更新于：2024-11-01

DCR

更新于：2024-11-01

基本信息

别名

DCR、Down syndrome chromosome region、DSCR

简介-

关联

100 项与 DCR 相关的临床结果

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100 项与 DCR 相关的转化医学

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0 项与 DCR 相关的专利（医药）

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148

项与 DCR 相关的文献（医药）

2024-06-01·Advanced Healthcare Materials

Engineering Improved CAR T Cell Products with A Multi‐Cytokine Particle Platform for Hematologic and Solid Tumors

Article

作者: Shanmugam, Mala ; Dreaden, Erik C ; Rafiq, Sarwish ; Dhodapkar, Kavita M ; Koff, Jean L ; Neffling, Milla ; Hossian, Akm Nawshad ; Legier, Jonathan M ; Doxie, Deon B ; Lin, Heather K ; He, Zhulin ; Freeman, Ruby ; Nair, Remya ; Uricoli, Biaggio ; Anderson, Ji Young L ; Blake, Dejah A

AbstractDespite the remarkable clinical efficacy of chimeric antigen receptor (CAR) T cells in hematological malignancies, only a subset of patients achieves a durable complete response (dCR). DCR has been correlated with CAR T cell products enriched with T cells memory phenotypes. Therefore, reagents that consistently promote memory phenotypes during the manufacturing of CAR T cells have the potential to significantly improve clinical outcomes. A novel modular multi‐cytokine particle (MCP) platform is developed that combines the signals necessary for activation, costimulation, and cytokine support into a single “all‐in‐one” stimulation reagent for CAR T cell manufacturing. This platform allows for the assembly and screening of compositionally diverse MCP libraries to identify formulations tailored to promote specific phenotypes with a high degree of flexibility. The approach is leveraged to identify unique MCP formulations that manufacture CAR T cell products from diffuse large B cell patients with increased proportions of memory‐like phenotypes MCP‐manufactured CAR T cells demonstrate superior anti‐tumor efficacy in mouse models of lymphoma and ovarian cancer through enhanced persistence. These findings serve as a proof‐of‐principle of the powerful utility of the MCP platform to identify “all‐in‐one” stimulation reagents that can improve the effectiveness of cell therapy products through optimal manufacturing.

2024-03-15·ChemPhysChem

Effect of NO₂ on N₂O production and NO_x emission reduction in NH₃ Selective Catalytic Reduction

Article

作者: Liu, Mingshun ; Lv, Heyin ; Li, Zhijun ; Li, Shilong ; Yang, Miansong

AbstractWith the introduction of increasingly strict emission regulations, reducing nitrogen oxide (NOx) emissions and nitrous oxide (N2O) production from diesel engines have become the focus of research. At high temperature, the reaction of NO2 in the catalyst generates the intermediate product NH4NO3, which first crystallizes below 300 °C. These crystals tend to block the pores and inhibit the reaction. Subsequently, N2O is produced through the decomposition of NH4NO3, leading to additional pollution. Therefore, the concentration of NO2 has a direct impact on both the NOx conversion efficiency and the generation of N2O, requiring consideration of the optimal proportion of NO2 in SCR. Considering these two factors, it is concluded that the optimal amount of NO2 varies with temperature. To improve the NOx conversion rate of the Cu‐SSZ‐13 catalyst at low temperatures and reduce N2O generation, the optimal NO2 ratio of the Cu‐SSZ‐13 catalyst under various operating conditions is studied using numerical simulations. As the temperature rises, the optimal NO2/NOx ratio first increases and then decreases. Under the optimal NO2/NOx ratio, the NOx conversion rate significantly increases, while N2O generation decreases considerably. The optimal NO2/NOx ratio also provides suggestions for the optimization of the DOC‐DPF‐DCR system.

2024-01-01·New Phytologist

Dicer‐dependent heterochromatic small RNAs in the model diatom species Phaeodactylum tricornutum

Article

作者: Richard, Hugues ; Jaubert, Marianne ; Verret, Frédéric ; Kalantidis, Kriton ; Grypioti, Emilia ; Kryovrysanaki, Nikoleta ; Falciatore, Angela

Summary

Diatoms are eukaryotic microalgae responsible for nearly half of the marine productivity. RNA interference (RNAi) is a mechanism of regulation of gene expression mediated by small RNAs (sRNAs) processed by the endoribonuclease Dicer (DCR). To date, the mechanism and physiological role of RNAi in diatoms are unknown.

We mined diatom genomes and transcriptomes for key RNAi effectors and retraced their phylogenetic history. We generated DCR knockout lines in the model diatom species Phaeodactylum tricornutum and analyzed their mRNA and sRNA populations, repression‐associated histone marks, and acclimatory response to nitrogen starvation.

Diatoms presented a diversification of key RNAi effectors whose distribution across species suggests the presence of distinct RNAi pathways. P. tricornutum DCR was found to process 26–31‐nt‐long double‐stranded sRNAs originating mostly from transposons covered by repression‐associated epigenetic marks. In parallel, P. tricornutum DCR was necessary for the maintenance of the repression‐associated histone marks H3K9me2/3 and H3K27me3. Finally, PtDCR‐KO lines presented a compromised recovery post nitrogen starvation suggesting a role for P. tricornutum DCR in the acclimation to nutrient stress.

Our study characterized the molecular function of the single DCR homolog of P. tricornutum suggesting an association between RNAi and heterochromatin maintenance in this model diatom species.