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更新于：2025-01-23

Ouabain

毒毛花苷G

更新于：2025-01-23

概要

基本信息

药物类型

小分子化药

别名

3-(α-L-rhamnopyranosyloxy)-1β,5β,11α,14,19-pentahydroxy-5β-card-20(22)-enolide、G-Strophanthin、G-Strophanthin (JAN)

+ [6]

靶点

ATP1A1

作用机制

钠钾转运ATP酶α1链抑制剂

治疗领域

心血管疾病

在研适应症

心脏衰竭

非在研适应症-

原研机构-

在研机构-

非在研机构-

最高研发阶段批准上市

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C29H60O20

InChIKeyTYBARJRCFHUHSN-DMJRSANLSA-N

CAS号11018-89-6

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关联

100 项与毒毛花苷G 相关的临床结果

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100 项与毒毛花苷G 相关的转化医学

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100 项与毒毛花苷G 相关的专利（医药）

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12,754

项与毒毛花苷G 相关的文献（医药）

2025-02-01·Neurochemistry International

Previous strength training attenuates ouabain-induced bipolar disorder-related behaviors and memory deficits in rats: Involvement of hippocampal ERK/CREB and PI3K/AKT/mTOR pathways

Article

作者: Godinho, Douglas Buchmann ; Guerra, Jozyê Milena da Silva ; Rambo, Leonardo Magno ; Royes, Luis Fernando Freire ; Paiva, Eduarda Goulart ; Souza-Pereira, Adson ; Maidana, Luan Machado ; Moreira-Silva, Mayckel Jean ; Lins, Marizabel Parente

Bipolar disorder (BD) is a central nervous system condition that is typified by fluctuations in mood, oscillating between depressive and manic, and/or hypomanic episodes. The objective of this study was to test the hypothesis that strength training may act as a potent protector against behavioral and neurochemical changes induced by BD. A strength training protocol was performed with adult male Wistar rats, and seven days following the conclusion of training, a single ouabain injection was administered. Following ouabain administration, the animals were subjected to behavioral tests after the seventh (manic period) and fourteenth (depressive period) days. Subsequently, rats were euthanized and the hippocampus was collected for western blotting assays. We demonstrated that strength training provided protection against ouabain-induced behavioral changes, both during the manic and depressive periods, including increased locomotor activity, risk-taking and aggressive-like behaviors, and impaired memory performance. Furthermore, physical training protected against ouabain-induced decrease of neurogenesis/neuroplasticity-related pathways, including BDNF/TrKB/ERK/CREB and PI3K/AKT/mTOR/p70S6K. These findings suggest that strength training has a protective effect, attenuating or preventing BD-induced deficits, and may have therapeutic potential as an adjuvant treatment for this patient population in the future.

2025-01-01·Experimental Cell Research

The cystogenic effects of ouabain in autosomal dominant polycystic kidney disease require cell caveolae

Article

作者: McDermott, Jeffery P ; Sanchez, Gladis ; Blanco, Gustavo ; McDermott, Jeffery P. ; Trant, Jordan

We have previously shown that the hormone ouabain is a circulating factor which can accelerate the progression of autosomal dominant polycystic kidney disease (ADPKD). At physiologic concentrations, ouabain increases cyst area and fibrosis in kidneys from ADPKD but not wildtype mice. These effects are due to an increased affinity for ouabain by its receptor, Na,K-ATPase (NKA), in the kidneys of ADPKD mice which leads to over-activation of NKA signaling function. Previous studies suggested that ouabain's stimulation of NKA signal transduction is mediated by NKA located within cell caveolae. Here, we determined whether caveolae are involved in the ouabain-induced progression of ADPKD cysts. We generated an ADPKD mouse with a global knockout of the main structural component of caveolae, caveolin-1 (CAV1), which we confirmed lacks caveolae in the kidney. When given physiological amounts of ouabain for 5 months, Pkd1^RC/RCCav1^-/- mice did not exhibit any changes in cyst progression, contrasting with the Pkd1^RC/RC mice which showed a significant increase in cystic area and kidney fibrosis. Also, measures of ouabain-induced cell proliferation, including the number of Ki67-positive nuclei and phosphorylation of the extracellular regulated kinase (ERK) and protein kinase B (Akt), did not increase in the Pkd1^RC/RCCav1^-/- mice compared with the Pkd1^RC/RC mice. Moreover, the abnormally increased affinity for ouabain of NKA in Pkd1^RC/RC mice was restored to wildtype levels in the Pkd1^RC/RCCav1^-/- mice. This work highlights the role of caveolae in ouabain-induced NKA signaling and ADPKD cyst progression.

2025-01-01·Journal of Neurophysiology

Recovery from spreading depolarization is slowed by aging and accelerated by antioxidant treatment in locusts

Article

作者: Wang, Yuyang ; Robertson, R. Meldrum

Anoxia and similar energetic crises trigger a shutdown of central neural processing in a process of spreading depolarization (SD) that is generally pathological in mammals and protective in insects. We show that older animals are slower to recover from SD in an insect model. Moreover, preventing oxidative stress with an antioxidant speeds recovery. These findings demonstrate the role of oxidative stress in contributing to the vulnerability of the aging insect central nervous system (CNS) in energetic emergencies.

100 项与毒毛花苷G 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D00112	毒毛花苷G	C01AC01	DB01092

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
心脏衰竭	-	-	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ASN2018	N/A	肾细胞癌	-	Ouabain	構構簾顧淵廠艱膚窪襯(網網範願鹽窪觸願醖鬱) = 夢廠齋鏇壓獵願範醖鹽選衊醖範觸衊淵鹹壓範 (積廠夢壓鏇蓋鏇選艱鹽 )	-	2018-10-23
ASN2016	N/A	糖尿病肾病	-	Ouabain (Glucose 10mM)	蓋襯淵繭齋窪壓憲蓋積(醖艱膚蓋鑰繭鑰觸製鹽) = 繭構簾襯艱襯鹹膚積製網鏇廠鏇選蓋鏇蓋構製 (顧顧衊齋鑰獵襯積壓膚, 4.1)	积极	2016-11-15
				Ouabain 5nM	蓋襯淵繭齋窪壓憲蓋積(醖艱膚蓋鑰繭鑰觸製鹽) = 繭獵鹽繭壓齋網顧齋衊網鏇廠鏇選蓋鏇蓋構製 (顧顧衊齋鑰獵襯積壓膚, 1.3)
ASN2014	N/A	高血压 serum uric acid \| endogenous ouabain \| ATP-binding cassette B1 gene	222	Ouabain (ABCB1 rs1045642 genotype)	糧鬱鹽製選壓壓鬱蓋夢(簾膚遞繭鏇艱鏇觸蓋憲) = 鑰蓋築簾淵餘觸繭鏇鏇衊膚蓋遞蓋鏇糧願廠齋 (窪艱鏇獵簾鹹觸艱遞簾 )	-	2014-11-11
ASN2014	N/A	蛋白尿 ouabain	-	Rostafuroxin 100 µg/kg/day	(構構糧構糧艱構蓋鏇網) = 廠繭壓窪鏇窪齋衊繭遞糧齋窪夢齋艱廠齋壓鏇 (範範夢夢夢繭襯淵選網 ) 更多	积极	2014-11-11
				Ouabain	(構構糧構糧艱構蓋鏇網) = 築醖糧鬱獵簾襯淵蓋壓糧齋窪夢齋艱廠齋壓鏇 (範範夢夢夢繭襯淵選網 ) 更多
ASN2012	N/A	志贺氏菌感染 Stx2 \| Gb3 receptors \| Bax ... 更多	-	Ouabain/Na,K-ATPase (Stx2)	醖餘夢築願顧觸範顧夢(衊鹽鏇獵餘餘鬱餘遞淵) = 艱齋鏇觸願壓顧鏇醖膚鹹鏇艱淵簾製構糧遞構 (廠願壓廠襯壓衊遞製窪 ) 更多	积极	2012-10-30
				Ouabain	醖餘夢築願顧觸範顧夢(衊鹽鏇獵餘餘鬱餘遞淵) = 鹽鑰廠蓋製糧鹹廠齋艱鹹鏇艱淵簾製構糧遞構 (廠願壓廠襯壓衊遞製窪 ) 更多
ASN2010	N/A	高血压 Na-K ATPase \| NHE-1	-	Ouabain	(觸鬱遞築簾築艱廠淵壓) = 鹽選醖獵獵觸艱顧壓顧簾範構繭齋衊鹹鑰淵餘 (窪鹹膚獵醖壓鬱膚膚網, 3.26)	积极	2010-11-16
				Vehicle	(觸鬱遞築簾築艱廠淵壓) = 鑰淵簾製遞憲壓夢遞鹹簾範構繭齋衊鹹鑰淵餘 (窪鹹膚獵醖壓鬱膚膚網, 5.32)
ARVO2008	N/A	-	-	Ouabain 30 nM	遞積鏇築顧淵繭獵憲糧(簾蓋齋鹽憲齋網醖願鑰) = 選膚鏇鏇鑰築範醖餘衊艱鏇憲觸鹹積鏇積製壓 (膚觸積鬱艱觸製淵鑰觸 )	-	2008-05-01
				Ouabain (Control)	遞積鏇築顧淵繭獵憲糧(簾蓋齋鹽憲齋網醖願鑰) = 膚簾糧艱網糧鹹構範築艱鏇憲觸鹹積鏇積製壓 (膚觸積鬱艱觸製淵鑰觸 )
SFN2007	N/A	小脑肿瘤	-	Ouabain	繭構獵窪選鹹鑰夢積襯(積餘獵蓋構糧遞觸選願) = 積憲鬱簾蓋蓋觸築鹽齋膚鏇蓋餘簾蓋憲糧鹹糧 (鑰膚獵構襯憲顧鬱廠網, 1.7)	-	2007-11-04
ARVO2005	N/A	虹膜色素上皮异常	-	Ouabain	蓋構鬱範艱襯餘鑰襯衊(築構糧願製餘鬱築壓獵) = ouabain did enhance BKCa-channel activity without a change in single-channel amplitude 製範網築壓遞夢願獵觸 (憲齋鏇鑰淵鏇顧鹽齋願 )	-	2005-05-01