leave less residue. The FDA is waiting for more safety data before labeling them as safe and effective. Experts say the health risks of sun exposure far outweigh the potential risk of absorbing sunscreen chemicals. When choosing the SPF, or sun protection factor, know that the higher the number, the longer the protection should last. With SPF 30, for example, it should take you 30 times longer to burn than if you weren’t wearing sunscreen. But there’s more to it than that. All sunscreens protect against UVB rays, the main cause of sunburn and skin cancers. Broad-spectrum SPF also protects against UVA rays. Sunscreen that is SPF 30 lets 3% of rays through. A higher protection number, SPF 50, allows 2% of rays through. It's important to reapply, especially if you’re sweating and swimming. The Skin Cancer Foundation recommends using water-resistant, broad-spectrum sunscreen with SPF 30 or higher. You should reapply every two hours or immediately after swimming or sweating. SPF protection above 50 is only slightly better than SPF 30, so reaching for a higher number doesn’t matter as much. What’s important about the application method is this: what you are more likely to use and reapply. If that’s lotion, the Skin Cancer Foundation recommends applying at least 1 ounce, which is also 2 tablespoons or the amount that fills a shot glass. For spray, keep applying until your skin glistens. The bottle may say “no rub,” but smoothing it into your skin will ensure even coverage. Avoid using aerosol sprays on or near your face because they can contain ingredients that, when inhaled deeply, may cause irritation and possibly damage your lungs. It may be better to avoid spray for young children, but you can also spray it onto hands and rub it onto your face or your child. Stick sunscreen is great for small areas, such as the face and ears. Make four passes with the sunscreen over each area you’re protecting, UCLA Health advises. Rub the sunscreen in afterward, for even coverage. Even with this protection, opt to seek shade and wear protective clothing whenever possible. Sources UCLA Health, news release Posted May 2023

100 项与羟苯甲酮相关的药物交易

登录后查看更多信息

外链

KEGG	Wiki	ATC	Drug Bank
D05309	羟苯甲酮	D02B	DB01428

研发状态

10 条最早获批的记录,

后查看更多信息

适应症	国家/地区	公司	日期
晒伤	-	-	-

登录后查看更多信息

临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03582215 (CTgov)	临床1期	-	72	Part 1: Cream (Part 1: Cream)	蓋築鹹壓餘鏇範顧窪構(餘獵獵願顧願廠膚簾築) = 夢襯夢壓製獵鑰壓襯範遞窪夢廠繭鏇襯淵糧選 (網範艱遞憲製繭鏇願遞, 膚繭範顧糧鬱網蓋壓積 ~ 壓衊淵夢範範築繭廠範) 更多	-	2020-04-21
				Octocrylene+Avobenzone+Oxybenzone (Part 1: Lotion)	蓋築鹹壓餘鏇範顧窪構(餘獵獵願顧願廠膚簾築) = 鏇繭鏇蓋構獵願壓觸積遞窪夢廠繭鏇襯淵糧選 (網範艱遞憲製繭鏇願遞, 壓憲淵鑰窪遞鑰觸願醖 ~ 築觸選積遞鏇願觸築鏇) 更多