更新于：2024-11-01

Ethylene glycol poisoning (disorder)

乙二醇中毒

更新于：2024-11-01

基本信息

别名

Anti-freeze poisoning、Antifreeze causing toxic effect、ETHYLENE GLYCOL TOXICITY

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简介

Ethylene glycol poisoning is a rare poisoning resulting in elevated anion gap metabolic acidosis, due to the production of glycolic acid, glyoxylic acid, and oxalic acid by alcohol dehydrogenase (ADH) in the liver when ethylene glycol is metabolized, characterized initially by euphoria, slurred speech, encephalopathy, coma and seizures, and followed by late manifestations such as tachycardia, arrhythmias, myocardial depression, hemodynamic imbalance and, finally, acute renal failure.

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100 项与乙二醇中毒相关的临床结果

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100 项与乙二醇中毒相关的转化医学

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0 项与乙二醇中毒相关的专利（医药）

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737

项与乙二醇中毒相关的文献（医药）

2024-06-01·Medicina Intensiva (English Edition)

Urine fluorescence in suspected ethylene glycol intoxication

Letter

作者: Fariña-González, Tomás Francisco ; González-Gallego, Miguel Angel ; Fernandez-Bada, Isabel Troncoso

2024-04-09·Langmuir

Extended Temperature Range of the Ice-Binding Protein Activity

Article

作者: Sirotinskaya, Vera ; Bar Dolev, Maya ; Bahari, Liat ; Braslavsky, Ido ; Yashunsky, Victor

Ice-binding proteins (IBPs) are expressed in various organisms for several functions, such as protecting them from freezing and freeze injuries. Via adsorption on ice surfaces, IBPs depress ice growth and recrystallization and affect nucleation and ice shaping. IBPs have shown promise in mitigating ice growth under moderate supercooling conditions, but their functionality under cryogenic conditions has been less explored. In this study, we investigate the impact of two types of antifreeze proteins (AFPs): type III AFP from fish and a hyperactive AFP from an insect, the Tenebrio molitor AFP, in vitrified dimethylsulfoxide (DMSO) solutions. We report that these AFPs depress devitrification at -80 °C. Furthermore, in cases where devitrification does occur, AFPs depress ice recrystallization during the warming stage. The data directly demonstrate that AFPs are active at temperatures below the regime of homogeneous nucleation. This research paves the way for exploring AFPs as potential enhancers of cryopreservation techniques, minimizing ice-growth-related damage, and promoting advancements in this vital field.

2024-04-08·Cureus

Beyond the Usual Suspects: Ethylene Glycol Poisoning Complicated by Rare Neurological Sequelae

作者: Srinivasan, Ragunanthanan ; Ezhilarasu, Preetham

Ethylene glycol poisoning is a known clinical entity with established diagnostic and management protocols. However, instances presenting with rare neurological complications pose diagnostic challenges and necessitate prompt recognition and intervention. This report details the case of ethylene glycol poisoning in a 38-year-old male patient who initially presented with a history of brake oil consumption at his residence, followed by a delayed presentation with vomiting, abdominal pain, and reduced urine output, and subsequently developed unusual neurological sequelae, including unsteadiness, hearing difficulties, and an inability to close his eyes. Diagnostic assessment revealed cerebellar ataxia with bilateral sensory-neural hearing loss and facial nerve palsy. The patient was subsequently managed primarily for ethylene glycol poisoning, with conservative management for the neurological sequelae, and improved with no residual deficits. This case underscores the importance of promptly managing ethylene poisoning to prevent complications and sequelae as well as reduce morbidity for patients.