Fibrin glue(Foundation For Biomedical Research And Innovation)(Fibrin glue(Foundation For Biomedical Research And Innovation))

概要

基本信息

药物类型

非重组凝血因子

别名

靶点

Fibrinogen

作用机制

纤维蛋白原刺激剂

治疗领域

耳鼻咽喉疾病其他疾病

在研适应症

鼓膜穿孔

非在研适应症-

原研机构

Foundation For Biomedical Research And Innovation

在研机构

Foundation For Biomedical Research And Innovation

非在研机构-

最高研发阶段临床3期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

10

项与 Fibrin glue(Foundation For Biomedical Research And Innovation) 相关的临床试验

CTRI/2023/12/060958

/ Completed临床2/3期IIT

Pterygium Extended Removal Followed by Minor Ipsilateral Simple Limbal Epithelial Transplantation Versus Conjunctival Autograft Fixation With Fibrin Glue After Pterygium Excision : A Randomised Control Trial - Nil

开始日期2024-01-15

申办/合作机构-

CTRI/2023/11/059480

/ Not yet recruiting临床2期IIT

Evaluation of rate of Canine Retraction and expression of pain marker in GCF after the administration of i-PRF - NIL

开始日期2023-11-10

申办/合作机构-

CTRI/2023/07/055464

/ Not yet recruiting临床4期IIT

Effectiveness of tissue glue and silk sutures after periodontal flap surgery: A split-mouth clinical study

开始日期2023-07-30

申办/合作机构-

100 项与 Fibrin glue(Foundation For Biomedical Research And Innovation) 相关的临床结果

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100 项与 Fibrin glue(Foundation For Biomedical Research And Innovation) 相关的转化医学

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100 项与 Fibrin glue(Foundation For Biomedical Research And Innovation) 相关的专利（医药）

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3,682

项与 Fibrin glue(Foundation For Biomedical Research And Innovation) 相关的文献（医药）

2025-06-01·Biomaterials

Gelatin-DOPA-knob/fibrinogen hydrogel inspired by fibrin polymerization and mussel adhesion for rapid and robust hemostatic sealing

Article

作者: Wang, Weilin ; Mao, Zhengwei ; Liu, Zhaodi ; Ding, Yuan ; Yu, Lisha ; Ding, Yihang

Tissue adhesives have attracted significant interest in the field of hemostasis. However, challenges including weak tissue adhesion, inadequate biocompatibility, and instability limit their clinical applications. Here, we have developed a gelatin-DOPA-knob/fibrinogen hydrogel inspired by the fibrin polymerization and mussel adhesion, resulting in a biocompatible bioadhesive with outstanding adhesion performance and great storage stability. This strategy involves modifying gelatin with knob peptides and catechol groups inducing crosslinking with fibrinogen to form a hydrogel via knob-hole interactions, and enhancing interfacial adhesion performance by interacting with the blood-covered tissue through catechol groups and knob peptides. This hydrogel exhibits rapid gelation, enhanced mechanical strength and adhesion properties, compared to the commonly used fibrin glue in surgery. The hydrogel significantly reduces the time required to hemostasis and the amount of blood loss in severe hemorrhage models. It ensures superior hemostatic efficacy, excellent biocompatibility, and long-term storage stability, which holds significant promise in medical settings.

2025-04-01·Tissue and Cell

Fibrin scaffold encapsulated with epigallocatechin gallate microspheres promote neural regeneration and motor function recovery after traumatic spinal cord injury in rats

Article

作者: Alissa, Mohammed ; Alshehri, Mohammed A ; Alghamdi, Abdullah

Traumatic spinal cord injury (TSCI) is a serious medical issue where there is a loss of sensorimotor function. Current interventions continue to lack the ability to successfully enhance these conditions, therefore, it is crucial to consider alternative effective strategies. Currently, we investigated the effects of fibrin scaffold encapsulated with epigallocatechin gallate (EGCG) microspheres in the recovery of SCI in rats. A total of sixty mature male Sprague-Dawley rats were separated into four groups of the same size: TSCI, fibrin, EGCG, and Fibrin+EGCG. Samples of tissue were gathered at the location of the injury for additional examination. The treatment groups showed significantly higher levels of neurons, antioxidative biomarkers (T-AOC: total antioxidant capacity, GSH: glutathione, and SOD: superoxide dismutase), neurofilament light polypeptide (NEFL) and interleukin 10 (IL-10) genes, and neurological function scores compared to the TSCI group, with the Fibrin+EGCG group displaying the most noticeable improvements. Throughout the treatment process, there was a notable reduction in the amounts of apoptotic and glial cells, as well as levels of malondialdehyde (MDA) and proinflammatory genes (TNF-α: tumor necrosis factor alpha and IL-1β: interleukin-1 beta), especially in the Fibrin+EGCG group compared to the TSCI group. Our findings suggest that EGCG enclosed in microspheres could enhance the prevention of injury spreading and the enhancement of pathological and behavioral symptoms when delivered to the location of spinal cord injury using a fibrin scaffold.

2025-02-01·Neuroimaging Clinics of North America

Image-guided Epidural Blood Patching and Fibrin Glue Occlusion of Cerebrospinal Fluid Leaks and Venous Fistulas

Review

作者: Mamlouk, Mark D. ; Mamlouk, Mark D

There have been major advances in the diagnosis and treatment of spontaneous intracranial hypotension (SIH). While once thought to be a rare condition, the occurrence is not uncommon if diagnosed adequately. Our greater understanding of SIH is based on three main points: (1) awareness of the various types of spontaneous spinal cerebrospinal fluid (CSF) leaks; (2) advanced myelography with the precision to detect dural tears and CSF-venous fistulas; and (3) updated treatment techniques of epidural patching, embolization, and surgery. This review discusses the various types of epidural patching for CSF leaks.

100 项与 Fibrin glue(Foundation For Biomedical Research And Innovation) 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
鼓膜穿孔	临床3期	-	Foundation For Biomedical Research And Innovation	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


P291 (EBMT2018)	N/A	出血性膀胱炎	63	Fibrin-glue	(窪壓鹹鏇醖願網繭襯餘) = 壓鬱襯齋蓋選觸築築願餘選鹽窪願鏇積蓋鬱廠 (窪製鑰顧顧襯糧鬱範艱 ) 更多	-	2018-11-19
AAO2013	N/A	-	23	Fibrin glue-assisted intrascleral fixation of PC-IOL	(艱鹽蓋範築憲艱壓醖構) = 願網簾製鹽憲鏇觸顧範願蓋獵繭鹽窪糧膚築繭 (齋醖齋製顧繭憲鏇壓遞 ) 更多	积极	2013-11-17
ARVO2002	N/A	水疱	20	Cultured skin + Fibrin glue	(齋繭壓簾衊憲淵觸繭鹽) = 選鏇鏇壓艱鹽範鬱齋鑰膚壓鬱鏇獵獵願簾艱艱 (積觸遞範簾觸製醖築獵 )	积极	2002-12-01
ARVO2002	N/A	水疱	20	Free Electron Laser-treated Fibrin Glue (Cultured skin + Fibrin glue + FEL @ 7.7µm)	(齋繭壓簾衊憲淵觸繭鹽) = 鹹窪顧繭繭鑰觸簾廠簾膚壓鬱鏇獵獵願簾艱艱 (積觸遞範簾觸製醖築獵 )	积极	2002-12-01