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项与 68Ga-NOTA-H006 相关的临床试验A Study to Evaluate 5T4 Expression in Malignant Tumors Using 68Ga-NOTA-H006
5T4, also known as trophoblast glycoprotein, is an oncofoetal antigen expressing in fetal development and cancer but rarely in adult. The high expression of 5T4 in malignancy was found be associated with poor clinical outcomes in ovarian, gastric and colorectal cancers. Several antibody drug conjugates are currently under development for cancer therapy in preclinic and clinic stages.
Previously, investigators engineered a 5T4-specific biomolecule with nanomolar binding affinity. Radiolabeling with gallium-68 resulted in 68Ga-NOTA-H006 which showed 5T4 expression in a variety of xenograft models. Thus, the aims of current study are to evaluate the distribution and dosimetry of this novel tracer, and to explore the diagnostic values of 68Ga-NOTA-H006 in malignant tumors.
100 项与 68Ga-NOTA-H006 相关的临床结果
100 项与 68Ga-NOTA-H006 相关的转化医学
100 项与 68Ga-NOTA-H006 相关的专利(医药)
100 项与 68Ga-NOTA-H006 相关的药物交易