To assess the effectiveness of silver diamine fluoride application with delayed glass ionomer cement restoration in dentinal caries of differently abled children An in-vivo study - Nil

开始日期2024-09-02

申办/合作机构-

CTRI/2024/08/072965 / Not yet recruiting临床3期

Comparative Evaluation of Selective Caries Removal Techniques Followed by SDF Application In Primary Molars - An In Vivo Study - NIL

开始日期2024-09-02

申办/合作机构-

CTRI/2024/08/071768 / Not yet recruiting临床4期

Comparing Child Acceptance Silver Diamine Fluoride versus Sodium Varnish for Pediatric Dental Treatment

开始日期2024-08-29

申办/合作机构

Saveetha Engineering College

100 项与银氮烷氟化物相关的临床结果

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100 项与银氮烷氟化物相关的转化医学

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100 项与银氮烷氟化物相关的专利（医药）

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708

项与银氮烷氟化物相关的文献（医药）

2024-12-01·JOURNAL OF DENTISTRY

The anti-caries effects of copper tetraamine fluoride on enamel: An in vitro study

Article

作者: Yin, Iris Xiaoxue ; Xu, Veena Wenqing ; Niu, John Yun ; Yu, Ollie Yiru ; Nizami, Mohammed Zahedul Islam ; Chu, Chun Hung

OBJECTIVE:

To investigate the antibacterial, remineralising, and discolouring effects of copper tetraamine fluoride (CTF) on artificial enamel caries.

METHOD:

Human enamel blocks with artificial caries were treated with CTF, silver diamine fluoride (SDF, positive control) and water (negative control) before being challenged with Streptococcus mutans. The morphology, viability, and growth kinetics of biofilm were evaluated using scanning electron microscopy (SEM), confocal laser scanning microscopy (CLSM), and colony-forming unit (CFU) counting. The lesion depths, mineral loss, micro-hardness, and crystal characteristics were assessed using micro-computed tomography, Knoop Hardness Tester, and X-ray diffraction (XRD), respectively. The discolouring property was assessed by spectrophotometry.

RESULTS:

SEM showed that bacteria completely covered the enamel surface treated with water, but not the enamel surface treated with CTF and SDF. CLSM showed dead-to-live ratio of biofilm treated with CTF, SDF and water were 0.8 ± 0.1, 0.9 ± 0.2 and 0.5 ± 0.1 (p < 0.001, CTF, SDF>Water). Log₁₀ CFU values of biofilm treated with CTF, SDF and water were 7.7 ± 0.2, 7.7 ± 0.1 and 8.1 ± 0.1 (p < 0.001, CTF, SDF-3) of the CTF, SDF and water groups were 0.4 ± 0.1, 0.4 ± 0.2 and 1.0 ± 0.2 (p < 0.001, CTF, SDFWater). XRD revealed well-crystallised hydroxyapatite in enamel treated with CTF and SDF, but not water. Spectrophotometry showed ΔE values of the CTF, SDF and water groups were 5 ± 3, 54 ± 6 and 6 ± 2 (p < 0.001, CTF, water

CONCLUSION:

CTF inhibited Streptococcus mutans biofilm and remineralised artificial enamel caries without discolouration.

CLINICAL SIGNIFICANCE:

If CTF is successfully translated into clinical use, it can be a simple agent for clinicians to arrest enamel caries.

2024-12-01·JOURNAL OF DENTISTRY

Antibacterial and mineralising properties of copper tetraamine fluoride on dentine caries: A laboratory study

Article

作者: Yin, Iris Xiaoxue ; Xu, Veena Wenqing ; Niu, John Yun ; Yu, Ollie Yiru ; Nizami, Mohammed Zahedul Islam ; Chu, Chun Hung

OBJECTIVE:

To investigate the antibacterial, mineralising, and discolouring properties of copper tetraamine fluoride (CTF) on artificial dentine caries.

METHOD:

Demineralised human dentine blocks were treated with CTF, silver diamine fluoride (SDF, positive control) and water (negative control) before they were subjected to cariogenic challenge with Streptococcus mutans biofilm. The morphology, viability, and growth kinetics of the biofilm were assessed by scanning electron microscopy (SEM), confocal laser scanning microscopy (CLSM), and colony-forming unit (CFU) counting. The lesion depths, mineral loss, chemical structure, and crystal characteristics were measured using micro-computed tomography, Fourier transform infrared (FTIR), and X-ray diffraction (XRD). The discolouring property on demineralised dentine was assessed by spectrophotometry. One-way analysis of variance with the Bonferroni post hoc test was performed to assess and compare the data.

RESULTS:

SEM revealed confluent bacterial growth covering the surface of dentine treated with Water but not CTF and SDF. CLSM showed the dead-to-live ratio of the biofilm treated with CTF, SDF and Water were 0.7 ± 0.1, 0.8 ± 0.1 and 0.5 ± 0.1 (p < 0.001, CTF, SDF>Water). The Log₁₀ CFU values of the biofilm treated with CTF, SDF and Water were 7.8 ± 0.1, 7.8 ± 0.1 and 8.1 ± 0.2 (p < 0.001, CTF, SDF-3) of dentine treated with CTF, SDF and Water were 0.19 ± 0.04, 0.18 ± 0.04 and 0.30 ± 0.04 (p < 0.001, CTF, SDF

CONCLUSION:

CTF inhibited Streptococcus mutans. It mineralised but not discoloured artificial dentine caries.

CLINICAL SIGNIFICANCE:

If CTF is successfully translated into clinical application, it may be a non-discolouring anti-caries agent for clinicians to arrest dentine caries.

2024-11-01·JOURNAL OF DENTISTRY

Minimizing tooth discoloration caused by topical silver diamine fluoride application: A systematic review

Review

作者: Zhao, Irene S ; Lo, Edward CM ; Lo, Edward Cm ; Xu, Grace Y ; Yin, Iris X ; Lung, Christie YK ; Lung, Christie Yk ; Chu, Chun Hung

OBJECTIVE:

The objective of this systematic review is to examine the methods used to minimize discoloration of the carious lesions after topical silver diamine fluoride (SDF) application.

DATA/SOURCES:

Two independent researchers conducted a search of English literature published up to 30th April 2024 in three databases (PubMed, Scopus, and Web of Science). They screened titles and abstracts, excluding conference proceedings, books, reviews and publications unrelated to SDF. They included only original research on methods to minimize SDF-induced discoloration. The publications lacking comparative color change data were excluded. Full texts of the included articles were then analyzed. The Cochrane guidelines for clinical trials and the guidelines for in-vitro studies on dental materials were used for the risk of bias assessment.

RESULTS:

The systematic review included 33 publications from 1,283 identified publications (26 laboratory studies and 7 clinical studies). Thirteen laboratory studies and five clinical studies were rated as having 'low risk'. Three main methods to minimize discoloration were identified: masking with restoration, using chemicals, and substituting silver with nano-silver. Nine studies used resin composite or glass ionomer cement to mask the SDF-induced discoloration. Twenty-nine studies used chemicals to reduce SDF-induced discoloration. These chemicals included precipitating agents like potassium iodide, oxidizing agents like hydrogen peroxide, and chelating agents like glutathione. Seven publications used chemicals (potassium iodide or glutathione) before restoration and six of them found improved masking effect. Four studies substituted silver ions with silver nanoparticles which did not discolor carious lesion.

CONCLUSIONS:

Masking with restoration, using chemicals, and substituting silver ions with nano-silver particles have been reported to address the discoloring effects of SDF therapy. However, most are laboratory studies, and more clinical trials are needed to confirm their effectiveness in reducing SDF-induced discoloration.

CLINICAL SIGNIFICANCE:

SDF effectively arrests caries, but it discolors carious lesions. This review summarizes the methods and their outcomes for reducing SDF-induced discoloration. This study is supported by the General Research Fund of Research Grant Council No. 17,100,222.

项与银氮烷氟化物相关的新闻（医药）

2024-01-03

·Business Wire

MouthWatch Marks 2023 a Year of Virtual-First Care Innovation and Leading Intraoral Photography Growth

METUCHEN, N.J.--( BUSINESS WIRE )--MouthWatch, LLC, an industry leader in teledentistry solutions and dental intraoral cameras , is marking 2023 as a year defined by its commitment to continuous innovation, development of new technology solutions, and helping dental professionals increase access to care, improve oral health, and deliver excellence in patient experience. “As we reflect on 2023 and look ahead to 2024 and beyond, we are so proud of what we have accomplished, grateful for the recognition we have received, and excited about the growing role MouthWatch solutions play in addressing the needs of today’s patients, healthcare professionals, and organizations focused on patient health,” said Brant Herman, Founder and Chief Executive Officer of MouthWatch and Dentistry One . 2023 was an exciting year for MouthWatch, as it continued to bring new and exciting solutions to the marketplace: Virtual Care Innovation: MouthWatch launched Dentistry.One; a virtual-first dental care network built to break down barriers to oral health care, address the expectations of today’s modern healthcare consumers, the need for greater efficiency in healthcare, and the proven connection between good oral health and overall health. Dentistry.One features on-demand dental consultations, personalized care coordination, and oral health coaching for prioritizing oral health. Congressional Briefing : Mr. Herman joined other distinguished leaders in dental innovation at a Congressional Briefing in Washington, D.C., hosted by the Dental Trade Alliance, to share insights and experience about how teledentistry and artificial intelligence can improve both access to dental care and patient outcomes. Founder Recognition: Mr. Herman was named among NJBIZ Magazine’s “2023 People to Watch in Healthcare.” He was also named by the American Mobile and Teledentistry Alliance as one of the "Top 50 Teledentistry Leaders to Know in 2023," along with three other company Directors. Leadership Team Growth: New leadership roles were created to ensure continued growth and success of MouthWatch and Dentistry One: Carolyn Brown, DDS: Dr. Brown assumed the role of Chief Dental Officer at Dentistry One. She first joined MouthWatch in 2022 as Chief Health Innovation Officer, a position she continues to hold. Dr. Brown is nationally recognized for her focus on helping individuals and organizations achieve growth, improve health outcomes, leverage digital innovation, and bridge the gap across the medical-dental divide. She was instrumental in helping to launch Dentistry.One. Dr. Brown’s training at Dartmouth during the early days of value-based care and ACO formation is invaluable in the understanding of big data, diagnostic codes, healthtech, and risk-based partnerships. Previously, Dr. Brown has held academic positions at two dental schools, with over $20 million in research-related grant funding, and was amongst the first in the country to explore new models of dental care, including mobile and teledentistry. Sharity Ludwig, EPDH, MS: Ms. Ludwig joined Dentistry One as Senior Director of Clinical Operations. In this pivotal role, she oversees the development and implementation of innovative clinical strategies and processes for ensuring a seamless Dentistry One Provider-Patient experience. Prior to joining Dentistry One, Ms. Ludwig worked for 12+ years in various roles at DentaQuest, the largest Medicaid dental benefits administrator in the US. Her primary role was responsible for collaborating with clinical providers and operations management to develop and implement non-traditional services and care models across more than 70 practices and 200 providers. She played a key role in developing high-value clinical business opportunities and defining strategic and tactical objectives to oversee community-based care coupled with integrated care models for physical, behavioral, and oral health systems. Ms. Ludwig, in addition to dental care administration, treated at-risk patient populations as a clinical dental hygienist in both a federally qualified health center and private practice. Her background also includes coordinating dental services among various public and private dentistry stakeholders for a public health department and serving as project director for a Phase 3 randomized clinical trial of silver diamine fluoride. Susan Vassallo: Ms. Vassallo was promoted to Director of Marketing for MouthWatch and Dentistry One. In this role, she is responsible for driving visibility for the company’s products, services, and solutions to help ensure their sustained success. Ms. Vassallo brings over two decades of leadership experience in marketing communications and brand management to the company. Prior to joining MouthWatch and Dentistry One, her work in creating and deploying marketing communications strategies and initiatives contributed to growing a $1.5 billion national healthcare distributor into a multi-billion-dollar global Fortune 500 health solutions company serving dental and medical practitioners. Ms. Vassallo is passionate about raising awareness for important health topics and uncovering opportunities to increase access to care. Product Awards: The MouthWatch Intraoral Camera continued its winning streak by taking a 2023 Dentaltown Magazine Townie Choice Award in its category for the fourth consecutive year. In addition, the dental industry online forum and community, Nifty Thrifty Dentists, awarded the MouthWatch Intraoral Camera with a best product award based on its value and performance. The company’s newest product, The MouthWatch Plus+ HD Intraoral Camera was recognized with three separate awards by Dentistry Today Magazine : “Top 50 Technology Products,” “Readers’ Choice Top 100 Products,” and “Top Innovative Products.” “The success we achieved during 2023 was possible because of the outstanding expertise of the MouthWatch and Dentistry One team and the deep commitment we share to improve oral health and help our customers achieve their goals,” said Mr. Herman. “We look forward to taking on 2024 and beyond with the same vigor and enthusiasm we experienced this past year.” About MouthWatch, LLC MouthWatch, LLC, is a leader in developing digital technology solutions that drive success for dental professionals, improve oral health care, and enhance the overall patient experience. Headquartered in Metuchen, New Jersey, MouthWatch is widely known for its intraoral cameras that help engage patients in treatment planning through high-quality, affordable imaging technology, and its TeleDent software that provides practices and organizations with a teledentistry option to engage patients with providers remotely. MouthWatch launched Dentistry.One, a virtual-first care network that addresses the expectations of today’s modern healthcare consumers, the need for greater efficiency in healthcare, and the proven connection between good oral health and total health. Dentistry.One features on-demand dental consultations, personalized care coordination, and oral health coaching for prioritizing oral health. MouthWatch hardware and software are in use at over 40,000 practices, over 40 leading Dental Service Organizations (DSOs), and over 100 dental and hygiene schools. The company has been recognized three times in the Inc. 5000. For more information, visit mouthwatch.com . or dentistry.one .

高管变更临床3期

2023-02-10

·Science Daily

School dental program prevents 80 percent of cavities with one-time, non-invasive treatment

In a study of nearly 3,000 schoolchildren, silver diamine fluoride -- a liquid that is brushed onto the surface of teeth to prevent cavities or keep them from worsening -- was as effective against cavities as dental sealants, the standard of care. A single dose of either topical treatment given in elementary schools prevented roughly 80% of cavities and kept 50% of cavities from worsening when children were seen two years later. In a study of nearly 3,000 schoolchildren, silver diamine fluoride -- a liquid that is brushed onto the surface of teeth to prevent cavities or keep them from worsening -- was as effective against cavities as dental sealants, the standard of care. A single dose of either topical treatment given in elementary schools prevented roughly 80% of cavities and kept 50% of cavities from worsening when children were seen two years later. The findings, published in JAMA Network Open, offer an efficient and cost-effective approach to improving children's oral health through school-based care. Dental cavities are the most common chronic disease in children, and kids from low-income families are twice as likely to have cavities as those from higher-income families. Without proper and timely intervention, cavities can lead to severe infections, reduce children's quality of life, and are associated with lower student academic performance and school attendance. But getting kids to a dentist for the recommended twice-yearly visits can be challenging, especially when parents need to take time off of work. To reduce the barriers to seeing a dentist, some basic dental services can be offered in schools, especially those serving children from low-income families. For example, the Centers for Disease Control and Prevention recommends and funds school sealant programs. In 2017, NYU College of Dentistry researchers received funding from the Patient-Centered Outcomes Research Institute (PCORI) to run the nation's largest school-based cavity prevention study, which they named CariedAway. CariedAway is a randomized trial comparing the effectiveness of two cavity-prevention techniques: a "simple" treatment using silver diamine fluoride (SDF) and fluoride varnish, and a "complex" treatment using traditional glass ionomer sealants and fluoride varnish. Both are non-invasive and applied to the surface of teeth to prevent and arrest cavities in children, but for the same time and cost, providers can treat more children with the simpler SDF therapy. The study included 2,998 children in kindergarten through third grade at 47 New York City schools. The schools -- which serve a racially diverse group of students, most of whom are from low-income families -- were randomized to receive either the simple or complex treatment. Upon visiting each school, the clinical research team -- which included a supervising dentist, dental hygienists, registered nurses, and assistants -- did baseline exams to measure any tooth decay, and then applied fluoride varnish and either sealants or SDF, depending on whether the school was assigned to receive the complex or simple treatment. The initial visits took place in 2019 and early 2020, and were paused when the COVID-19 pandemic temporarily closed New York City schools and halted all school-based care. Two years later, schools allowed the clinical research team to resume, and they returned to each school for follow-up visits. The researchers found that both the simple and complex treatments were successful: just one cavity prevention treatment prevented more than 80% of cavities (81% for SDF and 82% for sealants) and stopped half of cavities from progressing (56% for SDF and 46% for sealants). "Without prevention, dental cavities grow continuously if not treated. One CariedAway cavity prevention treatment, provided just before schools closed during the pandemic, was remarkably effective over the following two-year period," said Richard Niederman, DMD, professor in the Department of Epidemiology & Health Promotion at NYU College of Dentistry, co-principal investigator of CariedAway, and the study's senior author. "I know of no other dental preventive intervention that had this great a beneficial impact across the pandemic." While the limited availability of trained dental professionals can pose challenges for school sealant programs, as sealants are applied by a dentist or dental hygienist, SDF may be an attractive alternative, as it can also be applied by nurses -- a workforce already in place in many schools. "Our results support the use of SDF for cavity prevention in school-based oral health programs and offer an opportunity for expanding access to critical oral health care," said Ryan Richard Ruff, MPH, PhD, associate professor in the Department of Epidemiology & Health Promotion at NYU College of Dentistry, co-principal investigator of CariedAway and the study's first author. Tamarinda Barry-Godín, DDS, MPH, was a study co-author. This research was funded by the Patient-Centered Outcomes Research Institute (award PCS-1609-36824).

临床结果

2021-04-07

·MedCity News

Trends in the dental industry: Dental technology in the next decade

With the prevailing situation created by the Covid-19 pandemic – and the resultant dental industry market recession – there is one thing on every dentist’s mind: “What does the future hold for us?” While we can’t control the future, we can be sure of one thing — 10 years down the road, we can expect remarkable changes in the dental industry that will completely revolutionize dental healthcare facilities worldwide. 3D Printing Technology As we move forward, dental treatment is expected to become less time-consuming. Compared with conventional laboratory-made restorations, dental restorations fabricated using the CAD-CAM technology are not only dimensionally accurate and aesthetically more pleasant, but they also possess lesser structural flaws, making them much more durable. Although more and more dentists are investing in 3D printing technology, the next decade will witness an unprecedented reliance of dentists on the fabrication of dental restorations with the computer-aided design and computer-aided manufacturing (CAD-CAM) technology. The possibilities are endless. It’s not just dental restorations; the day is not far when dentists will be able to 3D print teeth as well. Artificial Intelligence The medical industry has already started to benefit from artificial intelligence in various ways. Unfortunately, the dental industry has been slow in adopting this promising technology. But this is going to change in the near future. From caries diagnosis to early detection of malignant lesions, patient record management, and diagnostic imaging, computers and software will be assisting dentists in making more accurate and effective clinical decisions in the years to come. Digital Dentistry In a world where every industry is increasingly relying upon digital systems and equipment, why should the dental market be left behind? Even today, many dentists use physical impressions for the fabrication of crowns and veneers – even in implant dentistry. Digital impressions are much more accurate and dimensionally stable. More importantly, they can be seamlessly integrated with CAD-CAM systems for the chairside fabrication of dental restorations. Tooth Remineralization According to the World Health Organization (WHO), the worldwide number of individuals older than 60 is expected to rise from 900 million in 2015 to 2 billion by 2050. Consequently, there has been a rise in the global incidence of root caries. The current surgical-restorative model for managing dental caries – especially root caries – has become globally unfeasible. Hence, over the years, the trend is expected to shift from “surgical” restoration to a “minimally invasive, medical model” using novel remineralizing agents such as sodium fluoride and amorphous calcium phosphate. Among these agents, silver diamine fluoride (SDF) has gained considerable attention due to its ability to effectively arrest and prevent root caries. It is expected that more and more dentists will adopt this novel remineralization agent, which will prove especially beneficial in caries management in rural, under-developed areas – or for high-risk patients. Not only this, a team of researchers is working on a novel remineralization method – electrically accelerated and enhanced remineralization (EAER). This method, which is expected to be clinically available in the coming years, will allow for the remineralization of enamel and dentine tissue, restoring mild to moderate caries without the need for restorative treatment. Augmented Reality Imagine practicing your clinical skills – or teaching your students without the need for live patients. This is going to be a reality soon, thanks to augmented reality. In the coming years, dental students will learn and practice various clinical procedures anytime, anywhere. Not only this, dentists will be able to use augmented reality for educating and counseling their patients. From oral hygiene instructions to showing tooth defects in realtime and suggesting appropriate treatment modalities, the opportunities are endless for augmented reality in dentistry. Teledentistry The Covid-19 pandemic has completely revolutionized the dental industry. Dentists now only ask patients to come to their offices only when physical treatment is needed. When it comes to regular oral hygiene checkups – or other services that do not require the physical presence of the patients, dentists now offer teledentistry services. While the Covid-19 will hopefully be a thing of the past soon, teledentistry is here to stay. According to the American TeleDentistry Association, around 20% of Americans live in rural areas that lack dental care access. Teledentistry can solve this problem in the coming years. How convenient would it be for the patients? No matter where you live, you don’t need to take a break from work or pick your kids from school for a dentist’s appointment. Simply log in from your smartphones and let your dentist examine your oral health or your Invisalign treatment progress. Similarly, in case of an emergency, teledentistry will allow patients to seek immediate advice from the dentist while waiting for a physical appointment. The list of changes we can expect in the years to come is endless. But we can be sure about one thing – the future is promising for the dental industry and dental patients. We can expect the introduction of novel and groundbreaking technologies that will immensely benefit both the dentists and the patients over the years. So, let’s hope for the best and be a part of that change.

100 项与银氮烷氟化物相关的药物交易

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KEGG	Wiki	ATC	Drug Bank
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牙根龋	日本	Toyo Pharmar Co. Ltd.	2009-09-25
牙本质敏感症	日本	Toyo Pharmar Co. Ltd.	2009-02-24

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT05761041 (Pubmed \| BMC Oral Health)	临床3期	龋齿	165	silver diamine fluoride (38% SDF solution)	觸膚膚蓋築鹽願遞顧鏇(衊製積構積鹽築醖選鬱) = 鑰齋鑰淵構膚鬱襯衊構廠衊憲鏇窪鑰蓋積糧簾 (簾糧鑰窪遞選積衊襯鬱 ) 更多	积极	2023-10-04
				silver diamine fluoride (5% NaF varnish + MI)	觸膚膚蓋築鹽願遞顧鏇(衊製積構積鹽築醖選鬱) = 簾獵壓襯醖鹹觸鏇艱積廠衊憲鏇窪鑰蓋積糧簾 (簾糧鑰窪遞選積衊襯鬱 ) 更多
Pubmed	N/A	龋齿	190	38% silver diamine fluoride	繭壓繭鑰醖簾鏇鬱衊艱(醖醖醖範願鬱觸顧選廠) = 鏇網繭窪窪醖衊網鹽願鹽顧膚窪製構衊醖簾網 (廠憲夢築範艱鏇蓋蓋選 )	积极	2022-04-29
NCT04186663 (CTgov)	临床2期	龋齿	59	Silver Diamine Fluoride	蓋糧壓齋齋觸願蓋艱遞(網夢鏇膚鑰襯願鬱憲獵) = 願製餘襯鑰壓構顧鑰醖淵壓蓋壓夢餘鹹築餘簾 (顧壓網範鹽醖顧構醖獵, 夢簾遞夢餘構壓憲鬱膚 ~ 餘鏇顧獵網範選齋構顧) 更多	-	2022-03-10
NCT03186261 (CTgov)	临床3期	龋齿	44	Nano silver fluoride solution (Nano Silver Fluoride Solution)	醖蓋獵範積艱鹹鏇窪構(憲願壓鏇積齋餘淵製憲) = 鏇廠構構鹽淵廠艱鏇顧鏇選簾憲鬱憲範鏇廠憲 (繭餘選遞膚鬱製窪鹹遞, 鬱顧淵蓋願鬱簾糧廠艱 ~ 獵餘簾鹹構糧構襯網膚) 更多	-	2021-09-16
				Cavity Cleanser (Cavity Cleanser)	醖蓋獵範積艱鹹鏇窪構(憲願壓鏇積齋餘淵製憲) = 糧艱襯衊遞膚蓋構繭窪鏇選簾憲鬱憲範鏇廠憲 (繭餘選遞膚鬱製窪鹹遞, 淵糧鏇餘製夢鹽憲築鹽 ~ 憲鏇鏇製獵遞醖繭憲襯) 更多
NCT04184271 (CTgov)	临床2期	龋齿	16	38% silver diamine fluoride	淵顧遞鹽蓋觸獵簾築繭(繭艱願蓋窪積衊壓鬱衊) = 範夢製選窪遞廠網簾衊鏇窪顧糧範觸選窪蓋鹹 (鑰艱鹹遞顧淵壓顧簾獵, 艱艱遞壓窪選積遞齋鏇 ~ 獵窪簾遞繭憲鑰鏇衊繭) 更多	-	2020-08-14
NCT02536040 (CTgov)	临床3期	龋齿	66	38% diammine silver fluoride (38% Diamine Silver Fluoride)	衊廠積獵憲簾鏇糧廠鬱(築獵觸蓋餘齋艱憲鏇夢) = 夢窪壓繭艱壓簾餘壓鏇窪醖醖網憲網鏇蓋淵顧 (網遞築糧夢網鏇遞遞鑰, 鹽鹹夢淵夢齋鬱築積遞 ~ 顧繭鬱觸夢糧膚憲淵窪) 更多	-	2020-01-23
				Water (Water)	衊廠積獵憲簾鏇糧廠鬱(築獵觸蓋餘齋艱憲鏇夢) = 衊壓鏇選壓構壓構獵選窪醖醖網憲網鏇蓋淵顧 (網遞築糧夢網鏇遞遞鑰, 窪醖窪鑰選獵膚觸築顧 ~ 顧淵窪構鑰繭齋憲選膚) 更多
NCT02360124 (CTgov)	临床2/3期	牙根龋	323	Water as placebo (Control)	廠遞鏇蓋淵糧遞鬱構鹹(壓鹹築鏇蓋範鏇願構壓) = 襯構壓鹹餘範膚築膚鬱構願網鹹顧鹽鏇鏇蓋膚 (遞鏇積壓廠壓齋簾蓋網, 簾餘選襯簾繭築壓築窪 ~ 憲簾壓觸選選蓋製鏇觸) 更多	-	2016-05-19
				silver diammine fluoride (Silver Diammine Fluoride)	廠遞鏇蓋淵糧遞鬱構鹹(壓鹹築鏇蓋範鏇願構壓) = 餘選醖築獵窪壓膚艱淵構願網鹹顧鹽鏇鏇蓋膚 (遞鏇積壓廠壓齋簾蓋網, 衊壓築淵憲鏇鹹衊願鏇 ~ 鹹齋膚艱膚觸齋餘壓遞) 更多