别名 Breast cancer metastasis-suppressor 1、BRMS1、BRMS1 transcriptional repressor and anoikis regulator + [1] |
简介 Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma. |
作用机制 ADAM8 antagonists [+8] |
在研适应症 |
非在研适应症- |
最高研发阶段临床1/2期 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
开始日期2024-05-01 |
申办/合作机构 |
开始日期2023-07-31 |
申办/合作机构 |