[18F]3F-PHPG([18F]3F-PHPG) - 在研适应症：嗜铬细胞瘤_专利_临床

概要

基本信息

药物类型

化学药、诊断用放射药物

别名-

靶点-

作用机制-

治疗领域

肿瘤其他疾病

在研适应症

嗜铬细胞瘤

非在研适应症-

原研机构

Rogel Cancer Center: University of Michigan

在研机构

Rogel Cancer Center: University of Michigan

非在研机构-

最高研发阶段早期临床1期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

3

项与 [18F]3F-PHPG 相关的临床试验

NCT04510311

/ Completed早期临床1期IIT

An Exploratory Study of 3-[18F]Fluoro-para-hydroxyphenethylguanidine ([18F]3F-PHPG) in Patients With Neuroendocrine Tumors

The goal of this exploratory study is to test whether [18F]3F-PHPG can be used reliably to map the locations of tumors in patients with neuroendocrine tumors. If so, the results of this study will be used to support further development of [18F]3F-PHPG as a clinical tool for neuroendocrine tumor localization and staging.

开始日期2020-10-19

申办/合作机构

Rogel Cancer Center: University of Michigan

NCT02669563

/ Completed早期临床1期IIT

An Exploratory Study of 18F-Labeled Hydroxyphenethylguanidines in Heart Failure Patients

The main goal of this study is to test two new radioactive drugs, 4-[18F]fluoro-meta-hydroxyphenethylguanidine ([18F]4F-MHPG) and 3-[18F]fluoro-para-hydroxyphenethylguanidine ([18F]3F-PHPG) in human subjects with congestive heart failure.
Evaluations of these imaging agents will include their uptake in heart, lungs and liver, their metabolic breakdown in blood, and their kinetics in the heart. Based on these studies, the better of the two drugs will be chosen for further studies in patients with heart disease. After the better compound is chosen, additional measures of its imaging properties, metabolism and pharmacokinetics will be done in subjects with heart failure.

开始日期2015-12-01

申办/合作机构

University of Michigan

NCT02385877

/ Completed早期临床1期IIT

Clinical Translation of 18F-Labeled Hydroxyphenethylguanidines for Quantification of Regional Cardiac Sympathetic Nerve Density With PET

The purpose of this study is to perform first-in-human PET imaging studies of two new cardiac sympathetic nerve imaging agents, 4-[18F]fluoro-meta-hydroxyphenethylguanidine ([18F]4F-MHPG) and 3-[18F]fluoro-para-hydroxyphenethylguanidine ([18F]3F-PHPG).

开始日期2015-03-01

申办/合作机构

University of Michigan

100 项与 [18F]3F-PHPG 相关的临床结果

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100 项与 [18F]3F-PHPG 相关的转化医学

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100 项与 [18F]3F-PHPG 相关的专利（医药）

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100 项与 [18F]3F-PHPG 相关的药物交易

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