Delving into the Latest Updates on Squarix Gmbh with Synapse

概览

疾病领域	数量

感染	1

排名前五的药物类型	数量

小分子化药	1

关联

1

项与 Squarix Gmbh 相关的药物

Negamycin

靶点-

作用机制

核糖体调节剂

在研机构

Heinrich-Heine-Universität Düsseldorf [+4]

原研机构

Heinrich-Heine-Universität Düsseldorf [+4]

在研适应症

革兰氏阴性菌感染 [+1]

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

100 项与 Squarix Gmbh 相关的临床结果

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0 项与 Squarix Gmbh 相关的专利（医药）

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2

项与 Squarix Gmbh 相关的文献（医药）

2021-03-18·Antimicrobial Agents and Chemotherapy2区 · 医学

The Antibiotic Negamycin Crosses the Bacterial Cytoplasmic Membrane by Multiple Routes

2区 · 医学

Article

作者: Ciglia, Catherine ; Bendas, Gerd ; Brötz-Oesterhelt, Heike ; Haustedt, Lars Ole ; Glüsenkamp, Karl-Heinz ; Berscheid, Anne ; Hörömpöli, Daniel ; Falkenstein-Paul, Hildegard

Negamycin is a natural pseudodipeptide antibiotic with promising activity against Gram-negative and Gram-positive bacteria, including Enterobacteriaceae , Pseudomonas aeruginosa , and Staphylococcus aureus , and good efficacy in infection models. It binds to ribosomes with a novel binding mode, stimulating miscoding and inhibiting ribosome translocation.

2002-02-01·Bioorganic & Medicinal Chemistry Letters4区 · 医学

New indene-derivatives with anti-proliferative properties

4区 · 医学

Article

作者: Christoph Geisen ; Tarik Möröy ; Anette Langerak ; Volker Ullrich ; Oliver Müller ; Günther Winde ; Ioanna-Maria Karaguni ; Karl-Heinz Glüsenkamp

Metabolites of the non-steroidal anti-inflammatory drug Sulindac inhibit cell proliferation by affecting several intracellular signaling pathways including the tumorigenic Ras/Raf/MAPK pathway. Here, we report the synthesis of eight new indene derivatives derived from the Sulindac structure, and present data on their anti-proliferative properties and their effects on the p21ras protein.

100 项与 Squarix Gmbh 相关的药物交易

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100 项与 Squarix Gmbh 相关的转化医学

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