National Center For Children & Families

SANTA MONICA, Calif., Aug. 22, 2022 (GLOBE NEWSWIRE) -- Opiant Pharmaceuticals, Inc. (Opiant) (NASDAQ: OPNT) today announced that the United States Patent and Trademark Office (USPTO) has issued a Notice of Allowance for Opiant’s pipeline candidate OPNT004 (drinabant) for the treatment of cannabinoid hyperemesis syndrome (CHS), a condition among cannabis users that leads to repeated and severe bouts of vomiting. A Notice of Allowance is issued after the USPTO decides that a patent can be granted from an application. "This patent allowance is welcome news, and a testament to our commitment of bringing innovative science to the treatment of addictions and drug overdose,” said Roger Crystal, M.D., President and Chief Executive Officer of Opiant. “With the consumption of cannabis increasing, due in large part to the legalization of its recreational use, we are developing OPNT004 in anticipation that emergency departments may receive more and more cases of side effects related to chronic or heavy use.1 Drinabant is being developed as an injection, which is ideal for these patients, who have frequent bouts of intractable nausea and vomiting that are generally unresponsive to traditional anti-emetics.” The USPTO issued a Notice of Allowance for U.S. Patent Application 16/904,359, entitled “Compositions and methods for treating cannabinoid hyperemesis syndrome with a cannabinoid receptor antagonist” for OPNT004. This patent covers OPNT004 as a method of treatment for CHS using drinabant administered as a parenteral formulation. Opiant expects this patent to issue within the next few months and expire no earlier than 2040. About OPNT004 OPNT004 (drinabant) is a high affinity, CB-1 antagonist for the treatment of excessive cannabinoid use. Cannabinoids are compounds found in the cannabis plant or made synthetically, that bind to cannabinoid receptors found in the central nervous system, gastrointestinal tract and immune system. With support from the National Center for Advancing Translational Sciences (NCATS), Opiant is developing a formulation for the parenteral administration of OPNT004 for the potential treatment of cannabinoid-related toxicities, which include cannabinoid hyperemesis syndrome (CHS) and acute cannabinoid overdose (ACO), a condition when excessive tetrahydrocannabinol (THC) can cause anxiety, paranoia, visual and auditory hallucinations, and nausea. There are currently no FDA approved therapeutics for either CHS or ACO. Opiant expects to initiate Phase I studies for OPNT004 in 2023. Opiant is developing drinabant under a license from Sanofi-Aventis. About cannabis hyperemesis syndrome (CHS) Cannabinoid hyperemesis syndrome (CHS) is a syndrome of cyclic vomiting associated with cannabis use. While the onset of symptoms is sudden, CHS occurs in people who use cannabis regularly, and has been linked to long term cannabis use. People with CHS experience reoccurring episodes of nausea, vomiting, dehydration, and abdominal pain, which can result in frequent visits to the emergency department. The condition is generally unresponsive to traditional anti-emetics, which are medications used to prevent or treat nausea and vomiting. However, CHS can lead to health complications if left untreated. Only a small portion of people who regularly use cannabis develop CHS. Because CHS was first described in the medical literature less than 20 years ago, many people may have it and either not report it or are misdiagnosed. One analysis found that CHS was responsible for up to 6% of patients who visited the emergency room for vomiting.2 About Opiant Pharmaceuticals, Inc. Opiant Pharmaceuticals, Inc., the company that developed NARCAN® Nasal Spray, is building a leading franchise of new medicines to combat addictions and drug overdose. For more information visit: www.opiant.com.