更新于：2024-11-01

Bacterial enteritis

细菌性肠炎

更新于：2024-11-01

基本信息

别名

Bacterial enteritis、Bacterial enteritis (diagnosis)、Bacterial enteritis NOS

+ [12]

简介-

关联

项与细菌性肠炎相关的药物

OPS-2071

靶点

Bacterial DNA gyrase x Bacterial top IV

作用机制

细菌DNA旋转酶复合体抑制剂 [+1]

在研机构

Otsuka Pharmaceutical Co., Ltd. [+1]

原研机构

Otsuka Holdings Co., Ltd.

在研适应症

腹泻型肠易激综合征 [+1]

非在研适应症

细菌性肠炎 [+2]

最高研发阶段临床2期

首次获批国家/地区-

首次获批日期1800-01-20

项与细菌性肠炎相关的临床试验

NCT02473393 / Completed临床2期

A Clinical Trial to Assess Three Different Doses of OPS-2071 in Patients With Bacterial Enteritis

To assess safety, efficacy and pharmacokinetics of multiple dosesin patients with Bacterial Enteritis caused by Clostridium difficile infection(CDI) or Enteric infection.

开始日期2015-08-20

申办/合作机构

Otsuka Pharmaceutical Co., Ltd.

NCT02440633 / Completed临床1期

A Phase 1,Open -Label Study to Assess the Absorption, Metabolism and Excretion of 14C-OPS-2071 Following a Single Oral Dose to Healthy Male Japanese Subjects

To obtain absorption, metabolism and excretion data for parent drug and any metabolites.

开始日期2015-05-01

申办/合作机构

Otsuka Pharmaceutical Co., Ltd.

100 项与细菌性肠炎相关的临床结果

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100 项与细菌性肠炎相关的转化医学

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0 项与细菌性肠炎相关的专利（医药）

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551

项与细菌性肠炎相关的文献（医药）

2025-01-01·Bioactive Materials

Silver-quercetin-loaded honeycomb-like Ti-based interface combats infection-triggered excessive inflammation via specific bactericidal and macrophage reprogramming

Article

作者: Su, Zheng ; Wu, Ting ; Yang, Rong ; Ma, Ruixiang ; Zhu, Chen ; Hu, Xianli ; Jiang, Wei ; Yang, Ning ; Li, Meng

Excessive inflammation caused by bacterial infection is the primary cause of implant failure. Antibiotic treatment often fails to prevent peri-implant infection and may induce unexpected drug resistance. Herein, a non-antibiotic strategy based on the synergy of silver ion release and macrophage reprogramming is proposed for preventing infection and bacteria-induced inflammation suppression by the organic-inorganic hybridization of silver nanoparticle (AgNP) and quercetin (Que) into a polydopamine (PDA)-based coating on the 3D framework of porous titanium (SQPdFT). Once the planktonic bacteria (e.g., Escherichia coli, Staphylococcus aureus) reach the surface of SQPdFT, released Que disrupts the bacterial membrane. Then, AgNP can penetrate the invading bacterium and kill them, which further inhibits the biofilm formation. Simultaneously, released Que can regulate macrophage polarization homeostasis via the peroxisome proliferators-activated receptors gamma (PPARγ)-mediated nuclear factor kappa-B (NF-κB) pathway, thereby terminating excessive inflammatory responses. These advantages facilitate the adhesion and osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs), concomitantly suppressing osteoclast maturation, and eventually conferring superior mechanical stability to SQPdFT within the medullary cavity. In summary, owing to its excellent antibacterial effect, immune remodeling function, and pro-osteointegration ability, SQPdFT is a promising protective coating for titanium-based implants used in orthopedic replacement surgery.

2024-12-01·Molecular Biology Reports

Advancements in understanding bacterial enteritis pathogenesis through organoids

Review

作者: Wang, Xianli ; Wu, Zhengyang ; Liu, Hongyuan

Bacterial enteritis has a substantial role in contributing to a large portion of the global disease burden and serves as a major cause of newborn mortality. Despite advancements gained from current animal and cell models in improving our understanding of pathogens, their widespread application is hindered by apparent drawbacks. Therefore, more precise models are imperatively required to develop more accurate studies on host-pathogen interactions and drug discovery. Since the emergence of intestinal organoids, massive studies utilizing organoids have been conducted to study the pathogenesis of bacterial enteritis, revealing new mechanisms and validating established ones. In this review, we focus on the advancements of several bacterial pathogenesis mechanisms observed in intestinal organoid/enteroid models, exploring the host response and bacterial effectors during the infection process. Finally, we address the features that warrant additional investigation or could be enhanced in existing organoid models in order to guide future research endeavors.

2024-11-12·Neurology

Pearls & Oy-sters: Neurologic Involvement in Shiga Toxin–Associated Hemolytic Uremic Syndrome

Article

作者: Brücke, Christof ; Fodor, Tekla A. ; Schmook, Maria T.

Shiga toxin-producing Escherichia coli (STEC) is among the most common pathogens that cause bacterial enteritis. They can also lead to extraintestinal manifestations including hemolytic uremic syndrome (HUS), which is defined by the triad of hemolytic anemia, thrombocytopenia, and acute renal dysfunction due to Shiga toxin-mediated damage to the vascular endothelium with a subsequent inflammatory reaction and thrombotic microangiopathy. The thrombotic microangiopathy mainly affects the small blood vessels of the kidneys and brain. Neurologic involvement, especially in adults, is rare but can include nonspecific symptoms such as a decreased consciousness, altered mental status, seizures, and hyperreflexia. Although HUS is often assumed to cause isolated involvement of small vessels, in this case report, a 52-year-old woman with a STEC-HUS-encephalopathy developed multiple craniocervical dissections during the course of her disease in the absence of any trauma or cardiovascular risk factors. This case thus could possibly indicate that Shiga toxin-mediated damages are not limited to the small vessels but can also affect larger vessels.