Ligelizumab(Ligelizumab) - 药物靶点：IgE_在研适应症：食物过敏_专利_临床

概要

基本信息

药物类型

单克隆抗体

别名

Ligelizumab (USAN/INN)、QGE-031

靶点

IgE

作用机制

IgE抑制剂(免疫球蛋白E抑制剂)

治疗领域

在研适应症

非在研适应症

原研机构

在研机构

Novartis Pharmaceuticals Corp.

Novartis AG

非在研机构-

最高研发阶段临床3期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

Sequence Code 9975801H

来源: *****

Sequence Code 319372739L

来源: *****

关联

30

项与 Ligelizumab 相关的临床试验

NCT05678959

/ Active, not recruiting临床3期

A Three-year, Multi-center, Double-blind, Extension Study to Evaluate the Long-term Safety and Efficacy of Ligelizumab in Patients Who Completed Ligelizumab's Phase III Studies in Food Allergy

This is an extension study to evaluate the long-term safety and efficacy of ligelizumab in participants who have completed a ligelizumab Phase III study in food allergy.

开始日期2023-04-27

申办/合作机构

Novartis Pharmaceuticals Corp.

NCT04984876

/ Terminated临床3期

A 52 Week, Multi-center, Randomized, Double-blind Placebo-controlled Study to Assess the Clinical Efficacy and Safety of Ligelizumab (QGE031) in Decreasing the Sensitivity to Peanuts in Patients With Peanut Allergy

This was a 52-week, Phase 3 multi-center, randomized, double-blind and placebo-controlled study to assess the safety and clinical efficacy of two dosing regimens of ligelizumab (240 mg and 120 mg) SC q4w (subcutaneous injection every 4 weeks) in participants with a medically confirmed diagnosis of Immunoglobulin E (IgE) mediated peanut allergy.

开始日期2021-12-07

申办/合作机构

Novartis Pharmaceuticals Corp.

NCT05024058

/ Terminated临床3期

A Multi-center, Randomized, Double-blind, Placebo Controlled Study to Investigate the Efficacy and Safety of Ligelizumab (QGE031) in the Treatment of Chronic Inducible Urticaria (CINDU) in Adolescents and Adults Inadequately Controlled With H1-antihistamines

This was a placebo controlled, phase 3 study designed to evaluate the efficacy and safety of ligelizumab in participants with chronic inducible urticaria who are inadequately controlled with H1-antihistamines

开始日期2021-11-16

申办/合作机构

Novartis Pharmaceuticals Corp.

100 项与 Ligelizumab 相关的临床结果

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100 项与 Ligelizumab 相关的转化医学

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100 项与 Ligelizumab 相关的专利（医药）

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55

项与 Ligelizumab 相关的文献（医药）

2025-01-01·ALLERGOLOGY INTERNATIONAL

Long term safety and efficacy of ligelizumab in the treatment of Japanese patients with chronic spontaneous urticaria

Article

作者: Ichishita, Ryohei ; Takahashi, Hidetoshi ; Severin, Thomas ; Fukunaga, Atsushi ; Burciu, Alis ; Hide, Michihiro ; Tomimatsu, Naoko ; Varanasi, Vineeth ; Fujishige, Ayako ; Hayama, Koremasa ; Hua, Eva ; Sasajima, Takayoshi

BACKGROUND:

In Japan, urticaria is a common skin disorder with chronic spontaneous urticaria (CSU) being the most frequent subtype. This study evaluated the safety of ligelizumab (anti-IgE monoclonal antibody) in Japanese CSU patients.

METHODS:

This was a Phase 3 multicenter, open-label, single-arm 52-week study in adult Japanese patients with CSU inadequately controlled with locally approved doses of H1-antihistamines. The primary objective reported the safety of ligelizumab 120 mg subcutaneously every 4 weeks, by evaluation of treatment emergent adverse events (TEAE). Secondary objectives evaluated efficacy by absolute change from baseline (CFB) in weekly urticaria activity score (UAS7), and the proportion of patients with UAS7 = 0, and dermatology life quality index (DLQI) = 0-1 over time.

RESULTS:

From a total of 66 CSU patients (80.3% females; mean ± SD age 46.4 ± 13.2 years; mean ± SD baseline UAS7 28.7 ± 6.5) enrolled, 53 patients (80.3%) reported ≥1 TEAE during the study, with no severe or serious adverse events, no anaphylaxis events and low frequency of TEAEs leading to treatment discontinuations (6.1%). Absolute mean CFB of UAS7 showed a rapid onset of response at Week 4 (-14.2) with further improvement until end of treatment at Week 52 (-22.9). The proportion of patients achieving UAS7 = 0 improved over time (14.5% at Week 4; 50.0% at Week 52). A sizable proportion of patients achieved DLQI 0-1 with the first dose of ligelizumab (38.5%), and improvements observed throughout the study until Week 52 (68.8%).

CONCLUSIONS:

Treatment with ligelizumab 120 mg was well-tolerated with mild to moderate adverse events and was efficacious in Japanese patients.

2024-10-01·EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Time-course and dose-effect of omalizumab in treating chronic idiopathic urticaria/chronic spontaneous urticaria

Article

作者: Ye, Kaihe ; Zhang, Ke ; Zhao, Aiping ; Zhu, Guanghu ; Xu, Zhaosi ; Wang, Zhen ; Gong, Xiao

PURPOSE:

Several studies have shown that subcutaneous injections of omalizumab can treat chronic idiopathic/spontaneous urticaria (CIU/CSU) patients by only assessing the efficacy on specific endpoints. This study aimed to quantitatively analyze different doses of omalizumab in CIU/CSU and compare it with ligelizumab.

METHODS:

Literature searches were performed in PubMed, Embase, and Web of Science databases. A model-based meta-analysis (MBMA) was utilized to develop a model incorporating time since the initiation of treatment and dose for omalizumab, with the change from baseline in Urticaria Activity Score (CFB-UAS7) as the primary efficacy endpoint. The time-course and dose-effect relationship throughout the omalizumab treatment period was analyzed, and the findings were compared with those of the investigational ligelizumab.

RESULTS:

The model equation for the CFB-UAS7 was established as E = -E_max × time/(ET₅₀ + time) × (b₀ + b₁ × dose). The estimated values of the model parameters __-mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"-__E max , __-mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"-__ ET 50 , __-mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"-__b 0 , and __-mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"-__b 1 were -1.16, 1.26 weeks, -9.90, and -0.0361 mg^-1, respectively. At week 12 after the first dose, the model-predicted CFB-UAS7 for 150 mg and 300 mg of omalizumab were -16.0 (95% CI, -17.2 to -14.8) and -21.7 (95% CI, -22.9 to -20.5), respectively. In the PEARL-1 trial, the CFB-UAS7 for 72 mg and 120 mg of ligelizumab were -19.4 (95% CI, -20.7 to -18.1) and -19.3 (95% CI, -20.6 to -18.0), respectively. In the PEARL-2 trial, these values were -19.2 (95% CI, -20.5 to -17.9) and -20.3 (95% CI, -21.6 to -19.0), respectively.

CONCLUSION:

Omalizumab showed a significant dose-dependent effect in the treatment of CSU. Both 72 mg and 120 mg ligelizumab might have the potential to outperform 150 mg (but not 300 mg) omalizumab.

2024-06-01·Current opinion in allergy and clinical immunology

Role of biologics in severe food allergy

Review

作者: Cafarotti, Arianna ; Dinardo, Giulio ; Miraglia del Giudice, Michele ; Fiocchi, Alessandro ; Artesani, Maria Cristina ; Fierro, Vincenzo ; Indolfi, Cristiana

Purpose of review:

This review examine the dynamic landscape of food allergy treatment within the context of emerging biologics. Our purpose is to comprehensively evaluate the potential benefits, challenges, and transformative impact associated with the utilization of biologics in comparison to conventional therapeutic modalities.

Recent findings:

This document synthesizes recent scientific investigations to various biologics, such as omalizumab, ligelizumab, dupilumab, and tezepelumab, providing a nuanced understanding of their roles in oral immunotherapy, rapid desensitization, and overall food allergy management. Recent studies and clinical trials highlight the impact of anti-IgE treatment on food allergies, revealing critical findings such as dose-related efficacy, facilitation of rapid desensitization in peanut allergies, and the sustained positive outcomes observed in individuals with multifood allergies.

Summary:

The use of biologics presents a groundbreaking approach in the treatment of food allergies. The multifaceted action of these agents, along with their potential to overcome the challenges associated with traditional therapies, marks a significant advancement. Despite the persisting challenges of economic constraints and the need for further safety studies, biologics offer a promising avenue for improving the quality of life for individuals with food allergies. Ongoing research and collaborative efforts are imperative to fully realize the transformative potential inherent in these emerging therapeutic frontiers.

22

项与 Ligelizumab 相关的新闻（医药）

2024-11-26

·Endpoints

Food allergy biotech Alladapt closes after Phase 3 talks with FDA

Alladapt Immunotherapeutics, a well-financed biotech working in the food allergy field, shut down following talks with the FDA, according to a source familiar with the company. After claiming success in a Phase 1/2 trial in June 2023, Alladapt prepared for a Phase 3 of its experimental food allergy drug. Codenamed ADP101, the oral candidate had received the FDA fast track tag for mono- and multi-food allergies. But a late-stage trial proved too financially daunting. The “FDA guidance for the Phase 3 trial made it economically unviable,” according to the source, who confirmed the company closure to Endpoints News on the condition of anonymity. Investors got a “partial recovery on their investment,” the source added. The Menlo Park, CA-based startup was co-founded in 2018 by CEO Ashley Dombkowski and Kari Nadeau, a former Stanford allergist and now chair of the Department of Environmental Health at Harvard School of Public Health. Dombkowski didn’t respond to an Endpoints inquiry. Alladapt disclosed a $119 million funding round in June 2022 and a $50 million loan with Hercules Capital two months later. The biotech disclosed construction of a manufacturing facility on the outskirts of Philadelphia the year prior. The facility was expected to be completed in “late 2024,” according to architecture and engineering firm Genesis. The company’s investors included Patient Square Capital’s Enavate Sciences, Gurnet Point Capital, AllerFund, Red Tree Venture Capital, Novartis and others. Its equipment was listed for auction in July. Rock Creek Advisors, a firm that works on liquidations and restructurings, lists Alladapt as a client on its website. Some of its top executives left this year for posts at Eccogene and Navigator Medicines . The food allergy space has been through a series of ups and downs in recent years. Nestlé’s attempt to market a peanut allergy drug — known as Palforzia, from its $2.6 billion Aimmune acquisition — had failed commercially. There was a major win in February with the FDA approval of Novartis and Genentech’s Xolair for children and adults with one or more food allergies. Novartis had also axed a peanut allergy Phase 3 trial earlier this year, but said it expected to start a new study of the anti-inflammatory, dubbed ligelizumab, later in 2024. With its ADP101 candidate, Alladapt aimed to deliver small bits of protein from the “big nine” food allergies — milk, eggs, wheat, fish, shellfish, peanuts, tree nuts, soy and sesame — so that patients wouldn’t be as sensitized to the allergens. The startup also terminated an open-label extension study this year. Also in the food allergy space are Leaps by Bayer-backed Ukko and Regeneron, which is testing Dupixent combined with its hematology drug linvoseltamab in Phase 1 .

临床3期并购快速通道临床1期

2024-11-15

·Pharmaceutical Technology

FDA reviews Sanofi and Regeneron’s Dupixent label expansion for urticaria

Chronic spontaneous urticaria is a skin condition characterised by persistent, itchy hives that last six weeks or longer. Credit: wisely via Shutterstock. The US Food and Drug Administration (FDA) has accepted for review the resubmitted supplemental Biologics License Application (sBLA) for Sanofi and Regeneron’s Dupixent (dupilumab) in chronic spontaneous urticaria (CSU). The application seeks to expand Dupixent’s use to treat adults and adolescents (aged 12 and older) with CSU inadequately controlled by H1 antihistamine therapy. The FDA’s target decision date is 18 April 2025. Dupixent, a fully human monoclonal antibody, inhibits the signalling of IL-4 and IL-13 pathways and is different from other immunosuppressants used to treat this condition. The resubmission builds on data from the LIBERTY-CUPID Phase III clinical trial (NCT04180488), which included three studies (Study A, Study B, and Study C). The sBLA adds pivotal results from Study C, conducted in biologic-naive patients with uncontrolled CSU who were receiving standard-of-care antihistamines. Study C met both its primary and key secondary endpoints, demonstrating that Dupixent significantly reduced itch and urticaria activity (hives and itch severity), aligning with earlier results from Study A. Safety data across the LIBERTY-CUPID programme were consistent with Dupixent’s established safety profile, with common adverse events including injection site reactions and Covid-19 infections. Dupixent has already been approved for CSU in Japan and the United Arab Emirates (UAE) and is under regulatory review in the European Union. Outside of Japan and the UAE, the safety and efficacy of Dupixent in CSU remain under evaluation. The potential new indication for CSU comes as Regeneron and Sanofi continue to expand Dupixent’s market presence. In September 2024, the FDA approved Dupixent for chronic obstructive pulmonary disease (COPD), marking its sixth indication and making it the first biologic approved for COPD. Dupixent is also approved for conditions including atopic dermatitis, asthma, chronic rhinosinusitis with nasal polyposis, eosinophilic esophagitis, and prurigo nodularis. Dupixent generated $11.3bn (€10.7bn) in global sales in 2023, as per Regeneron’s financials. Projections from GlobalData’s Pharma Intelligence Center suggest revenue could reach $23.6bn by 2030. GlobalData is the parent company of Pharmaceutical Technology. CSU is a skin condition characterised by persistent, itchy hives that last six weeks or longer. While antihistamines and anti-inflammatory treatments are used to manage symptoms, there is an unmet need for more effective options in patients with uncontrolled disease. Meanwhile, Novartis is advancing its CSU pipeline with promising data for its investigational drug, ligelizumab. Results from the Phase III study (NCT03907878) released in May 2024 showed that almost half of patients were completely free of itch and hives as assessed at week 52 using urticaria activity scores. Novartis said it plans to submit ligelizumab for regulatory approval in the second half of 2024.

临床结果上市批准临床3期免疫疗法

2024-10-08

·生物制品圈

石药集团「奥马珠单抗」生物类似药获批上市

今日（10月8日），中国国家药监局（NMPA）官网最新公示，石药集团以注册分类3.3类申报的注射用奥马珠单抗生物类似药上市申请已获得上市批准。根据石药集团早先新闻稿，该产品是人免疫球蛋白E（IgE）人源化单克隆抗体，适用于H1抗组胺药治疗后仍有症状的成人和青少年（12岁及以上）慢性自发性荨麻疹患者。截图来源：NMPA官网慢性自发性荨麻疹（CSU）是慢性荨麻疹中最常见的类型，其特征为在无特定外部触发因素的情况下发生瘙痒性荨麻疹、血管性水肿或两者均持续超过6周。CSU相关症状将对日常活动和睡眠产生不利影响，并对整体生活质量产生潜在负面影响。该疾病的潜在发病机制虽然尚不完全清楚，但涉及自身过敏原IgE与皮肤肥大细胞表面高亲和力IgE受体FcɛRI的交联及随后的脱颗粒。这导致组胺和促炎介质释放，引起CSU体征和症状[2]。作为一款IgE人源化单克隆抗体，奥马珠单抗可通过降低游离IgE水平、下调高亲和力IgE受体和限制肥大细胞的脱颗粒化，减少过敏性炎症级联反应中多种介导因子的释放；它还能降低IgE介导的哮喘患者的哮喘加重率。奥马珠单抗原研产品已在中国获批用于治疗过敏性哮喘、慢性自发性荨麻疹等适应症。 2019年，石药集团与兴盟生物订立协议，获得后者授出奥马珠单抗生物类似药SYN008的独家权利。根据石药集团早先新闻稿介绍，该公司奥马珠单抗生物类似药遵循生物类似药相关研究指南，通过药学、非临床、临床药代动力学、临床有效性及安全性等一系列递进研究，确证了其与原研产品在质量、安全性和有效性方面高度相似，无临床意义上的差异。参考资料： [1] 2024年10月08日药品批准证明文件送达信息. Retrieved Oct 08, 2024, from https://www.nmpa.gov.cn/zwfw/sdxx/sdxxyp/yppjfb/20241008142557142.html [2] Maurer M, Ensina LF, Gimenez-Arnau AM, et al. (2024) Efficacy and safety of ligelizumab in adults and adolescents with chronic spontaneous urticaria: results of two phase 3 randomised controlled trials. Lancet. https://pubmed-ncbi-nlm-nih-gov.libproxy1.nus.edu.sg/38008109/ [3] 石药集团奥马珠单抗上市申请获受理 . Retrieved Jun 26, 2023, from https://mp.weixin.qq.com/s/wVdiI9tZXUg-ZgIJ9JXQZQ

生物类似药上市批准

100 项与 Ligelizumab 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D11761	Ligelizumab	-	DB11856

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
食物过敏	临床3期	日本	Novartis Pharmaceuticals Corp.	2023-04-27
食物过敏	临床3期	澳大利亚	Novartis Pharmaceuticals Corp.	2023-04-27
食物过敏	临床3期	加拿大	Novartis Pharmaceuticals Corp.	2023-04-27
食物过敏	临床3期	法国	Novartis Pharmaceuticals Corp.	2023-04-27
食物过敏	临床3期	德国	Novartis Pharmaceuticals Corp.	2023-04-27
食物过敏	临床3期	意大利	Novartis Pharmaceuticals Corp.	2023-04-27
食物过敏	临床3期	荷兰	Novartis Pharmaceuticals Corp.	2023-04-27
食物过敏	临床3期	西班牙	Novartis Pharmaceuticals Corp.	2023-04-27
花生过敏	临床3期	美国	Novartis Pharmaceuticals Corp.	2021-12-07
花生过敏	临床3期	日本	Novartis Pharmaceuticals Corp.	2021-12-07

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03907878 (CTgov)	临床3期	慢性荨麻疹	66	Ligelizumab	廠鬱簾築簾蓋壓壓製構(積憲網簾廠願繭醖窪夢) = 夢鏇鹽鏇衊衊遞鏇淵憲鏇衊鑰獵憲繭鑰簾淵鑰 (鹽顧襯顧糧壓膚鑰糧淵, 餘鬱鹽顧願糧壓餘選廠 ~ 製願築齋餘衊窪淵窪壓) 更多	-	2024-03-08
NCT03580369 (CTgov)	临床3期	慢性荨麻疹	1,072	Ligelizumab (Ligelizumab 72 mg)	衊積選製構積艱觸餘網(鬱鹽顧夢鏇簾製餘構遞) = 膚醖蓋遞網憲艱選繭齋構鹹鬱鬱築選築製餘構 (廠鹹憲醖糧淵鏇範膚廠, 廠範範範襯鑰鹹衊夢膚 ~ 廠醖夢鏇獵選獵憲衊艱) 更多	-	2022-12-30
NCT03580369 (CTgov)	临床3期	慢性荨麻疹	1,072	Ligelizumab (Ligelizumab 120 mg)	衊積選製構積艱觸餘網(鬱鹽顧夢鏇簾製餘構遞) = 顧醖鹹簾壓窪鹹淵築鹽構鹹鬱鬱築選築製餘構 (廠鹹憲醖糧淵鏇範膚廠, 窪選製繭憲構憲選憲窪 ~ 願艱糧觸構選膚選願餘) 更多	-	2022-12-30
NCT03907878 (Corporate Publications) 人工标引	临床3期	慢性荨麻疹	66	ligelizumab	鏇鬱襯鬱齋齋憲窪獵鬱(鹽夢壓淵獵糧範構繭鹽) = 膚簾製製網獵網遞鬱糧蓋餘積蓋鑰鹹構觸構鏇 (願糧簾簾淵夢選繭積憲 ) 更多	积极	2022-10-12
NCT02477332 \| NCT02649218 (Pubmed \| J Allergy Clin Immunol \| Allergy) 人工标引	临床2期	慢性荨麻疹	226	ligelizumab	觸範築艱鑰艱築遞簾繭(範醖鹹願鹽簾鏇繭鏇構) = 築醖醖網網襯積糧範築壓鬱鬱醖鬱淵積遞醖淵 (憲壓築膚壓繭簾鑰壓鬱 ) 更多	积极	2021-11-13
NCT03437278 (CTgov)	临床2期	慢性荨麻疹	49	Ligelizumab (Ligelizumab 24 mg)	繭選廠齋窪衊襯醖齋鏇(遞製壓淵糧窪遞遞簾壓) = 觸繭襯鑰築願範餘鏇顧網築網鹹襯構憲蓋齋廠 (簾餘鹹積齋醖蓋構淵醖, 夢齋獵獵鬱觸窪範構憲 ~ 網範顧獵選簾選製簾獵) 更多	-	2021-08-24
NCT03437278 (CTgov)	临床2期	慢性荨麻疹	49	Ligelizumab (Ligelizumab 120 mg)	繭選廠齋窪衊襯醖齋鏇(遞製壓淵糧窪遞遞簾壓) = 築願鏇鏇糧糧選製糧糧網築網鹹襯構憲蓋齋廠 (簾餘鹹積齋醖蓋構淵醖, 鏇淵獵積壓繭積衊遞窪 ~ 糧餘糧鬱鬱鏇衊觸鏇積) 更多	-	2021-08-24
NCT02649218 (CTgov)	临床2期	慢性荨麻疹	226	Ligelizumab	襯窪廠願壓艱淵願觸願(遞繭製積蓋窪構壓構築) = 簾網網鹽鏇願壓顧構構膚廠繭鏇簾積築衊齋夢 (膚選構齋製選觸窪壓鬱, 蓋願願構獵襯夢選鑰鏇 ~ 窪鬱顧範範壓獵積夢構) 更多	-	2020-08-14
NCT02477332 (CTgov)	临床2期	慢性荨麻疹	382	QGE031 (QGE031 24 mg s.c. q4w)	餘鹹艱淵鹹齋餘蓋膚餘(顧淵窪選網鑰艱鹹憲鑰) = 廠膚積糧艱夢餘壓膚餘範艱選襯鹹觸觸襯壓蓋 (築窪餘遞鬱構製淵膚製, 糧選簾積鹽繭鬱淵壓鹹 ~ 鹽觸憲獵製獵憲鹹鹹遞) 更多	-	2018-09-14
NCT02477332 (CTgov)	临床2期	慢性荨麻疹	382	QGE031 (QGE031 72 mg s.c. q4w)	餘鹹艱淵鹹齋餘蓋膚餘(顧淵窪選網鑰艱鹹憲鑰) = 餘繭淵鑰廠鬱積膚簾積範艱選襯鹹觸觸襯壓蓋 (築窪餘遞鬱構製淵膚製, 遞壓範蓋廠鹽獵齋淵繭 ~ 醖觸鬱鏇襯夢糧壓鹹蓋) 更多	-	2018-09-14
NCT02075008 (CTgov)	临床2期	过敏性哮喘	270	QGE031	願齋憲窪遞襯製廠製築(積築廠夢顧遞觸餘鏇醖) = 淵蓋憲製蓋鹽觸壓廠顧衊憲鏇齋鹽糧蓋簾構艱 (蓋壓顧齋鏇網憲鬱範餘, 築蓋選繭顧積艱蓋鹹簾 ~ 憲醖壓願壓艱淵選廠壓) 更多	-	2017-04-25
NCT02336425 (CTgov)	临床2期	哮喘	10	QGE031 (QGE031 240 mg)	範鬱獵壓膚觸衊簾衊鏇(夢願憲糧獵醖膚壓蓋築) = 廠構膚鬱積範築壓鏇製餘積壓願鹹鬱簾積壓窪 (夢繭鬱鏇鑰蓋壓廠網構, 壓醖糧醖衊鬱壓願淵醖 ~ 蓋鏇遞窪鹹築窪壓窪齋) 更多	-	2017-04-07
NCT02336425 (CTgov)	临床2期	哮喘	10	QGE031 (QGE031 72 mg)	範鬱獵壓膚觸衊簾衊鏇(夢願憲糧獵醖膚壓蓋築) = 鹹構選鹽蓋鹽鹹蓋範選餘積壓願鹹鬱簾積壓窪 (夢繭鬱鏇鑰蓋壓廠網構, 積蓋壓淵夢繭窪鹽積壓 ~ 衊淵窪築艱艱蓋淵餘夢) 更多	-	2017-04-07
NCT01716754 (CTgov)	临床2期	哮喘	471	Placebo	鏇齋襯觸觸襯製鏇構廠(顧鬱觸顧襯壓獵憲鹹觸) = 鹹構鹹築壓淵鬱廠繭觸積願繭觸繭夢選顧鏇衊 (艱遞膚艱衊鹹憲醖網壓, 衊淵齋製製衊遞窪製蓋 ~ 製觸廠衊鹽壓憲選壓築) 更多	-	2017-03-08