Birch pollen allergy vaccine(Anergis)(Birch pollen allergy vaccine(Anergis))

概要

基本信息

药物类型

变应原提取物

别名

AllerT、AllerT-Birch

靶点-

作用方式

调节剂

作用机制

免疫调节剂

治疗领域

免疫系统疾病感染眼部疾病+ [2]

在研适应症-

非在研适应症

过敏性鼻结膜炎过敏过敏性鼻炎+ [2]

原研机构

University of Lausanne

在研机构-

非在研机构

Anergis SA

最高研发阶段终止临床2期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

5

项与 Birch pollen allergy vaccine(Anergis) 相关的临床试验

EUCTR2016-000076-23-DE

/ Not yet recruiting临床2期

A MULTICENTRE, DOUBLE-BLIND, PLACEBO-CONTROLLED, RANDOMIZED TRIAL TO ASSESS THE EFFICACY AND TOLERABILITY OF TWO DOSING REGIMENS OF ALLERT, A COMBINATION OF CONTIGUOUS OVERLAPPING PEPTIDES DERIVED FROM BET V 1, IN ADULTS WITH BIRCH POLLEN ALLERGIC RHINITIS/RHINOCONJUNCTIVITIS

开始日期2016-11-03

申办/合作机构

Anergis SA

NCT02943720

/ Completed临床2期

A Multicentre, Double-blind, Placebo-Controlled, Randomized Trial to Assess the Efficacy and Tolerability of Two Dosing Regimens of AllerT in Adults With Birch Pollen Allergic Rhinitis

A multicentre, Double-blind, Placebo-Controlled, Randomized Trial to Assess the Efficacy and Tolerability of Two Dosing Regimens of AllerT, a Combination of Contiguous Overlapping Peptides Derived from Bet v 1, in Adults with Birch Pollen Allergic Rhinitis/Rhinoconjunctivitis

开始日期2016-09-01

申办/合作机构

Anergis SA

NCT02271009

/ Completed临床2期

A Double-Blind, Placebo-Controlled, Randomized Trial to Compare the Efficacy and Tolerability of Three Dose Regimens of AllerT, in Adults With Allergic Rhino-Conjunctivitis to Birch Pollen Studied in Environmental Exposure Chamber

The purpose of this study is to find the optimal dose of AllerT that should be used to treat moderate to severe allergies due to birch tree pollen.
There are 4 treatment groups in this study; 3 treatment groups will receive AllerT at different doses and 1 treatment group will receive placebo.
This study will also assess the effectiveness and safety of AllerT compared to placebo in relieving allergy symptoms.

开始日期2014-10-01

申办/合作机构

Anergis SA

[+1]

100 项与 Birch pollen allergy vaccine(Anergis) 相关的临床结果

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100 项与 Birch pollen allergy vaccine(Anergis) 相关的转化医学

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100 项与 Birch pollen allergy vaccine(Anergis) 相关的专利（医药）

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1

项与 Birch pollen allergy vaccine(Anergis) 相关的文献（医药）

2014-07-01·Journal of Allergy and Clinical Immunology1区 · 医学

Safety and immunogenicity of immunotherapy with Bet v 1–derived contiguous overlapping peptides

1区 · 医学

Letter

作者: Audran, Régine ; Boudousquié, Caroline ; Thierry, Anne-Christine ; Pellaton, Céline ; Reymond, Christophe ; Perrin, Yannick ; Spertini, François ; Barbier, Nathalie ; Charlon, Vincent

This article presents the safety and immunogenicity of immunotherapy with Bet v 1-derived contiguous overlapping peptides.Clin. trial showed that 5 injections of AllerT administered over 2 mo elicit a strong immune response in the range of that observed after 50 injections and 3 years with other allergens and led to long-term immunol. memory were presented.Changes from baseline in Bet v 1-specific IgG4 and IgE levels were determined, and the ratios of normalized anti-Bet v 1 IgG4 and anti-Bet v 1 IgE over baseline were shown graphically.On an exploratory basis, P values for the median fold difference in IgG4 and IgE levels between AllerT- and placebo-treated patients were determined by using the nonparametric, nonpaired Mann-Whitney test.

100 项与 Birch pollen allergy vaccine(Anergis) 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
季节性过敏性鼻炎	临床2期	法国	Anergis SA	2012-10-01
季节性过敏性鼻炎	临床2期	拉脱维亚	Anergis SA	2012-10-01
鼻结膜炎	临床2期	立陶宛	Anergis SA	2012-10-01
鼻结膜炎	临床2期	拉脱维亚	Anergis SA	2012-10-01
鼻结膜炎	临床2期	瑞士	Anergis SA	2012-10-01
鼻结膜炎	临床2期	瑞典	Anergis SA	2012-10-01
鼻结膜炎	临床2期	波兰	Anergis SA	2012-10-01
鼻结膜炎	临床2期	丹麦	Anergis SA	2012-10-01
鼻结膜炎	临床2期	法国	Anergis SA	2012-10-01
过敏	临床2期	瑞士	Anergis SA	2008-08-01

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临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01720251 (CTgov)	临床2期	鼻结膜炎 \| 季节性过敏性鼻炎	240	placebo (Placebo)	廠遞獵衊鬱鑰蓋鹹願鏇(觸願網鏇鹽選願餘窪網) = 鹹鑰鹽艱網艱範願顧夢夢鬱築夢構餘艱顧鏇鹹 (獵獵選夢鏇鑰夢觸窪鬱, 憲願築願醖獵憲網蓋衊 ~ 範窪衊鹹選築艱憲顧鏇) 更多	-	2015-04-13
				AllerT low dose (AllerT Low Dose)	廠遞獵衊鬱鑰蓋鹹願鏇(觸願網鏇鹽選願餘窪網) = 齋衊積鏇鬱齋鏇淵艱鏇夢鬱築夢構餘艱顧鏇鹹 (獵獵選夢鏇鑰夢觸窪鬱, 膚顧網繭壓鏇構製艱壓 ~ 鹹艱窪膚觸壓網鑰膚獵)