预约演示
更新于：2025-02-28
JNJ-39393406
更新于：2025-02-28
概要
基本信息
登录后查看时间轴
结构/序列
分子式C19H18F2N6O3 |
InChIKeyIURMHZBQEYNQOH-UHFFFAOYSA-N |
CAS号953428-73-4 |
关联
8
项与 JNJ-39393406 相关的临床试验NCT02677207
The Effects of JNJ-39393406 on Psychometric Performance and Residual Depressive Symptoms in 80 Patients With Unipolar or Bipolar Depression: a Phase II Exploratory add-on Double Blind Placebo Controlled 2 Week Trial
EUCTR2015-002106-36-RO
The effects of JNJ-39393406 on psychometric performance and residual depressive symptoms in 80 patients with unipolar or bipolar depression: a phase II exploratory add-on double blind placebo controlled 2 week trial
NCT02217527
Development of a Novel Therapeutic for Smoking Cessation
100 项与 JNJ-39393406 相关的临床结果
登录后查看更多信息
100 项与 JNJ-39393406 相关的转化医学
登录后查看更多信息
100 项与 JNJ-39393406 相关的专利（医药）
登录后查看更多信息
7
项与 JNJ-39393406 相关的文献（医药）2021-10-01European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology3区 · 医学
The effects of JNJ-39393406 a positive allosteric nicotine modulator on mood and cognition in patients with unipolar depression: A double-blind, add-on, placebo-controlled trial
3区 · 医学
Article
作者: Carla Canuso ; Linda Levi ; Igor Nastas ; Lisa Ford ; Jinyoung Park ; John M. Davis ; Michael Davidson ; Mark Weiser ; Stefanie Rassnick
Nicotinic agonists have been shown to improve cognition and mood, but this improvement is inconsistent and short-lived, possibly due to receptor desensitization. Positive Allosteric Modulators (PAMs) of the nicotinic alpha-7 nicotinic-acetyl-choline receptor (a7nAChR) are hypothesized to change the configuration of the nicotinic receptor and delay desensitization, potentially increasing the duration of the activation of the receptor, and improving clinical efficacy. This was a randomized controlled trial (RCT) adding JNJ-39393406 9 (a PAM of the a7nAChR) (n=35) or placebo (n=36) to treatment as usual for two weeks in 71 patients with unipolar depression. Mixed models for repeated measures analyses were performed Primary outcome measures were the Brief Assessment of Cognition in Schizophrenia (BACS) composite and the Montgomery-Asperg Depression Rating Scale (MADRS) scores. The drug was well tolerated, however mixed models for repeated measures comparing JNJ-39393406 to placebo showed no significant difference for MADRS total score (p=0.78), BACS composite score (p=0.34), or any of the secondary outcome measures. There was no significant difference in adverse events between the study groups (p=0.44). In conclusion, this study's findings do not support the hypothesis that a positive nicotinic receptor modulator can improve cognitive or depressive symptomatology in patients with unipolar depression.
2020-01-01International journal of pharmaceutics2区 · 医学
Comparison of induction methods for supersaturation: pH shift versus solvent shift
2区 · 医学
Article
作者: Rades, Thomas ; Müllertz, Anette ; Pérez-Alós, Laura ; Palmelund, Henrik ; Bavnhøj, Christoffer ; Plum, Jakob
In order to investigate the supersaturation propensity of drugs in a simple and small-scale setup, induction of supersaturation is often performed via solvent shift. For weak bases, a potentially more biorelevant induction method would be a pH shift, as it is often hypothesized that the induction method will impact the supersaturation and precipitation. However, this has not been investigated systematically in a pharmaceutical context. This study investigates the impact of the induction method of supersaturation for nine basic drugs, A0619, A2853, albendazole, cinnarizine, dipyridamole, intraconazole, JNJ39393406, ketoconazole, and posaconazole, on four parameters: highest apparent degree of supersaturation, induction time, precipitation rate and solid form of the precipitate, using a novel standardized small-scale supersaturation and precipitation method. For eight of the nine drugs, the same highest apparent degree of supersaturation was obtained with both induction methods. For the induction time, precipitation rate and the solid form of the precipitate, no systematic differences between the induction methods were detected, however individual drugs did show differences. The study shows that, if a drug is sufficiently soluble at low pH, the solvent shift and pH shift induction methods of supersaturation yield comparable results.
2019-12-01Stem cell research4区 · 医学
Alpha7 nicotinic acetylcholine receptors and neural network synaptic transmission in human induced pluripotent stem cell-derived neurons
4区 · 医学
ArticleOA
作者: Larsen, Hjalte M ; Hyttel, Poul ; Stummann, Tina C ; Hansen, Susanne K ; Mikkelsen, Jens D
The α7 nicotinic acetylcholine receptor has been extensively researched as a target for treatment of cognitive impairment in Alzheimer's disease and schizophrenia. Investigation of the α7 receptor is commonly performed in animals but it is critical to increase the biologically relevance of the model systems to fully capture the physiological role of the α7 receptor in humans. For example most humans, in contrast to animals, express the hybrid gene CHRFAM7A, the product of which modulates α7 receptor activity. In the present study, we used human induced pluripotent stem cell (hiPSC) derived neurons to establish a humanized α7 model. We established a cryobank of neural stem cells (NSCs) that could reproducibly be matured into neurons expressing neuronal markers and CHRNA7 and CHRFAM7A. The neurons responded to NMDA, GABA, and acetylcholine and exhibited synchronized spontaneous calcium oscillations. Gene expression studies and application of a range of α7 positive allosteric modulators (PNU-120595, TQS, JNJ-39393406 and AF58801) together with the α7 agonist PNU-282987 during measurement of intracellular calcium levels demonstrated the presence of functional α7 receptors in matured hiPSC-derived neuronal cultures. Pharmacological α7 activation also resulted in intracellular signaling as measured by ERK 1/2 phosphorylation and c-Fos protein expression. Moreover, PNU-120596 increased the frequency of the spontaneous calcium oscillations demonstrating implication of α7 receptors in human synaptic networks activity. Overall, we show that hiPSC derived neurons are an advanced in vitro model for studying human α7 receptor pharmacology and the involvement of this receptor in cellular processes as intracellular signaling and synaptic transmission.
1
项与 JNJ-39393406 相关的新闻（医药）2024-09-12
临床2期快速通道临床1期并购
100 项与 JNJ-39393406 相关的药物交易
登录后查看更多信息
外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | - | - |
研发状态
10 条进展最快的记录, 后查看更多信息
登录
| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 抑郁症 | 临床2期 | 摩尔多瓦 | 2016-02-01 | |
| 抑郁症 | 临床2期 | 罗马尼亚 | 2016-02-01 | |
| 分裂情感性障碍 | 临床2期 | 美国 | 2014-09-01 | |
| 精神分裂症 | 临床2期 | 美国 | 2014-09-01 | |
| 尼古丁成瘾 | 临床2期 | 美国 | 2014-09-01 | |
| 烟草依赖 | 临床2期 | - | - | |
| 烟草依赖 | 临床2期 | - | - | |
| 烟草依赖 | 临床2期 | - | - | |
| 阿尔茨海默症 | 临床1期 | 德国 | 2009-08-01 | |
| 认知障碍 | 临床1期 | 德国 | 2009-08-01 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
临床2期 | 36 | placebo (Order 1--JNJ Active Then Plac) | 鹽構艱築範憲憲範襯網(繭遞鹹艱壓醖獵獵觸廠) = 窪鬱憲壓膚憲築艱襯鏇 觸製艱衊鹹積觸淵餘壓 (襯蓋襯壓鬱繭遞艱獵膚, 餘簾繭鏇艱蓋蓋衊製簾 ~ 遞淵獵繭獵鬱顧獵觸憲) 更多 | - | 2018-08-15 | ||
Placebo (Order 2--Placebo Then JNJ Active) | 鹽構艱築範憲憲範襯網(繭遞鹹艱壓醖獵獵觸廠) = 獵繭淵廠網鑰憲簾範餘 觸製艱衊鹹積觸淵餘壓 (襯蓋襯壓鬱繭遞艱獵膚, 獵醖簾淵醖繭壓夢獵遞 ~ 獵醖淵顧鬱顧鏇窪齋鑰) 更多 | ||||||
临床2期 | 62 | Placebo Pill+Active JNJ Drug (Active JNJ Drug) | 築鬱膚鏇觸鏇憲膚顧壓(壓窪壓廠襯廠膚願製窪) = 願繭選餘遞壓壓繭範窪 壓衊觸範襯憲醖廠衊範 (壓鏇襯鑰築積鬱廠顧製, 築顧壓範餘積簾蓋醖醖 ~ 齋構鹽繭顧憲鏇鬱醖範) 更多 | - | 2018-01-30 | ||
Placebo Pill+Active JNJ Drug (Placebo Pill) | 築鬱膚鏇觸鏇憲膚顧壓(壓窪壓廠襯廠膚願製窪) = 構築選顧製鹹製範壓構 壓衊觸範襯憲醖廠衊範 (壓鏇襯鑰築積鬱廠顧製, 範夢獵簾鹽選衊艱憲壓 ~ 壓廠餘簾憲醖蓋醖衊願) 更多 |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
来和芽仔聊天吧
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用