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更新于：2025-05-07

Kyasanur Forest Disease

夸赛纳森林病

更新于：2025-05-07

基本信息

别名

KF - Kyasanur Forest disease、KFD - Kyasanur Forest disease、Kyasanur Forest Disease

+ [18]

简介

Tick-borne flavivirus infection occurring in the Kyasanur Forest in India.

关联

项与夸赛纳森林病相关的药物

VSV-KFDV

靶点

Envelope (E) protein x M proteins

作用机制

包膜（E）蛋白调节剂 [+1]

在研机构

National Institutes of Health

原研机构

National Institutes of Health

在研适应症

夸赛纳森林病

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期1800-01-20

Kyasanur Forest Disease (Indian Immunologicals)

靶点-

作用机制-

在研机构

Indian Immunologicals Ltd.

原研机构

Indian Immunologicals Ltd.

在研适应症

夸赛纳森林病

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期1800-01-20

项与夸赛纳森林病相关的临床试验

CTRI/2025/04/084826

/ Not yet recruitingN/AIIT

A pilot retrospective study to understand the symptomatology of Kyasanur Forest Disease Virus (KFDV) infection to formulate possible homoeopathic prophylactics/ therapeutics and to identify the correlation with viral variations in the stored samples at Manipal Institute of Virology, Karnataka - NIL

开始日期2025-04-26

申办/合作机构-

CTRI/2024/10/075746

/ Not yet recruitingN/A

Incidence of acute kidney injury and their outcome in Kyasanur Forest disease patient - NIL

开始日期2024-11-01

申办/合作机构-

NCT05438953

/ Active, not recruitingN/AIIT

Follow-up of People at Risk of Monkeypox Infection: a Prospective Cohort Study

Since one month (first case confirmed the 05/06/2022), some cases of non-imported were reported by Portuguese and British authorities then in several Europeans countries, the US and the Canada. The 05/19/2022, a first case of Monkeypox was confirmed in France. The 06/01/2022, "Santé Publique France" (SPF) declared 33 confirmed cases of Monkeypox without a direct interaction with people returning from endemic area. No deaths are currently recorded.
Currently, data on efficiency of modified vaccinia Ankara virus (MVA) used in post-exposure prophylaxis are few. The Centers for Disease Control and Prevention (CDC) consider that 2 doses of MVA vaccine used in post-exposure vaccination do not prevent totally the infection but consider that one rapid vaccination of high-risk contacts could reduce the severity of symptoms.
In order to clarify clinical impact and safety of PEV, it is proposed to set up a national cohort including people at risk of Monkeypox infectionfalling within the indications for vaccination, i.e. seen within 14 days of last contact for post-exposition (PEP) cases and also in prevention :pre-exposition ( PrEP)cases.
The purpose of this study is to estimate the failure rate of the vaccinationby the VMA vaccine in PEP or PrEP administration in people at risk of Monkeypox infection after one dose.

开始日期2022-07-12

申办/合作机构

Assistance Publique des Hôpitaux de Paris SA

100 项与夸赛纳森林病相关的临床结果

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100 项与夸赛纳森林病相关的转化医学

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0 项与夸赛纳森林病相关的专利（医药）

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314

项与夸赛纳森林病相关的文献（医药）

2025-04-01·Journal of Clinical Virology

Molecular epidemiology of Kyasanur forest disease employing ONT-NGS a field forward sequencing

Article

作者: Dash, Paban Kumar ; Yadav, Pooja ; Dhankher, Suman ; Sharma, Shashi

The future of infectious agent detection and molecular characterization lies in field-forward, on-site strategies. The lack of genomic information for recently circulating Kyasanur Forest Disease virus strains is critical. Kyasanur Forest Virus Disease virus PCR-positive samples from 2018 to 2020 were selected for sequencing. Detailed molecular phylogenetic analyses were performed. In this study, we deciphered KFDV whole genomes using the ONT-NGS technique to analyze targeted KFD surveillance from 2018-2020. This study is the first to report recently circulating KFDV strains employing a simple on-site field-forward approach for viral surveillance. Altogether, 19 KFDV genomes were sequenced, and 28 non-synonymous variants were detected in the viral strains circulating from 2018-2020 in the Shivamogga district of Karnataka state in India. The prevailing Variant was detected in more than 10 changes in 80 % of the samples in the viral envelope protein. Recently, circulating KFDV has been the predominant lineage over the past years. India reports seasonal outbreaks almost every year from the Karnataka state of the KFD. The genomic sequences deciphered here belong to the period (2018-2020) that covers the KFDV sequences as the first information. This will contribute to the development and revisiting of diagnostic and vaccine strategies.

2025-04-01·Journal of Virological Methods

Purification and characterization of kyasanur forest disease virus EDIII domain of major envelope glycoprotein

Article

作者: Kumar, Rajesh ; Gupta, Rohit ; Choudhary, Shweta ; Tomar, Shailly ; Kumar, Vivek ; Das, Manjima ; Bhutkar, Mandar ; Kumar, Dilip ; Agarwal, Vidushi ; Madhukalya, Rishav

Current research efforts are underway to create novel approaches for the efficient diagnosis, monitoring, and mitigation of Kyasanur Forest Disease Virus (KFDV) infections. Flavivirus subunit-based vaccines based on envelope glycoprotein EDIII are now in preclinical and clinical research stages. Efficient purification and isolation methods for surface immunogenic viral antigens, including the recombinant envelope immunoglobulin-like domain III (rEDIII) protein, are crucial for the production and manufacturing of promising vaccine candidates that have been extensively assessed in previous literature. Here, we describe a method for high-yield expression, purification, and refolding of a KFDV rEDIII protein from a bacterial expression system. The KFDV rEDIII protein is extracted from the inclusion bodies in urea denaturing buffer followed by nickel-nitrilotriacetic acid (Ni-NTA) affinity chromatography. The purified, denatured KFDV rEDIII protein was subsequently refolded using a step-wise gradient urea dilution via the dialysis method. The circular dichroism and Fourier transform infrared spectroscopy analysis confirms that the refolded KFDV rEDIII maintains the native secondary conformation majorly containing β-strands. Our study provides valuable insights into the design and expression strategies of rEDIII as a novel subunit vaccine candidate against KFDV.

2025-04-01·Microbiology Spectrum

Differential effects of pine wilt disease on root endosphere, rhizosphere, and soil microbiome of Korean white pine

Article

作者: Wang, Mingwei ; Xu, Hongwei ; Hou, Zehai ; Wang, Minggang ; Hannula, S. Emilia

ABSTRACT Pine wilt disease (PWD), caused by pinewood nematodes, is highly destructive to pine forests in Asia and Europe, including Korean white pine ( Pinus koraiensis ). The microbiome in the needles and trunk of Pinus spp. are recognized to play key roles in resistance against PWD. However, the role of root and soil microbiomes in the resistance remains unclear. This study compares bacterial and fungal communities in the root endosphere, rhizosphere soil, and bulk soil of diseased versus healthy P. koraiensis . Results showed that PWD increased the α-diversity of fungi in rhizosphere soil but did not affect the microbial diversity in the root endosphere or bulk soil. The composition of bacterial and fungal communities in rhizosphere and bulk soils was significantly altered by PWD. Specifically, the relative abundance of Planctomycetes decreased, and the relative abundance of Tremellomycetes increased, while Agaricomycetes decreased in both rhizosphere and bulk soils after infestation with PWD, respectively. Relative abundances of Chloroflexi and Verrucomicrobia increased, while Proteobacteria decreased in bulk soil following PWD. Relative abundances of Leotiomycetes and Eurotiomycetes increased in the rhizosphere soil and bulk soil following PWD, respectively. Furthermore, with the host plant infestation by PWD, the relative abundance of ectomycorrhizal fungi decreases, while that of saprotrophic fungi increases in both rhizosphere and bulk soils. Our results revealed that PWD significantly affects the soil microbiomes of P. koraiensis , with varying impacts across different plant–soil compartments. This study provides insights into how root and soil microbiomes respond to PWD, enhancing our understanding of the disease’s ecological consequences. IMPORTANCEThe belowground microbiome is often sensitive to infection of forest diseases and is also recognized as a potential reservoir for selection of microbial agents against PWD. Our study demonstrates that the dynamics of belowground microbiome following natural infection of PWD are compartment and taxa specific, with varying degrees of responses in both diversity and composition of bacterial or fungal communities across the root endosphere, rhizosphere soil, and bulk soil. The results highlight the importance of utilizing appropriate plant–soil compartments and microbial taxa to understand the ecological consequences of the destructive PWD.

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