Recent studies that examined the treatment efficacy of Candida antigen injection for both non-genital and genital warts yield inconsistent results. To address this, a systematic review and meta-analysis was conducted, comparing the treatment response between Candida antigen injection therapy and other intralesional immunotherapies across all types of warts. PubMed, Cochrane Library, and Embase were searched for relevant randomized controlled trials (RCTs) from inception to 16 September 2023, and 24 eligible RCTs were identified. A protocol was developed using the PRISM A-P checklist. In terms of complete clearance, intralesional Candida injection therapy demonstrated a significant improvement compared with saline (risk ratio [RR] 5.39; 95% confidence interval [CI] 3.49-8.33; I2=0%). However, no statistically significant differences were observed when compared with other therapies such as mumps-measles-rubella vaccines, purified protein derivative, vitamin D3, bivalent human papillomavirus vaccine, and zinc sulphate. Adverse effects associated with intralesional Candida therapy were generally reported as mild and manageable. In conclusion, intralesional Candida injection therapy for cutaneous warts may exhibit a superior complete and distant response rate. Nevertheless, owing to a limited sample size and other limitations, future research should aim for larger studies to provide more conclusive evidence.

1980-07-01·Journal of Biological Standardization

Determination of phenol in injectable biological products by gas chromatography

Article

作者: Robert P. Barron ; Joan C. May ; Alfred V. Del Grosso

The USP (1975) gas chromatog. procedure for the determination of phenol [108-95-2] in injectable products was extended and validated as a method for the determination of PhOH in a wide variety of biol. products, such as, vaccines, tuberculin purified protein derivative, antivenins, and aqueous glycerinated and alum precipitated allergenic extractsThe average recovery of PhOH at 0.3-0.5% PhOH level was 99.6%.The average precision was measured as a relative standard deviation of 0.43%.Glycerin contained in glycerinated allergenic extracts and tuberculin purified protein derivative did not interfere with quantitation.Precipitate produced upon the addition of internal standard solution (PhCH₂OH in 100% MeOH) to horse serum-derived antitoxins, antivenins and antirabies serum was eliminated by the use of 5% (or 0%) MeOH in H₂O as the diluent in the internal standard solution

Annali Sclavo; rivista di microbiologia e di immunologia

Preparation and characterization of a large batch of tuberculin purified protein derivate (PPD-CT68).

Article

作者: Held, H R ; Landi, S

100 项与结核菌素纯蛋白衍生物(成都可恩生物) 相关的药物交易

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