P-gp and/or MRP1 inhibitors(Hokkaido University)(P-gp and/or MRP1 inhibitors(Hokkaido University))

概要

基本信息

药物类型

小分子化药

别名-

靶点

MRP1 x P-gp

作用方式

抑制剂

作用机制

MRP1抑制剂(ATP binding cassette subfamily C member 1 inhibitors)、P-gp抑制剂(P-糖蛋白-1抑制剂)

治疗领域

其他疾病

在研适应症-

非在研适应症

炎症

原研机构

Hokkaido University

在研机构-

非在研机构

Hokkaido University

最高研发阶段无进展临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 P-gp and/or MRP1 inhibitors(Hokkaido University) 相关的临床结果

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100 项与 P-gp and/or MRP1 inhibitors(Hokkaido University) 相关的转化医学

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100 项与 P-gp and/or MRP1 inhibitors(Hokkaido University) 相关的专利（医药）

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1

项与 P-gp and/or MRP1 inhibitors(Hokkaido University) 相关的文献（医药）

2012-09-27·Journal of medicinal chemistry1区 · 医学

Design and Synthesis of Indomethacin Analogues That Inhibit P-Glycoprotein and/or Multidrug Resistant Protein without Cox Inhibitory Activity

1区 · 医学

Article

作者: Nakamura, Tomonori ; Abe, Hiroshi ; Kasaya, Yayoi ; Arisawa, Mitsuhiro ; Ito, Mika ; Sasaki, Akito ; Shuto, Satoshi ; Araki, Takuya ; Yamano, Akihito ; Sasaki, Takuma ; Yamamoto, Koujirou ; Ito, Yoshihiro ; Obata, Tohru

We designed and synthesized conformationally restricted analogues and regioisomers of the nonsteroidal anti-inflammatory drug indomethacin. Evaluation of the inhibitory effects of these compounds on COX, P-glycoprotein, and multidrug resistance indicated that NSAIDS modulation of multidrug-resistant P-glycoprotein and multidrug-resistant protein-1 is not associated with COX-1 and COX-2 inhibitory activities.

100 项与 P-gp and/or MRP1 inhibitors(Hokkaido University) 相关的药物交易

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