圆叶葡萄皮提取物(Vitis rotundifolia Skin Extract) - 在研适应症：非转移性前列腺癌，晚期癌症，不可切除的恶性实体瘤_专利_临床

概要

基本信息

药物类型

中药

别名

MSKE、Muscadine Grape Skin Extract、Muscadine Plus

靶点-

作用机制-

治疗领域

肿瘤泌尿生殖系统疾病

在研适应症

非转移性前列腺癌晚期癌症不可切除的恶性实体瘤

非在研适应症

前列腺腺癌

原研机构-

在研机构

National Cancer Institute

Huntsman Cancer Institute

The Johns Hopkins University

+ [1]

非在研机构

The Sidney Kimmel Comprehensive Cancer Center

最高研发阶段临床3期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

登录后查看时间轴

关联

2

项与圆叶葡萄皮提取物相关的临床试验

NCT02583269 / Completed临床1期IIT

Phase I Study of Muscadine Grape Extract (MGE) in Advanced Malignancy

This phase I trial studies the side effects and the best dose of muscadine grape skin extract (MGE) in treating patients with malignancy (tumor or cancer) that has spread to other parts of the body or cannot be removed by surgery. MGE is a nutritional supplement containing an extract of the skin of muscadine grape that has shown anti-cancer activity in laboratory studies and may be able to fight or kill malignant cells.

开始日期2016-03-01

申办/合作机构

Wake Forest School of Medicine

[+1]

NCT01317199 / Completed临床1/2期IIT

Phase I/II Study of Safety and Efficacy of Muscadine Plus (MPX) in Men With Prostate Cancer: a Randomized,Double-blind,Placebo Controlled Study of the Effects of Two Doses of MPX Capsules on Rising Prostate-specific Antigen Levels in Men Following Initial Therapy for Prostate Cancer

This research is being done to test an investigational product called Muscadine Plus in the treatment of men who have received initial therapy (surgery and or radiation, cryotherapy or brachytherapy) for prostate cancer and are experiencing a rise in their prostate-specific antigens (PSA) level.

开始日期2011-07-01

申办/合作机构

The Sidney Kimmel Comprehensive Cancer Center

[+2]

100 项与圆叶葡萄皮提取物相关的临床结果

登录后查看更多信息

100 项与圆叶葡萄皮提取物相关的转化医学

登录后查看更多信息

100 项与圆叶葡萄皮提取物相关的专利（医药）

登录后查看更多信息

38

项与圆叶葡萄皮提取物相关的文献（医药）

2021-06-01·American Journal of Clinical Oncology4区 · 医学

Phase I Study of Muscadine Grape Extract for Patients With Advanced Cancer

4区 · 医学

Article

作者: Tooze, Janet A. ; Klepin, Heidi D. ; Alistar, Angela T. ; Pleasant, Katherine ; Bitting, Rhonda L. ; Thomas, Christopher Y. ; Isom, Scott ; Petty, W. Jeffrey ; Golden, Shannon L. ; Chappell, Mark C. ; Tallant, E. Ann ; Thomas, Alexandra ; Gallagher, Patricia E. ; Grant, Stefan C. ; Desnoyers, Rodwige J.

Objective:Preclinical studies with muscadine grape extract (MGE) show antitumor activity and decreased systemic inflammation. This phase I study (NCT02583269) assessed safety and tolerability of a proprietary MGE preparation in patients with advanced solid tumors.Methods:Patients with metastatic or unresectable cancers who were progressing on standard therapies were assigned to MGE in a standard 3+3 design. Five dose levels were tested (320 to 1600 mg total phenolics/d). Safety and maximum-tolerated dose were assessed after 4 weeks. Patients were evaluated for response at 8 weeks and continued on MGE if clinically stable. Secondary outcomes were response, survival, adherence, fatigue, and quality of life (QOL).Results:In total, 23 patients (lung, n=7; gastrointestinal, n=7; genitourinary, n=6; other, n=3) received MGE capsules by mouth twice daily. The cohort [median age 72 years, 48% Eastern Cooperative Oncology Group (ECOG) 2] was heavily pretreated. After 4 weeks on MGE, possibly attributable adverse events grade 2 or higher were fatigue (n=1), decreased lymphocyte count (n=1), and constipation (n=2), including 1 dose-limiting toxicity for grade 3 constipation. Maximum-tolerated dose was not reached. No partial responses were observed. Median time on therapy was 8 weeks, with 29% of patients treated beyond 16 weeks and a median overall survival of 7.2 months. QOL and fatigue levels were stable from baseline to 8 weeks. Higher MGE dose was correlated with improvement in self-reported physical well-being QOL at 8 weeks (r=0.6; P=0.04).Conclusions:MGE is safe and well-tolerated in heavily pretreated and older cancer patients. The potential anticancer properties and the effects of MGE on physical well-being and QOL metrics will be evaluated in future studies.

2020-09-01·Phytopathology®2区 · 农林科学

Grapevine Resistance to the NematodeXiphinema indexIs Durable in Muscadine-Derived Plants Obtained from Hardwood Cuttings but Not from In Vitro

2区 · 农林科学

Article

作者: Khallouk, Samira ; Lafargue, Maria ; Van Ghelder, Cyril ; Banora, Mohamed Youssef ; Esmenjaud, Daniel ; Portier, Ulysse ; Tandonnet, Jean-Pascal ; Ollat, Nathalie ; Nguyen, Van Chung

Breeding for varieties carrying natural resistance (R) against plant-parasitic nematodes is a promising alternative to nematicide ban. In perennial crops, the long plant−nematode interaction increases the risk for R breaking and R durability is a real challenge. In grapevine, the nematode Xiphinema index has a high economic impact by transmitting Grapevine fanleaf virus (GFLV) and, to delay GFLV transmission, rootstocks resistant to this vector are being selected, using Muscadinia rotundifolia in particular as an R source. To optimize in fine this strategy, the durability has been studied under controlled conditions in F1 and BC1 muscadine-derived resistant accessions previously obtained from either hardwood-cutting or in vitro propagation. After inoculation with a mix, in equal proportions, of four lines representative of the X. index diversity, multiplication on plants has been monitored 3 to 6 years. The nematode reproduction factor remained lower than 1 in resistant plants obtained from hardwood cuttings while it increased at values far beyond 1 in resistant plants of in vitro origin. Data for nematode numbers per gram of roots mostly paralleled those obtained for the reproduction factor. The effect of the propagation type on resistance over years was also evaluated for the ratio female/juvenile and the frequency of males. Altogether our results illustrate that the muscadine-derived resistance based on hardwood cuttings is durable. By contrast, in resistant and reference accessions obtained from in vitro, our data suggest that the increased nematode multiplication might be mainly due to the modification of root architecture consecutive to this propagation method.

2019-06-01·Journal of Food Biochemistry3区 · 农林科学

Comparison of non‐anthocyanin polyphenol accumulation in the berry skins of muscadine and European grapes during ripening in China

3区 · 农林科学

Article

作者: Wei, Zheng ; Huang, Yu ; Qu, Junjie ; Yin, Ling ; Song, Shiren ; Zhang, Yali ; Guo, Wenfeng ; Lu, Jiang

The non-anthocyanin polyphenol accumulation in the berry skins of muscadine grapes from South China during ripening was investigated, in comparison to European grapes, for two consecutive years, using ultra-performance liquid chromatography tandem triple quadrupole time-of-flight mass spectrometry. A total of 121 components were tentatively identified, consisting of 48 ellagic acids and precursors (EP), 38 flavonols, 20 hydroxybenzoic acids, 6 hydroxycinnamic acids, 5 flavan-3-ols, and 4 stilbenes. EP (mostly ellagic acid derivatives) and flavonols (mainly isorhamnetin and quercetin derivatives) were, respectively, accumulated abundantly in the muscadine and European grape skins. Additionally, their variation had considerable differences during berry maturation. EP in muscadine cv. "Noble" skins showed a small decrease before veraison and a slight increase post-veraison, yet the flavonols significantly increased as berry maturation in European skins, with a few exceptions. This is the interactional result between genotype and environmental factors, which obviously influences the polyphenol composition and concentration. PRACTICAL APPLICATIONS: Muscadine grapes, indigenous to the southeast of United States, have been introduced to South China in recent years. These grapes have unique polyphenol composition that differs from non-muscadine grapes. Their polyphenol properties have been studied extensively in many but there are a few studies in our knowledge about the variation of these compounds at different berry developmental stages. This article evaluates the accumulation of non-anthocyanin polyphenols in muscadine skins during berry maturation, in comparison to European grapes. The findings exhibit the polyphenol characteristics of these grapes cultivated in new locations across South China, and make further efforts to increase breeding quality and agronomic production, through improving preharvest treatments and agronomic performance during berry developmental stages, that lead to a high increase of polyphenol.

100 项与圆叶葡萄皮提取物相关的药物交易

登录后查看更多信息

研发状态

10 条进展最快的记录,

登录

后查看更多信息

适应症	最高研发状态	国家/地区	公司	日期
非转移性前列腺癌	临床3期	美国	The Johns Hopkins University	2024-01-25
非转移性前列腺癌	临床3期	美国	Huntsman Cancer Institute	2024-01-25
非转移性前列腺癌	临床3期	美国	Hope Medical Center	2024-01-25
晚期癌症	临床1期	美国	National Cancer Institute	2016-03-01
不可切除的恶性实体瘤	临床1期	美国	National Cancer Institute	2016-03-01
前列腺腺癌	药物发现	美国	The Sidney Kimmel Comprehensive Cancer Center	2018-10-30

登录后查看更多信息

临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT02583269 (ASCO2018)	临床1期	晚期癌症	23	Muscadine grape extract	醖簾鑰鏇衊繭衊鹹鬱鏇(願餘網壓鑰糧網餘鏇齋) = 艱顧顧積鏇窪鹽顧憲觸衊醖艱簾鹽築壓鑰衊鑰 (夢選範醖顧願鑰鬱鏇鹽 ) 更多	-	2018-06-01
NCT01317199 (ASCO_GU2014)	临床1期	非转移性前列腺癌	14	Muscadine Grape Skin (MPX)	鏇鬱醖範願觸簾夢鏇襯(鑰簾鑰網顧壓鹽網壓製) = 鏇齋築淵遞選夢網艱膚鏇顧衊鑰襯觸壓獵願廠 (鬱鑰艱製製夢艱夢衊範 )	-	2014-02-01
NCT01317199 (ASCO_GU2014)	临床1期	非转移性前列腺癌	14	Placebo	鏇鬱醖範願觸簾夢鏇襯(鑰簾鑰網顧壓鹽網壓製) = 簾積鹽遞鑰壓醖築蓋糧鏇顧衊鑰襯觸壓獵願廠 (鬱鑰艱製製夢艱夢衊範 )	-	2014-02-01