马钱子碱凝胶贴膏(Brucine Gel Plaster) - 在研适应症：膝关节炎，前列腺癌_专利_临床

概要

基本信息

药物类型

中药

别名

Brucine Cataplas

靶点-

作用方式-

作用机制-

治疗领域

免疫系统疾病皮肤和肌肉骨骼疾病肿瘤+ [1]

在研适应症

膝关节炎前列腺癌

非在研适应症-

原研机构

海南赛立克药业有限公司

在研机构

徐州医科大学

海南赛立克药业有限公司

非在研机构-

最高研发阶段临床1期

首次获批日期-

最高研发阶段(中国)临床1期

特殊审评-

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关联

1

项与马钱子碱凝胶贴膏相关的临床试验

CTR20250521

/ Not yet recruiting临床1期

马钱子碱凝胶贴膏在中国受试者中单次给药和多次给药后的安全性、耐受性和药代动力学特征的随机、双盲、安慰剂对照Ⅰ期临床研究

1、观察马钱子碱凝胶贴膏在受试者中不同剂量下单次给药和多次给药后的安全性与耐受性。 2、评价马钱子碱凝胶贴膏在受试者中不同剂量下单次给药和多次给药后的药代动力学特征。

开始日期-

申办/合作机构

海南赛立克药业有限公司

100 项与马钱子碱凝胶贴膏相关的临床结果

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100 项与马钱子碱凝胶贴膏相关的转化医学

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100 项与马钱子碱凝胶贴膏相关的专利（医药）

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1

项与马钱子碱凝胶贴膏相关的文献（医药）

2024-07-01·Current cancer drug targets

Brucine Inhibits Proliferation of Pancreatic Ductal Adenocarcinoma through PI3K/AKT Pathway-induced Mitochondrial Apoptosis

Article

作者: Li, Ping ; Wu, You ; Xu, Panling ; Zhang, Fenglin

Introduction::

The purpose of this research was to settle the role of brucine in pancreatic ductal adenocarcinoma (PDAC) and the mechanisms involved.

Methods::

The findings of this study suggest that brucine exerts inhibitory effects on cell growth, clonogenicity, and invasive potential of Panc02 and Mia Paca-2 cells. These effects may be linked to an increase in apoptotic-prone cell population.

Results::

Gene sequencing data suggests that these effects are mediated through the induction of apoptosis. Experimental evidence further supports the notion that brucine reduces mitochondrial membrane potential and upregulates Bax expression while downregulating Bcl-2 expression. These effects are believed to be a result of brucine-mediated suppression of PI3K/Akt activity, which serves as a regulatory factor of mTOR, Bax, and Bcl-2. Suppression of PI3K activity enhances the tumor-suppressing effects of brucine.

Conclusion::

Overall, these findings suggest that brucine has therapeutic potential as a remedy option for PDAC.

100 项与马钱子碱凝胶贴膏相关的药物交易

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