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更新于：2025-05-07

Cataract, Age-Related Nuclear

年龄相关性核性白内障

更新于：2025-05-07

基本信息

别名

Age-related nuclear cataract、CATARACT, AGE-RELATED NUCLEAR、Cataract, Age-Related Nuclear

+ [3]

简介

A type of age-related cataract that primarily affects the nucleus of the lens. [https://orcid.org/0000-0002-0736-9199, PMID:15708105]

关联

项与年龄相关性核性白内障相关的药物

C-KAD ophthalmic solution(Chakshu)

靶点-

作用机制-

在研机构-

原研机构

Chakshu Research, Inc.

在研适应症-

非在研适应症

年龄相关性核性白内障 [+2]

最高研发阶段无进展

首次获批国家/地区-

首次获批日期1800-01-20

项与年龄相关性核性白内障相关的临床试验

CTRI/2025/04/084360

/ Not yet recruiting临床4期IIT

Effect of temperature on Intraocular lens unfolding time in cataract surgery - nil

开始日期2025-04-21

申办/合作机构-

CTRI/2025/04/083982

/ Not yet recruitingN/AIIT

A comparative prospective clinical study of opticalperformance of two types of diffractive-refractivetrifocal intraocular lenses - NIL

开始日期2025-04-15

申办/合作机构-

CTRI/2025/03/083370

/ Not yet recruitingN/AIIT

A comparative study of surgically induced astigmatism (SIA) in temporal and on-axis clear corneal incision in patients undergoing phacoemulsification- Randomized controlled trial - NIL

开始日期2025-04-05

申办/合作机构-

100 项与年龄相关性核性白内障相关的临床结果

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100 项与年龄相关性核性白内障相关的转化医学

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0 项与年龄相关性核性白内障相关的专利（医药）

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192

项与年龄相关性核性白内障相关的文献（医药）

2025-03-14·Medicine

Hyperopia may exert a protective effect against senile cataracts: Evidence from a Mendelian randomization study

Article

作者: Yi, Xianglong ; Wang, Guoqing

Myopia has been extensively documented as a significant risk factor for cataracts; however, the relationship between hyperopia and cataract development remains poorly understood. Given the distinct refractive profiles of myopia and hyperopia, hyperopia may confer a protective effect against cataracts. In this study, we employed Mendelian randomization (MR) to examine the causal association between hyperopia and cataracts. A 2-sample MR framework was utilized to examine the causal relationship between hyperopia and cataracts, with multivariable MR implemented to account for potential confounding variables. The inverse variance weighted (IVW) method served as the primary analytical tool, complemented by multiple sensitivity analyses to ensure the robustness and reliability of the findings. Enrichment analyses were conducted to elucidate the underlying biological pathways, while Bayesian colocalization analysis pinpointed shared genetic loci that influence both hyperopia and cataracts. In our study, we found that hyperopia may exert a protective effect against cataracts (IVW odds ratio, 0.920 [95% confidence interval, 0.872–0.972]; P = .0029) and cataract surgery (IVW odds ratio, 0.811 [95% confidence interval, 0.754–0.873]; P < .0001). Multivariable MR, adjusting for confounding factors such as smoking, glaucoma, and diabetes, confirmed hyperopia’s protective association with cataracts. Bayesian colocalization identified rs12193446 as a high-probability shared causal variant, while enrichment analyses revealed potential biological mechanisms linking hyperopia to cataract development. Genetic evidence suggests that higher levels of hyperopia are associated with a reduced risk of age-related nuclear cataracts, cataract extraction, and lens implants. Given the opposite refractive states of myopia and hyperopia and their opposite effects on cataracts, these findings provide new insights into the pathogenesis of age-related cataracts.

2025-01-01·Journal of Ophthalmology

Subnuclear Phacoemulsification to Reduce Corneal Injury in Nuclear Cataract Surgery: Evidence From a Randomized Controlled Trial

Article

作者: Luo, Furong ; Li, Zebin ; Wang, Rong ; Wang, Han ; Liu, Rubing ; Kuang, Jifa ; Yang, Chengwu ; Wang, Xuyang ; Zeng, Mingbing

Objects: To assess the safety and effectiveness of subnuclear phacoemulsification (SNP), a new technique for reducing corneal injury in nuclear cataract surgery.Methods: This randomized controlled trial (RCT) was designed in March 2020 and carried it out from April 1 to September 30, 2020, including a 3 months’ follow‐up. We recruited 256 age‐related hard nucleus cataract patients and randomly assigned them to two groups: the experimental group receiving SNP, and the control group receiving conventional phacoemulsification (CP). A single surgeon performed all the surgeries. We compared the two groups on the cumulative dissipated energy (CDE), phacoemulsification ultrasound time (UST), and complications for safety, as well as at multiple postsurgery follow‐up timepoints on three major outcomes for effectiveness: visual acuity, central corneal thickness, and central corneal endothelial cell density.Results: The two groups were well‐matched in terms of demographics, nuclear density, and safety measures (ultrasound energy, phacoemulsification time, and complications). For effectiveness after surgery, compared to the CP group, the SNP group had better visual acuity and thinner central cornea postsurgery within 1 week and had higher central corneal endothelial cell density at the 1‐ and 3‐month follow‐up.Conclusions: Compared to CP, SNP is more effective for reducing corneal injury in cataract surgery. The widespread application of this technology will greatly improve the safety of cataract surgery, especially hard cataract surgery.Trial Registration: Chinese Clinical Trial Registry: ChiCTR2000031114

2023-12-05·Investigative Opthalmology & Visual Science

HO-1–Mediated Autophagic Restoration Protects Lens Epithelial Cells Against Oxidative Stress and Cellular Senescence

Article

作者: Lou, Wei ; Huang, Yang ; Zhang, Yao ; Jin, Haiying ; Chen, Ziang ; Wang, Lijun

PurposeOxidative stress and cellular senescence are risk factors for age-related cataract. Heme oxygenase 1 (HO-1) is a critical antioxidant enzyme and related to autophagy. Here, we investigate the crosstalk among HO-1, oxidative stress, and cellular senescence in mouse lens epithelial cells (LECs).MethodsThe gene expression of HO-1, p21, LC3, and p62 was measured in human samples. The protective properties of HO-1 were examined in hydrogen peroxide (H2O2)-damaged LECs. Autophagic flux was examined by Western blot and mRFP-GFP-LC3 assay. Western blotting and lysotracker staining were used to analyze lysosomal function. Flow cytometry was used to detect intracellular reactive oxygen species and analyze cell cycle. Senescence-associated β-galactosidase assay was used to determine cellular senescence. The crosstalk between HO-1 and transcription factor EB (TFEB) was further observed in TFEB-knockdown cells. The TFEB binding site in the promoter region of Hmox1 was predicted by the Jasper website and was confirmed by chromatin immunoprecipitation assay.ResultsHO-1 gene expression decreased in LECs of patients with age-related nuclear cataract, whereas mRNA expression levels of p21, LC3, and p62 increased. Upon H2O2-induced oxidative stress, LECs showed the characteristics of autophagic flux blockade, lysosomal dysfunction, and premature senescence. Interestingly, HO-1 significantly restored the impaired autophagic flux and lysosomal function and delayed cellular senescence. TFEB gene silencing greatly reduced the HO-1-mediated autophagic restoration, leading to a failure to prevent LECs from oxidative stress and premature senescence.ConclusionsWe demonstrated HO-1 effects on restoring autophagic flux and delaying cellular senescence under oxidative stress in LECs, which are dependent on TFEB.

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