Article
作者: Leavy, Olivia C ; Harris, Victoria C ; Bolton, Charlotte E ; McNarry, Melitta ; Duncan, Sallyanne ; Singh, Sally ; Evans, Rachael A ; Yates, Tom ; Saunders, Ruth M ; Singapuri, Amisha ; Coffey, Margaret ; Kulkarni, Amit ; Scott, Janet ; Horsley, Alex Robert ; Evison, Felicity ; Chalder, Trudie ; Bishop, Lettie ; Donaldson, Gavin ; Nolan, Claire Marie ; Docherty, Annemarie ; Poinasamy, Krisnah ; Whitney, Julie ; Hart, Nicholas ; Richardson, Matthew ; Houchen-Wolloff, Linzy ; Ho, Ling-Pei ; Wain, Louise V ; Marks, Michael ; Pimm, John ; Man, William ; Sereno, Marco ; Harrison, Ewen ; Sharma, Neil ; Chalmers, James ; Quint, Jennifer K ; Daynes, Enya ; Shikotra, Aarti ; Omer, Elneima ; Sargent, Jack ; Greening, Neil J ; Raman, Betty ; Dawson, Camilla ; McAuley, Hamish ; Clunie, Gemma ; Wallace, Sarah ; Brightling, Chris ; Lone, Nazir I ; Wootton, Dan Gower
ObjectiveIdentify prevalence of self-reported swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19.DesignMulticentre prospective observational cohort study using questionnaire data at visit 1 (2–7 months post discharge) and visit 2 (10–14 months post discharge) from hospitalised patients in the UK. Lasso logistic regression analysis was undertaken to identify associations.Setting64 UK acute hospital Trusts.ParticipantsAdults aged >18 years, discharged from an admissions unit or ward at a UK hospital with COVID-19.Main outcome measuresSelf-reported swallow, communication, voice and cognitive compromise.ResultsCompromised swallowing post intensive care unit (post-ICU) admission was reported in 20% (188/955); 60% with swallow problems received invasive mechanical ventilation and were more likely to have undergone proning (p=0.039). Voice problems were reported in 34% (319/946) post-ICU admission who were more likely to have received invasive (p<0.001) or non-invasive ventilation (p=0.001) and to have been proned (p<0.001). Communication compromise was reported in 23% (527/2275) univariable analysis identified associations with younger age (p<0.001), female sex (p<0.001), social deprivation (p<0.001) and being a healthcare worker (p=0.010). Cognitive issues were reported by 70% (1598/2275), consistent at both visits, at visit 1 respondents were more likely to have higher baseline comorbidities and at visit 2 were associated with greater social deprivation (p<0.001).ConclusionSwallow, communication, voice and cognitive problems were prevalent post hospitalisation for COVID-19, alongside whole system compromise including reduced mobility and overall health scores. Research and testing of rehabilitation interventions are required at pace to explore these issues.