Chlorpheniramine Maleate/Ibuprofen/Phenylephrine Hydrochloride

Neither histamine  [51-45-6] nor cimetidine  [51481-61-9] at 1-10 mM altered the motility of human sperm.Promethazine  [60-87-7] and chlorpheniramine maleate  [113-92-8], classical antihistamines, caused concentration-dependent decreases in sperm motility, promethazine being the more potent.Histamine antagonized the promethazine-induced inhibition, but the effect was reduced at higher histamine concentrations

The extent of drug-excipient interactions involving croscarmellose Na  [74811-65-7] was estimated by using chlorpheniramine maleate  [113-92-8] as the drug.Interactions were electrostatic involving ionized croscarmellose and cations.Any weakly basic drugs at pH >2 and at ≤pK_a of the weak base interacts with the polymer.An equation is given for estimating the percentage of the drug bound to the polymer.The effect of added Na⁺ concentration on the interaction was also investigated.Increases in the Na⁺ concentration decreased the amount of the drug bound.