Tavapadon

iStock, Prostock-Studio R&D spending across the global pharmaceutical sector climbed 1.5% in 2024, according to unreleased data from Evaluate Pharma. Even with strong macro headwinds —inflation, rising costs, geopolitical tensions —the global pharmaceuticals industry continued to pump more money into R&D investments in 2024. That’s according to data from analyst firm Evaluate Pharma, which in an email gave BioSpace a sneak peek at their World Preview 2025 report, set to be published in June 2025. Pharma R&D spending in 2024 grew by 1.5%, a relatively modest jump by the industry’s own standards, considering that from 2022 to 2023, budgets soared 11.5%. Still, R&D spending last year was staggering: drugmakers the world over pumped nearly $288 billion into research and development. “R&D is central to refreshing product portfolios, which have a natural lifecycle owing to patents and exclusivity periods,” Daniel Chancellor, VP of thought leadership at Norstella, Evaluate’s parent company, told BioSpace . “Without reinvestment into R&D (or business development), revenues are increasingly at risk of competition and will inevitably decline.” This is why Evaluate estimates that the industry will continue to grow their R&D budgets through the end of the decade—which, as per its yet-to-be-released data, could reach just under $340 billion by 2030—even as the political and economic environment grows increasingly unwelcoming. “R&D spending will continue to grow, thankfully because industry revenue growth is robust,” Chancellor assured BioSpace . He qualified this assertion, however, by noting that Evaluate “expects R&D margins to decline” as companies continue to enact “cost containment measures” to surmount the increasing number of external challenges to their businesses. These challenges include tariffs, drug pricing and the cost of capital. In the context of these high-level barriers, Guglielmo Bruni Roccia, senior pharmaceutical industry analyst at BMI, a Fitch Solutions company, offered a more pessimistic view of R&D spending patterns in the coming years. President Donald Trump’s Most Favored Nation drug pricing policy , for example, “could result in compression of U.S. revenues, which would in turn reduce available R&D funding,” Roccia told BioSpace . “With constrained revenue streams, we expect pharmaceutical companies will likely prioritize R&D projects with greater certainty of profitability and where they have a greater competitive advantage,” he added. Still, there is reason to be optimistic. Experts who spoke with BioSpace pointed to the industry’s spending spree, particularly in manufacturing , as a promising signal. “Infrastructure investments enhance R&D capabilities, indicating a complementary rather than competitive relationship,” Roccia explained, noting that a manufacturing push “will support and potentially boost R&D activities rather than hinder them.” Norstella’s Chancellor agreed, adding that “these new facilities will rely on the success of R&D to produce the drugs of tomorrow, as well as meeting demand for current portfolios.” Dealmaking appears to be continuing at pace, as well. Despite an increasingly tricky political thicket , the first quarter witnessed a rush of M&A and licensing deals, with the industry earmarking some $40 billion for business development initiatives. This bodes well for the industry, since deals contributed heavily to the encouraging R&D trend in 2024. All top spenders in this list are anchored by a major contract at least hundreds of millions of dollars in value, bolstered by additional spending to beef up their pipelines. Below, BioSpace looks at the pharma industry’s most prolific investors in R&D and how they are using these budgets to advance their business. Merck Reigns Even After Scaling Back R&D Spend: $17.9 billion YoY Change: -41% In 2023, Merck went on an expensive deal-making spree. The pharma acquired immune specialist Prometheus Biosciences for $10.8 billion , licensed three of Daiichi Sankyo’s antibody-drug conjugates for $4 billion upfront and inked a potential $2.55 billion molecular glue deal with Proxygen, among other transactions. With a particularly bloated R&D purse in 2023, the 41% decrease in spending last year is more of a rightsizing of Merck’s budget than a steep scale-back. Indeed, the company still came out ahead of its Big Pharma peers with a hefty $17.94 billion investment, corresponding to 28% of its total revenue. “With the looming loss of exclusivity of Merck’s Keytruda, Merck has ramped up R&D efforts to address the nearly $30 billion revenue gap left by the drug,” Ophelia Chan, senior business fundamentals analyst at GlobalData, told BioSpace. “It’s worth keeping a close eye on [Merck’s] pipeline, which includes around 20 potential new blockbuster candidates that could collectively generate over $50 billion in the future,” Chan added. Among them is ifinatamab deruxtecan, an antibody-drug conjugate (ADC) that targets B7-H3, a transmembrane protein over expressed in various cancers. Merck is running the Phase III IDeate-Esophageal01 study to test the ADC in advanced or metastatic esophageal squamous cell carcinoma. Ifinatamab deruxtecan is also being proposed for heavily pretreated advanced small cell lung cancer, for which it is in late-stage development . Merck is also testing tulisokibart (MK-7240), which was picked up in the $10.8 billion acquisition of Prometheus Biosciences, in multiple inflammatory diseases . Phase II data, published in the New England Journal of Medicine in September 2024, showed that a higher percentage of ulcerative colitis patients treated with the anti-TL1A antibody achieved clinical remission versus placebo. Tulisokibart is in Phase III development for ulcerative colitis and Crohn’s disease. Merck CEO Robert Davis told investors in February that he expects blockbuster opportunities from the pharma’s ophthalmology business, which received a $1.3 billion boost last year with the May acquisition of the eye specialist EyeBio. The centerpiece of the acquisition is the trispecific antibody Restoret being assessed for diabetic macular edema (DME) and neovascular age-related macular degeneration (AMD). In September 2024, Merck kicked off the Phase IIb/III trial for Restoret in DME. The study, dubbed BRUNELLO , is set to complete by the end of 2027. Johnson & Johnson Strong in Cancer and Immuno—but not Neuro R&D Spend: $17.2 billion YoY Change: 14.2% J&J started 2024 by renewing its focus on its three main priority therapeutic areas—“oncology, immunology and neuroscience,” CEO Joaquin Duato told investors during the pharma’s full-year 2023 earning call—and the pharma’s R&D spending last year largely reflected this. For instance, J&J paid $2 billion to acquire Ambrx in January 2024. The bet builds out the pharma’s portfolio of ADCs, which in recent years have become a major focus in cancer therapy. In addition, J&J last year made two hefty investments into its immuno business: the $850 million acquisition of Proteologix and its pipeline of anti-inflammatory dermatology assets, and a $1.25 billion payment to Numab Therapeutics for its bispecific antibody for atopic dermatitis. All told, J&J spent more than $17.2 billion on R&D last year, accounting for over 19% of its total revenue. This sum also covers its medtech investments. Even as these deals helped J&J populate its early- and mid-stage pipelines, the pharma last year likewise pushed its late-stage assets forward. In immuno, for instance, the company in August 2024 sought approval for its monoclonal antibody nipocalimab in myasthenia gravis, which was ultimately granted in April to be marketed as Imaavy. Notably, neuroscience was a weak point for J&J’s 2024 R&D agenda. In October 2024, the pharma pruned its early- and mid-stage neuro pipeline, leaving the investigational human orexin-2 receptor blocker seltorexant on the cutting room floor. J&J had been studying seltorexant for agitation and aggression in Alzheimer’s disease. The company also axed a Phase II ion channel blocker for bipolar depression and a Phase I Parkinson’s disease therapy. J&J seems set on changing that this year, however, starting 2025 strong with the massive $14.6 billion acquisition of Intra-Cellular Therapies. Roche’s Mixed Year for Cancer R&D Spend: CHF 13 billion ($15.8 billion) YoY Change: 1% During its full-year 2024 business report in February 2024, Roche leaders recognized that sales were stagnating, driven largely by tanking demand for its COVID-19 products and currency difficulties at the time. The company identified dealmaking as one of its care strategies to revitalize growth. Still, unlike Merck and J&J, which enacted substantial changes to their budgets, Roche’s R&D spending in 2024 remained largely flat year-on-year. The Swiss company poured just over CHF 13 billion ($15.8 billion) in its R&D and business development efforts last year, a slight 1% increase from 2023. 2024 also posed formidable challenges to Roche’s R&D efforts in cancer. In July 2024, for instance, the company’s anti-TIGIT antibody tiragolumab failed to significantly improve progression-free survival in the Phase II/III SKYSCRAPER-06 study in NSCLC, forcing Roche to discontinue that trial. A few months later, in November, tiragolumab again delivered disappointing NSCLC outcomes . Perhaps reflecting these difficulties in oncology development, Roche in April 2024 axed three early-stage cancer assets, including camonsertinib, which it was testing for solid tumors. In August, Roche closed down the cancer immunology unit of its subsidiary Genentech, with a spokesperson at the time pointing to “shifts in the science of immuno-oncology” as the reason for the shake-up. Despite some obstructions in oncology, Roche in 2024 saw notable progress in its obesity portfolio, anchored by the assets it obtained from its $2.7 billion acquisition of Carmot Therapeutics in December 2023. Last May, the pharma announced that Carmot’s CT-388, a dual GLP-1/GIP receptor agonist, could lower bodyweight by 18.8% versus placebo at 24 weeks. Roche followed this up with a July 2024 readout for another Carmot asset, the oral GLP-1 receptor agonist CT-996. Phase I data at the time showed that the pill can cut weight by 6.1% versus placebo after four weeks. Roche’s standout deal last year was the November 2024 acquisition of Poseida Therapeutics for $1 billion upfront. Roche and Poseida are long-time partners , and the acquisition strengthens their CAR T collaboration, targeting multiple myeloma and B cell lymphomas, among other blood cancers. With more than half of the year left to go, it remains unclear how Roche’s R&D budget will change in 2025—though it’s unlikely that the pharma will go on a big spending spree soon. During its full-year business report in February, CEO Thomas Schinecker said that Roche will remain “ disciplined ” with dealmaking this year, focusing only on assets that make strong financial sense for the company. AstraZeneca Upped Investment to Buff Pipeline R&D Spend: $13.6 billion YoY Change: 25% AstraZeneca opened 2024 with a commitment to “investing in new technologies and new products to shape the future of medicine,” CEO Pascal Soriot said in February 2024 during the pharma’s full-year 2023 earnings call. A month later, in March, AstraZeneca made good on this commitment by inking two high-ticket acquisitions to build out its late-stage pipeline. The first of these deals is with Amolyt Pharma, which the pharma acquired for $800 million upfront . A few days later, AstraZeneca dropped $2 billion to acquire Fusion Pharmaceuticals. From Amolyt, AstraZeneca received the hypoparathyroidism candidate eneboparatide, which recently aced a Phase III trial , along with other assets being developed for rare diseases. Meanwhile, Fusion gave AstraZeneca its radiopharma pipeline, anchored by FPI-2265, an actinium-225 radioconjugate therapy being proposed for the treatment of metastatic castration-resistant prostate cancer. AstraZeneca last year also poured money into the opposite end of its pipeline, expanding its early-stage portfolio with a $19 million deal with Nona Biosciences in May 2024 for several preclinical monoclonal antibodies for cancer. That same month, AstraZeneca started putting bets in the lucrative obesity arena by paying $80 million to support Versant Ventures startup SixPeaks, which will work on next-generation, muscle-preserving weight-loss drugs. One of AstraZeneca’s most closely watched assets is its Daiichi Sankyo-partnered antibody-drug conjugate Dato-DXd. Despite winning FDA approval earlier this year for breast cancer under the brand name Datroway, the molecule ran into a rough patch last year, failing two Phase III trials in September—one in breast cancer and another in non-small cell lung cancer . Elsewhere in AstraZeneca’s cancer pipeline, the AKT blocker Truqap in November 2024 delivered a late-stage victory , significantly improving radiographic progression-free survival in certain types of prostate cancer. In April, however, Truqap stumbled in a Phase III prostate cancer, pushing the pharma to axe the Phase III CAPItell-280 study. AstraZeneca appears to be sustaining the pace of its R&D spending into the new year. In March alone, for instance, the pharma put $1 billion on the line to acquire EsoBiotec and its cell therapy pipeline, and signed two agreements with South Korea’s Alteogen to collaborate on subcutaneous cancer therapies. All told, AstraZeneca’s payments to Alteogen could total $1.35 billion . AbbVie Makes Strong Neuro Push R&D Spend: $12.8 billion YoY Change: 60% Of all the companies on this list, AbbVie saw the biggest increase in its R&D spending, soaring 60% year-on-year to hit nearly $12.8 billion. Likely the biggest contributing factor is the pharma’s $8.7 billion acquisition of Cerevel Therapeutics in December 2023. The star of this buyout was the next-generation antipsychotic agent emraclidine, which ultimately failed a pair of Phase II trials, forcing investors to question AbbVie’s neuro strategy. The Cerevel acquisition wasn’t a complete wash for AbbVie, however. In September 2024, just a month after closing the transaction, the pharma notched a late-stage clinical win in Parkinson’s disease with tavapadon. Beyond Cerevel, AbbVie sustained its neuro push in 2024, linking up with Gilgamesh Pharmaceuticals in May 2024 for $65 million upfront and up to $1.95 billion in option and milestone fees. The partnership is focused on developing psychedelic therapies for psychiatric indications. Outside of neuro, AbbVie in 2024 leaned further into its main area of expertise—immunology —putting up $250 million to acquire Massachusetts biotech Celsius Therapeutics and its investigational antibody for inflammatory bowel diseases. Oncology also saw a lot of progress for AbbVie last year, including a slew of positive readouts in ovarian cancer, non-small cell lung cancer and other solid tumors at ESMO 2024. A few months later, in December, the pharma likewise released data supporting the use of its bispecific T cell–engaging antibody epcoritamab as a monotherapy or as part of a combination regimen in patients with diffuse large B cell lymphoma. Despite being among pharma’s top R&D spenders, AbbVie doesn’t seem to be resting on its laurels. Already, the company has made several deals this year that could top $1 billion. In January, AbbVie teamed up with Neomorph to develop molecular glue degraders, putting up to $1.64 billion on the line for this partnership.

TUESDAY, April 8, 2025 -- For patients with Parkinson disease with motor fluctuations, the oral once-daily, selective D1/D5 partial dopamine agonist tavapadon as an adjunct to levodopa increases total daily ON time versus placebo, according to a study presented at the annual meeting of the American Academy of Neurology, held from April 5 to 9 in San Diego. Hubert Fernandez, M.D., from the Cleveland Clinic, and colleagues conducted a phase 3, placebo-controlled, double-blind trial to examine adjunctive therapy with tavapadon in adults experiencing motor fluctuations while receiving stable levodopa treatment. A total of 507 patients (aged 40 to 80 years) were enrolled and randomly assigned to adjunctive tavapadon (titrated to maximum tolerated flexible dose: 5 to 15 mg daily) or placebo in a 1:1 ratio. The researchers found that tavapadon treatment significantly increased total daily ON time without troublesome dyskinesia (1.7 hours versus 0.6 hours with placebo). There was also a significant reduction in the change from baseline in daily OFF time compared with placebo. The safety profile of tavapadon was consistent with that seen in previous clinical trials; most adverse events were mild to moderate in severity. "These findings in adults with Parkinson's disease and motor fluctuations demonstrate the efficacy and acceptable safety profile of tavapadon as adjunctive therapy to levodopa," the authors write. The study was funded by AbbVie, the manufacturer of tavapadon. Abstract More Information Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.