作者: Françoise Bono ; Jacques Bonnet ; Isabelle Ader ; Paul Schaeffer ; Elizabeth Cohen-Jonathan-Moyal ; Nicolas Skuli ; Christine Toulas ; Caroline Delmas

Resistance of glioblastoma to radiotherapy is mainly due to tumour cell radioresistance, which is partially controlled by growth factors such as fibroblast growth factor (FGF). Because we have previously demonstrated the role of FGF-2 in tumour cell radioresistance, we investigate here whether inhibiting FGF-2 pathways by targeting fibroblast growth factor receptor (FGFR) may represent a new strategy to optimise the efficiency of radiotherapy in glioblastoma. Treating radioresistant U87 and SF763 glioblastoma cells with the FGFR inhibitor, SSR12819E, radiosensitises these cells while the survival after irradiation of the more radiosensitive U251 and SF767 cells was not affected. SSR128129E administration to U87 cells increases the radiation-induced mitotic cell death. It also decreased cell membrane availability of the FGFR-1 mainly expressed in these cells, increased this receptor's ubiquitylation, inhibited radiation-induced RhoB activation and modulated the level of hypoxia inducible factor, HIF-1α, a master regulator of hypoxia, thus suggesting a role of FGFR in the regulation of hypoxia pathways. Moreover, treating orthotopically U87 xenografted mice with SSR128129E before two subsequent local 2.5Gy irradiations significantly increased the animals neurological sign free survival (NSFS) compared to the other groups of treatment. These results strongly suggest that targeting FGFR with the FGFR blocker SSR128129E might represent an interesting strategy to improve the efficiency of radiotherapy in glioblastoma.

项与 Fibroblast growth factor pellets(Montefiore Medical Center) 相关的新闻（医药）

2023-08-09

·BioSpace

Anteris Technologies Commences US Early Feasibility Study

BRISBANE, Australia & MINNEAPOLIS--(BUSINESS WIRE)-- Anteris Technologies Ltd, (Anteris or the Company) (ASX: AVR, OTC: ANTTY) reported today that DurAVR™ Transcatheter Heart Valve (THV), a new class of biomimetic valve and the world’s only biomimetic, single-piece transcatheter aortic valve, was used to successfully to treat patients as part of the DurAVR™ THV Early Feasibility Study (EFS or the Study) in the United States. The EFS is an essential step towards receiving FDA approval in the US and commercialization of this innovative medical technology. This press release features multimedia. View the full release here: Dr Azeem Latib and his team from Montefiore Health System with Anteris Technologies employees. (Photo: Business Wire) Dr. Azeem Latib, Director of Interventional Cardiology, Director of Structural Heart Interventions at Montefiore Health System, New York, and Study National Principal Investigator (IC), performed the first group of US DurAVR™ THV procedures. The first group of severe aortic stenosis patients treated with DurAVR™ THV had intraoperatively, post-implant EOAs of 2.2cm2, and average mean gradients of 4mmHg. Dr. Latib commented: “Having previously traveled to Europe with Anteris to implant patients with DurAVR™ THV, I am delighted to note that the post-procedure patient outcomes seen in US patients at my center corroborate with data reported from previous cohorts. The ability to use this device with such excellent hemodynamic results, as well as ease of use, is incredible progress in the treatment of patients with severe aortic stenosis. We look forward to many more cases in the near future.” The EFS Study is evaluating the safety and feasibility of DurAVR™ THV in the treatment of subjects with symptomatic severe native aortic stenosis (AS). Enrolling ≥15 subjects at 7 Heart Valve Centers of Excellence within the United States. Dr. Mike Reardon, Chair of Cardiovascular Research at the Houston Methodist DeBakey Hospital, is the Study Chair. This is an FDA-designated category B study and approved by CMS for reimbursement. The primary endpoint of this Study at 30 days post-implantation will assess safety and device feasibility. This US EFS Study data will pave the way for a pivotal registrational trial. Wayne Paterson, CEO of Anteris Technologies, commented: “The successful treatment of these patients in the United States is yet another important milestone on our path to commercialization of the DurAVR™ TAVR system. The patients enrolled at Montefiore Hospital in New York this week add to our body of evidence that supports the use case of DurAVR™ THV and its clinical superiority and validates the reproducibility of our data and the stellar performance to date. Today’s patients had excellent outcomes with intraoperative mean gradients of 4mmHg. This further supports the case that DurAVR™ is both clinically viable and will be an important product for the treatment of aortic stenosis in the future, giving patients and physicians alternatives to current therapies.” Dr. Chris Meduri, CMO of Anteris Technologies, added: “We are pleased with the excellent results achieved by Dr. Latib and the team at Montefiore. We look forward to sharing the results at TCT 2023.” About Anteris Technologies Ltd (ASX: AVR) Anteris Technologies Ltd (ASX: AVR) is a structural heart company committed to designing, developing, and commercializing innovative medical devices. Founded in Australia, with a significant presence in Minneapolis, USA, a MedTech hub, Anteris is science-driven, with an experienced team of multidisciplinary professionals delivering transformative solutions to structural heart disease patients. The Company’s lead product, DurAVR™, is a transcatheter heart valve (THV) for the treatment of aortic stenosis. DurAVR™ THV has been designed in partnership with the world’s leading interventional cardiologists and cardiac surgeons and is the first transcatheter aortic valve replacement (TAVR) to use a single piece of bioengineered tissue. This biomimetic valve is uniquely shaped to mimic the performance of a healthy human aortic valve. DurAVR™ is made using ADAPT® tissue, Anteris’ patented anti-calcification tissue technology. ADAPT® tissue has been used clinically for over 10 years and distributed for use in over 50,000 patients worldwide. Controlled deployment and accurate placement of DurAVR™ THV is via Anteris’ proprietary ComASUR™ Delivery System. This system allows precision alignment with the heart’s native commissures to achieve optimal valve positioning. Anteris Technologies is set to revolutionize the structural heart market by delivering clinically superior solutions that meet significant unmet clinical needs. Authorization and Additional Information This announcement was authorized by the Board of Directors. View source version on businesswire.com: Contacts For more information: Investor contact (US) Malini Chatterjee, Ph.D. Managing Director Blueprint Life Science Group +1 917 330 4269 Investor contact (AUS) Dejan Toracki Corporate Development Anteris Technologies +61 409 340 641 Website Twitter @AnterisTech Facebook LinkedIn Source: Anteris Technologies Ltd, Smart Multimedia Gallery Photo Dr Azeem Latib and his team from Montefiore Health System with Anteris Technologies employees. (Photo: Business Wire) Photo Anteris Technologies DurAVR™ Transcatheter Heart Valve (Photo: Business Wire) Logo View this news release and multimedia online at:

临床研究快速通道

2022-06-15

·GlobeNewswire-Health Care

PolyPid Hosting Key Opinion Leader Webinar on Managing the Cost of Surgical Site Infections

PETACH TIKVA, Israel, June 15, 2022 (GLOBE NEWSWIRE) -- PolyPid Ltd. (Nasdaq: PYPD) (“PolyPid” or the “Company”), a late-stage biopharma company aiming to improve surgical outcomes, today announced that it will host a key opinion leader (“KOL”) webinar on the cost of managing surgical site infections (“SSIs”) on Thursday, June 23, 2022, at 10:00 AM Eastern Time. The webinar will feature presentations from KOLs Kyle Cologne, M.D., Los Angeles County General – USC Medical Center, who will provide a general-hospital perspective on the cost of managing SSIs, and Elliot Goodman, M.D., Mount Sinai Health System, who will discuss the impact SSIs have on quality measures and performance from an integrated delivery network (IDN) perspective. The PolyPid leadership team will provide a corporate update, including a discussion on the timing of the topline results following the recent completion of patient enrollment in the SHIELD I Phase 3 study of D-PLEX100 for the prevention of SSIs in abdominal surgery. A question and answer session will follow. To register for the event, please click here. About the Speakers Kyle Cologne, M.D., completed his general surgery training in Chicago at Rush University and Cook County Medical Centers, followed by a fellowship in Colon and Rectal Surgery at the University of Southern California, where he joined the faculty in 2012. He is the current fellowship director for the colorectal training program. Dr. Cologne is double board certified in general and colorectal surgery. He is the recipient of several awards including Castle Connelly, Pasadena and Los Angeles Top Doctor distinctions. He has performed more than 1,000 major colorectal procedures. Dr. Cologne serves as the Vice Chair of the Quality Committee in the Department of Surgery and is the physician champion for colorectal surgical site infections and National Surgical Quality Improvement Program (NSQIP). He serves as a section editor for the Diseases of the Colon and Rectum Journal where he is the host of a podcast and is the immediate past President of the Southern California Chapter of the American Society of Colon and Rectal Surgeons. Elliot Goodman, M.D., was born in London and educated at the University of Cambridge. After one year of postgraduate training in Cambridge and London, the United Kingdom, he moved to the United States in 1990 and trained as a general surgeon at Maimonides Medical Center in Brooklyn, New York. During this period of training, he spent two years as a research fellow at Columbia University. After spending time as a trauma fellow at the Coney Island Hospital in Brooklyn, New York, Dr. Goodman joined the faculty of the New Jersey Medical School. After two-and-a-half years in New Jersey, Dr. Goodman moved to Montefiore Medical Center (“Montefiore”), where he became Chief of Bariatric Surgery. After a successful four-and-a-half year tenure at Montefiore, Dr. Goodman was recruited by Beth Israel Medical Center to become their Chief of Bariatric Surgery in 2004. After engagements at the new Mount Sinai Beth Israel and Mount Sinai Brooklyn hospitals as Head of House Staff, Associate Chief of Surgery and Vice-Chair for Surgical Quality, he was appointed in January 2022 as Associate Director for Systems Quality and Performance in Surgery for the entire 8-hospital Mount Sinai Health System. Dr. Goodman is on the faculty of the Icahn School of Medicine at Mount Sinai. He is a visiting professor at Ben-Gurion University, Bar Ilan University (both in Israel) and EDU (in Malta) and is the North American coordinator for the global surgical community of The Upper Gastro-intestinal Surgeons society (TUGS). Dr. Cologne and Dr. Goodman both serve as advisors to PolyPid. About PolyPid PolyPid Ltd. (Nasdaq: PYPD) is a late-stage biopharma company aiming to improve surgical outcomes. Through locally administered, controlled, prolonged-release therapeutics, PolyPid’s proprietary PLEX (Polymer-Lipid Encapsulation matriX) technology pairs with Active Pharmaceutical Ingredients (APIs), enabling precise delivery of drugs at optimal release rates over durations ranging from several days to months. PolyPid’s lead product candidate D-PLEX100 is in Phase 3 clinical trials for the prevention of soft tissue abdominal and sternal bone surgical site infections. In addition, the Company is currently in preclinical stages to test the efficacy of OncoPLEX for treatment of solid tumors, beginning with glioblastoma. For additional Company information, please visit http://www.PolyPid.com and follow us on Twitter and LinkedIn. References and links to websites have been provided as a convenience, and the information contained on such websites is not incorporated by reference into this press release. PolyPid is not responsible for the contents of third-party websites. Corporate Contact: PolyPid Ltd.Dikla Czaczkes AkselbradEVP & CFOTel: +972-747195700 Investor Contact:Bob YedidLifeSci Advisors646-597-6989Bob@LifeSciAdvisors.com Media Contact:Nechama FeuersteinFINN Partners551-444-0784Nechama.Feuerstein@finnpartners.com

100 项与 Fibroblast growth factor pellets(Montefiore Medical Center) 相关的药物交易

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