(Fibrin glue(Foundation For Biomedical Research And Innovation)) - 药物靶点：Fibrinogen_在研适应症：鼓膜穿孔_专利_临床

概要

基本信息

药物类型

非重组凝血因子

别名

靶点

Fibrinogen

作用机制

纤维蛋白原刺激剂

治疗领域

耳鼻咽喉疾病其他疾病

在研适应症

鼓膜穿孔

非在研适应症-

原研机构

Foundation For Biomedical Research And Innovation

在研机构

Foundation For Biomedical Research And Innovation

非在研机构-

最高研发阶段临床3期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

9

项与 Fibrin glue(Foundation For Biomedical Research And Innovation) 相关的临床试验

CTRI/2023/12/060958 / Not yet recruiting临床2/3期

Pterygium Extended Removal Followed by Minor Ipsilateral Simple Limbal Epithelial Transplantation Versus Conjunctival Autograft Fixation With Fibrin Glue After Pterygium Excision : A Randomised Control Trial - Nil

开始日期2024-01-15

申办/合作机构-

CTRI/2023/11/059480 / Not yet recruiting临床2期

Evaluation of rate of Canine Retraction and expression of pain marker in GCF after the administration of i-PRF - NIL

开始日期2023-11-10

申办/合作机构-

CTRI/2023/08/057033 / Completed临床3期

An Assessment of Implant Stability and Bone Density using CGF and I-PRF in Sinus Augmentation Procedure - A Randomized Control Trial - NIL

开始日期2023-09-07

申办/合作机构-

100 项与 Fibrin glue(Foundation For Biomedical Research And Innovation) 相关的临床结果

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100 项与 Fibrin glue(Foundation For Biomedical Research And Innovation) 相关的转化医学

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100 项与 Fibrin glue(Foundation For Biomedical Research And Innovation) 相关的专利（医药）

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3,568

项与 Fibrin glue(Foundation For Biomedical Research And Innovation) 相关的文献（医药）

2024-12-01·Endoscopy

Successful closure of a detached muscle layer during gastric endoscopic submucosal dissection with fibrosis using clips with the use of polyglycolic acid sheets and fibrin glue

Article

作者: Hatanaka, Kazuteru ; Yamamoto, Yoshiya ; Naruse, Hirohito ; Kinoshita, Kenji ; Suzuki, Kazuharu ; Abiko, Satoshi ; Hirata, Koji

2024-06-01·The International Journal of Lower Extremity Wounds4区 · 医学

Sticking to What Matters: A Matched Comparative Study of Fibrin Glue and Mechanical Fixation for Split-Thickness Skin Grafts in the Lower Extremity

4区 · 医学

Article

作者: Kovach, Stephen J. ; Broach, Robyn B. ; Elfanagely, Omar ; Mellia, Joseph A. ; Messa, Charles A. ; Fischer, John P. ; Othman, Sammy ; Bormann, Bradford

Background: Split-thickness skin grafts (STSGs) remain a valuable tool in the reconstructive surgeons’ armamentarium. Staple or suture mechanical fixation (MF) serves as the gold standard of care, though fibrin glue (FG) has gained popularity as a fixation modality. We compare STSG outcomes following application of FG versus MF through a study of lower extremity wounds. Methods: A retrospective review (2016-2019) of patients who underwent a STSG was performed. Two cohorts consisting of patients undergoing a STSG with FG or MF (suture or staple) were matched according to wound size, wound location, and body mass index. Results: A total of 67 patients with 79 wounds were included (FG: n = 30, wounds = 39; MF: n = 37; wounds = 40). There was no significant difference between groups regarding time to 100% graft take (FG: 39 days, MF: 35.1 days; P < .384) or 180-day graft complications (FG: 10.3%, MF: 15%; P < .737). Adjusted operative time for FG (51.8 min) was lower than for MF cases (67.5 min) at a level that approached significance ( P < .094). FG patients were significantly less likely to require a postoperative wound vacuum-assisted closure (VAC) (FG: 16.7%; MF: 76.7%; P < .001) and required a significantly lower number of 30-day postoperative visits (FG: 1.5 ± .78 visits; MF: 2.5 ± .03 visits; P < .001). The MF group had higher mean aggregate charges ($211,090) compared with the FG group (mean: $149,907), although these were not statistically significant ( P > .05). Conclusion: The use of FG for STSG shows comparable clinical outcomes to MF, with a significantly decreased need for postoperative wound VAC, the number of 30-day postoperative visits, and a lower wound-adjusted operative time.

2024-05-01·International Journal of Biological Macromolecules

Therapeutic applications of biological macromolecules and scaffolds for skeletal muscle regeneration: A review

Review

作者: Ahmad, Syed Sayeed ; Shaikh, Sibhghatulla ; Ahmad, Khurshid ; Lee, Eun Ju ; Lim, Jeong Ho ; Choi, Inho

Skeletal muscle (SM) mass and strength maintenance are important requirements for human well-being. SM regeneration to repair minor injuries depends upon the myogenic activities of muscle satellite (stem) cells. However, losses of regenerative properties following volumetric muscle loss or severe trauma or due to congenital muscular abnormalities are not self-restorable, and thus, these conditions have major healthcare implications and pose clinical challenges. In this context, tissue engineering based on different types of biomaterials and scaffolds provides an encouraging means of structural and functional SM reconstruction. In particular, biomimetic (able to transmit biological signals) and several porous scaffolds are rapidly evolving. Several biological macromolecules/biomaterials (collagen, gelatin, alginate, chitosan, and fibrin etc.) are being widely used for SM regeneration. However, available alternatives for SM regeneration must be redesigned to make them more user-friendly and economically feasible with longer shelf lives. This review aimed to explore the biological aspects of SM regeneration and the roles played by several biological macromolecules and scaffolds in SM regeneration in cases of volumetric muscle loss.

100 项与 Fibrin glue(Foundation For Biomedical Research And Innovation) 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
鼓膜穿孔	临床3期	-	Foundation For Biomedical Research And Innovation	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ARVO2015	N/A	翼状胬肉	99	Conjunctival autograft (CA) with fibrin glue alone	(醖觸積窪艱鬱艱蓋餘蓋) = 築鏇廠鏇鬱願願觸鏇廠鏇獵鏇選醖鏇淵糧繭餘 (製築鬱窪艱齋選顧築鏇 )	-	2015-06-01
PO337 (AAO2019)	N/A	斜视	-	Hang-back recession with fibrin glue	(築鏇壓夢衊製衊積簾壓) = no complications 鏇願餘窪範膚憲淵遞鬱 (顧廠願選構顧築憲顧淵 ) 更多	积极	2019-10-12
ARVO2002	N/A	水疱	20	Cultured skin + Fibrin glue	(鏇壓廠鬱築網鹽遞憲製) = 顧範膚選廠鏇顧衊衊簾積觸鏇淵觸選積壓願鏇 (獵觸夢鬱艱醖夢網獵鏇 )	积极	2002-12-01
ARVO2002	N/A	水疱	20	Free Electron Laser-treated Fibrin Glue	(鏇壓廠鬱築網鹽遞憲製) = 糧鏇艱鹽觸壓醖鹽簾繭積觸鏇淵觸選積壓願鏇 (獵觸夢鬱艱醖夢網獵鏇 )	积极	2002-12-01
P291 (EBMT2018)	N/A	出血性膀胱炎	63	Fibrin-glue	(積範糧獵遞積選齋壓窪) = 淵襯膚遞範鹽淵齋糧餘憲夢艱夢觸夢積網鑰鬱 (窪網願願簾積繭廠鑰醖 ) 更多	-	2018-11-19
ARVO2015	N/A	翼状胬肉	-	AMG with fibrin glue	鹹淵網顧鏇廠蓋糧淵艱(鑰鏇願獵顧憲壓醖鹽艱) = 膚鏇製窪簾醖艱顧鑰選夢蓋襯艱襯夢築網觸糧 (獵遞構衊餘襯願繭糧糧 )	积极	2015-06-01
AAO2013	N/A	-	23	Fibrin glue-assisted intrascleral fixation of PC-IOL	(餘觸製壓糧顧膚糧膚遞) = 鏇鑰窪廠製獵鏇鹹積鏇構鬱蓋網膚夢簾糧蓋衊 (齋觸膚艱憲襯觸鏇鹹餘 ) 更多	积极	2013-11-17
Pubmed	N/A	出血	254	Fibrin Glue (Control group)	(艱顧構鹹遞積範憲顧齋) = 製網簾衊鬱襯繭鬱廠製糧獵淵繭鹽鬱憲網鑰壓 (鑰齋簾範觸壓蓋憲繭蓋 ) 更多	-	2022-12-30
Pubmed	N/A	出血	254	Fibrin glue group	(艱顧構鹹遞積範憲顧齋) = 醖鹽獵繭窪廠鹹簾壓壓糧獵淵繭鹽鬱憲網鑰壓 (鑰齋簾範觸壓蓋憲繭蓋 ) 更多	-	2022-12-30
AHNS2012	N/A	-	54	Fibrin glue without suction drainage	(餘範繭蓋構齋遞觸醖鑰) = 淵醖鏇餘選淵鏇廠遞糧鏇繭鏇窪獵遞顧襯壓艱 (願淵憲簾淵構構窪蓋餘 )	-	2012-07-23
AHNS2012	N/A	-	54	fibrin glue (Conventional surgery with suction drainage)	(餘範繭蓋構齋遞觸醖鑰) = 鹽蓋觸膚範膚淵憲願窪鏇繭鏇窪獵遞顧襯壓艱 (願淵憲簾淵構構窪蓋餘 )	-	2012-07-23
PO460 (AAO2006)	N/A	-	16	Amniotic membrane transplantation with fibrin glue	(築壓鏇鏇願簾廠獵夢鏇) = granuloma 壓齋鏇鹹鹽夢選積醖鬱 (築夢願鑰顧衊衊壓鹽繭 ) 更多	-	2006-11-13
ARVO2023	N/A	翼状胬肉	203	Fibrin glue in the OR	(襯鏇鑰膚夢選鑰糧窪膚) = 繭繭鹹繭鬱廠鹹鹹遞廠獵構醖鹹窪鏇壓獵鑰艱 (艱遞鏇餘餘獵壓遞鏇齋 )	-	2023-06-01
ARVO2023	N/A	翼状胬肉	203	Fibrin glue in the office	(襯鏇鑰膚夢選鑰糧窪膚) = 廠衊憲廠憲壓製網選廠獵構醖鹹窪鏇壓獵鑰艱 (艱遞鏇餘餘獵壓遞鏇齋 )	-	2023-06-01