更新于：2024-05-01
ERF
ETS2 repressor factor
更新于：2024-05-01
基本信息
别名 ERF、ETS domain-containing transcription factor ERF、ETS2 repressor factor + [2] |
简介 Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). |
关联
100 项与 ERF 相关的临床结果
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100 项与 ERF 相关的转化医学
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2024-02-25Sheng wu gong cheng xue bao = Chinese journal of biotechnology
[Tissue specific distribution of terpenoid biosynthesis in Sarcandra glabra based on transcriptome and metabolome analysis].
Article
作者: Di Wu ; Yanyan Zhang ; Nan Lin ; Yicong Wei
The leaves and roots of Sarcandra glabra (thunb) nakai have different therapeutic effects in some clinical applications. In order to explore the tissue specific distribution differences of terpenoids in the leaves and roots of S. glabra, and to analyze the molecular mechanism of the formation of their pharmacodynamic quality differences. In this study, liquid chromatography-mass spectrometry (LC-MS) and Illumina HiSeqTM high-throughput sequencing techniques were respectively used to obtain the metabolome and transcriptome data of the leaves and roots of S. glabra. The metabolomics analysis showed that there were 50 differential terpenoids metabolites between the leaves and roots, including farnesylcysteine, d-glyceraldehyde 3-phosphate, and (R)-5-phosphomevalonate. The transcriptomics analysis indicated that there were 57 differentially expressed metabolic enzyme coding genes, including ACTC, HMGCR, MVK, DXS, and KS. Moreover, there were seven transcription factors, including MYB, C2H2, AP2/ERF-ERF, which were predicted to participate in regulating the differences in terpenoid synthesis and accumulation between the leaves and roots of S. glabra. qRT-PCR results demonstrated that the expression changes of eight randomly selected enzyme genes involved in terpene synthesis between the leaves and roots of S. glabra, which were consistent with the transcriptome sequencing results. This study will help to elucidate the molecular mechanisms underlying the clinical efficacy differences between the leaves and roots of S. glabra, and facilitate the extraction, utilization, and resource development of S. glabra.
2024-02-19Molecular horticulture
Dissection of mRNA ac4C acetylation modifications in AC and Nr fruits: insights into the regulation of fruit ripening by ethylene.
Article
作者: Lili Ma ; Yanyan Zheng ; Zhongjing Zhou ; Zhiping Deng ; Jinjuan Tan ; Chunmei Bai ; Anzhen Fu ; Qing Wang ; Jinhua Zuo
N4-acetylcytidine (ac4C) modification of mRNA has been shown to be present in plant RNAs, but its regulatory function in plant remains largely unexplored. In this study, we investigated the differentially expressed mRNAs, lncRNAs and acetylation modifications of mRNAs in tomato fruits from both genotypes. By comparing wild-type (AC) tomato and the ethylene receptor-mutant (Nr) tomato from mature green (MG) to six days after the breaker (Br6) stage, we identified differences in numerous key genes related to fruit ripening and observed the corresponding lncRNAs positively regulated the target genes expression. At the post-transcriptional level, the acetylation level decreased and increased in AC and Nr tomatoes from MG to Br6 stage, respectively. The integrated analysis of RNA-seq and ac4C-seq data revealed the potential positive role of acetylation modification in regulating gene expression. Furthermore, we found differential acetylation modifications of certain transcripts (ACO, ETR, ERF, PG, CesA, β-Gal, GAD, AMY, and SUS) in AC and Nr fruits which may explain the differences in ethylene production, fruit texture, and flavor during their ripening processes. The present study provides new insights into the molecular mechanisms by which acetylation modification differentially regulates the ripening process of wild-type and mutant tomato fruits deficient in ethylene signaling.
2024-02-08Functional & integrative genomics
Genetics and metabolic responses of Artemisia annua L to the lake of phosphorus under the sparingly soluble phosphorus fertilizer: evidence from transcriptomics analysis.
Article
作者: Lingyun Wan ; Juan Huo ; Qiulan Huang ; Xiaowen Ji ; Lisha Song ; Zhanjiang Zhang ; Limei Pan ; Jine Fu ; Mohamed A Abd Elhamid ; Salma A Soaud ; Rania M Y Heakel ; Jihai Gao ; Shugen Wei ; Ahmed H El-Sappah
The medicinal herb Artemisia annua L. is prized for its capacity to generate artemisinin, which is used to cure malaria. Potentially influencing the biomass and secondary metabolite synthesis of A. annua is plant nutrition, particularly phosphorus (P). However, most soil P exist as insoluble inorganic and organic phosphates, which results to low P availability limiting plant growth and development. Although plants have developed several adaptation strategies to low P levels, genetics and metabolic responses to P status remain largely unknown. In a controlled greenhouse experiment, the sparingly soluble P form, hydroxyapatite (Ca5OH(PO4)3/CaP) was used to simulate calcareous soils with low P availability. In contrast, the soluble P form KH2PO4/KP was used as a control. A. annua's morphological traits, growth, and artemisinin concentration were determined, and RNA sequencing was used to identify the differentially expressed genes (DEGs) under two different P forms. Total biomass, plant height, leaf number, and stem diameter, as well as leaf area, decreased by 64.83%, 27.49%, 30.47%, 38.70%, and 54.64% in CaP compared to KP; however, LC-MS tests showed an outstanding 37.97% rise in artemisinin content per unit biomass in CaP contrary to KP. Transcriptome analysis showed 2015 DEGs (1084 up-regulated and 931 down-regulated) between two P forms, including 39 transcription factor (TF) families. Further analysis showed that DEGs were mainly enriched in carbohydrate metabolism, secondary metabolites biosynthesis, enzyme catalytic activity, signal transduction, and so on, such as tricarboxylic acid (TCA) cycle, glycolysis, starch and sucrose metabolism, flavonoid biosynthesis, P metabolism, and plant hormone signal transduction. Meanwhile, several artemisinin biosynthesis genes were up-regulated, including DXS, GPPS, GGPS, MVD, and ALDH, potentially increasing artemisinin accumulation. Furthermore, 21 TF families, including WRKY, MYB, bHLH, and ERF, were up-regulated in reaction to CaP, confirming their importance in P absorption, internal P cycling, and artemisinin biosynthesis regulation. Our results will enable us to comprehend how low P availability impacts the parallel transcriptional control of plant development, growth, and artemisinin production in A. annua. This study could lay the groundwork for future research into the molecular mechanisms underlying A. annua's low P adaptation.
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