A national, prospective single arm phase II study investigating the pharmacokinetics and safety of the 2% TD1414 cream when applied 3 times daily for 7 days to adult patients with impetigo or Secondarily Infected Traumatic Lesions (SITL). A total of 20 patients will be enrolled.

开始日期2008-12-01

申办/合作机构

Leo Pharma, Inc.

NCT00626795

/ Completed临床2期

Efficacy, Safety and Tolerability of TD1414 2% Cream in Impetigo and Secondarily Infected Traumatic Lesions (SITL)

An international, multi-centre, prospective three arm parallel-group, phase II proof of concept study comparing the efficacy and safety of two dosage regimens (BID 7 days and TID 7 days) of TD1414 2% cream and one dosage regimen (BID 7 days) of Bactroban® (mupirocin) 2% cream in adults and children down to 2 years of age with impetigo or SITL. Furthermore an evaluation of the pharmacokinetics of TD1414 2% cream TID for 7 days will be performed. A total of 664 patients will be enrolled in a stepwise manner according to age groups starting with the oldest age group.

开始日期2008-02-01

申办/合作机构

Leo Pharma, Inc.

100 项与 TD-1414 相关的临床结果

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100 项与 TD-1414 相关的转化医学

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100 项与 TD-1414 相关的专利（医药）

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项与 TD-1414 相关的文献（医药）

Nature Communications1区 · 综合性期刊

Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB

1区 · 综合性期刊

ArticleOA

作者: Tam, Heng-Keat ; Oswald, Christine ; Pos, Klaas M

AbstractThe deployment of multidrug efflux pumps is a powerful defence mechanism for Gram-negative bacterial cells when exposed to antimicrobial agents. The major multidrug efflux transport system in Escherichia coli, AcrAB–TolC, is a tripartite system using the proton-motive force as an energy source. The polyspecific substrate-binding module AcrB uses various pathways to sequester drugs from the periplasm and outer leaflet of the inner membrane. Here we report the asymmetric AcrB structure in complex with fusidic acid at a resolution of 2.5 Å and mutational analysis of the putative fusidic acid binding site at the transmembrane domain. A groove shaped by the interface between transmembrane helix 1 (TM1) and TM2 specifically binds fusidic acid and other lipophilic carboxylated drugs. We propose that these bound drugs are actively displaced by an upward movement of TM2 towards the AcrB periplasmic porter domain in response to protonation events in the transmembrane domain.

100 项与 TD-1414 相关的药物交易

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
人咬伤	临床2期	美国	Leo Pharma, Inc.	2008-12-01
烧伤	临床2期	美国	Leo Pharma, Inc.	2008-12-01
脓疱疮	临床2期	南非	Leo Pharma, Inc.	2008-02-01
脓疱疮	临床2期	美国	Leo Pharma, Inc.	2008-02-01
创伤和损伤	临床2期	南非	Leo Pharma, Inc.	2008-02-01
复杂的皮肤和软组织感染	临床2期	美国	LEO Pharma A/S	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT00758862 (CTgov)	临床2期	烧伤 \| 脓疱疮 \| 创伤和损伤 \| 人咬伤	20	TD1414	鑰構憲構鏇鏇構鬱顧鹹(餘糧築獵廠鏇鬱鑰繭襯) = 構鹽鏇鬱構窪鹽鏇齋構餘顧構衊糧淵鏇積窪鑰 (簾廠糧積簾範觸膚糧顧, 鬱膚積顧淵顧艱範廠鹹 ~ 築觸築餘窪積餘製醖壓) 更多	-	2018-07-23
NCT00626795 (CTgov)	临床2期	脓疱疮 \| 创伤和损伤	773	TD1414 (TD1414 BID)	(餘夢願鹽繭夢觸網鑰鑰) = 醖襯鏇鹹觸顧構糧製憲積積鹹淵範淵蓋製鬱夢 (膚艱顧淵壓繭艱製餘蓋, 壓鏇選網選遞蓋鏇膚壓 ~ 襯觸鹹網簾鏇鏇製餘憲) 更多	-	2018-07-23
NCT00626795 (CTgov)	临床2期	脓疱疮 \| 创伤和损伤	773	TD1414 (TD1414 TID)	(餘夢願鹽繭夢觸網鑰鑰) = 遞衊鹹廠鹽簾繭鏇網構積積鹹淵範淵蓋製鬱夢 (膚艱顧淵壓繭艱製餘蓋, 壓廠選鏇積選顧積蓋夢 ~ 鬱襯醖簾淵鹽膚遞憲簾) 更多	-	2018-07-23