Study Evaluating the Safety and Efficacy of Autologous T-cells Transfected With mRNA Encoding Hepatitis-B Virus (HBV)-Antigen-specific T Cell Receptor (TCR) in Combination With Nucleos(t)Ide Analogue (NUC) for Chronic Hepatitis B
This is a single center, single arm, open label study to assess the safety, tolerability and effectiveness of the autologous HBV specific T cell receptor (HBV-TCR) redirected T cells in patients with chronic hepatitis B with ongoing with nucleos(t)ide analogue (NUC) treatment. This study will be conducted sequentially starting with Stage-1, followed by Stage-2.
A Randomized, Double-blind, Multicenter, Multinational, Active-controlled, Parallel-designed Phase 3 Clinical Trial to Evaluate the Immunogenicity and Safety of Inactivated Hepatitis A Vaccine in Healthy Children Aged From 24months to 15yrs
The purpose of this study is to evaluate immunogenicity and safety of inactivated hepatitis A vaccine in healthy children aged from 24 months to 15 years when administered an initial dose followed by a booster dose (a total of 2 doses administered with 6 months interval).
Safety and Immunogenicity of Measles Vaccine, Varicella Vaccine and Hepatitis-A Vaccine in HIV-exposed and HIV-unexposed South African Children
This trial will evaluate the safety and immunogenicity of: i) measles vaccine (CAM-70) after primary dose at 6 months (MV1) and booster vaccination at 12 months (MV2); ii) a single dose of varicella vaccination at 18 months; and iii) a single dose of hepatitis-A vaccination at 18 months in HIV-exposed and HIV-unexposed South African children.
Human papillomavirus (HPV) vaccination across a cascade of knowledge, willingness, and uptake among gay, bisexual, and other men who have sex with men in Canada's three largest cities.
3区 · 医学
Article
作者: R Grewal ; S L Deeks ; T A Hart ; J Cox ; A De Pokomandy ; T Grennan ; G Lambert ; D Moore ; F Coutlée ; M Gaspar ; C George ; D Grace ; J Jollimore ; N J Lachowsky ; R Nisenbaum ; G Ogilvie ; C Sauvageau ; D H S Tan ; A Yeung ; A N Burchell
2019-11-20·Science translational medicine1区 · 医学
Antigenic competition in CD4+ T cell responses in a randomized, multicenter, double-blind clinical HIV vaccine trial.
1区 · 医学
Article
作者: Esper G Kallas ; Nicole A Grunenberg ; Chenchen Yu ; Bryce Manso ; Giuseppe Pantaleo ; Martin Casapia ; Lindsey R Baden ; Javier Valencia ; Magdalena Sobieszczyk ; Hong Van Tieu ; Mary Allen ; John Hural ; Barney S Graham ; James Kublin ; Peter B Gilbert ; Lawrence Corey ; Paul A Goepfert ; M Juliana McElrath ; R Paul Johnson ; Yunda Huang ; Nicole Frahm